DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34353 and Kirrel2

DIOPT Version :9

Sequence 1:	NP_001287571.1	Gene:	CG34353 / 5740590	FlyBaseID:	FBgn0085382	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_766486.1	Gene:	Kirrel2 / 243911	MGIID:	2442334	Length:	700	Species:	Mus musculus

Alignment Length:	403	Identity:	76/403 - (18%)
Similarity:	127/403 - (31%)	Gaps:	129/403 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 NEPMFISRSETFKFITGETIVLPCEVANTDTY--VVAW-KRGIAILTAGSVKVTPDPRVRLVNG- 144
            :.|.|:.:.|....:.||...|||.:.   .|  :|.| |.|:|:   |..:..|......::|
Mouse    19 SSPHFLQQPEDMVVLLGEEARLPCALG---AYRGLVQWTKDGLAL---GGERDLPGWSRYWISGN 77

  Fly   145 -----FNLQIRDALPTDAGDYICQIATMDPREITHTVEILVPPRIHHISTGGHLQVKKGSSVRIE 204
                 .:|.|:.....|...|.||.:....|.....:.::|||....:..|..:.:..|....:.
Mouse    78 SASGQHDLHIKPVELEDEASYECQASQAGLRSRPAQLHVMVPPEAPQVLGGPSVSLVAGVPGNLT 142

  Fly   205 CSATGN--PMPNVTWSR--------------------------------------------KNNI 223
            |.:.|:  |.|.:.|.|                                            ::..
Mouse   143 CRSRGDSRPAPELLWFRDGIRLDGSSFHQTTLKDKATGTVENTLFLTPSSHDDGATLICRARSQA 207

  Fly   224 LPNGEE-------------KLHSHVLSIENVDR------------------HKGGVYI------- 250
            ||.|.:             .|.:...:::..::                  .|||..:
Mouse   208 LPTGRDTAVTLSLQYPPMVTLSAEPQTVQEGEKVTFLCQATAQPPVTGYRWAKGGSPVLGARGPR 272

  Fly   251 ---------------CTANNRVGQPASSQVVLHVLFSPEISVERPVVFSGEGHEATLVCIVHGET 300
                           |..:|.||. |:....|.||:.|.:..:...|....|.:|:..|:..|..
Mouse   273 LEVVADATFLTEPVSCEVSNAVGS-ANRSTALEVLYGPILQAKPKSVSVDVGKDASFSCVWRGNP 336

  Fly   301 QPEVIWFKDTMQLDTTERHIMETRGSRHTLIIRKVHPQDFGNYSCVAENQL-----GKARKTLQL 360
            .|.:.|         |.....:...|..||.:..|..:|.|:|.|.||.:.     |||:..|.:
Mouse   337 LPRITW---------TRMGGSQVLSSGPTLRLPSVALEDAGDYVCRAEPRRTGLGGGKAQARLTV 392

  Fly   361 SGKPNVAVFNSPP 373
            :..|.|......|
Mouse   393 NAPPVVTALQPAP 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34353	NP_001287571.1	IG_like	100..180	CDD:214653	21/88 (24%)
		Ig	103..177	CDD:143165	19/82 (23%)
		IG_like	191..269	CDD:214653	20/176 (11%)
		IGc2	198..258	CDD:197706	16/158 (10%)
		I-set	273..360	CDD:254352	23/91 (25%)
		Ig	290..359	CDD:143165	19/73 (26%)
		FN3	<466..524	CDD:238020
Kirrel2	NP_766486.1	IG	27..116	CDD:214652	22/94 (23%)
		Ig	122..220	CDD:416386	11/97 (11%)
		Ig strand A	123..126	CDD:409353	0/2 (0%)
		Ig strand A'	129..133	CDD:409353	0/3 (0%)
		Ig strand B	140..147	CDD:409353	1/6 (17%)
		Cell attachment site. /evidence=ECO:0000255	146..148		0/1 (0%)
		Ig strand C	153..158	CDD:409353	1/4 (25%)
		Ig strand C'	161..163	CDD:409353	0/1 (0%)
		Ig strand D	166..173	CDD:409353	0/6 (0%)
		Ig strand E	180..188	CDD:409353	0/7 (0%)
		Ig strand F	197..205	CDD:409353	0/7 (0%)
		Ig strand G	211..217	CDD:409353	1/5 (20%)
		Ig_3	223..292	CDD:404760	5/68 (7%)
		Ig strand B	241..245	CDD:409353	0/3 (0%)
		Ig strand C	255..259	CDD:409353	0/3 (0%)
		Ig strand E	272..275	CDD:409353	0/2 (0%)
		Ig strand F	281..290	CDD:409353	1/8 (13%)
		Ig strand G	298..301	CDD:409353	0/2 (0%)
		Ig	315..392	CDD:416386	22/85 (26%)
		Ig strand A'	316..321	CDD:409353	1/4 (25%)
		Ig strand B	324..333	CDD:409353	2/8 (25%)
		Ig strand C	339..343	CDD:409353	1/12 (8%)
		Ig strand C'	346..348	CDD:409353	0/1 (0%)
		Ig strand D	351..354	CDD:409353	0/2 (0%)
		Ig strand E	355..360	CDD:409353	2/4 (50%)
		Ig strand F	368..376	CDD:409353	4/7 (57%)
		Ig strand G	382..392	CDD:409353	4/9 (44%)
		Ig	394..498	CDD:416386	3/12 (25%)
		Ig strand A	395..399	CDD:409353	1/3 (33%)
		Ig strand A'	401..404	CDD:409353	0/2 (0%)
		Ig strand B	412..419	CDD:409353
		Ig strand C	426..431	CDD:409353
		Ig strand C'	433..436	CDD:409353
		Ig strand D	444..451	CDD:409353
		Ig strand E	461..468	CDD:409353
		Ig strand F	479..486	CDD:409353
		Ig strand G	489..496	CDD:409353
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..576
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	671..700
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900