DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34353 and wrk-1

DIOPT Version :9

Sequence 1:	NP_001287571.1	Gene:	CG34353 / 5740590	FlyBaseID:	FBgn0085382	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001024651.1	Gene:	wrk-1 / 181093	WormBaseID:	WBGene00006942	Length:	452	Species:	Caenorhabditis elegans

Alignment Length:	490	Identity:	100/490 - (20%)
Similarity:	174/490 - (35%)	Gaps:	117/490 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 LAIAVVSLHFESVSAQSMMTKNEPMFISRSETFKFITGETIVLPCEVANTDTYVVAWKR------ 121
            |.:.::.|...|.||| :.||...:....        ||::.|.|||.:....:: |::
Worm     4 LVLLILGLLIASTSAQ-IRTKGGTLIAKE--------GESLTLRCEVEDPSVAII-WRKNTEVVA 58

  Fly   122 ----------GIAILTAGSVKVTPDPRVRLVNGFNLQIRDALPTDAGDYICQIATMDPREITHTV 176
                      |..|...||..|....||..:|..|.....|.|..:..::.::....|.:::...
Worm    59 VDDEILDTYGGYEISMEGSTSVLTIKRVEPINSANYSCALAEPEVSVTFVIKVQVFKPTQVSVKP 123

  Fly   177 EILVPP--RIHHISTGGHLQVKKGSSVRIECSA-TGNPMPNVTWSRKNNILPNGEEKLHSHV-LS 237
            .:::.|  .::|...|       ..::.|.|.. .|||.|.|.|:::...||...::.|... :.
Worm   124 LVVISPDTGVYHARVG-------EKNLVITCHVKEGNPKPGVVWTKQAAKLPEDIKREHGGARIV 181

  Fly   238 IENVDRHKGGVYICTANNRVGQPASSQVVLHVL--------FSPEISVERPVVFSGEGHEATLVC 294
            |..|.:|..|.|.|.|.|..|...:: :.:||.        ..|.:..|...:...:...|:..|
Worm   182 ITEVKKHHAGKYNCLAENIAGSDRAT-IDIHVAEPLQGEREEKPWVKNEDTFIPVRKNQNASFWC 245

  Fly   295 IVHGETQPEVIW--------FKDTMQLDTTERHIMETRGSRHTLIIRKVHPQDFGNYSCVAENQL 351
            ...|...|:|.|        |.|.....|:|........|:.||.:..:..:.||:|:|...|:|
Worm   246 TYDGTPVPQVEWLFNGYKINFNDEKFKKTSETAQRLNGYSKSTLTVGDISEEAFGDYACRISNKL 310

  Fly   352 GKARKTLQLSGKPNVAVFNSPPISQYKDRYNISWAVDSHSPIEEYKLSFRKLPQGHEVVGNAIDS 416
            |.....:.:||:|      .||...: |...::|.|.:...|.||:|..|.     |...:.:..
Worm   311 GSVTAVVHVSGRP------GPPQLSF-DESELTWTVRAFDKILEYQLCHRL-----ENADHFLPE 363

  Fly   417 SSSSSSMSSSSSQMYGSGLHAHRIGSNMGGLSGLSGSGSYSGYGNVIHWGHNDWRNVVLPAVPVS 481
            ..:|..:..|.:.                                    |.:.|.:    .:.:|
Worm   364 DCNSVRVKKSDNN------------------------------------GDDKWTH----TIDLS 388

  Fly   482 HHYAQGMSYMVRGLDPDQHYEATVQSRNRYGWSDL 516
            .....|..|.|:           :::||..||..:
Worm   389 TFLEHGNKYHVQ-----------LKARNALGWGSM 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34353	NP_001287571.1	IG_like	100..180	CDD:214653	19/95 (20%)
		Ig	103..177	CDD:143165	17/89 (19%)
		IG_like	191..269	CDD:214653	20/79 (25%)
		IGc2	198..258	CDD:197706	19/61 (31%)
		I-set	273..360	CDD:254352	22/94 (23%)
		Ig	290..359	CDD:143165	20/76 (26%)
		FN3	<466..524	CDD:238020	10/51 (20%)
wrk-1	NP_001024651.1	IG_like	25..113	CDD:214653	18/96 (19%)
		IGc2	31..96	CDD:197706	16/73 (22%)
		IG_like	132..212	CDD:214653	22/87 (25%)
		IGc2	142..202	CDD:197706	19/59 (32%)
		IG_like	235..320	CDD:214653	20/84 (24%)
		Ig	245..318	CDD:143165	19/72 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	41	1.000	Domainoid score	I8517
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	118	1.000	Inparanoid score	I3357
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28857
OrthoDB	1	1.010	-	-		D332048at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14108
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.980