DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34353 and Dscam

DIOPT Version :9

Sequence 1:	NP_001287571.1	Gene:	CG34353 / 5740590	FlyBaseID:	FBgn0085382	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	XP_038943864.1	Gene:	Dscam / 171119	RGDID:	619992	Length:	2034	Species:	Rattus norvegicus

Alignment Length:	487	Identity:	109/487 - (22%)
Similarity:	180/487 - (36%)	Gaps:	113/487 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 SVSAQSMMTKNEPMFISRSETFKFITGETIVLPCEVANTDTYV-VAWKRGIAILTAGSVKVTPDP 137
            |.|....:|...|.||...|..:|..|:.:.:||.|.:.|..: :.|::....:.| |:.||.|
  Rat   584 STSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPA-SLGVTID- 646

  Fly   138 RVRLVNGFNLQIRDALPTDAGDYICQIATMDPREITHTVEIL--VPPRIHHISTGGHLQVKK--- 197
            .:...:  :|:|.:......|:|.| ||..:...:.|..:::  |||:.       .:|.:.
  Rat   647 NIDFTS--SLRISNLSLMHNGNYTC-IARNEAAAVEHQSQLIVRVPPKF-------VVQPRDQDG 701

  Fly   198 --GSSVRIECSATGNPMPNVTWSRKNN--------ILPNGE-EKLHSHVLSIENVDRHKGGVYIC 251
              |.:|.:.|||.|.|:|.:.|.....        |..||. :.|.:..|.|::|.....|.|:|
  Rat   702 IYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLC 766

  Fly   252 TANNRVGQPASSQVVLHVLFSPEISVERPVVFSGEGHEATLVCIVHGETQPEVIWFKDTMQLD-T 315
            ..:|.||...|..:.|.|.....|:.......:.:|....:.|..|||....|.|.|:...:: .
  Rat   767 KVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQRKEMSCTAHGEKPIIVRWEKEDRIINPE 831

  Fly   316 TERHIMETR--GSR--HTLIIRKVHPQDFGNYSCVAENQLGKARKTLQLSGKPNVAVFNSPPISQ 376
            ..|:::.|:  |..  .||.|.....:|.|.:||.|.|..|:.|..:||:    |.....||..:
  Rat   832 MARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLT----VQEPPDPPEIE 892

  Fly   377 YKD----RYNISWAV--DSHSPIEEYKLSFRKLPQGHEVVGNAIDSSSSSSSMSSSSSQMYGSGL 435
            .||    ...:.|.:  |.:|||..|.:..:          |..||..|:......|.|:
  Rat   893 IKDVKARTITLRWTMGFDGNSPITGYDIECK----------NKSDSWDSAQRTKDVSPQL----- 942

  Fly   436 HAHRIGSNMGGLSGLSGSGSYSGYGNVIHWGHNDWRNVVLPAVPVSHHYAQGMSYMVRGLDPDQH 500
                                                                .|..:..:.|...
  Rat   943 ----------------------------------------------------NSATIIDIHPSST 955

  Fly   501 YEATVQSRNRYGWSDLTNSFVFST--SSNDGP 530
            |...:.::||.|.|:.:|....:.  ::.|||
  Rat   956 YSIRMYAKNRIGKSEPSNEITITADEAAPDGP 987

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34353	NP_001287571.1	IG_like	100..180	CDD:214653	19/82 (23%)
		Ig	103..177	CDD:143165	18/74 (24%)
		IG_like	191..269	CDD:214653	25/91 (27%)
		IGc2	198..258	CDD:197706	20/68 (29%)
		I-set	273..360	CDD:254352	23/91 (25%)
		Ig	290..359	CDD:143165	21/73 (29%)
		FN3	<466..524	CDD:238020	8/57 (14%)
Dscam	XP_038943864.1	Ig	26..121	CDD:416386
		Ig strand A'	33..37	CDD:409353
		Ig strand B	40..49	CDD:409353
		Ig strand C	55..61	CDD:409353
		Ig strand C'	63..66	CDD:409353
		Ig strand D	72..75	CDD:409353
		Ig strand E	80..85	CDD:409353
		Ig strand F	98..106	CDD:409353
		Ig strand G	109..121	CDD:409353
		Ig	125..210	CDD:416386
		Ig strand A	126..130	CDD:409353
		Ig strand A'	132..136	CDD:409353
		Ig strand B	139..149	CDD:409353
		Ig strand C	157..163	CDD:409353
		Ig strand C'	164..167	CDD:409353
		Ig strand E	179..185	CDD:409353
		Ig strand F	191..201	CDD:409353
		IGc2	239..300	CDD:197706
		Ig strand B	242..246	CDD:409353
		Ig strand C	255..259	CDD:409353
		Ig strand F	290..295	CDD:409353
		Ig	313..395	CDD:416386
		Ig strand A	314..319	CDD:409353
		Ig strand A'	322..326	CDD:409353
		Ig strand B	329..339	CDD:409353
		Ig strand C	344..350	CDD:409353
		Ig strand C'	351..354	CDD:409353
		Ig strand E	368..374	CDD:409353
		Ig strand F	381..389	CDD:409353
		Ig	406..501	CDD:416386
		Ig strand A	406..409	CDD:409353
		Ig strand A'	415..419	CDD:409353
		Ig strand B	422..431	CDD:409353
		Ig strand C	436..442	CDD:409353
		Ig strand C'	444..447	CDD:409353
		Ig strand D	452..460	CDD:409353
		Ig strand E	464..473	CDD:409353
		Ig strand F	480..488	CDD:409353
		Ig strand G	491..501	CDD:409353
		Ig	504..593	CDD:416386	2/8 (25%)
		Ig strand A	505..507	CDD:409353
		Ig strand A'	512..516	CDD:409353
		Ig strand B	519..526	CDD:409353
		Ig strand C	533..539	CDD:409353
		Ig strand C'	540..542	CDD:409353
		Ig strand D	549..553	CDD:409353
		Ig strand E	557..563	CDD:409353
		Ig strand F	571..579	CDD:409353
		Ig strand G	583..593	CDD:409353	2/8 (25%)
		Ig	596..686	CDD:416386	24/94 (26%)
		Ig strand A	597..599	CDD:409353	0/1 (0%)
		Ig strand B	611..620	CDD:409353	2/8 (25%)
		Ig strand C	625..632	CDD:409353	1/6 (17%)
		Ig strand C'	634..636	CDD:409353	0/1 (0%)
		Ig strand D	643..648	CDD:409353	3/5 (60%)
		Ig strand E	651..658	CDD:409353	2/8 (25%)
		Ig strand F	665..673	CDD:409353	5/8 (63%)
		Ig strand G	676..685	CDD:409353	1/8 (13%)
		Ig_DSCAM	689..784	CDD:409397	27/101 (27%)
		Ig strand B	707..711	CDD:409397	1/3 (33%)
		Ig strand C	720..724	CDD:409397	0/3 (0%)
		Ig strand E	749..753	CDD:409397	1/3 (33%)
		Ig strand F	763..768	CDD:409397	2/4 (50%)
		Ig strand G	777..780	CDD:409397	1/2 (50%)
Ig_DSCAM	785..884	CDD:409398	26/102 (25%)
Ig strand B	805..809	CDD:409398	0/3 (0%)
Ig strand C	818..822	CDD:409398	1/3 (33%)
Ig strand E	848..852	CDD:409398	2/3 (67%)
Ig strand F	862..867	CDD:409398	2/4 (50%)
Ig strand G	875..878	CDD:409398	1/2 (50%)
FN3	885..978	CDD:238020	24/159 (15%)
FN3	986..1083	CDD:238020	2/2 (100%)
FN3	1091..1184	CDD:238020
FN3	1189..1278	CDD:238020
Ig_3	1287..1363	CDD:404760
Ig strand B	1303..1307	CDD:409353
Ig strand C	1316..1320	CDD:409353
Ig strand E	1342..1346	CDD:409353
Ig strand F	1356..1361	CDD:409353
FN3	1380..1470	CDD:238020
FN3	1486..1555	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810