DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34353 and Fgfrl1

DIOPT Version :9

Sequence 1:	NP_001287571.1	Gene:	CG34353 / 5740590	FlyBaseID:	FBgn0085382	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_473412.1	Gene:	Fgfrl1 / 116701	MGIID:	2150920	Length:	529	Species:	Mus musculus

Alignment Length:	470	Identity:	95/470 - (20%)
Similarity:	171/470 - (36%)	Gaps:	100/470 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 PHILFLAIAVVSLHFESVSAQSMMTKNEPMFISRSETFKFITGETIVLPCEVANTDTYVVAW-KR 121
            |.:|.|.:..:.....:.....|..|..|..::|       .|.|:.|.|.|......:..| |.
Mouse     5 PALLLLLLGALPSAEAARGPPRMADKVVPRQVAR-------LGRTVRLQCPVEGDPPPLTMWTKD 62

  Fly   122 GIAILTAGS-VKVTPDPRVRLVNGFNLQIRDALPTDAGDYICQIAT-MDPREITHTVEIL--VPP 182
            |..|.:..| .:|.|.         .|::::....|||.|:|:... .....:.:|:.|:  :.|
Mouse    63 GRTIHSGWSRFRVLPQ---------GLKVKEVEAEDAGVYVCKATNGFGSLSVNYTLIIMDDISP 118

  Fly   183 RIHHISTGG-----------------HLQVKK----------GSSVRIECSATGNPMPNVTWSRK 220
            .......||                 ..|..|          |||||::|.|:|:|.|::.|.:.
Mouse   119 GKESPGPGGSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDIMWMKD 183

  Fly   221 NNILPNGEEKLH---SHVLSIENVDRHKGGVYICTANNRVGQPASS---QVVLHVLFSPEISVER 279
            :..|.:.|...|   ...||::|:.....|.|.|..:|:.|...::   .|:......|.::...
Mouse   184 DQTLTHLEASEHRKKKWTLSLKNLKPEDSGKYTCRVSNKAGAINATYKVDVIQRTRSKPVLTGTH 248

  Fly   280 PVVFSGE-GHEATLVCIVHGETQPEVIWFKDTMQLDTTERH--IMETRGSR-------------- 327
            ||..:.: |...:..|.|..:.:|.:.|.| .::..:..||  .::..|.:
Mouse   249 PVNTTVDFGGTTSFQCKVRSDVKPVIQWLK-RVEYGSEGRHNSTIDVGGQKFVVLPTGDVWSRPD 312

  Fly   328 ----HTLIIRKVHPQDFGNYSCVAENQLGKARKTLQLSGKPNVAVFNSPPISQYKDRYNISWAVD 388
                :.|:|.:....|.|.|.|:..|.:|.:.::..|:..|:... ..||::......::.|.|.
Mouse   313 GSYLNKLLISRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKP-PGPPMASSSSSTSLPWPVV 376

  Fly   389 SHSP---------IEEYKLSFRKLP---------QGHEVVGNAIDSSSSSS--SMSSSSSQMYGS 433
            ...|         :..:....:|.|         .||...|.:.:.|....  |::....:.:||
Mouse   377 IGIPAGAVFILGTVLLWLCQTKKKPCAPASTLPVPGHRPPGTSRERSGDKDLPSLAVGICEEHGS 441

  Fly   434 GL---HAHRIGSNMG 445
            .:   |....||..|
Mouse   442 AMAPQHILASGSTAG 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34353	NP_001287571.1	IG_like	100..180	CDD:214653	20/84 (24%)
		Ig	103..177	CDD:143165	17/76 (22%)
		IG_like	191..269	CDD:214653	26/110 (24%)
		IGc2	198..258	CDD:197706	21/62 (34%)
		I-set	273..360	CDD:254352	20/107 (19%)
		Ig	290..359	CDD:143165	16/88 (18%)
		FN3	<466..524	CDD:238020
Fgfrl1	NP_473412.1	I-set	29..112	CDD:369462	22/98 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	116..151		4/34 (12%)
		Ig2_FGFRL1-like	153..234	CDD:143264	22/80 (28%)
		Ig	257..351	CDD:386229	18/94 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	405..427		4/21 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910