DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34353 and ncam2

DIOPT Version :9

Sequence 1:	NP_001287571.1	Gene:	CG34353 / 5740590	FlyBaseID:	FBgn0085382	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	XP_012811963.1	Gene:	ncam2 / 100151722	XenbaseID:	XB-GENE-1217730	Length:	865	Species:	Xenopus tropicalis

Alignment Length:	505	Identity:	112/505 - (22%)
Similarity:	197/505 - (39%)	Gaps:	117/505 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 KFITGETIVLPCEVANTDTYVVAWKRGIAILTAGSVKVTPDPRVRLVNGFNLQIRDALPTDAGDY 160
            :|..||...:.|.|:::...:|.|     :.....|....|.|..::...||||::....|.|.|
Frog   154 EFKRGENAEVLCLVSSSPAPMVRW-----LNNREDVTDIDDRRFAMLPNNNLQIKNISKRDEGIY 213

  Fly   161 ICQ-----IATMDPREITHTVEILVPPRIHHISTGGHLQVKKGSSVRIECSATGNPMPNVTWSRK 220
            .|:     ...:|.|:|  :|.:.|||.|.......:....:...:.:.|.|||:|.|.:||.|.
Frog   214 RCEGRVEVRGEIDFRDI--SVIVNVPPEILAQQRSFNATADRLEDITLFCRATGSPKPYITWHRN 276

  Fly   221 NNILPNGEE---KLHSHVLSIENVDRHKGGVYICTANNRVGQPASSQVVLHVLFSPEISVERPVV 282
            ..::...|:   :..:..|:::|:.....|:|:|.|.|:.|. ...|..|.|...|.|...:...
Frog   277 GKLVEENEKYDLREDNTELTVKNIISTDSGLYVCRATNKAGF-TEKQSFLQVFVQPHIVQLQNET 340

  Fly   283 FSGEGHEATLVCIVHGETQPEVIWFKDTMQL-----DTTERHIMETRG--SRHTLIIRKVHPQDF 340
            ....|| .||.|...||..||:.|.:.:..:     |.::...:|:.|  .:.:|.|:.|...|.
Frog   341 TIEHGH-VTLTCEAEGEPIPEITWKRSSDGMIFYDGDKSQDGRIESTGHHGKSSLHIKSVMLSDA 404

  Fly   341 GNYSCVAENQLGKARKTLQLS------------------GKP-NVA--VFNSPP----------- 373
            |.|.|.|.:::|..:|::.|:                  ..| |::  |.::||
Frog   405 GRYDCEAASRIGGHQKSMYLNIEYAPKFISNQTIYYSWENNPINISCDVTSNPPSSIYWSRDKLL 469

  Fly   374 --------ISQYKD-----------------RYNISWAVDS-HSPIEEYKLSFRKLPQ---GHEV 409
                    |..|:|                 |||.: |::| .|.|:||.|:...:|.   |..|
Frog   470 LPARNITNIKTYRDGKRILLEITPLSDNDFGRYNCT-AINSIGSRIQEYILTLADVPSSPYGLRV 533

  Fly   410 VGNAIDSSSSSSSMSSSSSQMYGSGLHAHRIGSNMGGLSGLSGSGSYSGYGNVIHWGHNDWRNVV 474
            :           .:|.:.::::.:...:|      ||:.              ||....|::.|.
Frog   534 I-----------ELSQTYAKVFFNKPDSH------GGVP--------------IHHYQMDFKEVS 567

  Fly   475 LPAVPVSHHYAQGMSYMVRGLDPDQHYEATVQSRNRYGWSDLTNSFVFST 524
            .....|...:......::..||.:..||..|.:.|..|..:.:.:.:|.|
Frog   568 SEIWKVVRSHGTQTIIVLGNLDANTTYEVKVAAVNGKGKGEYSKTEIFQT 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34353	NP_001287571.1	IG_like	100..180	CDD:214653	21/84 (25%)
		Ig	103..177	CDD:143165	18/78 (23%)
		IG_like	191..269	CDD:214653	20/80 (25%)
		IGc2	198..258	CDD:197706	17/62 (27%)
		I-set	273..360	CDD:254352	25/93 (27%)
		Ig	290..359	CDD:143165	21/75 (28%)
		FN3	<466..524	CDD:238020	11/57 (19%)
ncam2	XP_012811963.1	Ig	50..141	CDD:386229
		IG_like	150..234	CDD:214653	22/86 (26%)
		Ig	237..330	CDD:386229	24/93 (26%)
		Ig	329..426	CDD:386229	26/97 (27%)
		IG_like	442..520	CDD:214653	17/78 (22%)
		FN3	525..617	CDD:238020	20/122 (16%)
		fn3	623..706	CDD:365830
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910