Protein Alignment CG34370 and Cubn

DIOPT Version :10

• Sequence 1: NP_995921.2
• Gene: CG34370 / 5740565
• FlyBaseID: FBgn0085399
• Length: 952
• Species: Drosophila melanogaster
• Sequence 2: NP_001074553.1
• Gene: Cubn / 65969
• MGIID: 1931256
• Length: 3623
• Species: Mus musculus
• Alignment Length: 1120
• Identity: 223/1120 - (19%)
• Similarity: 343/1120 - (30%)
• Gaps: 439/1120 - (39%)

  Fly    81 TVDIFE--DISSPEVSNQNVGRPLTCWYRFRTLKGAPRDFVLRLRFKKFKV--GQLLNAT----- 136
            |::|:.  |..||.::......|..     ..::.:..|..|.:|||....  |:..||:
Mouse  1448 TLEIYTGLDFHSPRIAQLCSRSPSA-----NPMQISSTDNELAIRFKTDSSLNGRGFNASWRAVP 1507

  Fly   137 -HCEGGYLQIVDGNAKTDVSNRREPGMFCGEAEQPQTFISETSYVKVLFHTDNF----TDQTYFT 196
             .| ||..|:..|    ::.:...|..:....| ....|....|.:||.:..:|    ||....|
Mouse  1508 GGC-GGIFQVSRG----EIHSPNYPNNYRANTE-CSWIIQVEKYHRVLLNITDFDLEATDSCLMT 1566

  Fly   197 FDSRAEQQTEVYLRYG-QHPELYPN-------------RRGEVVQGSYCEREYRDCRLQTC---- 243
            :|..:...|.|....| |.|   ||             :.|...|......::|    |.|
Mouse  1567 YDGSSSANTRVATVCGRQQP---PNSITSSGNSLFVRFQSGSSSQSRGFRAQFR----QECGAHI 1624

  Fly   244 ------YVQSPAYPGLYPRALNCRYKLHTRQPYIKLYLQNEQFAVDGQRCENVMTCPIRPIGSGN 302
                  .:.||.||..||...||.:.:..:.|:..:.|....|.:                 ..:
Mouse  1625 ITDSSDSISSPLYPANYPNNQNCTWIIEAQPPFNHIALSFTHFHL-----------------QSS 1672

  Fly   303 EHCPYDWLAVYDGRDEHSPLIGKFCGLGKFPFSIIGTSQYMYVEFV-----------------TS 350
            ..|..|::.:.||||..:|:.|::||. ..|..||.....:.|.||                 ||
Mouse  1673 TDCTRDFVEILDGRDSDAPVQGRYCGT-SLPHPIISFGNALTVRFVSDSVYGFDGFHAIYSASTS 1736

  Fly   351 PAGPLLNTGFHFNVGNWPGHVETAGIKHGVCDWLLSSD------------SLKDSSASEGIFLSI 403
            ..|....||  ..:.|.||:.|... .:..|.|.::|.            .|::|......|:.|
Mouse  1737 ACGGTFYTG--DGIFNSPGYPEDYH-SNTECVWNIASSPGNHLQLSFLSFQLENSLNCNKDFVEI 1798

  Fly   404 --------------AHWYPPNTSCSYHIKGH---------------------------------V 421
                          .:..|.|.|   .|:||                                 .
Mouse  1799 REGNATGHLMGRYCGNSLPGNYS---SIEGHNLWVRFVSDGSGTGMGFQARFKNIFGNDNIVGTH 1860

  Fly   422 GEIVRLYFP-SFRIN-----------------RIESPILKYEGDC-GESLTIYDSDHADPARIIK 467
            |:|...::| ::.:|                 ||....::...:| .:||.|||..... :|:|.
Mouse  1861 GKIATPFWPGNYPLNSNYRWTVNVDSSHIIHGRILEMDIELTTNCFYDSLKIYDGFDIH-SRLIG 1924

  Fly   468 TFCDTFSRPMEKVDFVSTSPSLYVQFDSKTGSYSGSSLYYWAHYDFFNNTRFGDPVPNT---LCD 529
            |:|.|     ::..|.|:..||..||.|.:.......|..|...|..|.|     :|..   .|.
Mouse  1925 TYCGT-----QRESFSSSRNSLTFQFSSDSSKSGRGFLLEWFAVDVSNVT-----LPTIAPGACG 1979

  Fly   530 EVMY-----------AWKHPGGRLRSPLNSLIFKRTGGSDVRCQYKFVTDRRLYA-RAIIEVNSV 582
            ..|.           .|..|.|              .|:|  |.:      .:|| .:.:|:|.:
Mouse  1980 GYMVTGDTPVFFFSPGWPGPYG--------------NGAD--CIW------IIYAPDSTVELNIL 2022

  Fly   583 SFKELPYNSNACTRCHEERVDKLVIWEERDKYQNNLACFCD-NIPRAVRVISSADQMNLEMIVQG 646
            |.     :..|...|   ..|||:|.:...:....||..|. ::|..:|  |:.:.|.:.....|
Mouse  2023 SM-----DIEAQLSC---SYDKLIIKDGDSRLSQQLAVLCGRSVPGPIR--STGEYMYIRFTSDG 2077

  Fly   647 Q------------------HA----ITS------YFKNPN--------------PLFEATYEF-- 667
            .                  ||    |||      |..|.|              ..||..::.
Mouse  2078 SVTGAGFNASFQKSCGGYLHADRGIITSPKYPDNYLPNLNCSWHVLVQSGLTIAVHFEQPFQIQN 2142

  Fly   668 ----------------------------AHGPLCG---PITLGPSPDGELVFPY----------- 690
                                        .:|..||   |.||..| |.|:...:
Mouse  2143 RDSSCSQGDYLVLRNGPDNHSPPLGPSGGNGRFCGIYTPSTLFTS-DNEMFIQFISDNSNGGQGF 2206

  Fly   691 -----KKALA--------------MVSGPMAP---PEHHYRREKCIWELKVAAQRDLWL------ 727
                 .|:||              .|:.|..|   |:|    .:|||.|:..:.|.:.|
Mouse  2207 KIRYEAKSLACGGTIYIHDANSDGYVTSPNYPANYPQH----AECIWILEAPSGRSIQLQFEDQF 2267

  Fly   728 NLEKARFADRSCDSAKIEVYLAGRLEPRFVVCPENISLARDLPILTTAELGATGADQEPLPVLIQ 792
            |:|:.    .:|.::.:|:                    ||            ||:.. .|||.:
Mouse  2268 NIEET----PNCSASYLEL--------------------RD------------GANSN-APVLSK 2295

  Fly   793 YTGDGQPGRNIFRLVWTE---LFHLPRNPDG-------SLAASLLQDGGCDFRCPGDT----EVC 843
            ..|...| ||     |..   |.:|..:.:|       ....|::..||   ...||:    .|.
Mouse  2296 LCGHTLP-RN-----WVSSRGLMYLKFHTEGGSGYMGFKAKYSIVSCGG---TVSGDSGVIESVG 2351

  Fly   844 IPKHLLCNGIANCPNVTHTSTLSQLTRHIEWNLEQLGLLHHAGDYQQLVLHD---ESPEICLKRD 905
            .|..|..|.:                 ..:|:::.|     .|.|..:...|   :|...|.| |
Mouse  2352 YPTRLYANNV-----------------FCQWHIQGL-----PGHYLTIRFEDFNLQSSPGCAK-D 2393

  Fly   906 LSELPYGKLSLIALG 920
            ..|:.....|.|.||
Mouse  2394 FVEIWENHTSGILLG 2408

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34370	NP_995921.2	CUB	88..195	CDD:238001	25/118 (21%)
		CUB	244..363	CDD:238001	32/135 (24%)
		CUB	407..509	CDD:238001	31/153 (20%)
Cubn	NP_001074553.1	cubilin_NTD	38..132	CDD:412063
		Interaction with AMN. /evidence=ECO:0000250|UniProtKB:O60494	39..46
		EGF_CA	133..164	CDD:238011
		EGF_CA	167..207	CDD:238011
		EGF_CA	260..301	CDD:214542
		EGF_3	306..344	CDD:463759
		EGF_3	350..387	CDD:463759
		EGF_CA	400..430	CDD:238011
		EGF_CA	432..468	CDD:238011
		CUB	474..585	CDD:238001
		CUB	590..699	CDD:238001
		CUB	708..815	CDD:238001
		CUB	817..927	CDD:238001
		CUB	932..1041	CDD:238001
		CUB	1052..1158	CDD:238001
		CUB	1165..1275	CDD:238001
		CUB	1278..1388	CDD:238001
		CUB	1391..1505	CDD:238001	14/61 (23%)
		CUB	1510..1599	CDD:238001	23/97 (24%)
		CUB	1620..1733	CDD:238001	28/130 (22%)
		CUB	1738..1847	CDD:238001	20/114 (18%)
		CUB	1859..1962	CDD:238001	26/108 (24%)
		CUB	1978..2089	CDD:238001	27/142 (19%)
		CUB	2092..2212	CDD:238001	19/120 (16%)
		CUB	2217..2333	CDD:238001	30/162 (19%)
		CUB	2336..2447	CDD:238001	22/99 (22%)
		CUB	2452..2564	CDD:238001
		CUB	2570..2686	CDD:238001
		CUB	2689..2800	CDD:238001
		CUB	2805..2918	CDD:238001
		CUB	2920..3034	CDD:238001
		CUB	3037..3148	CDD:238001
		CUB	3157..3273	CDD:238001
		CUB	3278..3392	CDD:238001
		CUB	3395..3506	CDD:238001
		CUB	3511..3623	CDD:238001