DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34370 and Nrx-IV

DIOPT Version :9

Sequence 1:	NP_001097404.2	Gene:	CG34370 / 5740565	FlyBaseID:	FBgn0085399	Length:	952	Species:	Drosophila melanogaster
Sequence 2:	NP_524034.2	Gene:	Nrx-IV / 39387	FlyBaseID:	FBgn0013997	Length:	1284	Species:	Drosophila melanogaster

Alignment Length:	848	Identity:	166/848 - (19%)
Similarity:	244/848 - (28%)	Gaps:	321/848 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 LLNATHCEGGYLQIVDGNAKTDVSNRREPGMFCGEAEQPQT--FISETSYVKVLFHTDNFTDQTY 194
            |.|..|.:    |.|:.|...|.|...||        .|.|  |.|:...:..|.|:...|.
  Fly   590 LKNVQHVQ----QRVNLNLDVDGSGPLEP--------FPVTCEFYSDGRVITTLSHSQEHTT--- 639

  Fly   195 FTFDSRAE----QQTEVYLRYGQHPELYPNRRGEVVQGSYCEREYRDCRLQTCYVQSPA------ 249
             |.|...|    :|:.:|.......|...||     ..|..:|....||....: .||:
  Fly   640 -TVDGFQEPGSFEQSIMYDANQLQIEALLNR-----SHSCWQRLSYSCRSSRLF-NSPSEAGNFR 697

  Fly   250 ---------------YPGLYPRALNCRY----KLHTRQPYIKLYLQNEQFAVDGQRCENVMTCPI 295
                           :.|..|.:..|..    |.|....:......:.::..||.........|:
  Fly   698 PFSWWISRHNQPMDYWAGALPGSRKCECGILGKCHDPTKWCNCDSNSLEWMEDGGDIREKEYLPV 762

  Fly   296 RPIGSGNEHCPYDWLAVYDGRDEHSPLIGK----FCGLGKF----------PFSIIGTSQYMYVE 346
            |.:..|:...|.|...   ||....||..:    |..:..|          ||. :|.|..:|:|
  Fly   763 RAVKFGDTGTPLDEKM---GRYTLGPLRCEGDDLFSNVVTFRIADASINLPPFD-MGHSGDIYLE 823

  Fly   347 F-----------VTSP---------------------AGPL---LNTGFHFNVGNWPGHVETAGI 376
            |           .|.|                     :|||   :.|.:|.|..||    .|..:
  Fly   824 FRTTQENSVIFHATGPTDYIKLSLNGGNKLQFQYQAGSGPLGVNVGTSYHLNDNNW----HTVSV 884

  Fly   377 KHGVCDWLLSSDSLKDSSASEGIFLSIAHWYPPNTSCSYHI-------------KGHV------- 421
            :....:..|..|....:...|          ||....:.|:             .|:|
  Fly   885 ERNRKEARLVVDGSIKAEVRE----------PPGPVRALHLTSDLVIGATTEYRDGYVGCIRALL 939

  Fly   422 --GEIVRLYFPSFR---------INRIESPILKYEGDCGESLTIYDSD----------------- 458
              |::|.|...|.|         :.|.||......|.|.|....|..|
  Fly   940 LNGKMVDLKEYSKRGLYGISTGCVGRCESNPCLNNGTCIERYDGYSCDCRWSAFKGPICADEIGV 1004

  Fly   459 HADPARIIK-----TFCDTFSRPMEKVDFVSTSP-SLYVQFDSK-TGSYSGSSLYYWAH----YD 512
            :...:.||:     :|..|.:..: :|.|.:|.| ...:.|.|. ||.|....:....|    :|
  Fly  1005 NLRSSSIIRYEFEGSFRSTIAENI-RVGFTTTIPKGFLLGFSSNLTGEYLTIQISNSGHLRCVFD 1068

  Fly   513 F-FNNTRFGDPVPNTLCDEVMYAWKHPGGRLRSPLNSLIFKRTGGSDV--------RCQYKFVTD 568
            | |..            .|:::..||.|  |....:....::.|||.|        ..:|.|
  Fly  1069 FGFER------------QEIIFPKKHFG--LGQYHDMHFMRKNGGSTVVLKVDNYEPVEYNF--- 1116

  Fly   569 RRLYARAIIEVNSVSFKELPYNSNACTRCHEERVDKLVIWEER----DKYQNNLACFCDNIPRAV 629
             .:.|.|..:.|::.:..:..|        |...|..|....|    |.|...| .|..|.|:.|
  Fly  1117 -DIKASADAQFNNIQYMYIGKN--------ESMTDGFVGCVSRVQFDDIYPLKL-MFQQNPPKNV 1171

  Fly   630 RVISSADQMNLEMIVQGQHAITSYFKNPNPLFEATYEFAHGPLCG--PITLGPSPDGELVFPYKK 692
            :.:.:                           :.|.:|     ||  |:|..|
  Fly  1172 KSLGT---------------------------QLTEDF-----CGVEPVTHPP------------ 1192

  Fly   693 ALAMVSGPMAPPEHHYRREKCIWELKVAAQRDLWLNLEKARFADRSCDSAKIE------------ 745
             :.:.:.|  ||                     .::.||.|.|....||..:.
  Fly  1193 -IEIETRP--PP---------------------LVDEEKLRKAYNEVDSVLLACLLVILFLLLIL 1233

  Fly   746 -VYLAGRLEPRFVVCPENISLARDLPILTTAELGATGADQEPLPVLIQYTGDGQPGRNIFRLVWT 809
             .:|.||...|           .....||..:.||.|||.....||...||.....|       |
  Fly  1234 MFFLIGRYLHR-----------HKGDYLTHEDQGADGADDPDDAVLHSTTGHQVRKR-------T 1280

  Fly   810 ELF 812
            |:|
  Fly  1281 EIF 1283

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34370	NP_001097404.2	CUB	88..195	CDD:238001	17/64 (27%)
		CUB	244..363	CDD:238001	34/192 (18%)
		CUB	407..509	CDD:238001	31/156 (20%)
Nrx-IV	NP_524034.2	FA58C	46..185	CDD:214572
		FA58C	57..184	CDD:238014
		LamG	192..340	CDD:238058
		LamG	376..514	CDD:238058
		EGF	546..575	CDD:278437
		Laminin_G_2	824..943	CDD:280389	20/132 (15%)
		EGF_CA	966..998	CDD:238011	7/31 (23%)
		Laminin_G_2	1032..1156	CDD:280389	31/149 (21%)
		4.1m	1239..1255	CDD:128590	5/26 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444879
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930