Protein Alignment CG34370 and Cubn2

DIOPT Version :10

• Sequence 1: NP_995921.2
• Gene: CG34370 / 5740565
• FlyBaseID: FBgn0085399
• Length: 952
• Species: Drosophila melanogaster
• Sequence 2: NP_729748.3
• Gene: Cubn2 / 39334
• FlyBaseID: FBgn0259140
• Length: 3613
• Species: Drosophila melanogaster
• Alignment Length: 1052
• Identity: 211/1052 - (20%)
• Similarity: 336/1052 - (31%)
• Gaps: 404/1052 - (38%)

  Fly    65 GGSGSSSDVSRDHCNKTVDIFEDISSPEVSNQNVGRPLT----------CWYRFRTLKGAPRDFV 119
            |.:|::....|..|..|      |..|  |.|....|.|          |.:..||    .|:.|
  Fly   490 GYTGTTCSHQRFFCGVT------IRGP--SGQLHYPPNTADGDYQADERCPFIIRT----NRNMV 542

  Fly   120 LRLRFKKFKVGQLLNATHCEGGYLQIVDGNAKTDVSNRREPGMFCGEAEQPQTFISETSYVKVLF 184
            |.|.|.:|   ||.::..|...:||:.|||:.:.    |..|.||| :..|.|   ..|.:..
  Fly   543 LNLTFTQF---QLEDSADCTADFLQLHDGNSLSS----RLIGRFCG-SRLPMT---NGSVITT-- 594

  Fly   185 HTDNFTDQTYFTFDSRAEQQTEVYLRYGQHPELYPNRRGEVVQGSY---CEREYRDCRLQTCYVQ 246
                 .:|.:|.|  |::.||:   ..|.|          |:..|.   |.........||..::
  Fly   595 -----QEQVFFWF--RSDNQTQ---GKGFH----------VIWNSLPFSCGETINLTSTQTGVLR 639

  Fly   247 SPAYPGLYPRALNCRYKLHTRQPY---IKLY--------------LQNEQFAVDGQR-----CEN 289
            ||.|||.....|:||::|.....|   ::.|              .|:.....|..|     |::
  Fly   640 SPGYPGQARPELDCRWQLTAPFGYRLLLRFYDISLGSSEASAGNCSQDSLIVYDSDRQLLRACQS 704

  Fly   290 VMTCP----------------IRPIGSGNEH---------------------------------- 304
            :...|                ||...|...|
  Fly   705 IQPPPVYSSSNSLRLDFHTDAIRSDSSFQMHYEVVPGHPGCGGVYTESRGRISGYMNFEVCLYLI 769

  Fly   305 ----------------------CPYDWLAVYDGRDEHSPLIGKFCGLGK----FPFSIIGTSQYM 343
                                  |.|..:.::|||...:||:.:.||..:    .|...||....:
  Fly   770 EQPRGTQVKLVIDRVSLVQSLSCHYLKIEIFDGRSTDAPLLRRICGSHEESELEPIISIGNVILV 834

  Fly   344 YVEFVTSPAGPLLNTGF----------HFNVG-------NWP--------------GHVETAGIK 377
            ..|:..|  |..|:..|          :||..       |:|              |.::|| ::
  Fly   835 RYEYALS--GVRLSKSFDLTYTRVCTGNFNTNSGIISTPNYPGPYFDDMTCTYNLTGPLDTA-VR 896

  Fly   378 HGVCDWLLSSDSLKDSSASEGIFLS----------------IAHWYPPNTSCSYHIKGHVGEIVR 426
            ..:.|..|.:.:.::.::...::||                ::|  ....|..:|..|. |..:|
  Fly   897 MRITDLSLGTANNENDTSYLDVYLSADQKRHIVKSTDNLILLSH--SNRASLVFHGSGG-GRGMR 958

  Fly   427 LYFPSFRINRIESPILKYEGDCGESLTIYDSDHADPAR-----IIKTFCDTF----SRPMEKVDF 482
            |.: :|..|:           ||..|.       :|.|     :..|||..|    .|....:..
  Fly   959 LEY-NFVPNQ-----------CGGFLN-------EPGRRYVTAVRGTFCQWFIDFPGRKKISIHT 1004

  Fly   483 VSTSPSLYVQFDSKT------GSYSGS------------SLY-YWAHYDFFNNTRFGDPVPNTLC 528
            :..:||:.: :|:.|      .|||||            :|: .|...:.: :.:| |.|....|
  Fly  1005 LGPTPSISI-YDNSTSPGKLVNSYSGSVGDVFDGDLLTINLHTNWPRLEIY-SIQF-DIVQQDSC 1066

  Fly   529 DEVMYAWKHPGGRLRSPLNSLIFKRTGGSDVRCQYKFVTDRRLYARAI-IEVNSVSFKELPYNSN 592
            .....|   ..|.::||    .:.:..|....|::..   |..:...| :.|::.:.:| .|:|.
  Fly  1067 GGTFTA---RFGYIKSP----NWPKNYGESQMCEWIL---RAPFGHRIELVVHNFTLEE-EYSST 1120

  Fly   593 ACTRCHEERVDKLVIWEERDKYQNN-------LACFCDN-IPRAVRVISSADQMNLEMIVQGQHA 649
            .|             |.:..:.:|.       :..:|.| ||.  |:.|..:.::|:
  Fly  1121 GC-------------WTDWLEIRNGDSESSPLIGRYCGNEIPS--RIPSFGNVLHLK-------- 1162

  Fly   650 ITSYFKNPNPLFEATYEFA---HGPLCGPITLG--PSPDGELVFPYKKALAMVSGPMAPPEHHYR 709
                ||:.:.:.|..:..:   .|..||    |  .|..|.:..|:  .||...|.:|
  Fly  1163 ----FKSDDSMEEKGFLLSWQQMGAGCG----GKLSSSMGTIHSPH--LLAGNRGILA------- 1210

  Fly   710 REKCIWELKVAAQRDLWLNLEKARFADRSCDSAKIEVYLAGRLEPRFVVCPENISLARDLPILTT 774
               |.|::.||....:.|.|       ||.|:.               :|...::| .|.|  ||
  Fly  1211 ---CDWQIIVAEGSRVSLQL-------RSNDNR---------------ICSGQLTL-YDGP--TT 1247

  Fly   775 AE----LGATGADQEPLP-----VLIQY-TGDGQPGRNIFRLVWTELFHLPRNPDGSLAASLLQD 829
            |.    :...|...:||.     ||::| .|...|....|.|.:                    .
  Fly  1248 ASNPIVIRCNGTIAKPLQSTGNRVLVRYDVGHDAPDGTDFMLNY--------------------Q 1292

  Fly   830 GGCDFRCPGDTEVCIPKHLLCNGIANCPNVTHTSTLSQLTRHIEWNLEQLGLLHHAGDYQQLVLH 894
            ..|..|..|           ..|....||........|   ..||::...|..:|.    ||:..
  Fly  1293 TNCRVRLEG-----------LQGAIETPNFPENYPPGQ---DCEWDIRAGGRKNHL----QLIFS 1339

  Fly   895 DESPE----ICL 902
            ..|.|    |||
  Fly  1340 HLSVEKFSSICL 1351

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34370	NP_995921.2	CUB	88..195	CDD:238001	32/116 (28%)
		CUB	244..363	CDD:238001	37/226 (16%)
		CUB	407..509	CDD:238001	28/129 (22%)
Cubn2	NP_729748.3	cubilin_NTD	38..141	CDD:412063
		EGF_CA	156..190	CDD:238011
		EGF_CA	192..233	CDD:238011
		EGF_CA	290..328	CDD:214542
		EGF_CA	330..374	CDD:214542
		EGF	427..455	CDD:394967
		EGF_CA	462..496	CDD:238011	2/5 (40%)
		CUB	503..619	CDD:238001	42/160 (26%)
		CUB	624..738	CDD:238001	23/113 (20%)
		CUB	745..854	CDD:238001	17/110 (15%)
		CUB	857..963	CDD:238001	18/110 (16%)
		CUB	1066..1179	CDD:238001	26/150 (17%)
		CUB	1185..1293	CDD:238001	36/168 (21%)
		CUB	1303..1406	CDD:238001	15/56 (27%)
		CUB	1411..1523	CDD:238001
		CUB	1530..1648	CDD:238001
		CUB	1754..1862	CDD:238001
		CUB	1979..2091	CDD:238001
		CUB	2210..2321	CDD:238001
		CUB	2327..2441	CDD:238001
		CUB	2688..2782	CDD:412131
		CUB	2810..2911	CDD:238001
		CUB	3029..3143	CDD:238001
		CUB	3169..3249	CDD:412131
		CUB	3499..3607	CDD:238001