DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34370 and Cubn

DIOPT Version :9

Sequence 1:	NP_001097404.2	Gene:	CG34370 / 5740565	FlyBaseID:	FBgn0085399	Length:	952	Species:	Drosophila melanogaster
Sequence 2:	NP_727348.2	Gene:	Cubn / 326235	FlyBaseID:	FBgn0052702	Length:	3750	Species:	Drosophila melanogaster

Alignment Length:	864	Identity:	170/864 - (19%)
Similarity:	284/864 - (32%)	Gaps:	284/864 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 GGGGSGSSSDVSRDHCNKTVDIFEDISSPEVSNQNVGRPLTCWYRFRTLKGAPRDFVLRLRFKKF 127
            |....|.....|.||..  :.:.:|..:.|.         ||::...    ||.:..:||.:..|
  Fly   974 GNDKCGGVHTRSGDHIR--LPVHDDSYAGEA---------TCYWVIM----APANKAIRLHWNSF 1023

  Fly   128 KVGQLLNATHCEGGYLQIVDGNAKTDVSNRREP-GMFCGEAEQPQTFISETSYVKVLF-----HT 186
               .|.||..|...||:|.|.........|.:| ..:||.: .|:..:|.:..:.:.|     .:
  Fly  1024 ---SLENAVDCIYDYLEIYDSLGAQVNDERSKPLAKYCGNS-VPEDLLSHSRQLVLKFVSDYSES 1084

  Fly   187 DNFTDQTYFTFDSRAEQQTEVYLRYGQHPELYPNRRGEVVQGSYCEREYRDCRLQTCYVQSPAYP 251
            |...|.|| ||:.||:....::...|:                               :.||.||
  Fly  1085 DGGFDLTY-TFEDRAKCGGHIHASSGE-------------------------------LTSPEYP 1117

  Fly   252 GLYPRALNCRYKLHTRQPYIKLYLQNEQFAVDGQRCENVMTCPIRPIGSGNEHCPYDWLAVYDGR 316
            ..|...|:|.:.|.....:: |.:|.|.|.::                 .:.:|..|:|.|.:|.
  Fly  1118 ANYSAGLDCDWHLTGTIDHL-LEIQVENFELE-----------------QSPNCSADYLEVRNGG 1164

  Fly   317 DEHSPLIGKFCGLGKFPFSIIGTSQYMYVEFVTSPAGPLLNTGFHFNVGNWPGHVETAGIKHGVC 381
            ...|||||:||| ...|..|.|.|..|.:...|..|  :...||..   .|  .:...|     |
  Fly  1165 GTDSPLIGRFCG-RDIPARIPGFSHEMRLILHTDSA--INGRGFRL---RW--RIFAFG-----C 1216

  Fly   382 DWLLSSDSLKDSSASEGIFLSIAHWYPPNTSCSYHIKGHVGEIVRL-------------YFPSFR 433
            ...|.|:....||.      ...:.||....|.:.|..|.|..:.|             |:.|.:
  Fly  1217 GGSLRSNMGAISSP------RYPNSYPNMAHCEWRISLHPGSGISLLIEDLELEGLSNCYYDSVK 1275

  Fly   434 I------------------NRIESPILKYEGDCGESLTIYDSDHADPARIIKTFCDTFSRPMEKV 480
            |                  :.:.:|:::.|.:.|  ..::|||.::..|..:
  Fly  1276 IYTGIKLPNQSPCKVLCKDDDLHNPLIQLENNKG--TIVFDSDASNTFRGFR------------- 1325

  Fly   481 DFVSTSPSLYVQFDSKTGSYSGSSLYY----WAHYDFFNNTRFGDPVPNTLCDEVMYAWKH---- 537
              :|...:......:.||:.  .||.|    |.......:.....|..|.:..||.:..:|
  Fly  1326 --ISYKANCIRNLTATTGTI--ESLNYMEPFWETIPINCSWTIRAPKGNRVLVEVSHLARHEQHV 1386

  Fly   538 -----PGGRLRSPLNSLIFKRTGGSDVRCQYKFVTDRRL-----YARAIIEVNSVSFKELPYNSN 592
                 |||          .....|.:|:   :.||.:.:     ....:...::|:| :|.|..:
  Fly  1387 PTATMPGG----------LYIVDGRNVQ---EIVTPQAMNISGEVLTVVHNASNVNF-QLDYRID 1437

  Fly   593 ACTRCHEERVDKLVIWEERD---KYQNNLACF--------------------------------- 621
            .|.   ||.......::..:   .|.|||.|:
  Fly  1438 GCM---EELRGTFGFFQSPNYPKMYPNNLECYWLITVEQDSAIELTINNIDLEDSPNCTKDALTV 1499

  Fly   622 -------------CDNIPRAVRVISSADQMNLEMIVQGQHAITSYFKNPNPL-FEATYEFAHGPL 672
                         |.:..:.| :.||..::::..|....|         |.| |||||.......
  Fly  1500 SNHKNSVEVHERHCGSTTKLV-ITSSGHRLHVRFISDNSH---------NGLGFEATYRTVKATC 1554

  Fly   673 CGPITLGPSPDGELVFPYKKALAMVSGPMAPPEHHYRREKCIWELKVAAQRDLW-----LNLEKA 732
            .|.:|   :.:|.:..|        :.|:..|.|    .:|.|:::|:....:.     ||||
  Fly  1555 GGKLT---ARNGVIESP--------NYPLNYPAH----SRCEWQVEVSQHHQIVFEMADLNLE-- 1602

  Fly   733 RFADRSCDSAKIEVY------LAGRLEPRFVVCPENISLARDLPILTTAELGATGADQEPLPVLI 791
              :...|:...:|.|      ..|  |..|.||.:.   ..|..:|:::...|          ::
  Fly  1603 --SGYDCNWDYLEAYDLTEDDTEG--ERLFKVCGDE---TEDDKLLSSSSNMA----------VV 1650

  Fly   792 QYTGDGQPGRNIFRLVWTE 810
            ::..|....:..|||.:.|
  Fly  1651 RFISDDSVSKKGFRLHFHE 1669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34370	NP_001097404.2	CUB	88..195	CDD:238001	26/112 (23%)
		CUB	244..363	CDD:238001	34/118 (29%)
		CUB	407..509	CDD:238001	23/136 (17%)
Cubn	NP_727348.2	EGF_CA	156..190	CDD:238011
		EGF_CA	192..233	CDD:238011
		EGF_CA	282..322	CDD:214542
		EGF_3	328..366	CDD:289699
		EGF	430..457	CDD:278437
		EGF_CA	469..503	CDD:238011
		CUB	509..622	CDD:238001
		CUB	627..737	CDD:238001
		CUB	744..849	CDD:294042
		CUB	853..970	CDD:238001
		CUB	978..1094	CDD:238001	32/135 (24%)
		CUB	1100..1211	CDD:238001	36/167 (22%)
		CUB	1216..1330	CDD:238001	23/136 (17%)
		CUB	1446..1549	CDD:238001	18/112 (16%)
		CUB	1554..1667	CDD:238001	29/146 (20%)
		CUB	1792..1899	CDD:238001
		CUB	1910..1998	CDD:294042
		CUB	2019..2133	CDD:238001
		CUB	2140..2242	CDD:238001
		CUB	2263..2379	CDD:238001
		CUB	2385..2511	CDD:238001
		CUB	2516..2630	CDD:238001
		CUB	<2833..2892	CDD:294042
		CUB	2898..3008	CDD:238001
		CUB	3011..3127	CDD:238001
		CUB	3130..3241	CDD:238001
		CUB	3254..3363	CDD:238001
		CUB	3379..3508	CDD:238001
		CUB	3531..3601	CDD:294042
		CUB	3623..3733	CDD:238001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444868
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840