DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34448 and LPL

DIOPT Version :9

Sequence 1:	NP_001097059.1	Gene:	CG34448 / 5740554	FlyBaseID:	FBgn0085477	Length:	344	Species:	Drosophila melanogaster
Sequence 2:	NP_000228.1	Gene:	LPL / 4023	HGNCID:	6677	Length:	475	Species:	Homo sapiens

Alignment Length:	302	Identity:	84/302 - (27%)
Similarity:	134/302 - (44%)	Gaps:	48/302 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 ILIHGFIGN---RNLTPNLEVRDVLLQTQP-INVISVDYGTLVRWPCYYPWAVNNAPIVSECLAQ 138
            ::|||:...   .:..|.|..  .|.:.:| .|||.||:  |.|...:||.:.....:|.:.:|:
Human    77 MVIHGWTVTGMYESWVPKLVA--ALYKREPDSNVIVVDW--LSRAQEHYPVSAGYTKLVGQDVAR 137

  Fly   139 MINNLISAGISRREDIHLIGFSLGAQVAGMVANYVSQPLARITGLDPAGPGF--MMQPSLQQKLD 201
            .||.:........:::||:|:||||..||:..:..::.:.||||||||||.|  ...||   :|.
Human   138 FINWMEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTNKKVNRITGLDPAGPNFEYAEAPS---RLS 199

  Fly   202 ASDADFVDIIHTDPFFFSMLP--------PMGHADFYPN-------------LDQLNQRGCSYIS 245
            ..||||||::||   |....|        |:||.|.|||             :..:.:||...:.
Human   200 PDDADFVDVLHT---FTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAERGLGDVD 261

  Fly   246 NWRFYNCNHYRAAVYYGESIISERG-FWAQQCGGWFDFFSQRCSHYSNMPNTQMGYFVSE---DA 306
              :...|:|.|:...:.:|:::|.. ..|.:|.....|....|..........:||.:::   ..
Human   262 --QLVKCSHERSIHLFIDSLLNEENPSKAYRCSSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKR 324

  Fly   307 SGSYFLTTHEVAPFAKGPL-VEVEFDVSELRNFT----EIEL 343
            |...:|.|....|:..... |::.|..:|....|    ||.|
Human   325 SSKMYLKTRSQMPYKVFHYQVKIHFSGTESETHTNQAFEISL 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34448	NP_001097059.1	Pancreat_lipase_like	44..316	CDD:238363	76/268 (28%)
LPL	NP_000228.1	Interaction with GPIHBP1. /evidence=ECO:0000269\|PubMed:30559189	32..53
		Lipase	33..473	CDD:332983	84/302 (28%)
		Essential for determining substrate specificity. /evidence=ECO:0000269\|PubMed:7592706	243..266		2/24 (8%)
		Important for interaction with lipoprotein particles. /evidence=ECO:0000269\|PubMed:27929370	417..421
		Important for heparin binding. /evidence=ECO:0000269\|PubMed:11342582	430..434
		Interaction with GPIHBP1. /evidence=ECO:0000269\|PubMed:26725083, ECO:0000269\|PubMed:30559189	443..467
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100