Protein Alignment futsch and MDC1

DIOPT Version :9

• Sequence 1: NP_001096864.1
• Gene: futsch / 5740544
• FlyBaseID: FBgn0259108
• Length: 5495
• Species: Drosophila melanogaster
• Sequence 2: XP_005249549.1
• Gene: MDC1 / 9656
• HGNCID: 21163
• Length: 2110
• Species: Homo sapiens
• Alignment Length: 2599
• Identity: 505/2599 - (19%)
• Similarity: 876/2599 - (33%)
• Gaps: 723/2599 - (27%)

  Fly   334 THPTLYVFPGGQGDAALFGINGFNMLVDGGFNRKACFWDFARHLDRLDAVLMTRLNNSNVQGLGA 398
            |.||...||   ...|.|.|......:|         ||.....:...:....|   .||:.:|.
Human     5 TFPTCQQFP---SRVAYFQIMEDTQAID---------WDVEEEEETEQSSESLR---CNVEPVGR 54

  Fly   399 VVSRKRDAHVY-----PQ------IG-HFFGNVPD-RKGLPSPDGDK----------DRDPLLID 440
            :       |::     |:      :| :..|.:|| ...||.|...|          |:.|:|.|
Human    55 L-------HIFSGAHGPEKDFPLHLGKNVVGRMPDCSVALPFPSISKQHAEIEILAWDKAPILRD 112

  Fly   441 LFE-RGHGIVSDLKALDLKPQCCYRNQEPVNL------YHKVGHGTLDMYVISPARDSKEVKEFL 498
            ... .|..|:...|.|........|:||.:..      ||:     ||:.:...:|....|:|..
Human   113 CGSLNGTQILRPPKVLSPGVSHRLRDQELILFADLLCQYHR-----LDVSLPFVSRGPLTVEETP 172

  Fly   499 Q-KWHAGDQRLFAARDSR---DF----NFPLQNLVSICALLVWQPANPDDTITRILFPGSTPDFK 555
            : :.....|||..|.||.   ||    ....::..:..:::|  |.:.::..:.:| .|..|.|.
Human   173 RVQGETQPQRLLLAEDSEEEVDFLSERRMVKKSRTTSSSVIV--PESDEEGHSPVL-GGLGPPFA 234

  Fly   556 IQEGLEKLKHLEFMKHSTCTAKSIAPAIQTVTSTRKSLKSAIEATPAPPSASYKTTKFSPVASAA 620
            ..           :...|...:...||.:..:|..:. .:.:||         |.::...|....
Human   235 FN-----------LNSDTDVEEGQQPATEEASSAARR-GATVEA---------KQSEAEVVTEIQ 278

  Fly   621 LAVQHP--QQQDNKAKEAAAAAAAAAAAAASAATIARAKADSMDTDAEPEHEADP--EPADTGDE 681
            |....|  :::||..|....|......|   ...:.|::....|:|.:.:.::.|  .||:...|
Human   279 LEKDQPLVKERDNDTKVKRGAGNGVVPA---GVILERSQPPGEDSDTDVDDDSRPPGRPAEVHLE 340

  Fly   682 AAPTEQEPEAETEPEPEHEPEAEQDKDVGEEKKVEVLIMKPQQATPAVIAASGK---DGVDAASA 743
            .|......:::|:.|.|..|                       |||.||....:   .||.....
Human   341 RAQPFGFIDSDTDAEEERIP-----------------------ATPVVIPMKKRKIFHGVGTRGP 382

  Fly   744 DATPTGKLSKASA-------KGKADK----PRAEVKPVVRSRIDTKPPKSMDRKLAKRDEKKSSP 797
            .|.....|.::.|       :|||.:    .:::...|:.|..|              ||::.|.
Human   383 GAPGLAHLQESQAGSDTDVEEGKAPQAVPLEKSQASMVINSDTD--------------DEEEVSA 433

  Fly   798 TTTPAARAPVAQNAKPKVLSRPATKSSPSSTPAKSAKEANNRKVLESKQQAARVQATSTVSRRVT 862
            ..|.|.    .:.::|.:.:|.|.:..|                    |:...:|.:.|.:.|.:
Human   434 ALTLAH----LKESQPAIWNRDAEEDMP--------------------QRVVLLQRSQTTTERDS 474

  Fly   863 STASERR----VQQQAEAK-----TAATGATQATQRKPISRRPRGVSPSKRAPA----------- 907
            .|..|..    ..::|..|     .|...|.....:.|.......|...|.:|.
Human   475 DTDVEEEELPVENREAVLKDHTKIRALVRAHSEKDQPPFGDSDDSVEADKSSPGIHLERSQASTT 539

  Fly   908 ------------PGSPVKQAKPKAADLKKTRLDKGGT--TDSSLVSTP------SADEA------ 946
                        |||.:       ..:||.::...||  ||...|..|      |.:||
Human   540 VDINTQVEKEVPPGSAI-------IHIKKHQVSVEGTNQTDVKAVGGPAKLLVVSLEEAWPLHGD 597

  Fly   947 --TAAKKLQDLTASQELDAEKQRELDDLKEEQEVVREIEAVFSRDEMKRQQHQQIKAELREMPAE 1009
              |.|::...||||...|..|.:    |..|.:...|..|..    :|:::..::.|:
Human   598 CETDAEEGTSLTASVVADVRKSQ----LPAEGDAGAEWAAAV----LKQERAHEVGAQ------- 647

  Fly  1010 GTGDGENEPDEEEEYLIIEKEEVEQYTEDSIVEQESSMTKEEEIQKHQRDSQESEKKRKKSAEEE 1074
                |.....:.|:.|.|.:|.:.....|:....||:..:.|..|......:|......|.:|:.
Human   648 ----GGPPVAQVEQDLPISRENLTDLVVDTDTLGESTQPQREGAQVPTGREREQHVGGTKDSEDN 708

  Fly  1075 IEAAIAKVEAAERKARLEGASARQDESELDVEPEQSKIKAEVQDIIATAKDIAKSRTEEQLAKPA 1139
            .                      .|..:||::..|..::.:..:.:.:.:|           :|.
Human   709 Y----------------------GDSEDLDLQATQCFLENQGLEAVQSMED-----------EPT 740

  Fly  1140 EEELSSPTPEE----KLSKKTSDTKDDQIGAPVDVL---PVNLQESLPEE--KFSATIESGATTA 1195
            :..:.:| |:|    ..|.:|:.|.|:    |.:||   |..|:||...|  .|...:|:   ..
Human   741 QAFMLTP-PQELGPSHCSFQTTGTLDE----PWEVLATQPFCLRESEDSETQPFDTHLEA---YG 797

  Fly  1196 PTLPEDERIPLDQIKEDLVIEEKYVKEETKEAEAIVVATVQTLPEAAPLAIDTILASATKDAPKD 1260
            |.|.....||.||..|..|..|                         |:.|        :...:.
Human   798 PCLSPPRAIPGDQHPESPVHTE-------------------------PMGI--------QGRGRQ 829

  Fly  1261 ANAEALGELPDSGERVLPMKMTFEAQQNLLRDVIKTPDEVADLPVHEEADLGLYEKDSQDAGAKS 1325
            ...:.:|...::.|||.|.:...|.:...|     .|:...|:...||...|..:::.:...|:.
Human   830 TVDKVMGIPKETAERVGPERGPLERETEKL-----LPERQTDVTGEEELTKGKQDREQKQLLARD 889

  Fly  1326 ISHKEESAKEEKETDDEKENKVGEIELGDEPNKVDISHVLLKESVQEVAEKVVVIETTVEKKQEE 1390
             :.::||.|..:....|::.         |..||:|      |:.:|:.||.|..:|...|..|.
Human   890 -TQRQESDKNGESASPERDR---------ESLKVEI------ETSEEIQEKQVQKQTLPSKAFER 938

  Fly  1391 IVEATTVITQENQEDLMEQVKDKEEHEQKIESGII---TEKEAKKSASTPEEKETSDITSDDELP 1452
            .||....    |:|      .|..|.|:|:...|:   |::...:..|..::.:.|..|.:..:.
Human   939 EVERPVA----NRE------CDPAELEEKVPKVILERDTQRGEPEGGSQDQKGQASSPTPEPGVG 993

  Fly  1453 A-QLADPTTVPPKSAKDREDTGSIESPPTIEEA-IEVEVQAKQEAQKPVPAPEEAIKTEKSPLAS 1515
            | .|..||:.|..|.......||..||...::. :..::...::|.:...|.:.:...::||.|.
Human   994 AGDLPGPTSAPVPSGSQSGGRGSPVSPRRHQKGLLNCKMPPAEKASRIRAAEKVSRGDQESPDAC 1058

  Fly  1516 KETSRPESATGSVKEDTEQTKSKKSPVPSRPESEAKDKKSPFASGEASRPESVAESVKDEAGKAE 1580
            ...:.||:.....|....|::...:|.|         ..||           :..|:|
Human  1059 LPPTVPEAPAPPQKPLNSQSQKHLAPPP---------LLSP-----------LLPSIK------- 1096

  Fly  1581 SRRESIAKTHKDESSLDKAKEQESRRESLAESIKPESGIDEKSALASKEASR--PESVTDKSKEP 1643
               .::.||.:|.|       ||:....|:..::|   ...|..:.::::||  |...|..:.||
Human  1097 ---PTVRKTRQDGS-------QEAPEAPLSSELEP---FHPKPKIRTRKSSRMTPFPATSAAPEP 1148

  Fly  1644 SRRESIAESLKAESTKDEKSAPPSKEASRPGSVVESVKDETEKSKEPSRRESIAESAKPPIEFRE 1708
            ....|.|:.:         :..|:.:|:|         ..|.:|                    .
Human  1149 HPSTSTAQPV---------TPKPTSQATR---------SRTNRS--------------------S 1175

  Fly  1709 VSRPESVIDGIKDESAKPESRRDSPLASKEASRPESVLESVKDEPIKSTEKSR--RESVAESFKA 1771
            |..||.|:....:  .:|.:..|.|:.|               ||.....:.|  |.||......
Human  1176 VKTPEPVVPTAPE--LQPSTSTDQPVTS---------------EPTSQVTRGRKSRSSVKTPETV 1223

  Fly  1772 DSTKDEKSPLTSKDISRPESAVENVMDAVGSAERSQ---PESVTASRDVSRPESVAESEKDDTDK 1833
            ..|..|..|.||.|  ||.::........|...||.   ||.|..:....:|.:       .||:
Human  1224 VPTALELQPSTSTD--RPVTSEPTSQATRGRKNRSSVKTPEPVVPTAPELQPST-------STDQ 1279

  Fly  1834 PESVVESVIPASDVVEIEKGAADKEKGVFVSLEIGKPDSPSEVISRPG-----PVVESVKPESRR 1893
            |       :.:....:..:|..::.     |::..:|..|:....||.     ||  :.||.||.
Human  1280 P-------VTSEPTYQATRGRKNRS-----SVKTPEPVVPTAPELRPSTSTDRPV--TPKPTSRT 1330

  Fly  1894 ESSTEIVLPCHAEDSKEPSRPESKVECLKDESEVLKGSTRRESVAESDKSSQPFKETSRPESAV- 1957
            ..|...:......::..|:.||.::....|:....|.::|      :.:|.........|||.|
Human  1331 TRSRTNMSSVKTPETVVPTAPELQISTSTDQPVTPKPTSR------TTRSRTNMSSVKNPESTVP 1389

  Fly  1958 -------GSMKDESMSKEPSRRESVKDGAAQSRETSRPASVAESAKDGADDLKELS------RPE 2009
                   .:..::.::.||:.|      |.:.|:........|:....|..|:..:      .||
Human  1390 IAPELPPSTSTEQPVTPEPTSR------ATRGRKNRSSGKTPETLVPTAPKLEPSTSTDQPVTPE 1448

  Fly  2010 STTQSKEAGSIKDEKSPLASEEASRPASVAESVKDEAEKSKEESRRESVAEKSPLPSKEASRPAS 2074
            .|:|:...   :..:|.:.:.|...|.:        .|.....|..:.|   :|.|:.:|:|..:
Human  1449 PTSQATRG---RTNRSSVKTPETVVPTA--------PELQPSTSTDQPV---TPEPTSQATRGRT 1499

  Fly  2075 VAESIKDEAEKSKEESRRESVAEKSPLPSKEASRPASVAESIKDEAEKSKEESRRESVAEKSPLP 2139
            ...|:|..          |:|...:|    |....||..:.:..|........|:...:.|:|
Human  1500 DRSSVKTP----------ETVVPTAP----ELQASASTDQPVTSEPTSRTTRGRKNRSSVKTP-- 1548

  Fly  2140 SKEASRPASVAESIKDEAEKSKEESRRESVAEKSPLPSKEASRPASVAESIKD-------EAEKS 2197
              |...||:        .|.....|..:.|   :|.|:..|:|..:...|:|.       ..|..
Human  1549 --ETVVPAA--------PELQPSTSTDQPV---TPEPTSRATRGRTNRSSVKTPESIVPIAPELQ 1600

  Fly  2198 KEESRRESVAEKSPLPSKEASRPASVAESIKDEAEKSKEESRRESVAEKSPLPSKEASRPASVAE 2262
            ...||.:.|   :|.|:..|:|..:...|:|..          |.|...:|.|....|....|..
Human  1601 PSTSRNQLV---TPEPTSRATRCRTNRSSVKTP----------EPVVPTAPEPHPTTSTDQPVTP 1652

  Fly  2263 SIKDEAEKSKEESRRESVAEKSPL-----------PSKEASRPASVAESIKDEAEKSKEETRRES 2316
            .:...|.:.|  :.|.||....|:           |:.::..|.::|:.       .:.:|.|.|
Human  1653 KLTSRATRRK--TNRSSVKTPKPVEPAASDLEPFTPTDQSVTPEAIAQG-------GQSKTLRSS 1708

  Fly  2317 VAEKSPLP-SKEASRPASVAESIKDEAEKSKEESRRESAAEK-----SPLPSKEASRPASVAESV 2375
            .....|:| :.|...|.:..:.|..|........:|:.||..     :|:..|..|.|
Human  1709 TVRAMPVPTTPEFQSPVTTDQPISPEPITQPSCIKRQRAAGNPGSLAAPIDHKPCSAP------- 1766

  Fly  2376 KDEADKSKEESRRESMAESGKAQSIKGDQSPLKEVSRPESVAESVKDDPVKSKEP---------- 2430
               .:...:.||.:.......|:|:    :.:.|.:.|:.:...:....::..||
Human  1767 ---LEPKSQASRNQRWGAVRAAESL----TAIPEPASPQLLETPIHASQIQKVEPAGRSRFTPEL 1824

  Fly  2431 ------SRRESVAGSVTADSARDDQSPLESKGASRPESVVDSVKDEAEKQESRRESKTESVIPPK 2489
                  ||:.|:|   |.||....:.|  .:|....::|:  :|:| |:..:.:..|.|.|:.||
Human  1825 QPKASQSRKRSLA---TMDSPPHQKQP--QRGEVSQKTVI--IKEE-EEDTAEKPGKEEDVVTPK 1881

  Fly  2490 AKDDKSPKEVLQPVSMTETIREDADQPMKPSQAESR--------RESIAESIKAS---SPRDEKS 2543
            ....|               |:.|::  :|::..||        :||.|..:..:   ..|.|::
Human  1882 PGKRK---------------RDQAEE--EPNRIPSRSLRRTKLNQESTAPKVLFTGVVDARGERA 1929

  Fly  2544 PLASKEASRPGSVAESIKYDLDKPQIIKDDKSTEHSRRESLEDKSAVTSEKSVSRPLSVAS---- 2604
            .|| ...|..||.||:            ....|:..||       .|....::.|.:.:.|
Human  1930 VLA-LGGSLAGSAAEA------------SHLVTDRIRR-------TVKFLCALGRGIPILSLDWL 1974

  Fly  2605 --DHEAAVAIEDDAKSSISPKDKSRPGF-VAETVSSPIEEATMEFSKIEVV-------EKSSLAL 2659
              ..:|...:..|......|:.:...|| :.:.:|...|...:|..:|.|.       .:....:
Human  1975 HQSRKAGFFLPPDEYVVTDPEQEKNFGFSLQDALSRARERRLLEGYEIYVTPGVQPPPPQMGEII 2039

  Fly  2660 SLQGGSGGKLQTDSSP--------VDVAEGDFSHAVASVSTVTPTLTKPAELAQIGAAKTVSSP 2715
            |..||:    ...|.|        |.....||.|....:....|.|:  .|....|..|..:.|
Human  2040 SCCGGT----YLPSMPRSYKPQRVVITCPQDFPHCSIPLRVGLPLLS--PEFLLTGVLKQEAKP 2097

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
futsch	NP_001096864.1	DUF966	<1925..>2112	CDD:283735	36/200 (18%)
MDC1	XP_005249549.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000