Protein Alignment futsch and TP53BP1

DIOPT Version :9

• Sequence 1: NP_001096864.1
• Gene: futsch / 5740544
• FlyBaseID: FBgn0259108
• Length: 5495
• Species: Drosophila melanogaster
• Sequence 2: NP_001135452.1
• Gene: TP53BP1 / 7158
• HGNCID: 11999
• Length: 1977
• Species: Homo sapiens
• Alignment Length: 2414
• Identity: 467/2414 - (19%)
• Similarity: 801/2414 - (33%)
• Gaps: 774/2414 - (32%)

  Fly  3189 GSRRDSVAESIKSDITKGEKSPLPSKEVSRPESVVGSIKDEKAE-----SRRESVAESVKPESSK 3248
            |.:.|.....:.||.:: :.:|....|.|:|||.|  ::|:...     ||.....::.|.....
Human     3 GEQMDPTGSQLDSDFSQ-QDTPCLIIEDSQPESQV--LEDDSGSHFSMLSRHLPNLQTHKENPVL 64

  Fly  3249 DATSAPPSKEHSRPESVLGSLKDEGDKTTSRRV---SVADSIKDEKSL-------LVSQEASRPE 3303
            |..        |.||...|..:.:|:...:..:   .|||.: |..:|       .|.::..:|.
Human    65 DVV--------SNPEQTAGEERGDGNSGFNEHLKENKVADPV-DSSNLDTCGSISQVIEQLPQPN 120

  Fly  3304 --SEAESLKDAAAPSQETSRPESVTESVKD-------------GKSPVASK-------EASRPAS 3346
              |....:...:||:.|..:.|.:.:..|:             |....||.       |.|:...
Human   121 RTSSVLGMSVESAPAVEEEKGEELEQKEKEKEEDTSGNTTHSLGAEDTASSQLGFGVLELSQSQD 185

  Fly  3347 VAENAKDSADESKEQRPESLPQSKAGSIKDEKSPLASKDEAEKSKEESRRESVAEQFPLVSKEVS 3411
            |.||.. ..:..|||.......|....:.|..:..|.|.| |:|.|:.   .:|||   .||::
Human   186 VEENTV-PYEVDKEQLQSVTTNSGYTRLSDVDANTAIKHE-EQSNEDI---PIAEQ---SSKDI- 241

  Fly  3412 RPASVAESVKDEAEKSKEESPLMSKEASRPASVAGSVKDEAEKSKEESRRESVAE------KSPL 3470
             |.: |:..|| ....||::|..::....|.|...||  .|.::||:...:.:.|      |||.
Human   242 -PVT-AQPSKD-VHVVKEQNPPPARSEDMPFSPKASV--AAMEAKEQLSAQELMESGLQIQKSPE 301

  Fly  3471 PSKEASRPASVAESVKDEADKS------KEESRRESGAEKSPLASKEASRPASVAESIKDEAEKS 3529
            |     ...|..|.:.|:::|:      ...||.|.|...       ||.||:....::...::|
Human   302 P-----EVLSTQEDLFDQSNKTVSSDGCSTPSREEGGCSL-------ASTPATTLHLLQLSGQRS 354

  Fly  3530 KEESRRESVAEKSPLPSKEASRPTSVAESVKDEAEKSKEESRRDSVAEKSPLASKEASRPASVAE 3594
            ..:....:.:.....||.:|.|.|....    .:..:::|.|:|...:.|.| |:|...|.
Human   355 LVQDSLSTNSSDLVAPSPDAFRSTPFIV----PSSPTEQEGRQDKPMDTSVL-SEEGGEPF---- 410

  Fly  3595 SVQDEAEKSKEESRRESVAEKSPL-----ASKEASRPASVAESI--------------------- 3633
                   :.|.:|......|..||     .|.:||.|.|.:..:
Human   411 -------QKKLQSGEPVELENPPLLPESTVSPQASTPISQSTPVFPPGSLPIPSQPQFSHDIFIP 468

  Fly  3634 KDEAEKSKEESRRESVAEKSPLASKEASRPTSVAESVKDEAEKSKEESSRDSVAE--KSPLASKE 3696
            ....|:...:.:::.....|.| :.|.|:.:.:      |.:.|.|:.......:  |..|::.|
Human   469 SPSLEEQSNDGKKDGDMHSSSL-TVECSKTSEI------EPKNSPEDLGLSLTGDSCKLMLSTSE 526

  Fly  3697 ASRPASVAESVQDEAEKSKEESRRESVAEKSPLASKE---------ASRPASVAE---SVKDDAE 3749
            .|:...:........::..|.::.|.....||:.:.:         ...||...|   |..||..
Human   527 YSQSPKMESLSSHRIDEDGENTQIEDTEPMSPVLNSKFVPAENDSILMNPAQDGEVQLSQNDDKT 591

  Fly  3750 KSKEESRRESVAEKSPLASKEASRPASVAESVKDEAEKSKEESRRESVAEKSPLPSKEASRPTSV 3814
            |..:...|:.:   |.||:....|..:|||.|..:.       ..:|.::..|.|:..:...:||
Human   592 KGDDTDTRDDI---SILATGCKGREETVAEDVCIDL-------TCDSGSQAVPSPATRSEALSSV 646

  Fly  3815 AESVKDEAEKSKEESRRESVAEKSSLASKKASRPASVAESVKDEAEKSKEESRRESVAEKSPLAS 3879
            .:  ::||.:.||..     .|:.|..|:....|.:..||   :.|:.|||: .|||    ||
Human   647 LD--QEEAMEIKEHH-----PEEGSSGSEVEEIPETPCES---QGEELKEEN-MESV----PL-- 694

  Fly  3880 KEASRPASVAESVKDEAEKSKEESRRESVAEKSPLPSKEASRPTSVAESV------------KDE 3932
                             ..|..|::.:.:..:..:|.||.|....|..||            ..|
Human   695 -----------------HLSLTETQSQGLCLQKEMPKKECSEAMEVETSVISIDSPQKLAILDQE 742

  Fly  3933 ADKSKEESRRESGAEKSPLASMEASRPTSVAESVKDETEKSKEESRRESVTEKSPLPSKEASRPT 3997
            .:..::|:..|:.:|.|.:..::.                 ||.|.|..|: ..||...|....:
Human   743 LEHKEQEAWEEATSEDSSVVIVDV-----------------KEPSPRVDVS-CEPLEGVEKCSDS 789

  Fly  3998 SVAESVKDEAEKSKEESRRESVAEKSPLASKESSRPASVAESIKDEAEGTKQESRRESMPESGKA 4062
            ...|.:..|.|.. .|:|.::..|||  ...|....:..||:     |..:|:|.:.|:|
Human   790 QSWEDIAPEIEPC-AENRLDTKEEKS--VEYEGDLKSGTAET-----EPVEQDSSQPSLP----- 841

  Fly  4063 ESIKGDQSSLASKETSRPDSVVESVKDETEKPEGSAIDKSQVASRPESVAVSAKDEKSPLHSRPE 4127
             .::.|......:|..:|.:        .||...|..:.|::|        :||...|      :
Human   842 -LVRADDPLRLDQELQQPQT--------QEKTSNSLTEDSKMA--------NAKQLSS------D 883

  Fly  4128 SVADKSPDASKEASRSL--SVAETASSPIEEGPRSIADLSLPLNLTGEAKGKLPTLSSPIDVAEG 4190
            :.|.|....|..||:|.  |.:||                 |.:.|      ||        .||
Human   884 AEAQKLGKPSAHASQSFCESSSET-----------------PFHFT------LP--------KEG 917

  Fly  4191 DFLEVKAESSPRPAVLSKPAEFSQPDTGHTASTPVDEASPVLEEIEVVEQHTTSGVGATGATAET 4255
            |.:.....::|             |..||....|...::|:
Human   918 DIIPPLTGATP-------------PLIGHLKLEPKRHSTPI------------------------ 945

  Fly  4256 DLLDLTETKSETVTKQSETTLFETLTSKVESKVEVLESSVKQVEEKVQTSVKQAETTVTDSLEQL 4320
                       .::...|:|:   .||.|.|
Human   946 -----------GISNYPESTI---ATSDVMS---------------------------------- 962

  Fly  4321 TKKSSEQLTEIKSVLDTNFEEVAKIVADVAKVLKSDKDITDIIPDFDERQ-LEEKLKSTADTEEE 4384
                       :|:::|:           ..:|.|.|..:...||.|::. |..||.| .:||
Human   963 -----------ESMVETH-----------DPILGSGKGDSGAAPDVDDKLCLRMKLVS-PETE-- 1002

  Fly  4385 SDKSTRDEKSLEISVKVEIESEKSSPDQKSGPISIEEKDKIEQSEKAQLRQGILTSSRPESVASQ 4449
                 ..|:||:.:::     :.::.::|:|..::.|  .:...:|.......:..:|.|:.|..
Human  1003 -----ASEESLQFNLE-----KPATGERKNGSTAVAE--SVASPQKTMSVLSCICEARQENEARS 1055

  Fly  4450 PESVPSPSQ-------SAASHEHKEVELSESHKAEKSSRPESVASQVSEKDMKTSRPASSTSQFS 4507
            .:...:|.:       |:...|.|| :|...|...:|.:|....|.|.:       |.|..||..
Human  1056 EDPPTTPIRGNLLHFPSSQGEEEKE-KLEGDHTIRQSQQPMKPISPVKD-------PVSPASQKM 1112

  Fly  4508 TKEGDEETTESLLHSLTTTETVETKQMEEKSSFESVSTSVTKSTVLSSQSTVQLREESTSESLSS 4572
            ..:|.         |....|.:.|..:|::
Human  1113 VIQGP---------SSPQGEAMVTDVLEDQ----------------------------------- 1133

  Fly  4573 SLKVEDSSRRESLSSLLAEKGGIATNTSLKEDTSASASQLEELLVQSEECSSESIVSEIQTSIAQ 4637
              |...|:.:|:.|..|.|:                .|| ..:.:|:.|||..
Human  1134 --KEGRSTNKENPSKALIER----------------PSQ-NNIGIQTMECSLR------------ 1167

  Fly  4638 KSNKEIKDARETKVTSQFTTTTSSATKDDSLKETVAEFLATEKIVSAKEAFSTEATKSADDCLKK 4702
                                          :.|||:  .||:.|.:..|    :.|.:.|....|
Human  1168 ------------------------------VPETVS--AATQTIKNVCE----QGTSTVDQNFGK 1196

  Fly  4703 TTASAVSSTSASQRALFVGTDESRRESLLSQASESRLTHSDPEDE-----EPADDVDER--SSVK 4760
            ..|:..:...:.::.:....|::  |||          ||..|:|     .|...|..|  .:::
Human  1197 QDATVQTERGSGEKPVSAPGDDT--ESL----------HSQGEEEFDMPQPPHGHVLHRHMRTIR 1249

  Fly  4761 ESRSKSIATIMMTSIYKPSEDMEPISKLVEEEHEHVEELAQEVTSTSKTTTLLQSSEQSSTTTSS 4825
            |.|  ::.|.::|.:|. .:..|...|:.||..|.:.|..:..|..|.:.|...|.:....::.|
Human  1250 EVR--TLVTRVITDVYY-VDGTEVERKVTEETEEPIVECQECETEVSPSQTGGSSGDLGDISSFS 1311

  Fly  4826 TSKTGASRVESIT-LTQMDQQTSQSQG-DPADRKTPPTAPV---------SPGV----KAMSSTG 4875
            :..:...|..|.| |:.|....|..:| .|...||..|.|.         .||.    |.:|.||
Human  1312 SKASSLHRTSSGTSLSAMHSSGSSGKGAGPLRGKTSGTEPADFALPSSRGGPGKLSPRKGVSQTG 1376

  Fly  4876 SAGSVIGAGAG-AVAAGGKCESSAASIVSSSGPMSPKDISGKSSPGALTSESQ--SIPTPLGRES 4937
            :........|| .:..|||            .|::|:....:..|.:.|:.::  ::|.|||.|.
Human  1377 TPVCEEDGDAGLGIRQGGK------------APVTPRGRGRRGRPPSRTTGTRETAVPGPLGIED 1429

  Fly  4938 HTDTPESSPKPTS---PFPRVSKDELKSLEMQHHSQEQMLAGAAAAAGAECEGDIPEL------- 4992
              .:|..||...|   ..||| .|..:..::              .|||....|.||:
Human  1430 --ISPNLSPDDKSFSRVVPRV-PDSTRRTDV--------------GAGALRRSDSPEIPFQAAAG 1477

  Fly  4993 -----------HELRGLECTTALSGS----TDKIITTTITTVTKVISADGKEIVTEQKTVTTTDS 5042
                       :...||......|.:    :.||.........|::..||.|.....|.:...|.
Human  1478 PSDGLDASSPGNSFVGLRVVAKWSSNGYFYSGKITRDVGAGKYKLLFDDGYECDVLGKDILLCDP 1542

  Fly  5043 SEPDSEKV-----------VVTTTRTTS-------ESERDQLLPKEVALLRGL------------ 5077
            ...|:|..           ||...|..|       |.|..:...|.:|::..|
Human  1543 IPLDTEVTALSEDEYFSAGVVKGHRKESGELYYSIEKEGQRKWYKRMAVILSLEQGNRLREQYGL 1607

  Fly  5078 --YRASTPGSEDDEDLL-------------LGSPRSATS------------YELQHSSSGV--SK 5113
              |.|.||.::..:..|             :.||.:.|:            .|...:|.||  .|
Human  1608 GPYEAVTPLTKAADISLDNLVEGKRKRRSNVSSPATPTASSSSSTTPTRKITESPRASMGVLSGK 1672

  Fly  5114 RSDLDADGDESQDDIPPQYGSEEHST------ARSILLP-----RTADPMA------------TS 5155
            |..:.::.:.|    |.:.|.:..:.      |...:.|     .|.:|.|            |.
Human  1673 RKLITSEEERS----PAKRGRKSATVKPGAVGAGEFVSPCESGDNTGEPSALEEQRGPLPLNKTL 1733

  Fly  5156 FYGALPDSFDVVMKPSTEPI----PIQGAPSGDSQSSES-----------VESSSQTWAGHKFLD 5205
            |.|.   :|.:.|..:::.:    .:...|:|.|:..|.           .||..:..||:...|
Human  1734 FLGY---AFLLTMATTSDKLASRSKLPDGPTGSSEEEEEFLEIPPFNKQYTESQLRAGAGYILED 1795

  Fly  5206 ----QADKDFQRAL--EEHVQARG-----AEVMSSVTAKYSYSPSKAEEMEQ-----IVSG-TAE 5253
                |.:..:|..|  ::|.:.|.     |..:..|:..:.:....|.:::.     :.:| :.|
Human  1796 FNEAQCNTAYQCLLIADQHCRTRKYFLCLASGIPCVSHVWVHDSCHANQLQNYRNYLLPAGYSLE 1860

  Fly  5254 RQRF--------PLSDVQRARVAE---------SGFATVGSVASQQQQQEKGGEVEQAVPTTTAV 5301
            .||.        |..:::...|::         |.....|..||.:|........:.|:.....|
Human  1861 EQRILDWQPRENPFQNLKVLLVSDQQQNFLELWSEILMTGGAASVKQHHSSAHNKDIALGVFDVV 1925

  Fly  5302 TASTTATAS 5310
            ....:..||
Human  1926 VTDPSCPAS 1934

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
futsch	NP_001096864.1	DUF966	<1925..>2112	CDD:283735
TP53BP1	NP_001135452.1	53-BP1_Tudor	1488..1609	CDD:286170	22/120 (18%)
		BRCT	1774..1841	CDD:237994	12/66 (18%)
		BRCT	1871..1956	CDD:214602	11/64 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000