DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment futsch and phf3

DIOPT Version :9

Sequence 1:	NP_001096864.1	Gene:	futsch / 5740544	FlyBaseID:	FBgn0259108	Length:	5495	Species:	Drosophila melanogaster
Sequence 2:	XP_005157087.1	Gene:	phf3 / 553518	ZFINID:	ZDB-GENE-090313-207	Length:	1691	Species:	Danio rerio

Alignment Length:	2041	Identity:	417/2041 - (20%)
Similarity:	691/2041 - (33%)	Gaps:	639/2041 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  2249 LPSKEASRPASVAESIK----DEAEKSKEESRRESVAEKSPL-------------------PSKE 2290
            :||.:......:.::::    ||.|...|:|.:..:::|.|:                   .|.:
Zfish    12 VPSDQLDDSLLLGQNLECEASDEFEAKPEDSLKNMLSDKDPMFGSASTQFHLLENEDFKLGSSAD 76

  Fly  2291 ASRP---ASVAESIKD---------EAEKSKEETRRESVAEKSPLPSKEASRPASVAESIKDEAE 2343
            |...   |.|.:|..|         :..:...:.:|...|.:..:..:........|||...|:.
Zfish    77 ADHEMTGAGVRQSPSDGEHNQSGFLQDRRQAGQMQRRQTASRGRVRGRRLGPARKAAESYNREST 141

  Fly  2344 KSKEESRRESAAEKSPLPSKEA--SRPASVAESVKDEADKSKEE---SRRESMAESG-KAQSIKG 2402
            .|:|..|..|..||     :||  ||...|     .|.|.|...   .||.::...| |.:.:.|
Zfish   142 CSEEHDRDNSPDEK-----REALLSRRFGV-----HEVDSSMNPVVVLRRLTVTVGGYKIELLPG 196

  Fly  2403 DQSPLKEVSRPESVAESVKDDPVKSKEPSRRESVAGSVTADSARDDQSPLESKGASRPESVVDSV 2467
            ........|.....:...:||               .:.||....|      .|.::.|.|||:.
Zfish   197 PSQSFGSFSTSALQSLGFQDD---------------GIIADGLGLD------LGQNQDEQVVDNS 240

  Fly  2468 KDEAEKQESRRESKTESV-------IPPKAKDDKSPKEVLQPVSMTETIREDADQPMKPSQAESR 2525
            ..||..:.|..:|.:..|       :.|....|.:...||:| .:.....|||.:  |.:|.:::
Zfish   241 TPEAVGEVSIDQSTSHDVPMDFGPYVNPNEVQDTNSTMVLKP-KVENATSEDAKK--KNNQIKTQ 302

  Fly  2526 RESIAESIKASSPRDEKSPLASKEASRPG-----------SVAESIKYDLDKPQIIKDDKSTEHS 2579
            :      :.|..|.::..     .|:||.           |.|::......||.:::  |.::|.
Zfish   303 K------LSAQKPGNKNG-----TAARPAVKKLLKNKQSLSAAKNKPSSPTKPGLLQ--KESKHP 354

  Fly  2580 RRESLEDKSAVTSEKSV--SRPLSVASDHEAAVAIEDDAKSSISPKDKSRPGFVAETVSSPIEEA 2642
                 :||...|.:..|  .:|:.|......|         ::.|||.
Zfish   355 -----QDKKIHTGQPEVHKGKPIKVGLKRPGA---------ALGPKDG----------------- 388

  Fly  2643 TMEFSKIEVVEKSSLALSLQGGSGGKLQTDSSPVDVAEGDFSHAVASVSTVTPTLTKPAELAQIG 2707
                |||:.::        .|.|..|..:.|.|                 ::||:||
Zfish   389 ----SKIQKIQ--------DGHSASKTASPSGP-----------------LSPTITK-------- 416

  Fly  2708 AAKTVSSPLDEALRTPSAPEHISRADSPAECASEEIASQDKSPQVLKESSRPAWVAESKDDAAQL 2772
            .:.:.|.||                 ||   .:....|.|..|.....|.:|:
Zfish   417 KSSSESGPL-----------------SP---TNSRKPSSDSVPLSPTNSRKPS------------ 449

  Fly  2773 KSSVEDLRSPVASTEISRPASAGETASSPIEEAPKDFAEFEQAEKAVLPLTIELKGNLPTLSSPV 2837
             :||     |::||...:|:|.....|......|                    ..||..||
Zfish   450 -NSV-----PLSSTNSRKPSSNSVPLSPSNSRKP--------------------SSNLVPLS--- 485

  Fly  2838 DVAHGDFPQTSTPTSSPTVASVQPAELSKVDIEKTASSPIDEAPKSLIGCPAEERPESPAESAKD 2902
                        ||:|..::|                               :..|.||..|.|.
Zfish   486 ------------PTNSRKLSS-------------------------------DSGPLSPTNSRKP 507

  Fly  2903 AAESVEKSKDASRPPSVVESTKADSTKGDISPSPESVLEGPKDDVEKSKESSRPPSVSASITGDS 2967
            :::||..|...||.||   |......|...||.|....:.|    ..|...:.||  .|:..||.
Zfish   508 SSDSVPLSPTNSRRPS---SESGPGVKSVQSPHPPKKPQNP----PTSGNKTNPP--VANSQGDE 563

  Fly  2968 TKDVSRPASVVESVKDEHD-----------------------KAESRRESIAKVESVIDE----- 3004
            .:|..: |..:|..:..|.                       |.|:..:::|:.|:|.|.
Zfish   564 EQDKVK-AKKIEKTQQRHKSRNSRSISIEEPQLFIPDNAPVVKKEAEGDALAESETVWDPTKNCV 627

  Fly  3005 -------------AGKSD----------SKSSSQDSQKDEKSTLASKEASRRESVVESSK--DD- 3043
                         .|:.|          ..:..|..:|:::..:..|..::.:...::|:  ||
Zfish   628 LCKKPHNNRFMVGCGRCDDWFHGDCVGLDLAKVQQMEKEDQEYVCLKCCAQEDEKTQASELSDDK 692

  Fly  3044 -AEKSESRPESVIASG--EPVPRESKSPLDSKDTSRPGSMVESVTAEDEKSEQQSR-------RE 3098
             |.|.:.||:..:.:|  .|..:::.....|:|:::.|..|:..|.:.:.|...|:       |.
Zfish   693 SAAKQKQRPQQSLTAGGIRPFRKDAGERRPSEDSAQKGPNVKHETKKVKISPVSSKKPSTGHIRR 757

  Fly  3099 SVAESVKADTKKDGKSQE----ASRPSSVDE--------LLKDDDEKQESRRQSITGSHKAMST- 3150
            ||.:|::....|..|..:    :.||:.|..        |.:..|.|.:::.:|:|.:.|....
Zfish   758 SVRDSLEEILLKRSKESDLKISSDRPAEVARRTEKELFALFQGVDSKYKNKYRSLTFNLKDAKNN 822

  Fly  3151 -------MGDESPMDKADKSKEPSRPESVAESIKHENTKDEESPLGSRRDSVAESIKSDITKGE- 3207
                   .|:.||.|....:.|....:.:|...|.||....|.....:|:.....|.....|||
Zfish   823 VLFKRVLKGEVSPADLVRMTAEELASKELAAWRKRENRHTIEMIEKEQREVERRPITKITHKGEI 887

  Fly  3208 --KSPLPSK-----EVSRPESV--VGSIKDEK-AESRRESVAESVKPESSKDATS---------- 3252
              ::..|:|     || .||.|  |..:.:|| .|.:.||      |:.|.|.|:
Zfish   888 EIENQEPAKAPEAIEV-EPEPVLKVVEVPEEKPPEIKVES------PKKSIDTTNLHKSHLFDLN 945

  Fly  3253 --------APPSKEHS-----------RPESVLGSLKDEGDKTTSRRVSVADSIKDEKSLLVSQE 3298
                    |||::|.|           |.:|   |..:|...:|:...|   ::.|:.:|...:|
Zfish   946 CKICTGRMAPPTEEASTKVVKVATTVVRRQS---SATEESQPSTTTPTS---ALMDDLTLRAMEE 1004

  Fly  3299 A---SRPESEAESLKDAAAPSQETSRPESVTESVKDG--KSPVASKEASRPASVAENAKDSADES 3358
            .   ..|||   |..|:....::|:...|..||:..|  ..|..::..::...|:    .:.|..
Zfish  1005 GLLNFLPES---SRADSLCSKEDTATFLSSLESLWGGYVDMPAVARFLTKSYLVS----GTLDHL 1062

  Fly  3359 KEQRPESLPQSKAGSIKDEKSPLASKDEAEKSKEESRRESVAEQF--PLVSKEVS---------- 3411
            .:..|:::  ...|.|    ||....|..||.:....:|....:|  .....|:|
Zfish  1063 TQDLPDNI--QVGGRI----SPQIVWDYVEKIRASGTKEICVIRFSPDTEEDEISYTLLYAYFSS 1121

  Fly  3412 --RPASVAESVKDEAEK------SKEESPLM-------SKEASRPASVAGSVKDEAEKSKEESRR 3461
              |...||.:.|...:.      |.|:.|..       ..|.:||..:.|.:..:..|     |.
Zfish  1122 RRRYGVVANNRKQVKDMYLIPLGSTEKIPHQIVPFDGPGLETNRPNLLLGLIIRQRPK-----RD 1181

  Fly  3462 ESVAEKSPLPSKEASRPASVAESVKDEADKSKEESRRESGAEKSPLASKEASRPASVAESIKDEA 3526
            ..|.    |||..:..|:.:||| |.:.| ..:::......|:|.::....:|.....:.||...
Zfish  1182 FGVI----LPSDVSEAPSFLAES-KPQVD-YPQKTPVALDTEQSFISDLGNARKKDTTDLIKSVV 1240

  Fly  3527 EKS-KEESRRESVAEK-----SPLPSKEA--SRPTSVAESVKDEAEKSKEESRRDSVAEKSPLAS 3583
            |:. .:....|:|:.:     ..||.|.|  |.....::|.|.||:....:|..::.....|:||
Zfish  1241 EEPILDTETDENVSLRFLPGVLKLPEKAASCSNDNMKSDSTKTEAKTPSVDSGNNATVSPKPIAS 1305

  Fly  3584 KEASRPASVAESVQDEAEKSKEESRRESVAEKSPLASKEASRPASVAESIKDEAEKSKEESRRES 3648
              |.|                  ..|..:.:|.|.|.|....|.||:..|..|    |:|
Zfish  1306 --APR------------------LDRFVIKKKEPKAVKTEQAPVSVSLEISSE----KKE----- 1341

  Fly  3649 VAEKSPLASKEASRPTSVAESVKDEAEKSKEESSRDSVAEKSPLASKEASRPASVAESVQDEAEK 3713
                           |:|..|:.|:......||...|:....|
Zfish  1342 ---------------TAVVLSLSDKPADVSTESFLSSLTNTKP---------------------- 1369

  Fly  3714 SKEESRRESVAEKSPLASKEASRPASVAESVKDDAEKSKEESRRESVAEKSPLASKEASRPASV- 3777
             ||||  ||.:..|| .|:|.|:..|...|.....|.|....:.|:::  ||.|:.:.| ||.:
Zfish  1370 -KEES--ESCSTASP-TSQETSQTTSSGTSKDSVDEGSSSAPKNETIS--SPTATTKVS-PAGIL 1427

  Fly  3778 --AESVKDEAEKSKEESRRESVAEK-SPLPSKEASRPTSVAESVKDEAEKSKEESRRESVAEKSS 3839
              |.|..:..|....||..|...:| :|.||.:..:.....:::...:...|.|..::|   :||
Zfish  1428 KRASSAPEPTESKLPESSSEKPEQKVTPQPSTQECKAIEDIQAITTISSIGKNEGLKQS---RSS 1489

  Fly  3840 LASKKASR-------------------PASVAESVKDEAE--------------KSKEESRRESV 3871
            ..:.|...                   ||:.|..:..:|.              :...:|....:
Zfish  1490 SFNPKVYNPPVFHSYLSGPPDPQFYPPPANPAHFLPLQAHLPPPFQFPPGPPPLQMFPQSDPHML 1554

  Fly  3872 AE-----------KSPLASKEASRPASVAESVKDEAEKSKEESRRESVAEKSPLPSKEASRPTSV 3925
            |.           ..|..:.|:|.|.::..| ||  ||..|:|..:.| :|....|:|..|..|
Zfish  1555 APPWPQTVPPQTLPPPPMAYESSLPTALPLS-KD--EKVSEKSYSDFV-DKLSRRSEETHRKDS- 1614

  Fly  3926 AESVKDEADKSKEESRR-ESGAEKSPLASMEASRPTSVAESVKDETEKSKEESRRESVTEKSPLP 3989
              ..::..||...:||. |...||    ..|.|.......|..:..||.:|  ||.|...:.  .
Zfish  1615 --RDREHYDKHHHKSRHYERDREK----HRERSHSHKERHSKDERYEKHRE--RRHSSHHRD--R 1669

  Fly  3990 SKEASRPTSVAESVKDEAEKSKEESR 4015
            .|..||.:        :.||.:::||
Zfish  1670 DKHRSRDS--------DHEKHRKDSR 1687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
futsch	NP_001096864.1	DUF966	<1925..>2112	CDD:283735
phf3	XP_005157087.1	DUF4045	<341..732	CDD:330572	104/574 (18%)
		PHD_PHF3	625..675	CDD:277108	4/49 (8%)
		TFIIS_M	755..863	CDD:311443	24/107 (22%)
		SPOC	1027..1176	CDD:311609	30/158 (19%)
		Endomucin	1271..>1449	CDD:330316	59/250 (24%)
		RRM	1605..>1690	CDD:330708	27/102 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000