DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment futsch and MAP1B

DIOPT Version :9

Sequence 1:NP_001096864.1 Gene:futsch / 5740544 FlyBaseID:FBgn0259108 Length:5495 Species:Drosophila melanogaster
Sequence 2:NP_005900.2 Gene:MAP1B / 4131 HGNCID:6836 Length:2468 Species:Homo sapiens


Alignment Length:2950 Identity:676/2950 - (22%)
Similarity:1118/2950 - (37%) Gaps:736/2950 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    90 TACSDADGGAPSSLAGGIVGPPSPLTGC----------YLLIVLGEPHSEEHKDNILQHLLKGFL 144
            |...:|....||   |.|..|.:..:..          |||:|:||..:|||....:.::..|..
Human     3 TVVVEATEPEPS---GSIANPAASTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRAIGNIELGIR 64

  Fly   145 SWDVS--DCHVDLEEELNTITQHAPEGEEARHGERLIQYASENLVTEVLIHPQYNTLIQCMRNLL 207
            |||.:  :|::|.|.:| .:::|:........|::::.:.|:.|.|.|||:|....:...:|.::
Human    65 SWDTNLIECNLDQELKL-FVSRHSARFSPEVPGQKILHHRSDVLETVVLINPSDEAVSTEVRLMI 128

  Fly   208 SSFTRHRHIIHAGYTFSGNGSWILQDGTFSVADFSEAFQEHDVQRVIRAY--ADTITMNIHCADA 270
            :...||:.::..|..|...|..|||.|:||..:|.|.|.:.::..::...  |:..::.:.|.:.
Human   129 TDAARHKLLVLTGQCFENTGELILQSGSFSFQNFIEIFTDQEIGELLSTTHPANKASLTLFCPEE 193

  Fly   271 GLW-------HTLPEKAFARQCRIRINPVDVLDTSSECINGFIDYLAPMVMPTSLRELLETSDVV 328
            |.|       |.|.:     ...|::|...:| ...|.::.|.:||:..|...|..::||.....
Human   194 GDWKNSNLDRHNLQD-----FINIKLNSASIL-PEMEGLSEFTEYLSESVEVPSPFDILEPPTSG 252

  Fly   329 GNIRFTHPTLYVFPGGQGDAALFGINGFNMLVDGGFNRKACFWDFARHLDRLDAVLMTRLNNSNV 393
            |.::.:.|..|:||||:||:|||.:||||||::||..||:|||...|||||:|::|:|.:.:.|:
Human   253 GFLKLSKPCCYIFPGGRGDSALFAVNGFNMLINGGSERKSCFWKLIRHLDRVDSILLTHIGDDNL 317

  Fly   394 QGLGAVVSRK------------------RDAHVYPQIGHFFGNVPDRKGLPSPDGDKDRDPLLID 440
            .|:.:::.||                  ....:.|.:|..|.|||:....|.|:....|.     
Human   318 PGINSMLQRKIAELEEEQSQGSTTNSDWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRS----- 377

  Fly   441 LFERGHGIVSDLKALDLKPQCCYRNQ----EPVNLYHKVGHGTLDMYVISPARDSKEVKEFLQKW 501
             .|.....:..|..|.:||:..:|:.    :||.|:.|:|.|.|:|||::|.:.|||::.|:|:|
Human   378 -IEEACFTLQYLNKLSMKPEPLFRSVGNTIDPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQW 441

  Fly   502 HA--GDQRLFAARDSRDFNFPLQNLVSICALLVWQPANPDDTITRILFPGSTPDFKIQEGLEKLK 564
            ..  .|:..|...:.::.:.|:..|.|:.:|:||.||||.:.|.|:||||::..:.|.|||||||
Human   442 TGTNKDKAEFILPNGQEVDLPISYLTSVSSLIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLK 506

  Fly   565 HLEFMKHSTCTAKSIAPAIQTV----------TSTRKSLKSAIEATPAPPSASYKTTK-FSPVAS 618
            ||:|:|....|.|.:...:.|.          ..:|:|||.|  |.|.|..:..|.:| .:|..:
Human   507 HLDFLKQPLATQKDLTGQVPTPVVKQTKLKQRADSRESLKPA--AKPLPSKSVRKESKEETPEVT 569

  Fly   619 AALAVQHPQQQDNKAKEAAAAAAAAAAAAASAATIARAKADSMDTDAEPEHEADPEPADTGDEAA 683
            ....|:.|.:.::|.|                   ...|.|              :|..|..:.:
Human   570 KVNHVEKPPKVESKEK-------------------VMVKKD--------------KPIKTETKPS 601

  Fly   684 PTEQEPEAETEPEP-----------EHEPEAEQDKDVGEEKKVEVLIMKPQQATPAVIAASGKDG 737
            .||:|..::.||.|           :.:|:|.::|.|.:|.||:....|.::..|       |..
Human   602 VTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKP-------KKE 659

  Fly   738 VDAASADATPTGK------------LSKASAKGKADKPRAEVKPVVRSRIDTKPPKSMDRKLAKR 790
            | |...|.||..|            :.|...|.:..:|:.|||.....:...|..|..::|..|:
Human   660 V-AKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKK 723

  Fly   791 DEK------KSSPTTTPAARAPVAQNAKPKVLSRPATKSSPS----STPAKSAKEANNRKVLESK 845
            :||      |..|.....:..|:::..||..|.....|...|    |..|...||....||::.:
Human   724 EEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKE 788

  Fly   846 QQAARVQATSTVSRRVTSTASERRVQQQAEAKTAATGATQATQRKPISRRPRGVSPSKRAPAPGS 910
            .:||                       :|.|....||||.|           .|..:....|.| 
Human   789 GKAA-----------------------EAVAAAVGTGATTA-----------AVMAAAGIAAIG- 818

  Fly   911 PVKQAKPKAADLKKTRLDKGGTTDSSLVSTPSADEATAAKKLQDLTAS-QELDAEKQRELDDLKE 974
            |.|:.:                .:.||:|:|           :|||.. :||.||:.....|:|.
Human   819 PAKELE----------------AERSLMSSP-----------EDLTKDFEELKAEEVDVTKDIKP 856

  Fly   975 EQEVVREIEAVFSRDEMKR---QQHQQIKAELREMPAEG--TGDGENEPDE-EEEYLIIEK---E 1030
            :.|::.:.|.:...:.::.   |:.:::.....|.|.||  |.:||.|.:: .||...:||   :
Human   857 QLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEELEPVEKQGVD 921

  Fly  1031 EVEQYTEDSIVEQESSMTKEEEIQKHQRDSQESEK---------KRKKSAEEEIEAAIAKVEAAE 1086
            ::|::.::....:|||.|.:.|.:....:::|.|:         ..|.|..|:.|:|.|:.:|..
Human   922 DIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYI 986

  Fly  1087 RKARLEGASARQDESELDV-------EPEQSKIKAEVQDIIATAK----DIAKSRTEEQLAKPAE 1140
            |:.| |..::..|.:|.|:       |.|||:.:|:.:|....|:    :..|...|:.:....:
Human   987 REKR-ESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDAREEEYEPEKMEAEDYVMAVVD 1050

  Fly  1141 EELSSPTPEEKLSKKTSDTKDDQIGA------PV-----DVLPVNLQ-----------ESLPEEK 1183
            :...:...||:....|:.||  |:||      |.     :.||...:           |..||| 
Human  1051 KAAEAGGAEEQYGFLTTPTK--QLGAQSPGREPASSIHDETLPGGSESEATASDEENREDQPEE- 1112

  Fly  1184 FSATIESGATTAPTLPEDERIPLDQIK--EDLVIEEKYVKEETKEAEAIVVAT-------VQTLP 1239
            |:||  ||.|.:......|..|:|::.  .|::.:|...:|....::..|..|       .|...
Human  1113 FTAT--SGYTQSTIEISSEPTPMDEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYS 1175

  Fly  1240 EAAPLA-IDTILASATKDAP--KDANAEALGELPDSGERVLPMKMTFEA-QQNLLRDVIKTPDEV 1300
            :.|.:. ::.....:..||.  ||.||.|....|       |..|..:. .::.|||...:  ||
Human  1176 KPADVTPLNGFSEGSKTDATDGKDYNASASTISP-------PSSMEEDKFSRSALRDAYCS--EV 1231

  Fly  1301 ADLPVHEEADLGLYEKDSQDAGAKSISHKEESAKEEKETDDEKENKVGEIELGDE-------PNK 1358
                   :|...|..|||..|    :|.::.|..:.........:.:.:..||:.       ||:
Human  1232 -------KASTTLDIKDSISA----VSSEKVSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNE 1285

  Fly  1359 VDISHVLLKESVQEVAEKVVVIETTVEKKQEEIVEATTVITQENQEDLMEQVKDKEEHEQKIESG 1423
            :.:|                        .:.|:...:..:|||          ..|||       
Human  1286 IKVS------------------------AEAEVAPVSPEVTQE----------VVEEH------- 1309

  Fly  1424 IITEKEAKKSASTPEEKETSDITSDDELPAQLADPTTV---PPKSAKDREDTGSIESPPTIEEAI 1485
                      .::||:| |.::.|..:.....|..|..   |.........|..||.||.:..:.
Human  1310 ----------CASPEDK-TLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSF 1363

  Fly  1486 EVEVQAKQEAQK--------PVPAPEEAIKTEKSPLASKETSRPESATGSVKEDTEQTKSKKSPV 1542
            |.. .||.|.::        |||..|..|:...|||.|......|||             .:|.:
Human  1364 EFS-DAKDENERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESA-------------YESFL 1414

  Fly  1543 PSRPESEAKDKKSPF--ASGEASRPESVAESVKDEAGKAESRRESIAKTHKDESSLDKAKEQESR 1605
            .:..::..:..:|||  .||:...|:.|:.       .:|....|:.:..::..|.|.|      
Human  1415 SADDKASGRGAESPFEEKSGKQGSPDQVSP-------VSEMTSTSLYQDKQEGKSTDFA------ 1466

  Fly  1606 RESLAESIKPESGIDEKSALASKEASRPESVTDKSKEPSRRESIAESLKAESTKDEKSAPPSKEA 1670
                  .||.:.|.::|:          :.|...|.:|        :|..:..|....:|...:.
Human  1467 ------PIKEDFGQEKKT----------DDVEAMSSQP--------ALALDERKLGDVSPTQIDV 1507

  Fly  1671 SRPGSVVESVKDETEKSKEPSRRESIAESAKPPIEFREVSRPESVIDGIKDESAKPESRRDSPLA 1735
            |:.||..|..|            .||:|..                  :.|:||.|.   |..:|
Human  1508 SQFGSFKEDTK------------MSISEGT------------------VSDKSATPV---DEGVA 1539

  Fly  1736 SKEASRPESVLESVKDEPIKSTEKSRRESVAESFKADSTKDEKSPLTSKDISRPESAVENVMDAV 1800
            ....|..|.| .||      ||     .|||.|...:.|.|:.||....::..|.|.  .|.|::
Human  1540 EDTYSHMEGV-ASV------ST-----ASVATSSFPEPTTDDVSPSLHAEVGSPHST--EVDDSL 1590

  Fly  1801 GSAERSQPESVTASRDVSRPESVAESE----KDDTDKPESV---------VESVIPASD------ 1846
                     ||:.   |..|.:..|:|    |::..:|.|:         .:|..|..|      
Human  1591 ---------SVSV---VQTPTTFQETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRSEQS 1643

  Fly  1847 VVEIEKGAADKEKGVFVSLEIGKPDSPSE-----VISRPGPVVESVKPESRRESSTEIVLPCHAE 1906
            .:.||.|....|:.:.:......||.|:.     .|:..||......|...::||....:|    
Human  1644 SMSIEFGQESPEQSLAMDFSRQSPDHPTVGAGVLHITENGPTEVDYSPSDMQDSSLSHKIP---- 1704

  Fly  1907 DSKEPSRPESKVECLKDESEVLKGSTRRESVAESDKSSQPFKETSRPESAVGSMKDESMSKEPSR 1971
            ..:|||..:.     .|.||::       ||::.:.|  |...::...|.:.|         |.:
Human  1705 PMEEPSYTQD-----NDLSELI-------SVSQVEAS--PSTSSAHTPSQIAS---------PLQ 1746

  Fly  1972 RESVKDGAAQSRETSRPASVAESAKDGADDLKELSRPESTTQSKEAGSI--KDEKSPLASEEASR 2034
            .:::.| .|..|:.|..||:.                ....||.|...:  |.:.|||...|:|.
Human  1747 EDTLSD-VAPPRDMSLYASLT----------------SEKVQSLEGEKLSPKSDISPLTPRESSP 1794

  Fly  2035 PASVAESVKDEAEKSKEESRRESVAEKSPLPSKEASRPASVAESIKDEAEKSKEESRRESVAEKS 2099
            ..|...|....|           |.||:......:|.|.        :|..::....|.||...:
Human  1795 LYSPTFSDSTSA-----------VKEKTATCHSSSSPPI--------DAASAEPYGFRASVLFDT 1840

  Fly  2100 PLPSKEASRPASVAESIKDEAEKSKEESRRESVAEKSPLPSKEASRPASVAESIKDEAEKSKEES 2164
            .......:|..|.....||...|:..:.   |.|.:.|   :|.:|    :...:|...:|.|::
Human  1841 MQHHLALNRDLSTPGLEKDSGGKTPGDF---SYAYQKP---EETTR----SPDEEDYDYESYEKT 1895

  Fly  2165 RRES-----VAEKSPLPSKEASRPASVAESIKDEAEKSKEESRRESVAEKSPLPSKEASRPASVA 2224
            .|.|     ..||....:|..|......|:|....:..::......:.||:....:|......::
Human  1896 TRTSDVGGYYYEKIERTTKSPSDSGYSYETIGKTTKTPEDGDYSYEIIEKTTRTPEEGGYSYDIS 1960

  Fly  2225 ESIKDEAEKS------KEESRRESVAEKSPLPSKEASRPASVAESIKDEAEKSKEESRRESVAEK 2283
            |......|.|      .|.|||                       :.|:.....::|........
Human  1961 EKTTSPPEVSGYSYEKTERSRR-----------------------LLDDISNGYDDSEDGGHTLG 2002

  Fly  2284 SPLPSKEAS-RPASVAESIKDEAEKSKEETRRE-------SVAEKSPLPSKEASRPASVAESIKD 2340
            .|..|.|.: :..|..||.....|.|.:.||..       ..|||.....:.::.....::....
Human  2003 DPSYSYETTEKITSFPESEGYSYETSTKTTRTPDTSTYCYETAEKITRTPQASTYSYETSDLCYT 2067

  Fly  2341 EAEKSKEESRRE-------SAAEKSP----LPSKEASRPAS--VAESVKDEADKSKEESRRESMA 2392
            ..:||..|:|::       |...|.|    .||.....|..  .:|...:|::|...:|......
Human  2068 AEKKSPSEARQDVDLCLVSSCEYKHPKTELSPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPP 2132

  Fly  2393 ESGKAQSIKGDQSPLKEVSRPESVAESVKDDPVKSKEPSRRESVAGSVTADSARDDQSPLESKGA 2457
            ..||.|..:.|::|      |.||:||..........|...|  ..|:|||:..|.:        
Human  2133 PGGKQQGRQCDETP------PTSVSESAPSQTDSDVPPETEE--CPSITADANIDSE-------- 2181

  Fly  2458 SRPESVVDSVKDEAEKQESRRESKTESVIPPKAK-DDKSPKEVLQPVSMTE----TIREDADQPM 2517
                       ||:|...:.:....:.:.||.|. .|:||......|||.:    .|.::..:.:
Human  2182 -----------DESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPDVSMVDPEALAIEQNLGKAL 2235

  Fly  2518 KPSQAE-SRRESIAESIKASSP---RDEKS-PLASKEASRPGSVAESIKYDLDKPQIIKDDKSTE 2577
            |....| ::.:......|:|||   .|.|| |||:  :.:|..:.||    .||...:...|   
Human  2236 KKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAA--SPKPAGLKES----SDKVSRVASPK--- 2291

  Fly  2578 HSRRESLEDKSAVTSEKSVSRPLSVASDHEAAVAIEDDAKSSISPKDKSR-PGFVAETVSSPIEE 2641
              ::||:|..:..|:...|........|.|...|.  :|.:|.|.|..:. ||....|.||.:..
Human  2292 --KKESVEKAAKPTTTPEVKAARGEEKDKETKNAA--NASASKSAKTATAGPGTTKTTKSSAVPP 2352

  Fly  2642 ATMEFSKIEVVEKSSLALSLQGGSGGKLQTDSSPVDVAEGDFSHAVAS----VSTVTPTLTKPAE 2702
            ....:..:..:...|               :|..|||   :|...|.|    ||...|...:|:.
Human  2353 GLPVYLDLCYIPNHS---------------NSKNVDV---EFFKRVRSSYYVVSGNDPAAEEPSR 2399

  Fly  2703 LAQIGAAKTVSSPLDEALRTPSAPEHISRADSPAECASEEIASQDKSPQVLKESSRPAWVAESKD 2767
             |.:.|.....:.....::....|.|.|                    :|::|     |..|:.:
Human  2400 -AVLDALLEGKAQWGSNMQVTLIPTHDS--------------------EVMRE-----WYQETHE 2438

  Fly  2768 DAAQLKSSVEDLRSPVASTEISRPA 2792
            ....|...|....|.|...:.|.||
Human  2439 KQQDLNIMVLASSSTVVMQDESFPA 2463

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
futschNP_001096864.1 DUF966 <1925..>2112 CDD:283735 37/188 (20%)
MAP1BNP_005900.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26 7/25 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 522..781 66/301 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 872..1045 43/173 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1058..1160 27/106 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1173..1220 11/53 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1238..1277 8/42 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1291..1826 155/735 (21%)
PRK14949 <1531..>1829 CDD:237863 86/389 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1849..1896 13/56 (23%)
MAP1B 2 1895..1911 4/15 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1911..2037 26/148 (18%)
MAP1B 9 2031..2047 3/15 (20%)
MAP1B 10 2048..2064 0/15 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2093..2349 72/295 (24%)
Mediates interaction with TMEM185A. /evidence=ECO:0000269|PubMed:15525354 2294..2468 44/215 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 358 1.000 Domainoid score I975
eggNOG 1 0.900 - - E1_KOG3592
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 300 1.000 Inparanoid score I2703
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003086
OrthoInspector 1 1.000 - - otm42169
orthoMCL 1 0.900 - - OOG6_104538
Panther 1 1.100 - - O PTHR13843
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
98.910

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