DRSC/TRiP Functional Genomics Resources

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Protein Alignment futsch and MAP1A

DIOPT Version :9

Sequence 1:NP_001096864.1 Gene:futsch / 5740544 FlyBaseID:FBgn0259108 Length:5495 Species:Drosophila melanogaster
Sequence 2:NP_002364.5 Gene:MAP1A / 4130 HGNCID:6835 Length:2803 Species:Homo sapiens


Alignment Length:3348 Identity:763/3348 - (22%)
Similarity:1230/3348 - (36%) Gaps:855/3348 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   305 FIDYLAPMVMPTSLRELLETSDVVGNIRFTHPTLYVFPGGQGDAALFGINGFNMLVDGGFNRKAC 369
            |.:|::..|...|..:|||.....|.::.:.|..|:||||:||:|||.:||||:|||||.:||:|
Human     7 FSEYVSETVDVPSPFDLLEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNILVDGGSDRKSC 71

  Fly   370 FWDFARHLDRLDAVLMTRLNNSNVQGLGAVVSRK---------RDAHVY---------PQIGHFF 416
            ||...|||||:|:||:|.:...|:.|:..::.||         :.:..|         |::|..|
Human    72 FWKLVRHLDRIDSVLLTHIGADNLPGINGLLQRKVAELEEEQSQGSSSYSDWVKNLISPELGVVF 136

  Fly   417 GNVPDRKGLPSPDGDKDRDPLLIDLFERGHGIVSDLKALDLKPQCCYR----NQEPVNLYHKVGH 477
            .|||::..||.......|.      .|.....:..|..|.::.:..||    ..||:.|:||:|.
Human   137 FNVPEKLRLPDASRKAKRS------IEEACLTLQHLNRLGIQAEPLYRVVSNTIEPLTLFHKMGV 195

  Fly   478 GTLDMYVISPARDSKEVKEFLQKWHAGDQRL---FAARDSRDFNFPLQNLVSICALLVWQPANPD 539
            |.|||||::|.:||||::..:||| ||:.:.   ....:.::....:..|.||.||:||.||||.
Human   196 GRLDMYVLNPVKDSKEMQFLMQKW-AGNSKAKTGIVLPNGKEAEISVPYLTSITALVVWLPANPT 259

  Fly   540 DTITRILFPGSTPDFKIQEGLEKLKHLEFMKHSTCTAKSIAP-AIQTVTSTRKSLKSAIEATPAP 603
            :.|.|:||||:.|..||.||||||:||:|:::...|.|.:|. |:.|      :||.:.....|.
Human   260 EKIVRVLFPGNAPQNKILEGLEKLRHLDFLRYPVATQKDLASGAVPT------NLKPSKIKQRAD 318

  Fly   604 PSASYKTTKFSPVASAALAVQHPQQQDNKAKEAAAAAAAAAAAAASAATIARAKADSMDTDAEPE 668
            ...|.|.|..:.|:..|        :..:..|..|..|.:..|...|.|..:||..|   :..||
Human   319 SKESLKATTKTAVSKLA--------KREEVVEEGAKEARSELAKELAKTEKKAKESS---EKPPE 372

  Fly   669 HEADPEPADT-GDEAAPTEQEPEAETEPEPEHEPEAEQDKDVGEEKKVEVLIMKPQQATPAVIAA 732
            ..|.||...| ..||...|:.             :..:|| ||::...|                
Human   373 KPAKPERVKTESSEALKAEKR-------------KLIKDK-VGKKHLKE---------------- 407

  Fly   733 SGKDGVDAASADATPTGKLSKASAKGKADKPRAEVKPVVRSRIDTKPPKSMDRKLAKRDEKKSSP 797
                             |:||  .:.|.||.:.|:|   :.|.:.|  |...||..|:|.||...
Human   408 -----------------KISK--LEEKKDKEKKEIK---KERKELK--KDEGRKEEKKDAKKEEK 448

  Fly   798 TTTPAARAPVAQNAKP--KVLSRPATKSSPSSTPAKSAKEANNRKVLESKQQAARVQATSTVSRR 860
                      .::.||  |.:|:|..|   ..||       ..||.|                  
Human   449 ----------RKDTKPELKKISKPDLK---PFTP-------EVRKTL------------------ 475

  Fly   861 VTSTASERRVQQQAEAKTAATGATQATQRKPISRRPRGVSPSKRAPAPGSPVKQAKPKAADLKKT 925
                                                      .:|..||. ||        :.::
Human   476 ------------------------------------------YKAKVPGR-VK--------IDRS 489

  Fly   926 RLDKGGTTDSSLVSTPSADEATAAKKLQDLTASQELDAEKQRELDDLKEEQEVVREIEAVFSRDE 990
            |..:|....||...||.|.:.|.  .|..::..:||         .|...:::.::.|      |
Human   490 RAIRGEKELSSEPQTPPAQKGTV--PLPTISGHREL---------VLSSPEDLTQDFE------E 537

  Fly   991 MKRQQHQQIKAELREMPAEGTGDGENEPDEEEEYLIIEKEEVEQYTEDSI--VEQESSMTKEEEI 1053
            |||::    :|.|.|....|.||.....|..||.   ......|.|..|:  :.||..:.||:|:
Human   538 MKREE----RALLAEQRDTGLGDKPFPLDTAEEG---PPSTAIQGTPPSVPGLGQEEHVMKEKEL 595

  Fly  1054 QKHQRDSQESEKKRKKSAEEEIEAAIAKVEAAERKA-RLEGASARQDESELDVEPEQSKIKAEVQ 1117
            .....:.|.|:.:...|..|..|......|..:|:| ||...:..::|||.:|:.:..: |||::
Human   596 VPEVPEEQGSKDRGLDSGAETEEEKDTWEEKKQREAERLPDRTEAREESEPEVKEDVIE-KAELE 659

  Fly  1118 DIIATAKDIAKSRTEEQLAKPAEEELSSPTPEEKLSKKTSDTKDDQIGAPVDVLP---------- 1172
            ::            ||  ..|::||....|..|...:|       .:..|:.|.|          
Human   660 EM------------EE--VHPSDEEEEDATKAEGFYQK-------HMQEPLKVTPRSREAFGGRE 703

  Fly  1173 VNLQESLPEEK-----FSATIESGATTAPTLPEDERIPLDQIKEDLVIEEKYVKEETKE------ 1226
            :.||...||::     .|.|..:|||...:..:||.||.....|..:.:|: :.:|.:|      
Human   704 LGLQGKAPEKETSLFLSSLTTPAGATEHVSYIQDETIPGYSETEQTISDEE-IHDEPEERPAPPR 767

  Fly  1227 ----------------------AEAIVVAT---VQTLPE----------AAPLAIDTILASATKD 1256
                                  |::.|.||   |...||          |||||.:..::|||..
Human   768 FHTSTYDLPGPEGAGPFEASQPADSAVPATSGKVYGTPETELTYPTNIVAAPLAEEEHVSSATSI 832

  Fly  1257 APKD-ANAEALGELPDSGERVLPMKMTFE-AQQNLLRDVIKTPDEVADLP-VHEEADLGLYEKDS 1318
            ...| .::.|.....|.....|....|.| .:.:||.|.      |..:| ...||..||....|
Human   833 TECDKLSSFATSVAEDQSVASLTAPQTEETGKSSLLLDT------VTSIPSSRTEATQGLDYVPS 891

  Fly  1319 QDAGAKSISHKEESAKEEKETDDEKENKVGEIELGDEPNKVDISHVLLKESVQEVAEKVVVIETT 1383
              ||..|.:...|..|..|....|..:..||                 .|...|:..|.:..|..
Human   892 --AGTISPTSSLEEDKGFKSPPCEDFSVTGE-----------------SEKRGEIIGKGLSGERA 937

  Fly  1384 VEKKQEEIVEATTVITQENQEDLMEQ----VKDKEEHEQKIESGIITEKEAKKSASTPEEKETSD 1444
            ||:::||....      |..|.|..|    |.....|  .:..|.....||::...:|       
Human   938 VEEEEEETANV------EMSEKLCSQYGTPVFSAPGH--ALHPGEPALGEAEERCLSP------- 987

  Fly  1445 ITSDDELPAQLADPTTVPPKSAKDREDTGSIESPPTIEEAIEVEVQAKQEAQKPVPAPEEAIKTE 1509
                |:...::|.|   ||........|...:||  :||  :.|.|..|||       :....|:
Human   988 ----DDSTVKMASP---PPSGPPSATHTPFHQSP--VEE--KSEPQDFQEA-------DSWGDTK 1034

  Fly  1510 KSPLASKETSRPESATGSVKEDTEQTKSKKSPVPSRPESE-------------------AKDKKS 1555
            ::|...||.:..|:.....:|.|.: |.:|.|.|..|:::                   |:||..
Human  1035 RTPGVGKEDAAEETVKPGPEEGTLE-KEEKVPPPRSPQAQEAPVNIDEGLTGCTIQLLPAQDKAI 1098

  Fly  1556 PFASGEASRPESVAESVKDEAGKAESRRESIAKTHKDE--SSLDKAKEQESRRESLAESIKPESG 1618
            .|...||..|.......:...|...:..:...|..|||  ...|::...|.     |||:...|.
Human  1099 VFEIMEAGEPTGPILGAEALPGGLRTLPQEPGKPQKDEVLRYPDRSLSPED-----AESLSVLSV 1158

  Fly  1619 IDEKSALASKEASRPESVT------DKSKEPSRRESIAESLKAESTKDEKSAPPSKEASRPGSVV 1677
            ....:|........|..:|      |:..|.|..::.:.||..||        ||||.|      
Human  1159 PSPDTANQEPTPKSPCGLTEQYLHKDRWPEVSPEDTQSLSLSEES--------PSKETS------ 1209

  Fly  1678 ESVKDETEKSKEPSRRESIAESAKPPIEFREVSRPESVIDGIKDESAKPESRRDSPLASKEASRP 1742
               .|.:.|...|   ||:.     .::|.|::..:..:..:.  .|:..|...:|::..|   |
Human  1210 ---LDVSSKQLSP---ESLG-----TLQFGELNLGKEEMGHLM--QAEDTSHHTAPMSVPE---P 1258

  Fly  1743 ESVLESVKDEPIKSTEKSRRESVAESFKADSTKDEKSPLTSKDISRPESAVENVMDAVGSAERSQ 1807
            .:...|      ..|:.:.|.| |::...|.:.|.|||.:|...|.|....:.:..|:.|.:   
Human  1259 HAATAS------PPTDGTTRYS-AQTDITDDSLDRKSPASSFSHSTPSGNGKYLPGAITSPD--- 1313

  Fly  1808 PESVTASRDVSRPESVAESEKDDTDKPESVVESVIPASDVVEIEKGAADKEKGVFVSLEIGKPDS 1872
                         |.:...:...:..|||     :|...:.:|.....||..|:        .|.
Human  1314 -------------EHILTPDSSFSKSPES-----LPGPALEDIAIKWEDKVPGL--------KDR 1352

  Fly  1873 PSEVISRPGPVVESVKPESRRESSTEIVLPCHAEDSKEPSRPES---KVECLKDESEVL--KG-- 1930
            .||....|.|..|.::.:.:.....|:|.|   :|:....:.|:   |.|.:|.:.:.|  ||  
Human  1353 TSEQKKEPEPKDEVLQQKDKTLEHKEVVEP---KDTAIYQKDEALHVKNEAVKQQDKALEQKGRD 1414

  Fly  1931 -STRRESVAESDKSSQPFKETSRPESAVGSMKDESMSKEPSRRESVKDGAAQSRETS-RPASVAE 1993
             ..:..::.:.||:.:| |:....|      ||:::.::....|. ||.|.:.::|: .....|.
Human  1415 LEQKDTALEQKDKALEP-KDKDLEE------KDKALEQKDKIPEE-KDKALEQKDTALEQKDKAL 1471

  Fly  1994 SAKDGADDLKELSRPESTTQSKEAGSIKDEK-----SPLASEEASRPASVAESVKDE-------- 2045
            ..||     |:|.:.:...:.||  .|.:||     ..:.|.|...|......:||.        
Human  1472 EPKD-----KDLEQKDRVLEQKE--KIPEEKDKALDQKVRSVEHKAPEDTVAEMKDRDLEQTDKA 1529

  Fly  2046 -AEKSKEESRRESVAEKSPLPSKEASRPASVAESIKDEAEKSKEESRRES--VAEKSPLPSKEAS 2107
             .:|.:.:.:::.|:||    ..:|......|...||||.:...::..|:  ..|:..|..::.:
Human  1530 PEQKHQAQEQKDKVSEK----KDQALEQKYWALGQKDEALEQNIQALEENHQTQEQESLVQEDKT 1590

  Fly  2108 RPASVAESIKDEAEKSKEESRRESVAEKSPLPSKEASRPASVAESIKDEAEKSKEES---RRESV 2169
            |...:.|....|..|:.|| :.|::.||        ::...:.||:..|....::|.   |.:.|
Human  1591 RKPKMLEEKSPEKVKAMEE-KLEALLEK--------TKALGLEESLVQEGRAREQEEKYWRGQDV 1646

  Fly  2170 A----EKSPLPSKEASRPASVAESIKDEAEKSKEESR----RESVAEKSPLPSKEAS--RPASVA 2224
            .    |.||...:.|.....:|.:.:|.:  .::::|    ||.||.:.....:|.|  |.....
Human  1647 VQEWQETSPTREEPAGEQKELAPAWEDTS--PEQDNRYWRGREDVALEQDTYWRELSCERKVWFP 1709

  Fly  2225 ESIKDEAEKSKEESRRESV------AEKSPLPSKEASRPASVAESIKDEAEKSKEESRR-ESVAE 2282
            ..:..:..:......|||.      .::..:|.:|.:..:..|...||..|.|.::... |....
Human  1710 HELDGQGARPHYTEERESTFLDEGPDDEQEVPLREHATRSPWASDFKDFQESSPQKGLEVERWLA 1774

  Fly  2283 KSP--LPSKE-----------ASRPASVAESIKDEAEKSKEETRRESVAEKSPLP--------SK 2326
            :||  ||.:|           .|.|||..|.:......:.        .::||:|        ..
Human  1775 ESPVGLPPEEEDKLTRSPFEIISPPASPPEMVGQRVPSAP--------GQESPIPDPKLMPHMKN 1831

  Fly  2327 EASRPASVAESIKDEAEKSKE-ESRRESAAEKSPLPSKEASRPA----------SVAESVKDEA- 2379
            |.:.|:.:|: |.....|.:. .....|.|...|.|:.|:..||          ||..:|::.| 
Human  1832 EPTTPSWLAD-IPPWVPKDRPLPPAPLSPAPGPPTPAPESHTPAPFSWGTAEYDSVVAAVQEGAA 1895

  Fly  2380 ------------DKSKEESRRESMAESGKAQS--IKGDQSPLKEVSRPESVAESVKDDPVKSKEP 2430
                        |..|.|..||   |.|:|::  .....|.:.|.|:..:..|..:.:| :.:||
Human  1896 ELEGGPYSPLGKDYRKAEGERE---EEGRAEAPDKSSHSSKVPEASKSHATTEPEQTEP-EQREP 1956

  Fly  2431 S--------------RRESVAGSVTADSARDDQSPLESKGASRPESVVDSVKDEAEKQESRRESK 2481
            :              .:..:.|...|...|  :.||.:.|...|   ..|.|:.|..:.:..|.:
Human  1957 TPYPDERSFQYADIYEQMMLTGLGPACPTR--EPPLGAAGDWPP---CLSTKEAAAGRNTSAEKE 2016

  Fly  2482 TESVIPPKAKDDKSPKEVLQPVSMTETIREDADQPMKPSQAESRRESIAESIKASSPRDEKSPLA 2546
            ..|.|.||:....:|       :.:.........|.:|....|...|:..  .|..||   :|:.
Human  2017 LSSPISPKSLQSDTP-------TFSYAALAGPTVPPRPEPGPSMEPSLTP--PAVPPR---APIL 2069

  Fly  2547 SKEASRP--GSVAESIKYDLDKPQIIKDDKSTEHSRRESLEDKSAVTSEKSVSRPLSVASDHEAA 2609
            ||..|.|  |::. |...|...|       |.:.|.|...:|.   ||:..:.:......:.|| 
Human  2070 SKGPSPPLNGNIL-SCSPDRRSP-------SPKESGRSHWDDS---TSDSELEKGAREQPEKEA- 2122

  Fly  2610 VAIEDDAKSSISPKDKSRPGFVAET---VSSPIE------EATMEFSKIEVVEKSSLALSLQGGS 2665
                 .:.|...|.....|....||   ||.|::      ..:::|      ..|:...|....:
Human  2123 -----QSPSPPHPIPMGSPTLWPETEAHVSPPLDSHLGPARPSLDF------PASAFGFSSLQPA 2176

  Fly  2666 GGKLQTDSSPVDVAEGDFSHA---VASVSTVTPTLTKPAELAQIGAAKTVSSPLDEALRTPSAP- 2726
            ..:|.:.:.|.....|..:.:   ..:::...||.|:..|..::..|.::.|.|.: |.:||:| 
Human  2177 PPQLPSPAEPRSAPCGSLAFSGDRALALAPGPPTRTRHDEYLEVTKAPSLDSSLPQ-LPSPSSPG 2240

  Fly  2727 ----EHISRADSPAECASEEIASQDKSPQVLKESSRPAWVAESKDDAAQLKSSVEDLRSPVAS-- 2785
                .::.|..|||  .||..:|:..:|.:...:.|   .:.|.:.|.|....::....|.|.  
Human  2241 APLLSNLPRPASPA--LSEGSSSEATTPVISSVAER---FSPSLEAAEQESGELDPGMEPAAHSL 2300

  Fly  2786 ---TEIS-RPASAGETASSPIEEAPKDFAEFEQAEKAVLPLTIELKGNLPTLSSPVDVAHGDFPQ 2846
               |.:| .|.::.:.|.:|....|.|..:      .:||..:|.........||..|...|...
Human  2301 WDLTPLSPAPPASLDLALAPAPSLPGDMGD------GILPCHLECSEAATEKPSPFQVPSEDCAA 2359

  Fly  2847 TSTPTSSPTVASVQPAELSKVDIEKTASSPIDEAPKSLIGCPAEER---PESPAESAK-DAAESV 2907
            .....:||......||   |.:.|:.|:            |||.||   ||....|:: |...|.
Human  2360 NGPTETSPNPPGPAPA---KAENEEAAA------------CPAWERGAWPEGAERSSRPDTLLSP 2409

  Fly  2908 EK----SKDASRPPSVVE----------STKADSTKGDISPS------PESVLEGPKDDVEKSKE 2952
            |:    :..:..|||...          :|:....:|::|||      |.|:     ||.:.|.|
Human  2410 EQPVCPAGGSGGPPSSASPEVEAGPQGCATEPRPHRGELSPSFLNPPLPPSI-----DDRDLSTE 2469

  Fly  2953 SSRPPSVSA--SITGDSTKDVSRPASVVESVKDEHDKAESRRESIAKVESVIDEAGKSDSKSSSQ 3015
            ..|......  .:.|..|.....|      |.||.....:                 |||.||..
Human  2470 EVRLVGRGGRRRVGGPGTTGGPCP------VTDETPPTSA-----------------SDSGSSQS 2511

  Fly  3016 DS----QKDEKSTLASKEASRRESVVESSKDDAEKSESRPESVIASGEPVPRESKSPLDSKDTSR 3076
            ||    :.:|..::.:      |:.::|.:|.......:...|..:..|.|.....||...| .|
Human  2512 DSDVPPETEECPSITA------EAALDSDEDGDFLPVDKAGGVSGTHHPRPGHDPPPLPQPD-PR 2569

  Fly  3077 PGSMVESVTAEDEK--SEQQSRRESVAESVKADTKKDGKSQEASRPSSVDELLKDDDEKQESRRQ 3139
            |......|...|.:  |.:..|.|.:.|..|...:...::...::|:|            .:||.
Human  2570 PSPPRPDVCMADPEGLSSESGRVERLREKEKVQGRVGRRAPGKAKPAS------------PARRL 2622

  Fly  3140 SITGSHKAMSTMGDESPMDKADKSKEPSRPESVAESIKHENTKDEESPL------GSRRDSVAES 3198
            .:.|  |...|.| :.|.|:|  |:.|.||.|....:.....||..||:      |.:...:|.|
Human  2623 DLRG--KRSPTPG-KGPADRA--SRAPPRPRSTTSQVTPAEEKDGHSPMSKGLVNGLKAGPMALS 2682

  Fly  3199 IKSDITKGEK-SPLPSKEVSRPESVVGSIKDEKAESRRESVAESVKPESSKDATSAPPSKEHSRP 3262
                 :||.. :|:.......|....|...|.....|   |..|....|..|..:..||:     
Human  2683 -----SKGSSGAPVYVDLAYIPNHCSGKTADLDFFRR---VRASYYVVSGNDPANGEPSR----- 2734

  Fly  3263 ESVLGSLKDEGDKTTSRRVSVADSIKDEKSLLVSQEASRPESEAESLKDAAAPSQET-------- 3319
                               :|.|::.:.|:           ...|:|:....|:.:|        
Human  2735 -------------------AVLDALLEGKA-----------QWGENLQVTLIPTHDTEVTREWYQ 2769

  Fly  3320 ---SRPESVTESVKDGKSPVASKEASRPASVAE 3349
               .:.:.:...|....|.|..::.|.||...|
Human  2770 QTHEQQQQLNVLVLASSSTVVMQDESFPACKIE 2802

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
futschNP_001096864.1 DUF966 <1925..>2112 CDD:283735 44/208 (21%)
MAP1ANP_002364.5 metallo-hydrolase-like_MBL-fold 50..>101 CDD:304873 28/50 (56%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 302..466 56/247 (23%)
9 X 3 AA repeats of K-K-[DE] 415..541 46/236 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 486..516 9/31 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 539..712 49/201 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 734..806 13/72 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 847..1080 68/291 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1109..1548 110/531 (21%)
GBP_C <1364..1488 CDD:303769 29/139 (21%)
Tropomyosin_1 1397..1540 CDD:289488 34/157 (22%)
GBP_C <1434..1614 CDD:303769 43/198 (22%)
coiled coil 1456..1470 CDD:293879 2/13 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1573..1605 6/31 (19%)
coiled coil 1584..1595 CDD:293879 2/10 (20%)
coiled coil 1604..1614 CDD:293879 4/10 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1632..1684 10/53 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1713..1879 36/174 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1892..2673 194/903 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 150 1.000 Domainoid score I4391
eggNOG 1 0.900 - - E1_KOG3592
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 300 1.000 Inparanoid score I2703
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm42169
orthoMCL 1 0.900 - - OOG6_104538
Panther 1 1.100 - - LDO PTHR13843
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
87.910

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