DRSC/TRiP Functional Genomics Resources

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Protein Alignment futsch and Map1b

DIOPT Version :9

Sequence 1:NP_001096864.1 Gene:futsch / 5740544 FlyBaseID:FBgn0259108 Length:5495 Species:Drosophila melanogaster
Sequence 2:NP_062090.1 Gene:Map1b / 29456 RGDID:3043 Length:2461 Species:Rattus norvegicus


Alignment Length:2962 Identity:670/2962 - (22%)
Similarity:1108/2962 - (37%) Gaps:767/2962 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    90 TACSDADGGAPSSLAGGIVGPPSPLTG-----------CYLLIVLGEPHSEEHKDNILQHLLKGF 143
            |...:|....||    |.:|.|:..|.           .|||:|:||..:|||....:.::..|.
  Rat     3 TVVVEATEPEPS----GSIGNPAATTSPSLSHRFLDSKFYLLVVVGETVTEEHLRRAIGNIELGI 63

  Fly   144 LSWDVS--DCHVDLEEELNTITQHAPEGEEARHGERLIQYASENLVTEVLIHPQYNTLIQCMRNL 206
            .|||.:  :|::|.|.:| .:::|:........|::::.:.|:.|.|.|||:|....:...:|.:
  Rat    64 RSWDTNLIECNLDQELKL-FVSRHSARFSPEVPGQKILHHRSDVLETVVLINPSDEAVSTEVRLM 127

  Fly   207 LSSFTRHRHIIHAGYTFSGNGSWILQDGTFSVADFSEAFQEHDVQRVIRAY--ADTITMNIHCAD 269
            ::...||:.::..|..|...|..|||.|:||..:|.|.|.:.::..::...  |:..::.:.|.:
  Rat   128 ITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFIEIFTDQEIGELLSTTHPANKASLTLFCPE 192

  Fly   270 AGLW-------HTLPEKAFARQCRIRINPVDVLDTSSECINGFIDYLAPMVMPTSLRELLETSDV 327
            .|.|       |.|.:     ...|::|...:| ...|.::.|.:||:..|...|..::||....
  Rat   193 EGDWKNSNLDRHNLQD-----FINIKLNSASIL-PEMEGLSEFTEYLSESVEVPSPFDILEPPTS 251

  Fly   328 VGNIRFTHPTLYVFPGGQGDAALFGINGFNMLVDGGFNRKACFWDFARHLDRLDAVLMTRLNNSN 392
            .|.::.:.|..|:||||:||:|||.:||||||::||..||:|||...|||||:|::|:|.:.:.|
  Rat   252 GGFLKLSKPCCYIFPGGRGDSALFAVNGFNMLINGGSERKSCFWKLIRHLDRVDSILLTHIGDDN 316

  Fly   393 VQGLGAVVSRK------------------RDAHVYPQIGHFFGNVPDRKGLPSPDGDKDRDPLLI 439
            :.|:.:::.||                  ....:.|.:|..|.|||:....|.|:....|..   
  Rat   317 LPGINSMLQRKIAELEEERSQGSTSNSDWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRST--- 378

  Fly   440 DLFERGHGIVSDLKALDLKPQCCYRNQ----EPVNLYHKVGHGTLDMYVISPARDSKEVKEFLQK 500
               |.....:..|..|.:||:..:|:.    |||.|:.|:|.|.|:|||::|.:.|||::.|:|:
  Rat   379 ---EEACFTLQYLNKLSMKPEPLFRSVGNAIEPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQ 440

  Fly   501 WHA--GDQRLFAARDSRDFNFPLQNLVSICALLVWQPANPDDTITRILFPGSTPDFKIQEGLEKL 563
            |..  .|:......:.::.:.|:..|.|:.:|:||.||||.:.|.|:||||::..:.|.||||||
  Rat   441 WTGTNKDKAELILPNGQEVDIPISYLTSVSSLIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKL 505

  Fly   564 KHLEFMKHSTCTAKSI-----APAIQTV-----TSTRKSLKSAI-------------EATPAPPS 605
            |||:|:|....|.|.:     .|.::.|     ..:|:|||.|.             |..|....
  Rat   506 KHLDFLKQPLATQKDLTGQVSTPPVKQVKLKQRADSRESLKPATKPLSSKSVRKESKEEAPEATK 570

  Fly   606 ASY--KTTKFSPVASAALAVQHPQQQDNK---------AKEAAA---AAAAAAAAAASAATIARA 656
            ||.  ||.|........:....|.:.::|         :||..:   |..|..||..|...:.:.
  Rat   571 ASQVEKTPKVESKEKVIVKKDKPGKVESKPSVTEKEVPSKEEQSPVKAEVAEKAATESKPKVTKD 635

  Fly   657 KADSMDTDAEPEHEADPEPADTGDEAAPTEQEPEAETEPEPEHEPEAEQD--KDVGEEKKVEVLI 719
            |....:...:||.:.:.:|.   .|.|..|.:...:.:.:|:.| ||:::  |::.:|:|.| |.
  Rat   636 KVVKKEIKTKPEEKKEEKPK---KEVAKKEDKTPLKKDEKPKKE-EAKKEIKKEIKKEEKKE-LK 695

  Fly   720 MKPQQATPAVIAASGKDGVDAASADATPTGKLSKASAKGKADKPRAEVKPVVRSRIDTKPPKSMD 784
            .:.::.||                       |..|..:.|.|: :.|||.      :.|.||...
  Rat   696 KEVKKETP-----------------------LKDAKKEVKKDE-KKEVKK------EEKEPKKEI 730

  Fly   785 RKLAKRDEKKSSP---TTTPAARAP-VAQNAKPKVLSRPATKSSPSSTPAKSAKEANNRKVLESK 845
            :|::| |.|||:|   |..|||..| ||:..:|       ||..|.:  |...|:....||::.:
  Rat   731 KKISK-DIKKSTPLSDTKKPAALKPKVAKKEEP-------TKKEPIA--AGKLKDKGKVKVIKKE 785

  Fly   846 QQAARVQATSTVSRRVTSTASERRVQQQAEAKTAATGATQATQRKPISRRPRGVSPSKRAPAPGS 910
            .:.....||:..:..|.           |.|..||:|                  |:|...|   
  Rat   786 GKTTEAAATAVGTAAVA-----------AAAGVAASG------------------PAKELEA--- 818

  Fly   911 PVKQAKPKAADLKKTRLDKGGTTDSSLVSTPSADEATAAKKLQDLTAS-QELDAEKQRELDDLKE 974
                                   :.||:|:|           :|||.. :||.||:.....|:|.
  Rat   819 -----------------------ERSLMSSP-----------EDLTKDFEELKAEEIDVAKDIKP 849

  Fly   975 EQEVVREIEAVFSRDEMKR---QQHQQIKAELREMPAEG--TGDGENE----PDE---------- 1020
            :.|::.:.|.:...:..:.   |:..::.....|.|.||  |.:||.|    |:|          
  Rat   850 QLELIEDEEKLKETEPGEAYVIQKETEVSKGSAESPDEGITTTEGEGECEQTPEELEPVEKQGVD 914

  Fly  1021 ---------------------EEEYLIIEKEEVEQYTEDSIVEQES--SMTKEEEIQK-----HQ 1057
                                 ||:....|.||.|:..||::....|  |.|::|||.|     |.
  Rat   915 DIEKFEDEGAGFEESSEAGDYEEKAETEEAEEPEEDGEDNVSGSASKHSPTEDEEIAKAEADVHI 979

  Fly  1058 RDSQESEKKRKKSAEEEIEAAIAKVEA--AERKARLEGASARQDESELDVEPEQSKIKAEVQDII 1120
            ::.:||.......|||:::.|:.|.||  :|.:...|...| :|..|.|.||:    |.|.:|.:
  Rat   980 KEKRESVASGDDRAEEDMDEALEKGEAEQSEEEGEEEEDKA-EDAREEDHEPD----KTEAEDYV 1039

  Fly  1121 ATAKDIAKSR--TEEQ---LAKPAEEE-LSSPTPEEKLS---------KKTSDTKDDQIGAPVDV 1170
            ....|.|...  ||:|   |..||::. :.||:.|...|         .::..|..|:       
  Rat  1040 MAVVDKAAEAGVTEDQYDFLGTPAKQPGVQSPSREPASSIHDETLPGGSESEATASDE------- 1097

  Fly  1171 LPVNLQESLPEEKFSATIESGATTAPTLPEDERIPLDQIK--EDLVIEEKYVKEETKEAEAIVVA 1233
               ..:|..||| |:||  ||.|.:......|..|:|::.  .|::.:|...:|....::..|..
  Rat  1098 ---ENREDQPEE-FTAT--SGYTQSTIEISSEPTPMDEMSTPRDVMTDETNNEETESPSQEFVNI 1156

  Fly  1234 T-------VQTLPEAAPLAIDTILASATKDAP--KDANAEALGELPDSGERVLPMKMTFEA-QQN 1288
            |       .|...:....:.:.:...:..||.  :|.||.|....|       |..|..:. .::
  Rat  1157 TKYESSLYSQEYSKPVVASFNGLSDGSKTDATDGRDYNASASTISP-------PSSMEEDKFSKS 1214

  Fly  1289 LLRDVIKTPDEVADLPVHEEADLGLYEKDSQDAGAKSISHKEESAKEEKETDDEKENKVGEIELG 1353
            .|||..: |:| .|:....|.|:            |.:|.:..|..:.........:.:.:..||
  Rat  1215 ALRDAYR-PEE-TDVKTGAELDI------------KDVSDERLSPAKSPSLSPSPPSPIEKTPLG 1265

  Fly  1354 DEPNKVDISHVLLKESVQEVAEKVVVIETTVEKKQEEIVEATTVITQENQEDLMEQVKDKEEH-- 1416
            :.    .::..|....::..||.                |||.|::....:.::      |||  
  Rat  1266 ER----SVNFSLTPNEIKASAEG----------------EATAVVSPGVTQAVV------EEHCA 1304

  Fly  1417 --EQKIESGIITEKEAKKSAS-TPEEKETSDITSDDELPAQLADPTTVPPKS-----AKDREDTG 1473
              |:|....:...:....||. ||..:..:|..| ..||.::.:.....|.|     |||..:..
  Rat  1305 SPEEKTLEVVSPSQSVTGSAGHTPYYQSPTDEKS-SHLPTEVTENAQAVPVSFEFTEAKDENERS 1368

  Fly  1474 SIESPPTIEEAIEVEVQAKQEAQKPVPAPEEAIKTEKSPLASKETSRPESATGSVKEDTEQTKSK 1538
            || ||                ..:|||..|..|:...|||.|......|||........::...:
  Rat  1369 SI-SP----------------MDEPVPDSESPIEKVLSPLRSPPLIGSESAYEDFLSADDKALGR 1416

  Fly  1539 KSPVPSRPESEAKDKKSPFASGEASRPESVAESVKDEAGKAESRRESIAKTHKDESSLDKAKEQE 1603
            :|..|    .|.|:.|..|:..|:...:..::..:|:.                           
  Rat  1417 RSESP----FEGKNGKQGFSDKESPVSDLTSDLYQDKQ--------------------------- 1450

  Fly  1604 SRRESLAESIKPESGIDEKSA--LASKEASRPESVTDKSKEPSRRESIAESLKAES--TKDEK-- 1662
                            :||||  :..||...||          ::.|.||.:.::|  ..||:  
  Rat  1451 ----------------EEKSAGFIPIKEDFSPE----------KKASDAEIMSSQSALALDERKL 1489

  Fly  1663 ---SAPPSKEASRPGSVVESVKDETEKSKEPSRRESIAESAKPPIEFREVSRPESVIDGIKDESA 1724
               .:|...:.|:.||..|..|            .||:|..                  :.|:||
  Rat  1490 GGDGSPTQVDVSQFGSFKEDTK------------MSISEGT------------------VSDKSA 1524

  Fly  1725 KPESRRDSPLASKEASRPESVLESVKDEPIKSTEKSRRESVAESFKADSTKDEKSPLTSKDISRP 1789
            .|.   |..:|....|..|.| .||      ||     .|||.|...:.|.|:.||....::..|
  Rat  1525 TPV---DEGVAEDTYSHMEGV-ASV------ST-----ASVATSSFPEPTTDDVSPSLHAEVGSP 1574

  Fly  1790 ESAVENVMDAVGSAERSQPESVTASRDVSRPESVAESE----KDDTDKPESV---------VESV 1841
            .|.  .|.|::         ||:.   |..|.:..|:|    |::..:|.|:         .:|.
  Rat  1575 HST--EVDDSL---------SVSV---VQTPTTFQETEMSPSKEECPRPMSISPPDFSPKTAKSR 1625

  Fly  1842 IPASD------VVEIEKGAADKEKGVFVSLEIGKPDSPSE-----VISRPGPVVESVKPESRRES 1895
            .|..|      .:.||.|....|..:.:......||.|:.     .|:..||......|...::|
  Rat  1626 TPVQDHRSEQSSMSIEFGQESPEHSLAMDFSRQSPDHPTVGAGMLHITENGPTEVDYSPSDIQDS 1690

  Fly  1896 STEIVLPCHAEDSKEPSRPESKVECLKDESEVLKGSTRRESVAESDKSSQPFKETSRPESAVGSM 1960
            |....:|    .::|||..:.     .|.||::       ||::.:.|  |...::...|.:.| 
  Rat  1691 SLSHKIP----PTEEPSYTQD-----NDLSELI-------SVSQVEAS--PSTSSAHTPSQIAS- 1736

  Fly  1961 KDESMSKEPSRRESVKDGAAQSRETSRPASVAESAKDGADDLKELSRPESTTQSKEAGSI--KDE 2023
                    |.:.:::.| ....|:.|..||:|                ....||.|...:  |.:
  Rat  1737 --------PLQEDTLSD-VVPPRDMSLYASLA----------------SEKVQSLEGEKLSPKSD 1776

  Fly  2024 KSPLASEEASRPASVAESVKDEAEKSKEESRRESVAEKSPLPSKEAS----RPASVAESIKDEAE 2084
            .|||...|:|  .:.:....|....:||.:.....:...|:.:..|.    |.:.:.::::....
  Rat  1777 ISPLTPRESS--PTYSPGFSDSTSGAKESTAAYQTSSSPPIDAAAAEPYGFRSSMLFDTMQHHLA 1839

  Fly  2085 KSKE---ESRRESVAEKSPLPSKEA-SRPASVAESIKDEAEKSKEESRRESVA--------EKSP 2137
            .|::   .|..:....|:|.....| .:|.|..|| .||.:...|...:...|        ||:.
  Rat  1840 LSRDLTTSSVEKDNGGKTPGDFNYAYQKPESTTES-PDEEDYDYESHEKTIQAHDVGGYYYEKTE 1903

  Fly  2138 LPSKEASRPASVAESIKDEAEKSKEESRRESVAEKSPLPSKEASRPASVAESIKDEAEKS----- 2197
            ...|.........|:|:...:..::......:.||:....:|......::|......|.|     
  Rat  1904 RTIKSPCDSGYSYETIEKTTKTPEDGGYSCEITEKTTRTPEEGGYSYEISEKTTRTPEVSGYTYE 1968

  Fly  2198 -KEESRRESVAEKSPLPSKEASRPASVAESIKDEAEKSKEESRRESVAEKSPLPSKEASRPASVA 2261
             .|.|||                       :.|:.....:::      |.......:.|......
  Rat  1969 KTERSRR-----------------------LLDDISNGYDDT------EDGGHTLGDCSYSYETT 2004

  Fly  2262 ESIKDEAEKSKEESRRESVAEKSPLPSKEASRPASVAESIKDEAEKSKEETRRESVAEKSPLPSK 2326
            |.|....|.........:...:||..|      |...|:::...:..:..|.....:::...|.:
  Rat  2005 EKITSFPESESYSYETTTKTTRSPDTS------AYCYETMEKITKTPQASTYSYETSDRCYTPER 2063

  Fly  2327 EASRPASVAESIKDEAEKSKEESRRE------SAAE-KSP----LPSKEASRPAS--VAESVKDE 2378
                             ||..|:|::      |:.| |.|    .||.....|..  ..|...:|
  Rat  2064 -----------------KSPSEARQDVDLCLVSSCEFKHPKTELSPSFINPNPLEWFAGEEPTEE 2111

  Fly  2379 ADKSKEESRRESMAESGKAQSIKGDQSPLKEVSRPESVAESVKDDPVKSKEPSRRESVAGSVTAD 2443
            ::|...:|........||.|..:.|::|      |.||:||..........|...|  ..|:|||
  Rat  2112 SEKPLTQSGGAPPPSGGKQQGRQCDETP------PTSVSESAPSQTDSDVPPETEE--CPSITAD 2168

  Fly  2444 SARDDQSPLESKGASRPESVVDSVKDEAEKQESRRESKTESVIPPKA-KDDKSPKEVLQPVSMTE 2507
            :..|.:                   ||:|...:.:....:.:.||.| ..|:||......|||.:
  Rat  2169 ANIDSE-------------------DESETIPTDKTVTYKHMDPPPAPMQDRSPSPRHPDVSMVD 2214

  Fly  2508 ----TIREDADQPMKPSQAE-SRRESIAESIKASSP---RDEKSPLASKEASRPGSVAESIKYDL 2564
                .|.::..:.:|....| ::.:......|:|||   .|.||. .|..:.:||::.||    .
  Rat  2215 PEALAIEQNLGKALKKDLKEKAKTKKPGTKTKSSSPVKKGDGKSK-PSAASPKPGALKES----S 2274

  Fly  2565 DKPQIIKDDKSTEHSRRESLEDKSAVTSEKSVSRPLSVASDHEAAVAIEDDAKSSISPKDKSRPG 2629
            ||...:...|     ::||:|.....|:...|........|.|...|....|..|:... .:.||
  Rat  2275 DKVSRVASPK-----KKESVEKAMKTTTTPEVKATRGEEKDKETKNAANASASKSVKTA-TAGPG 2333

  Fly  2630 FVAETVSSPIEEATMEFSKIEVVEKSSLALSLQGGSGGKLQTDSSPVDVAEGDFSHAVAS----V 2690
            ......||.:......:..:..:...|               :|..|||   :|...|.|    |
  Rat  2334 TTKTAKSSTVPPGLPVYLDLCYIPNHS---------------NSKNVDV---EFFKRVRSSYYVV 2380

  Fly  2691 STVTPTLTKPAELAQIGAAKTVSSPLDEALRTPSAPEHISRADSPAECASEEIASQDKSPQVLKE 2755
            |...|...:|:. |.:.|.....:.....::....|.|.|                    :|::|
  Rat  2381 SGNDPAAEEPSR-AVLDALLEGKAQWGSNMQVTLIPTHDS--------------------EVMRE 2424

  Fly  2756 SSRPAWVAESKDDAAQLKSSVEDLRSPVASTEISRPA 2792
                 |..|:.:....|...|....|.|...:.|.||
  Rat  2425 -----WYQETHEKQQDLNIMVLASSSTVVMQDESFPA 2456

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
futschNP_001096864.1 DUF966 <1925..>2112 CDD:283735 36/196 (18%)
Map1bNP_062090.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..22 7/22 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 522..772 70/294 (24%)
PTZ00121 <531..1158 CDD:173412 176/755 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 856..1154 78/315 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1175..1277 23/126 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1299..1749 130/617 (21%)
Herpes_BLLF1 <1543..1875 CDD:282904 85/403 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1762..1819 13/58 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1843..1884 10/41 (24%)
MAP1B 1. /evidence=ECO:0000305 1871..1887 5/16 (31%)
MAP1B 2. /evidence=ECO:0000305 1888..1904 3/15 (20%)
MAP1B 3. /evidence=ECO:0000305 1905..1921 3/15 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1921..1969 6/47 (13%)
MAP1B 6. /evidence=ECO:0000305 1956..1972 2/15 (13%)
MAP1B 7. /evidence=ECO:0000305 1990..2006 1/15 (7%)
MAP1B 8. /evidence=ECO:0000305 2007..2023 2/15 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2009..2029 2/19 (11%)
MAP1B 9. /evidence=ECO:0000305 2024..2040 5/21 (24%)
MAP1B 10. /evidence=ECO:0000305 2041..2057 1/15 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2045..2071 5/42 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2087..2343 68/293 (23%)
PHA03247 <2095..2348 CDD:223021 66/290 (23%)
Mediates interaction with TMEM185A. /evidence=ECO:0000250|UniProtKB:P46821 2287..2459 42/215 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 347 1.000 Domainoid score I1005
eggNOG 1 0.900 - - E1_KOG3592
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003086
OrthoInspector 1 1.000 - - otm46319
orthoMCL 1 0.900 - - OOG6_104538
Panther 1 1.100 - - O PTHR13843
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
98.860

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