|
Fly 90 TACSDADGGAPSSLAGGIVGPPSPLTG-----------CYLLIVLGEPHSEEHKDNILQHLLKGF 143
|...:|....|| |.:|.|:..|. .|||:|:||..:|||....:.::..|.
Rat 3 TVVVEATEPEPS----GSIGNPAATTSPSLSHRFLDSKFYLLVVVGETVTEEHLRRAIGNIELGI 63
Fly 144 LSWDVS--DCHVDLEEELNTITQHAPEGEEARHGERLIQYASENLVTEVLIHPQYNTLIQCMRNL 206
.|||.: :|::|.|.:| .:::|:........|::::.:.|:.|.|.|||:|....:...:|.:
Rat 64 RSWDTNLIECNLDQELKL-FVSRHSARFSPEVPGQKILHHRSDVLETVVLINPSDEAVSTEVRLM 127
Fly 207 LSSFTRHRHIIHAGYTFSGNGSWILQDGTFSVADFSEAFQEHDVQRVIRAY--ADTITMNIHCAD 269
::...||:.::..|..|...|..|||.|:||..:|.|.|.:.::..::... |:..::.:.|.:
Rat 128 ITDAARHKLLVLTGQCFENTGELILQSGSFSFQNFIEIFTDQEIGELLSTTHPANKASLTLFCPE 192
Fly 270 AGLW-------HTLPEKAFARQCRIRINPVDVLDTSSECINGFIDYLAPMVMPTSLRELLETSDV 327
.|.| |.|.: ...|::|...:| ...|.::.|.:||:..|...|..::||....
Rat 193 EGDWKNSNLDRHNLQD-----FINIKLNSASIL-PEMEGLSEFTEYLSESVEVPSPFDILEPPTS 251
Fly 328 VGNIRFTHPTLYVFPGGQGDAALFGINGFNMLVDGGFNRKACFWDFARHLDRLDAVLMTRLNNSN 392
.|.::.:.|..|:||||:||:|||.:||||||::||..||:|||...|||||:|::|:|.:.:.|
Rat 252 GGFLKLSKPCCYIFPGGRGDSALFAVNGFNMLINGGSERKSCFWKLIRHLDRVDSILLTHIGDDN 316
Fly 393 VQGLGAVVSRK------------------RDAHVYPQIGHFFGNVPDRKGLPSPDGDKDRDPLLI 439
:.|:.:::.|| ....:.|.:|..|.|||:....|.|:....|..
Rat 317 LPGINSMLQRKIAELEEERSQGSTSNSDWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRST--- 378
Fly 440 DLFERGHGIVSDLKALDLKPQCCYRNQ----EPVNLYHKVGHGTLDMYVISPARDSKEVKEFLQK 500
|.....:..|..|.:||:..:|:. |||.|:.|:|.|.|:|||::|.:.|||::.|:|:
Rat 379 ---EEACFTLQYLNKLSMKPEPLFRSVGNAIEPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQ 440
Fly 501 WHA--GDQRLFAARDSRDFNFPLQNLVSICALLVWQPANPDDTITRILFPGSTPDFKIQEGLEKL 563
|.. .|:......:.::.:.|:..|.|:.:|:||.||||.:.|.|:||||::..:.|.||||||
Rat 441 WTGTNKDKAELILPNGQEVDIPISYLTSVSSLIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKL 505
Fly 564 KHLEFMKHSTCTAKSI-----APAIQTV-----TSTRKSLKSAI-------------EATPAPPS 605
|||:|:|....|.|.: .|.::.| ..:|:|||.|. |..|....
Rat 506 KHLDFLKQPLATQKDLTGQVSTPPVKQVKLKQRADSRESLKPATKPLSSKSVRKESKEEAPEATK 570
Fly 606 ASY--KTTKFSPVASAALAVQHPQQQDNK---------AKEAAA---AAAAAAAAAASAATIARA 656
||. ||.|........:....|.:.::| :||..: |..|..||..|...:.:.
Rat 571 ASQVEKTPKVESKEKVIVKKDKPGKVESKPSVTEKEVPSKEEQSPVKAEVAEKAATESKPKVTKD 635
Fly 657 KADSMDTDAEPEHEADPEPADTGDEAAPTEQEPEAETEPEPEHEPEAEQD--KDVGEEKKVEVLI 719
|....:...:||.:.:.:|. .|.|..|.:...:.:.:|:.| ||::: |::.:|:|.| |.
Rat 636 KVVKKEIKTKPEEKKEEKPK---KEVAKKEDKTPLKKDEKPKKE-EAKKEIKKEIKKEEKKE-LK 695
Fly 720 MKPQQATPAVIAASGKDGVDAASADATPTGKLSKASAKGKADKPRAEVKPVVRSRIDTKPPKSMD 784
.:.::.|| |..|..:.|.|: :.|||. :.|.||...
Rat 696 KEVKKETP-----------------------LKDAKKEVKKDE-KKEVKK------EEKEPKKEI 730
Fly 785 RKLAKRDEKKSSP---TTTPAARAP-VAQNAKPKVLSRPATKSSPSSTPAKSAKEANNRKVLESK 845
:|::| |.|||:| |..|||..| ||:..:| ||..|.: |...|:....||::.:
Rat 731 KKISK-DIKKSTPLSDTKKPAALKPKVAKKEEP-------TKKEPIA--AGKLKDKGKVKVIKKE 785
Fly 846 QQAARVQATSTVSRRVTSTASERRVQQQAEAKTAATGATQATQRKPISRRPRGVSPSKRAPAPGS 910
.:.....||:..:..|. |.|..||:| |:|...|
Rat 786 GKTTEAAATAVGTAAVA-----------AAAGVAASG------------------PAKELEA--- 818
Fly 911 PVKQAKPKAADLKKTRLDKGGTTDSSLVSTPSADEATAAKKLQDLTAS-QELDAEKQRELDDLKE 974
:.||:|:| :|||.. :||.||:.....|:|.
Rat 819 -----------------------ERSLMSSP-----------EDLTKDFEELKAEEIDVAKDIKP 849
Fly 975 EQEVVREIEAVFSRDEMKR---QQHQQIKAELREMPAEG--TGDGENE----PDE---------- 1020
:.|::.:.|.:...:..:. |:..::.....|.|.|| |.:||.| |:|
Rat 850 QLELIEDEEKLKETEPGEAYVIQKETEVSKGSAESPDEGITTTEGEGECEQTPEELEPVEKQGVD 914
Fly 1021 ---------------------EEEYLIIEKEEVEQYTEDSIVEQES--SMTKEEEIQK-----HQ 1057
||:....|.||.|:..||::....| |.|::|||.| |.
Rat 915 DIEKFEDEGAGFEESSEAGDYEEKAETEEAEEPEEDGEDNVSGSASKHSPTEDEEIAKAEADVHI 979
Fly 1058 RDSQESEKKRKKSAEEEIEAAIAKVEA--AERKARLEGASARQDESELDVEPEQSKIKAEVQDII 1120
::.:||.......|||:::.|:.|.|| :|.:...|...| :|..|.|.||: |.|.:|.:
Rat 980 KEKRESVASGDDRAEEDMDEALEKGEAEQSEEEGEEEEDKA-EDAREEDHEPD----KTEAEDYV 1039
Fly 1121 ATAKDIAKSR--TEEQ---LAKPAEEE-LSSPTPEEKLS---------KKTSDTKDDQIGAPVDV 1170
....|.|... ||:| |..||::. :.||:.|...| .::..|..|:
Rat 1040 MAVVDKAAEAGVTEDQYDFLGTPAKQPGVQSPSREPASSIHDETLPGGSESEATASDE------- 1097
Fly 1171 LPVNLQESLPEEKFSATIESGATTAPTLPEDERIPLDQIK--EDLVIEEKYVKEETKEAEAIVVA 1233
..:|..||| |:|| ||.|.:......|..|:|::. .|::.:|...:|....::..|..
Rat 1098 ---ENREDQPEE-FTAT--SGYTQSTIEISSEPTPMDEMSTPRDVMTDETNNEETESPSQEFVNI 1156
Fly 1234 T-------VQTLPEAAPLAIDTILASATKDAP--KDANAEALGELPDSGERVLPMKMTFEA-QQN 1288
| .|...:....:.:.:...:..||. :|.||.|....| |..|..:. .::
Rat 1157 TKYESSLYSQEYSKPVVASFNGLSDGSKTDATDGRDYNASASTISP-------PSSMEEDKFSKS 1214
Fly 1289 LLRDVIKTPDEVADLPVHEEADLGLYEKDSQDAGAKSISHKEESAKEEKETDDEKENKVGEIELG 1353
.|||..: |:| .|:....|.|: |.:|.:..|..:.........:.:.:..||
Rat 1215 ALRDAYR-PEE-TDVKTGAELDI------------KDVSDERLSPAKSPSLSPSPPSPIEKTPLG 1265
Fly 1354 DEPNKVDISHVLLKESVQEVAEKVVVIETTVEKKQEEIVEATTVITQENQEDLMEQVKDKEEH-- 1416
:. .::..|....::..||. |||.|::....:.:: |||
Rat 1266 ER----SVNFSLTPNEIKASAEG----------------EATAVVSPGVTQAVV------EEHCA 1304
Fly 1417 --EQKIESGIITEKEAKKSAS-TPEEKETSDITSDDELPAQLADPTTVPPKS-----AKDREDTG 1473
|:|....:...:....||. ||..:..:|..| ..||.::.:.....|.| |||..:..
Rat 1305 SPEEKTLEVVSPSQSVTGSAGHTPYYQSPTDEKS-SHLPTEVTENAQAVPVSFEFTEAKDENERS 1368
Fly 1474 SIESPPTIEEAIEVEVQAKQEAQKPVPAPEEAIKTEKSPLASKETSRPESATGSVKEDTEQTKSK 1538
|| || ..:|||..|..|:...|||.|......|||........::...:
Rat 1369 SI-SP----------------MDEPVPDSESPIEKVLSPLRSPPLIGSESAYEDFLSADDKALGR 1416
Fly 1539 KSPVPSRPESEAKDKKSPFASGEASRPESVAESVKDEAGKAESRRESIAKTHKDESSLDKAKEQE 1603
:|..| .|.|:.|..|:..|:...:..::..:|:.
Rat 1417 RSESP----FEGKNGKQGFSDKESPVSDLTSDLYQDKQ--------------------------- 1450
Fly 1604 SRRESLAESIKPESGIDEKSA--LASKEASRPESVTDKSKEPSRRESIAESLKAES--TKDEK-- 1662
:|||| :..||...|| ::.|.||.:.::| ..||:
Rat 1451 ----------------EEKSAGFIPIKEDFSPE----------KKASDAEIMSSQSALALDERKL 1489
Fly 1663 ---SAPPSKEASRPGSVVESVKDETEKSKEPSRRESIAESAKPPIEFREVSRPESVIDGIKDESA 1724
.:|...:.|:.||..|..| .||:|.. :.|:||
Rat 1490 GGDGSPTQVDVSQFGSFKEDTK------------MSISEGT------------------VSDKSA 1524
Fly 1725 KPESRRDSPLASKEASRPESVLESVKDEPIKSTEKSRRESVAESFKADSTKDEKSPLTSKDISRP 1789
.|. |..:|....|..|.| .|| || .|||.|...:.|.|:.||....::..|
Rat 1525 TPV---DEGVAEDTYSHMEGV-ASV------ST-----ASVATSSFPEPTTDDVSPSLHAEVGSP 1574
Fly 1790 ESAVENVMDAVGSAERSQPESVTASRDVSRPESVAESE----KDDTDKPESV---------VESV 1841
.|. .|.|:: ||:. |..|.:..|:| |::..:|.|: .:|.
Rat 1575 HST--EVDDSL---------SVSV---VQTPTTFQETEMSPSKEECPRPMSISPPDFSPKTAKSR 1625
Fly 1842 IPASD------VVEIEKGAADKEKGVFVSLEIGKPDSPSE-----VISRPGPVVESVKPESRRES 1895
.|..| .:.||.|....|..:.:......||.|:. .|:..||......|...::|
Rat 1626 TPVQDHRSEQSSMSIEFGQESPEHSLAMDFSRQSPDHPTVGAGMLHITENGPTEVDYSPSDIQDS 1690
Fly 1896 STEIVLPCHAEDSKEPSRPESKVECLKDESEVLKGSTRRESVAESDKSSQPFKETSRPESAVGSM 1960
|....:| .::|||..:. .|.||:: ||::.:.| |...::...|.:.|
Rat 1691 SLSHKIP----PTEEPSYTQD-----NDLSELI-------SVSQVEAS--PSTSSAHTPSQIAS- 1736
Fly 1961 KDESMSKEPSRRESVKDGAAQSRETSRPASVAESAKDGADDLKELSRPESTTQSKEAGSI--KDE 2023
|.:.:::.| ....|:.|..||:| ....||.|...: |.:
Rat 1737 --------PLQEDTLSD-VVPPRDMSLYASLA----------------SEKVQSLEGEKLSPKSD 1776
Fly 2024 KSPLASEEASRPASVAESVKDEAEKSKEESRRESVAEKSPLPSKEAS----RPASVAESIKDEAE 2084
.|||...|:| .:.:....|....:||.:.....:...|:.:..|. |.:.:.::::....
Rat 1777 ISPLTPRESS--PTYSPGFSDSTSGAKESTAAYQTSSSPPIDAAAAEPYGFRSSMLFDTMQHHLA 1839
Fly 2085 KSKE---ESRRESVAEKSPLPSKEA-SRPASVAESIKDEAEKSKEESRRESVA--------EKSP 2137
.|:: .|..:....|:|.....| .:|.|..|| .||.:...|...:...| ||:.
Rat 1840 LSRDLTTSSVEKDNGGKTPGDFNYAYQKPESTTES-PDEEDYDYESHEKTIQAHDVGGYYYEKTE 1903
Fly 2138 LPSKEASRPASVAESIKDEAEKSKEESRRESVAEKSPLPSKEASRPASVAESIKDEAEKS----- 2197
...|.........|:|:...:..::......:.||:....:|......::|......|.|
Rat 1904 RTIKSPCDSGYSYETIEKTTKTPEDGGYSCEITEKTTRTPEEGGYSYEISEKTTRTPEVSGYTYE 1968
Fly 2198 -KEESRRESVAEKSPLPSKEASRPASVAESIKDEAEKSKEESRRESVAEKSPLPSKEASRPASVA 2261
.|.||| :.|:.....::: |.......:.|......
Rat 1969 KTERSRR-----------------------LLDDISNGYDDT------EDGGHTLGDCSYSYETT 2004
Fly 2262 ESIKDEAEKSKEESRRESVAEKSPLPSKEASRPASVAESIKDEAEKSKEETRRESVAEKSPLPSK 2326
|.|....|.........:...:||..| |...|:::...:..:..|.....:::...|.:
Rat 2005 EKITSFPESESYSYETTTKTTRSPDTS------AYCYETMEKITKTPQASTYSYETSDRCYTPER 2063
Fly 2327 EASRPASVAESIKDEAEKSKEESRRE------SAAE-KSP----LPSKEASRPAS--VAESVKDE 2378
||..|:|:: |:.| |.| .||.....|.. ..|...:|
Rat 2064 -----------------KSPSEARQDVDLCLVSSCEFKHPKTELSPSFINPNPLEWFAGEEPTEE 2111
Fly 2379 ADKSKEESRRESMAESGKAQSIKGDQSPLKEVSRPESVAESVKDDPVKSKEPSRRESVAGSVTAD 2443
::|...:|........||.|..:.|::| |.||:||..........|...| ..|:|||
Rat 2112 SEKPLTQSGGAPPPSGGKQQGRQCDETP------PTSVSESAPSQTDSDVPPETEE--CPSITAD 2168
Fly 2444 SARDDQSPLESKGASRPESVVDSVKDEAEKQESRRESKTESVIPPKA-KDDKSPKEVLQPVSMTE 2507
:..|.: ||:|...:.:....:.:.||.| ..|:||......|||.:
Rat 2169 ANIDSE-------------------DESETIPTDKTVTYKHMDPPPAPMQDRSPSPRHPDVSMVD 2214
Fly 2508 ----TIREDADQPMKPSQAE-SRRESIAESIKASSP---RDEKSPLASKEASRPGSVAESIKYDL 2564
.|.::..:.:|....| ::.:......|:||| .|.||. .|..:.:||::.|| .
Rat 2215 PEALAIEQNLGKALKKDLKEKAKTKKPGTKTKSSSPVKKGDGKSK-PSAASPKPGALKES----S 2274
Fly 2565 DKPQIIKDDKSTEHSRRESLEDKSAVTSEKSVSRPLSVASDHEAAVAIEDDAKSSISPKDKSRPG 2629
||...:...| ::||:|.....|:...|........|.|...|....|..|:... .:.||
Rat 2275 DKVSRVASPK-----KKESVEKAMKTTTTPEVKATRGEEKDKETKNAANASASKSVKTA-TAGPG 2333
Fly 2630 FVAETVSSPIEEATMEFSKIEVVEKSSLALSLQGGSGGKLQTDSSPVDVAEGDFSHAVAS----V 2690
......||.:......:..:..:...| :|..||| :|...|.| |
Rat 2334 TTKTAKSSTVPPGLPVYLDLCYIPNHS---------------NSKNVDV---EFFKRVRSSYYVV 2380
Fly 2691 STVTPTLTKPAELAQIGAAKTVSSPLDEALRTPSAPEHISRADSPAECASEEIASQDKSPQVLKE 2755
|...|...:|:. |.:.|.....:.....::....|.|.| :|::|
Rat 2381 SGNDPAAEEPSR-AVLDALLEGKAQWGSNMQVTLIPTHDS--------------------EVMRE 2424
Fly 2756 SSRPAWVAESKDDAAQLKSSVEDLRSPVASTEISRPA 2792
|..|:.:....|...|....|.|...:.|.||
Rat 2425 -----WYQETHEKQQDLNIMVLASSSTVVMQDESFPA 2456
| 
