DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment futsch and Map1s

DIOPT Version :9

Sequence 1:	NP_001096864.1	Gene:	futsch / 5740544	FlyBaseID:	FBgn0259108	Length:	5495	Species:	Drosophila melanogaster
Sequence 2:	XP_038950238.1	Gene:	Map1s / 290640	RGDID:	1308266	Length:	979	Species:	Rattus norvegicus

Alignment Length:	933	Identity:	242/933 - (25%)
Similarity:	338/933 - (36%)	Gaps:	280/933 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 APSSL----AGGIVGPPSPLTGCYLLIVLGEPHSEEHKDNILQHLLKGFLSWDVSDCHV-DLEEE 158
            |||||    .||..|.|..|.                  .:|:.|.:|..||:..|..| .|:|:
  Rat    13 APSSLLLLVVGGECGCPGLLA------------------YVLEELERGVRSWEDVDPDVCSLDEQ 59

  Fly   159 LNT-ITQHAPEGEEARHGERLIQYASENLVTEVLIHPQYNTLIQC---------MRNLLSSFTRH 213
            |.. :::|:........|:|.:.:..|.|.|.||::|...:|  |         :||||.....|
  Rat    60 LKAFVSRHSATFSSIVKGQRSLHHRGETLETLVLLNPSDKSL--CDEGHPPHPQLRNLLMDPAPH 122

  Fly   214 RHIIHAGYTFSGNGSWILQDGTFSVADFSEAFQEHDVQRVIRAYADTITMNIHCADAGLWHTLPE 278
            :.::.||......|..:||.|.||...|.:...:.:||..:.:......:.:.|...|.|..|..
  Rat   123 KLLVLAGPCLEETGELLLQTGGFSAHHFLQVLGDKEVQDALASAPAAPALTVSCPTFGDWALLGP 187

  Fly   279 KAFARQCRIRINPVDVLDTSSECINGFIDYLAPMVMPTSLRELLETSDVVGNIRFTHPTLYVFPG 343
               |...|:|:||...| .|||.:..|::|:|..:.|.|..||||.....|.:|...|..|||||
  Rat   188 ---APGLRLRLNPPARL-PSSEGLRAFLEYVAESLEPPSPFELLEPPATGGFLRLARPCCYVFPG 248

  Fly   344 GQGDAALFGINGFNMLVDGGFNRKACFWDFARHLDRLDAVLMTRLNNSNVQGLGAVVSRK---RD 405
            |.||||.|.:|||.:||:||.|.|:.||...|||||:||||:|.....::.||.:::.||   |:
  Rat   249 GLGDAAFFAVNGFTVLVNGGSNPKSSFWKLVRHLDRVDAVLVTHAGADSLPGLNSLLRRKLAERE 313

  Fly   406 AHVYPQ--------------IGHFFGNVPDRKGLPSPDGDKDRDPLLIDLFERGHGIVSDLKALD 456
            |...||              :|..|.|.  |:......|.:|.......|. |..|||.......
  Rat   314 AAAGPQGQHEERLRRLLSPALGVVFLNA--REAGSRLRGGEDEAVCARSLL-RSLGIVPLPLQRG 375

  Fly   457 LKPQCCYRNQEPVNLYHKVGHGTLDMYVISPARDSKEVKEFLQKWHAGDQRLFAARDSRDFNFPL 521
            .:|.|      |..|:.|:|.|.|:::|:.|.              .||....|
  Rat   376 PQPSC------PTVLFEKLGVGRLELFVLHPP--------------PGDPAAPA----------- 409

  Fly   522 QNLVSICALLVWQPANPDDTITRILFPGSTPDFKIQEGLEKLKHLEFMKHSTCTAKSI------- 579
                  |||||||||.|.|.:.|:||||.||..::.:||::|:||..::....|.:.:
  Rat   410 ------CALLVWQPAAPGDKVVRVLFPGRTPPARLLDGLQRLQHLPCLRRPVVTTQDLEVPSRAN 468

  Fly   580 -APAIQTVTSTRK---------SLKSAIEATPAPPSASY-KTTKFSPVASAALAVQH-------- 625
             ..::.:..||||         :.:||:...||..:... |.||..|..|....|:.
  Rat   469 SQDSLASRDSTRKEPVRGTVGATSRSAVRREPALATRDQKKDTKPGPTRSTVRDVRRSGPGVVTT 533

  Fly   626 -PQQQDNKAKEAAAAAAAAAAA------------------------------------------- 646
             |:...|..:....||..||.|
  Rat   534 KPRVSQNGPRAPVPAAPPAAPAPEFPGEAENIVESERPPAPSPTLSPAQSPPPTAPGNSPERLSL 598

  Fly   647 ----------AASAAT---------------------------------------------IARA 656
                      |:.:||                                             :||.
  Rat   599 SPLRPEPAPDASPSATTPTLTTPSLPAELGSPHSTEVDESLSVSFEQVLPAGDAGLSLPLRLARR 663

  Fly   657 KADSMDTD------AEPEHEADPEPADTG--DEAAPTEQEPEAETEPEPEHE-----------PE 702
            .....|.|      .|..|...|.||..|  |.:|.:::.| .||.|....|           |.
  Rat   664 STSPHDVDLCLVSPCEFSHRKPPPPASPGSSDSSARSQERP-PETPPTSVSESLPTLSDSDPVPV 727

  Fly   703 AEQDKDVGEEK----------------------KVEVLIMKPQQATPAVIAASGKDGVDAASADA 745
            |:.|.|.|.|.                      .|:...:.|:...|...|.|.:    ...|.|
  Rat   728 ADSDDDAGSESAARDPLPTPRVPPPLPDAPGICMVDPEALPPRARQPLSTANSSR----GRKAPA 788

  Fly   746 TPTGKLSKASAKGKADKPRAEVKPVVRSRIDTKPPKSMDRKLAKRDEKKSSPTTTPAARAPVAQN 810
            .|    |.|||..:|....|:.|..|..|         .|.|:.|.|....|...|..|.|....
  Rat   789 RP----SSASAAPRAATVAAKTKGPVGDR---------SRPLSARSEPADKPGRVPLTRKPSVPK 840

  Fly   811 AKPKVLSRPATKSSPSSTPAKSA 833
            ..||:.|.....|.|||.||..|
  Rat   841 TVPKMASATRNSSGPSSRPAPLA 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
futsch	NP_001096864.1	DUF966	<1925..>2112	CDD:283735
Map1s	XP_038950238.1	PHA03247	<464..867	CDD:223021	82/418 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3592
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003086
OrthoInspector	1	1.000	-	-		otm46319
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13843
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.960