Protein Alignment futsch and Map2

DIOPT Version :9

• Sequence 1: NP_001096864.1
• Gene: futsch / 5740544
• FlyBaseID: FBgn0259108
• Length: 5495
• Species: Drosophila melanogaster
• Sequence 2: XP_008765420.1
• Gene: Map2 / 25595
• RGDID: 3044
• Length: 1942
• Species: Rattus norvegicus
• Alignment Length: 2403
• Identity: 510/2403 - (21%)
• Similarity: 865/2403 - (35%)
• Gaps: 671/2403 - (27%)

  Fly   886 ATQRKPISRRPRGVSPSKRAPAPGSPVKQAKPKAADLKKTRLDKGGTTDS---SLVSTPSADEAT 947
            |.:||...:.|...|.|....|       |.|.:.::|    |:||:.:.   |....|..:|..
  Rat     2 ADERKDEGKAPHWTSASLTEAA-------AHPHSPEMK----DQGGSGEGLSRSANGFPYREEEE 55

  Fly   948 AA----------KKLQDLTASQELDAEKQRELDDLKEE--QEVVREIEAVFSRDEMKRQQHQQIK 1000
            .|          ...::...:.||.:..:...:::...  |.|..|..||...::.|..||:...
  Rat    56 GAFGEHGSQGTYSDTKENGINGELTSADRETAEEVSARIVQVVTAEAVAVLKGEQEKEAQHKDQP 120

  Fly  1001 AELREMPAEGTGDGENEP------------DEEEEYLIIEKEEVEQYTEDSIVEQESSMTKEEEI 1053
            |.| .:.||.|.:....|            :||||.|  |....|:....::..:|....|..
  Rat   121 AAL-PLAAEETVNLPPSPPPSPASEQTAALEEEEETL--EGVMAEEMEPAALPGRECGAAKSS-- 180

  Fly  1054 QKHQRDSQE--SEKKRKKSAEEEI---EAAIAKV-------EAAERKARLE-GASARQD---ESE 1102
                 |:.:  ||.:.:.|||.:|   ::|:|..       |..|....:| .:||::|   .|:
  Rat   181 -----DNPQGLSEGRVESSAEAQIVPEDSALAGAPDEKSVKEVTEVAPEVEIPSSAKEDLLTASK 240

  Fly  1103 LDVEPEQSKIKAEVQDIIATAKDIAKSRTEEQL-AKPAEE-ELSSPTPEEKLSKKTSDTKD--DQ 1163
            ::. |||.|:.:      :.|:.:.|..||.:: :||.|: |.::..|:...||...|.||  |.
  Rat   241 MEF-PEQQKLPS------SFAEPLDKEETEFKMQSKPGEDFEHAALVPQPDTSKTPQDKKDPQDM 298

  Fly  1164 IGAPVDVLP------VNLQESLPEEKFSATIES-GATTAPTLPEDERIPLDQIKEDLVIEEKYVK 1221
            .|......|      .||::.....:.|.|:.| |.:..|..|:|::        |..||   :.
  Rat   299 EGEKSPASPFAQTFGTNLEDIKQITEPSITVPSIGLSAEPLAPKDQK--------DWFIE---MP 352

  Fly  1222 EETKEAEAIVVATVQTLPEAAPLAIDTILASATKDAPKDANAEALGELPD---SGERVLPMKMTF 1283
            .|:|:.|..:.|.:...| ..|:....:|    :|.|:....:....:|.   .|...||:
  Rat   353 VESKKDEWGLAAPISPGP-LTPMREKDVL----EDIPRWEGKQFDSPMPSPFHGGSFTLPL---- 408

  Fly  1284 EAQQNLLRDVIKTPDEVADLPVHEEADLGLYEKDSQDAGAKSISHKEESAKEEKETDDEKENKVG 1348
                :.::|...|.......||..::|    :|.|....:.|.:.||.|..||.:.|  |.:||.
  Rat   409 ----DTVKDERVTEGSQPFAPVFFQSD----DKMSLQDTSGSATSKESSKDEEPQKD--KADKVA 463

  Fly  1349 EIELGDEPNKVDISHVLLKESVQEVAEKVVVIETTVEKKQEEIVEATTVITQENQEDLMEQVKDK 1413
            ::                                       .:.|||||:              .
  Rat   464 DV---------------------------------------PVSEATTVL--------------G 475

  Fly  1414 EEHEQKIESGIITEKEA--KKSASTPEEKETSDITSDDELPAQLADPTTVPPKSAKDREDTGSIE 1476
            :.|...:| |.:.|..:  :|..:..|:||||        ...:.:||....:.....|:|..:.
  Rat   476 DVHSPAVE-GFVGENISGEEKGTTDQEKKETS--------TPSVQEPTLTETEPQTKLEETSKVS 531

  Fly  1477 SPPTI---EEAIEV------------EVQAKQEAQKPVPAPEEAIKTEKSPLA------------ 1514
            ...|:   ||::::            |....:|.||......||:|.:..|::
  Rat   532 IEETVAKEEESLKLKDDKAGVIQTSTEHSFSKEDQKGEEQTIEALKQDSFPISLEQAVTDAAMAT 596

  Fly  1515 ---SKETSRPESATGSVKEDTEQTKSKKSPVPSRPESEAKDKKSPFASGEASRPESVAESVKDEA 1576
               .|.||.||:.            |:|..:....|.:..||.....:|.|:..|......:|::
  Rat   597 KTLEKVTSEPEAV------------SEKREIQGLFEEDIADKSKLEGAGSATVAEVEMPFYEDKS 649

  Fly  1577 GKAESRRESIAK---THKDESSLDKAKEQESR---RESLAESIKPESGIDEKSALASKEASRPES 1635
            |.::....|..|   |.......|..:..:||   :||| :::.|::..|||..||  :||:|
  Rat   650 GMSKYFETSALKEDVTRSTGLGSDYYELSDSRGNAQESL-DTVSPKNQQDEKELLA--KASQP-- 709

  Fly  1636 VTDKSKEPSRRESIAESLKAESTKDEKSAPPSKEASRP--------GSVVESVKDETEKSKEP-S 1691
                  .|...|:...:|....|.|..|..| :|.|.|        ..|....:|...|:|:. :
  Rat   710 ------SPPAHEAGYSTLAQSYTSDHPSELP-EEPSSPQERMFTIDPKVYGEKRDLHSKNKDDLT 767

  Fly  1692 RRESIAESAKPPIEFREVS--RPESVIDGIKDESAKPESRRDSPLAS-----KEASRPES----- 1744
            ...|:....:..||.|.:|  .|.|.:|.|............|||||     ...|..|.
  Rat   768 LSRSLGLGGRSAIEQRSMSINLPMSCLDSIALGFNFGRGHDLSPLASDILTNTSGSMDEGDDYLP 832

  Fly  1745 ----VLESVKDEPIKSTEKSRRESVAESFKADSTKDE---KSPLTSKD------ISRPESAVENV 1796
                .:|.:...||:|.|:..:...|:.....:|:.|   :||..:|:      :..|:  :..:
  Rat   833 PTTPAVEKIPCFPIESKEEEDKTEQAKVTGGQTTQVETSSESPFPAKEYYKNGTVMAPD--LPEM 895

  Fly  1797 MDAVGSAERSQPESVTASRDVSRPESVAESEKDDTDKPESVVESVIPASDVVEIEKGAADKEKGV 1861
            :|..|:  ||:..||:|..:|:|.:||
  Rat   896 LDLAGT--RSRLASVSADAEVARRKSV-------------------------------------- 920

  Fly  1862 FVSLEIGKPDSPSEVISRPGPVVESVKPESRRESSTEIVLPCHAEDSKEPSRPESKVE----CLK 1922
                       |||.:.              .||||.  ||..|:|| :|.:|:|::|    |:.
  Rat   921 -----------PSEAVV--------------AESSTG--LPPVADDS-QPVKPDSQLEDMGYCVF 957

  Fly  1923 DESEVLKGSTRRESVAESDKSSQPFKETSRPESAVGSMKDESMSKEPSRRESVKDGAAQSRETSR 1987
            ::..|...|..::|                          |::|.|
  Rat   958 NKYTVPLPSPVQDS--------------------------ENLSGE------------------- 977

  Fly  1988 PASVAESAKDGADD--LKELSRPESTTQSK--EAGSIKDEKSPLASEEASRPASVAES--VKDEA 2046
                :.|..:|.||  .::|:...|..:.|  .||.:|||.:  |.:|||.|:|..:|  .::..
  Rat   978 ----SGSFYEGTDDKVRRDLATDLSLIEVKLAAAGRVKDEFT--AEKEASPPSSADKSGLSREFD 1036

  Fly  2047 EKSKEESRRESVAEKSP--LPSKEASRPASVAESIKDEAE------KSKEESRRESVAEKSPLPS 2103
            :..|...:.::|.|||.  :.|||   .|..:|.:.|:.|      ..::.|.:|.:..|...|.
  Rat  1037 QDRKANDKLDTVLEKSEEHVDSKE---HAKESEEVGDKVELFGLGVTYEQTSAKELITTKETAPE 1098

  Fly  2104 KEASRPASVAESIKDEAEKSKEESRRESVAEK----SPLPSKEASRPASVAESIKDEAEKSKEES 2164
            :.....:||.|..  |.|.:.:..:...||.|    |||..| .|....:|..:..:|.|:.|..
  Rat  1099 RAEKGLSSVPEVA--EVETTTKADQGLDVAAKKDDQSPLDIK-VSDFGQMASGMSVDAGKTIELK 1160

  Fly  2165 RR--ESVAEKSPLPSKEASRPASVAESIKDEAEKSKEESRRESVAEKSPLPSKEASRPASVAESI 2227
            ..  :.:...|..|.:..|.....:..:||.|:.|:.|     |.||       .::|..|.:..
  Rat  1161 FEVDQQLTLSSEAPQETDSFMGIESSHVKDGAKVSETE-----VKEK-------VAKPDLVHQEA 1213

  Fly  2228 KDEAEKSKEESRRESVAEKSPLP---SKEASRPASVAESIKDEAEKSKEESRRESVAEKSPLPSK 2289
            .|:.|..:.....||:..:|..|   .||.|...|:   |:||...        .::.:.|.|.
  Rat  1214 VDKEESYESSGEHESLTMESLKPDEGKKETSPETSL---IQDEVAL--------KLSVEIPCPP- 1266

  Fly  2290 EASRPASVAESIKDEAEKSKEETRRESVAEKSPLPSKEASRPASVAESIKDEAEKSKEESRRESA 2354
                |.|.|:|..||    |.|.:.|.:    .||.:|::....:.....|..:
  Rat  1267 ----PVSEADSSIDE----KAEVQMEFI----QLPKEESTETPDIPAIPSDVTQ----------- 1308

  Fly  2355 AEKSPLPSKEASRPASV---AESVKDEADKSKEESRRESMAESGKAQSIKGDQSPLKEVSRPE-- 2414
                |.|....|.||.|   .|.::.|.:..|...|.:::..:...  :.|.:....|....|
  Rat  1309 ----PQPEAVVSEPAEVRGEEEEIEAEGEYDKLLFRSDTLQITDLL--VPGSREEFVETCPGEHK 1367

  Fly  2415 SVAESV---KDDPVKSKEPSRRESVAGSVTADSARDDQSPLESKGASRPESVVDSVKDEAEKQES 2476
            .|.|||   :||.:...:.:..|...||.:...|    :|::.:...||.. .|...:.....|:
  Rat  1368 GVVESVVTIEDDFITVVQTTTDEGELGSHSVRFA----APVQPEEERRPYP-HDEELEVLMAAEA 1427

  Fly  2477 RRESKTESVIPPKAKDDKSPKEVLQPVSMTETIREDADQPMKPSQAESRRESI--AESIKASSPR 2539
            :.|.|..|   |.|......:||......|||..:..|:       .:..:||  |:|:...:..
  Rat  1428 QAEPKDGS---PDAPATPEKEEVPFSEYKTETYDDYKDE-------TTIDDSIMDADSLWVDTQD 1482

  Fly  2540 DEKSPLASKEASRPGSVAESIKYDLDKPQIIKDDKSTEHSRRESLE----DKSAVTSEKSVSRPL 2600
            |::|.|..:..:.|                 |::::.:.:||.|||    :|...|....:|.|
  Rat  1483 DDRSILTEQLETIP-----------------KEERAEKEARRPSLEKHRKEKPFKTGRGRISTP- 1529

  Fly  2601 SVASDHEAAVAIEDDAKSSISPKDKSRPGFVAETVSSPIEEATMEFSKIEVVEKSSLALSLQGGS 2665
                  |..||             |..|..|:.   ..:......:.|.|:.:||.:.
  Rat  1530 ------ERKVA-------------KKEPSTVSR---DEVRRKKAVYKKAELAKKSEVQ------- 1565

  Fly  2666 GGKLQTDSSPVDVAEGDFSHAVASVSTVTPTL--TKPAELAQIGAAKTVSSPLDEALRTPSAPEH 2728
                              :|:.:....:.|.:  |:|..|:.:....|.:|  .|:.:.|||.:.
  Rat  1566 ------------------AHSPSRKLILKPAIKYTRPTHLSCVKRKTTATS--GESAQAPSAFKQ 1610

  Fly  2729 ISRADSPAECASEEIASQ-DKSPQVLKESSRPAWV--------AESKDDAAQLKSSVEDLRSPVA 2784
                      |.:::... .|||:......||:.:        .:.::::..|.||:...|....
  Rat  1611 ----------AKDKVTDGITKSPEKRSSLPRPSSILPPRRGVSGDREENSFSLNSSISSARRTTR 1665

  Fly  2785 STEISRPASAG-ETASSPIEEAPKDFAEFEQAEKAVLPLTIELKGNLPTLSSPVDVAHG--DFPQ 2846
            |..|.|...:| .|.::|             ...|:.|      |..|:.||......|  .:|:
  Rat  1666 SEPIRRAGKSGTSTPTTP-------------GSTAITP------GTPPSYSSRTPGTPGTPSYPR 1711

  Fly  2847 T-STPTSSPTVASVQPAELSKVDIEKTASSPIDEAPKSLIGCPAEERPESPAESAKDAAESVEKS 2910
            | .||.|...|    |:|.....|.....||.......||..|..:     .::.|....|.:..
  Rat  1712 TPGTPKSGILV----PSEKKVAIIRTPPKSPATPKQLRLINQPLPD-----LKNVKSKIGSTDNI 1767

  Fly  2911 KDASRPPSV-VESTKADSTKGDISPSPESVLEGPKDDVEKSKESSRPPSVSASITGDSTKDVSRP 2974
            |...:...| :.:.|.|.:|.....       |.||:::.|........|:..|      |:|..
  Rat  1768 KYQPKGGQVRILNKKIDFSKVQSRC-------GSKDNIKHSAGGGNVQIVTKKI------DLSHV 1819

  Fly  2975 ASVVESVKDEHDKAESRRESIAKVESV-IDEAGKSDSKSSSQDSQ---------KDEKSTLASKE 3029
            .|...|:|:...:....|   .|:||| :|...|:.:|..|.|:.         |.:...|..:|
  Rat  1820 TSKCGSLKNIRHRPGGGR---VKIESVKLDFKEKAQAKVGSLDNAHHVPGGGNVKIDSQKLNFRE 1881

  Fly  3030 ASR------RESVVESSKDDAEKSESRPESVIASGEPVPRESKSPLDSKDTSRPGSMVESVTA 3086
            .::      .|.:.:|....:..|..|..:|.:||.         ::..::.:..::.|.|||
  Rat  1882 HAKARVDHGAEIITQSPSRSSVASPRRLSNVSSSGS---------INLLESPQLATLAEDVTA 1935

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
futsch	NP_001096864.1	DUF966	<1925..>2112	CDD:283735	41/200 (21%)
Map2	XP_008765420.1	MAP2_projctn	460..1593	CDD:369841	306/1478 (21%)
		PTZ00449	<1498..1772	CDD:185628	70/361 (19%)
		Tubulin-binding	1748..1775	CDD:395337	4/31 (13%)
		Tubulin-binding	1776..1806	CDD:395337	8/36 (22%)
		Tubulin-binding	1807..1837	CDD:395337	7/35 (20%)
		Tubulin-binding	1838..1869	CDD:395337	9/30 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000