|
Fly 71 DAGASSL--PPSEIGGRAPLDTACSDADGGAPSSLAGGIVGPPSPLTGCYLLIVLGEPHSEEHKD 133
:.|..|| ||:: .|.:..| :.|| .:......|....||||:|:..:|....
Rat 20 ELGLQSLGAPPTQ----NPAELLC---EAGA------AVAAARWDLRKYSLLIVIGDIGTESQLR 71
Fly 134 NILQHLLKGFLSWDVSDCHVDLEEELNT-ITQHAPEGEEARHGERLIQYASENLVTEVLIHPQYN 197
.:..||.:|.|||::.....||.::|.. ||:|.........|:|.:.:.||.|.|.:|::|..:
Rat 72 AVRAHLEQGILSWNIDLSSFDLNQQLRLFITRHLAHFSSEVKGQRTLCHQSEILETIILVNPSAD 136
Fly 198 TLIQCMRNLLSSFTRHRHIIHAGYTFSGNGSWILQDGTFSVADFSEAFQEHDVQRV-------IR 255
::...:.:||||.:.|:.:|.:|.|....|..|||.||:|..:|::...:.::.:: |:
Rat 137 SISSEVHHLLSSPSAHKLLILSGQTLEPEGDLILQSGTYSYQNFAQVLHKPEIAQLLSNRDPEIQ 201
Fly 256 AYADTITMNIHCADAGLWHTLPEKAFARQCRIRINPVDVLDTSSECINGFIDYLAPMVMPTSLRE 320
|: :.:.|...|.|..|...:......:|:||..||.| .:.:..|.:|::..|...|..:
Rat 202 AF-----LTVSCLGEGDWSHLGLSSSQETLHLRLNPEPVLPT-MDGVAEFSEYVSETVDVPSPFD 260
Fly 321 LLETSDVVGNIRFTHPTLYVFPGGQGDAALFGINGFNMLVDGGFNRKACFWDFARHLDRLDAVLM 385
|||.....|.::.:.|..|:||||:||:|||.:||||:|||||.:||:|||...|||||:|:||:
Rat 261 LLEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNILVDGGSDRKSCFWKLVRHLDRIDSVLL 325
Fly 386 TRLNNSNVQGLGAVVSRK---------RDAHVY---------PQIGHFFGNVPDRKGLPSPDGDK 432
|.:...|:.|:..::.|| :.:..| |::|..|.||||:..||......
Rat 326 THIGADNLPGINGLLQRKVAELEEEQSQGSSSYSDWVKNLISPELGVVFFNVPDKLRLPDASRKA 390
Fly 433 DRDPLLIDLFERGHGIVSDLKALDLKPQCCYR----NQEPVNLYHKVGHGTLDMYVISPARDSKE 493
.|. .|.....:..|..|.::.:..|| ..||:.|:||:|.|.|||||::|.:||||
Rat 391 KRS------IEEACLTLQHLNRLGIQAEPLYRVVSNTIEPLTLFHKMGVGRLDMYVLNPVKDSKE 449
Fly 494 VKEFLQKWHAGDQRL---FAARDSRDFNFPLQNLVSICALLVWQPANPDDTITRILFPGSTPDFK 555
::..:||| ||:.:. ....:.::....:..|.||.||:||.||||.:.|.|:||||:.|..|
Rat 450 MQFLMQKW-AGNSKAKTGIVLANGKEAEISVPYLTSITALVVWLPANPTEKIVRVLFPGNAPQNK 513
Fly 556 IQEGLEKLKHLEFMKHSTCTAKSIA----PA------IQTVTSTRKSLKSAIEATPAPPSASYKT 610
|.||||||:||:|:::...|.|.:| || |:....:::|||: ||.:|..|.
Rat 514 ILEGLEKLRHLDFLRYPVATQKDLAAGAVPANLKPSKIKHRADSKESLKA------APKTAVSKL 572
Fly 611 TKFSPVASAALAVQHPQQQDNKAKEAAAAAAAAAAAAASAATIARAKADSMDTDAEPEHEADPEP 675
.|...|. |..|..|.:..|...|.|..:||
Rat 573 AKREEVL-----------------EEGAKEARSELAKELAKTEKKAK------------------ 602
Fly 676 ADTGDEAAPTEQEPEAETEPEPEHEPEAEQDKDVGEEKKVEVLIMKPQQATPAVIAASGKDGVDA 740
.|:|:.|| :|........|..:.:..||: .::|.: :||..:..
Rat 603 -------EPSEKPPE---KPSKSERVRGESSEALKAEKR---RLIKDK---------AGKKHLKE 645
Fly 741 ASADATPTGKLSKASAKGKADKPRAEVKPVVRSRIDTKPPKSMDRKLAKRDEKKSSPTTTPAARA 805
|:|| .:.|.||.:.|:|. .|..:..:..:..::|.||:|||:
Rat 646 ---------KISK--LEEKKDKEKKEIKK-ERKELKKEEGRKEEKKDAKKDEKR----------- 687
Fly 806 PVAQNAKPKV--LSRPATKSSPSSTPAKSAKEANNRKVLESKQQAARVQATSTVSRRVTSTASER 868
::.||:| ||:|..| ..|| ..||.|...:...||
Rat 688 ---KDTKPEVKKLSKPDLK---PFTP-------EVRKTLYKAKAPGRV----------------- 722
Fly 869 RVQQQAEAKTAATGATQATQRKPISRRPRGVSPSKRAPAPGSPVKQAKPKAADLKKTRLDKGGTT 933
:.:...||.| .|.:|..|| ..|:::..||.:.|...:..|
Rat 723 ----KVDKGRAARG------EKELSSEPR-TPPAQKGAAPPAAVSGHRELA-------------- 762
Fly 934 DSSLVSTPSADEATAAKKLQDLTASQELDAEKQRELDDLKEEQEVVREIEAVFSRDEMKRQQHQQ 998
:|:| :||| ::.::||.|: :.
Rat 763 ----LSSP-----------EDLT----------QDFEELKREE--------------------RG 782
Fly 999 IKAELRE-------MPAEGTGDGE-------NEPDEEEEYLIIEKEEVEQYTE---DSIVEQESS 1046
:.||.|: :||:.|..|. .:|... ::|.|.||:..| ||..::.|:
Rat 783 LLAEQRDTGLGEKPLPADATEQGHPSAAIQVTQPSGP----VLEGEHVEREKEVVPDSPGDKGST 843
Fly 1047 MTKEEEIQKHQRDSQESEKKRKKSAEEEIEAAIAKVEAAERKARL--EGASARQDESELDVEPEQ 1109
....||....:|.|::.||. .:|:|.| |..:|| :|||.:|:.:.
Rat 844 --------NRGPDSGAEVEKEKETWEER----------KQREAELGPENTAAR-EESEAEVKEDV 889
Fly 1110 SKIKAEVQDIIAT---AKDIAKSRTEEQLAKPAEEEL-SSPTPEEKLSKKTSDTKDDQIGAPVDV 1170
.: |||::::..| .::..:::.|....|..:|.| :||...|.|..:
Rat 890 IE-KAELEEMEETHPSDEEGEETKAESFYQKHTQEALKASPKSREALGGR--------------- 938
Fly 1171 LPVNLQESLPEEKFSATIES-----GATTAPTLPEDERIPLDQIKEDLVIEEKYVKEETKEAEAI 1230
.:..|...||::.::.:.| |||...:..:||.||.....|..:.:|: :.:|..|..|
Rat 939 -DLGFQGKAPEKETASFLSSLATPAGATEHVSYIQDETIPGYSETEQTISDEE-IHDEPDERPA- 1000
Fly 1231 VVATVQTLPEAAPLAIDTILASATKDAPKDANAEALGELPDSGERVLPMKMTFEAQQNLLRDVIK 1295
|...| ::|.|. :..|..| .|||.|
Rat 1001 --------PPRFP--------TSTYDL---SGPEGPG--------------PFEASQ-------- 1024
Fly 1296 TPDEVADLPVHEEADLGLYEKDSQDAGAKSISHKEESAKEEKETDDEKENKVGEIELGDEPNKVD 1360
.||..:....|:..||. |.||...||.|
Rat 1025 ------------AADSAVPASSSKTYGAP------------------------ETELTYPPNMV- 1052
Fly 1361 ISHVLLKESVQEVAEKVVVIETTVEKKQEEIVEATTVITQENQEDLMEQVKDKEEHEQKIES--G 1423
...:|| ||.|.:.|.||:.: |:.| .
Rat 1053 ---------AAPLAE-------------EEHVSSATSITECD----------------KLSSFAT 1079
Fly 1424 IITEKEAKKSASTPEEKET--SDITSD--DELPAQLADPT----------TVPPKSAKDREDTGS 1474
.:.|.::..|.:.|:.:|| |.:..| ..:|:...:.| |:.|.|:.: ||.|
Rat 1080 SVAEDQSVASLTAPQTEETGKSSLLLDTVTSIPSSRTEATQGLDYVPSAGTISPTSSLE-EDKG- 1142
Fly 1475 IESPPTIEEAIEVEVQAKQEAQKPVPAPEEAI-KTEKSPLASKETSRP---------------ES 1523
.:|||..:.::..|.:.|.|......:.|:|: |.||..:.|::.|.. |.
Rat 1143 FKSPPCEDFSVTGESEKKGETVGRGLSGEKAVGKEEKYVVTSEKLSGQYAAVFGAPGHTLPPGEP 1207
Fly 1524 ATGSVKE----DTEQTKSKKSPVPSRPESEAKDKKSPFASGEASRPESVAESVKDEAGKAESRRE 1584
|.|.|:| ..:.|....||.||.|.|.| .:||.. ..|:|::...:.:.:
Rat 1208 ALGEVEERCLSPDDSTVKMASPPPSGPPSAA---HTPFHQ----------SPVEDKSEPRDFQED 1259
Fly 1585 SIAKTHKDESSLDKAKEQESRRESLAESIKPESGIDEKSALASKEASRPESVTDKSKEPSRRESI 1649
|..:| |.....|:.:|..:::|| ...|..:::.|.|..|...
Rat 1260 SWGET--------KHSPGVSKEDSEEQTVKP---------------GPEEGTSEEGKGPPTRSPQ 1301
Fly 1650 AE----SLKAESTKDEKSAPPSK------EASRPGSVVES------VKDETEKSKEPSRRESIA- 1697
|: |:....|.......|.: |....||::.: |:..||::.||.:.|.:.
Rat 1302 AQDTPVSIAGGQTGCTIQLLPEQDKAIVFETGEAGSILGAGTLPGEVRTSTEEATEPQKDEVLRF 1366
Fly 1698 --ESAKPPIEFREVSRPESVIDGIKDESAKPESRRDSPLASKEASRPESVLESVKDEPIKSTEKS 1760
:|..| |.:...||:..:..::.|.|:...||.:.||....:.:...|..|..:|.
Rat 1367 TDQSLSP-----EDAESLSVLSVVSPDTTKQEATPRSPCSLKEQQPHKDLWPMVSPEDTQSL--- 1423
Fly 1761 RRESVAESFKADSTKDEKS-PLTSKDISRPES------------------AVENVMDAVGSAERS 1806
||..:|...|.| .::||.:| ||| .::...|:...|..|
Rat 1424 -------SFSEESPSKETSLDISSKQLS-PESLGTLQFGELNLGKEERGPVMKAEDDSCHLAPVS 1480
Fly 1807 QPE----SVTASRD------------------VSRPESVAE----------SEKDDTDKPESVVE 1839
.|| :|:.|.| |.|..|..| |:...|..|||:..
Rat 1481 IPEPHRATVSPSTDETPAGTLPGGSFSHSALSVDRKHSPGEITGPGGHFMTSDSSLTKSPESLSS 1545
Fly 1840 SVIPASD--VVEIEKGAADKEKGVFVSLEIGKPDSPSEVISRPGPVVESVKPESRRESSTEIVLP 1902
||.: .||.|..|..||| :|:..||...:.|.:: ||.......::::
Rat 1546 ---PAMEDLAVEWEGKAPGKEK---------EPELKSETRQQKGQIL----PEKVAVVEQDLII- 1593
Fly 1903 CHAEDS--KEPSRPESKVECLKDESEVLKGS--TRRESVAESDKSSQPFKETSRPESAVGSMKDE 1963
|.:|. .|.::|..: :|::...||. ..:::.||.||..:| |::
Rat 1594 -HQKDGALDEENKPGRQ----QDKTPEQKGRDLDEKDTAAELDKGPEP--------------KEK 1639
Fly 1964 SMSKEPSRRE----SVKDGAAQSRET-------SRPASVAESAKDGADDLKELSRPESTTQSKEA 2017
.:.:|...:. :.||.|::.|:| :.|...|:..:|..:..|.|...:.|.:.|:.
Rat 1640 DLDREDQGQRAGPPAEKDKASEQRDTDLQQTQATEPRDRAQERRDSEEKDKSLELRDRTPEEKDR 1704
Fly 2018 GSIKDEKSPLASEEASRP-------ASVAESVKDEAEKSKEESRRESVAE-KSPLPSKEA---SR 2071
..::::::| |.|.| |...:...|:.:|.:....:|.|.| |.....||. .:
Rat 1705 ILVQEDRAP----EHSIPEPTQTDRAPDRKGTDDKEQKEEASEEKEQVLEQKDWALGKEGETLDQ 1765
Fly 2072 PASVAESIKDEAEKSKEESRRESVAEKSPLPSKEA---SRPASVAESIKDEAEKSKEESRRESVA 2133
.|..||...:..::.|.:.::.|..|.....|||. .:.|..|:|::.:...:.|::|...:
Rat 1766 EARTAEQKDETLKEDKTQGQKSSFVEDKTTTSKETVLDQKSAEKADSVEQQDGAALEKTRALGL- 1829
Fly 2134 EKSPLPSKEASRPASVAESIKDEAEKSKEES--RRESV-AEKSPLPSKEASRPASVAESIKDEAE 2195
|:||....:|..........:|..:..:|.| |.|.| .:|.|:|:.|...|.......:|...
Rat 1830 EESPAEGSKAREQEKKYWKEQDVVQGWRETSPTRGEPVGGQKEPVPAWEGKSPEQEVRYWRDRDI 1894
Fly 2196 KSKEES--RRESVAEKSPLPSK---EASRPASVAE---SIKDEAEKSKEESRRESVAE------- 2245
..:::: |..|...|...|.: :.:||....| :..||....:|.:..:....
Rat 1895 TLQQDAYWRELSCDRKVWFPHELDGQGARPRYCEERESTFLDEGPDEQEITPLQHTPRSPWTSDF 1959
Fly 2246 ---KSPLPSKEASRPASVAES---IKDEAEKSKEESRRESVA------------------EKSPL 2286
:.|||.|.......:||| :..|.|.....|..|.:: ::||:
Rat 1960 KDFQEPLPQKGLEVERWLAESPVGLPPEEEDKLTRSPFEIISPPASPPEMTGQRVPSAPGQESPV 2024
Fly 2287 PSKEASRPASVAESIKDEAEKSKEETRRESVAEKSP-LPSKEASRPASVAESIKDEAEKSKEESR 2350
|..|::.| ...|.|....:||..| :|......||.:
Rat 2025 PDTESTAP------------MRNEPTTPSWLAEIPPWVPKDRPLPPAPL---------------- 2061
Fly 2351 RESAAEKSPLPSKEASRPA----------SVAESVKDEA-------------DKSKEESRRESMA 2392
|.|...|.|:.|...|. ||..:|::.| |..|.|..|| .
Rat 2062 --SPAPAPPTPAPEPHTPVPFSWGLAEYDSVVAAVQEGAAELEGGPYSPLGKDYRKAEGERE--G 2122
Fly 2393 ESGKAQSIKGDQSPLKEVSRPESVAESVKDDPVKSKEPSRRE-------------------SVAG 2438
|.|.........|| ..||: .||:.....:..||.:|| .:.|
Rat 2123 EGGAGAPDSSSFSP----KVPEA-GESLATRDTEQTEPEQREPTPYPDERSFQYADIYEQMMLTG 2182
Fly 2439 SVTADSARDDQSPLESKGASRPESVVDSVKDEAEKQESRRESKTES------------------- 2484
...|...| :.||.:.|...|.. |.|:||....:..|.:|.|
Rat 2183 LGPACPTR--EPPLGASGDWPPHL---STKEEAAGCNTSAEKETSSPASPQNLQSDTPAFSYASL 2242
Fly 2485 ---VIPPKAKDDKSPKEVLQPVSMTETIREDADQPMKP-SQAESRRESIAESIKASSPRDEKSPL 2545
.:||:.:.|..|. ::| :|...|..|..| |.::.....:..|..:.|| |.::|
Rat 2243 AGPAVPPRQEPDPGPN--VEP-----SITPPAVPPRAPISLSKDLSPPLNGSTVSCSP-DRRTP- 2298
Fly 2546 ASKEASR----PGSVAESIKYDLDKPQIIKDDKSTEHSRRESLEDKSAVTSEKSVSRPLSVASDH 2606
:.||..| .|: :|...|...||..|.: |...|...|:.:.
Rat 2299 SPKETGRGHWDDGT----------------NDSDLEKGAREQPEKE---TRSPSPHHPMPMG--- 2341
Fly 2607 EAAVAIEDDAKSSISPKDKSRPGFVAETVSSPIEEATMEFSKIEVVEKSSLALSLQGGSGGKLQT 2671
.:::..|.:|.||:| ..|..|.|..::..| .:...||.::.... :|.:
Rat 2342 HSSLWPETEAYSSLS--SDSHLGSVRPSLDFP--ASAFGFSSLQPAPP-------------QLPS 2389
Fly 2672 DSSPVDVAEGDFS----HAVASVSTVTPTLTKPAELAQIGAAKTVSSPLDEALRTPSAP-----E 2727
.:.|.....|..: .|:|.|.. |||.|:..|..::..|.::.|.|.: |.:||:| .
Rat 2390 PAEPRSAPCGSLAFSGDRALALVPG-TPTRTRHDEYLEVTKAPSLDSSLPQ-LPSPSSPGGPLLS 2452
Fly 2728 HISRADSPAECASEEIASQDKSPQVLKESSR-PAWVAESKDDAAQLKSSVE-------DLR---- 2780
::.|..||| .||..:|:..:|.:...:.| |..:..::..|..|.|..| ||.
Rat 2453 NLPRPASPA--LSEGSSSEATTPVISSVAERFPPGLEAAEQSAEGLGSGKESAAHSLWDLTPLSP 2515
Fly 2781 SPVASTEISRPASAGETASSPIEEAPKDFAEFEQAEKAVLPLTIELKGNLPTLSSPVDVAHGDFP 2845
:|.||.::: ||.|...|.:|....|.|..: ..||...|..|.|....||.....||.
Rat 2516 APSASLDLA-PAPAPAPAPAPAPGLPGDLGD------GTLPCRPECTGELTKKPSPFLSPSGDH- 2572
Fly 2846 QTSTPTSSPTVASVQPAELSKVDIEKTASSPIDEAPKSLIGCPAEER---PESPAESAK-----D 2902
..:.|...|:.|... :..||.....|||. |.|| ||....|:: .
Rat 2573 ----EANGPGETSLNPPGF----VTATAEKEEAEAPH------AWERGSWPEGAERSSRPDTLLS 2623
Fly 2903 AAESVEKSKDASRPP----SVVE------STKADSTKGDISPS------PESVLEGPKDDVEKSK 2951
:.:.:...|.:..|| |.|| :|......|::||| |.|. ||.:.|.
Rat 2624 SEQPLRPGKSSGGPPCSLSSEVEAGPQGCATDPRPHCGELSPSFLNPPLPPST-----DDSDLST 2683
Fly 2952 ESSRPPSVSASITG-DSTKDVSRPASVVE--SVKDEHDKAESRRESIAKVESVIDEAGKSDSKSS 3013
|.:| :.| ...:.|.||.:... .:.||.....: |||.||
Rat 2684 EEAR-------LAGKGGRRRVGRPGATGGPCPMADETPPTSA-----------------SDSGSS 2724
Fly 3014 SQDS----QKDEKSTLASKEASRRESVVESSKDDAEKSESRPESVIASGEPVPRESKSPLDSKDT 3074
..|| :.:|..::.: |:.::|.:|.......:...|..:..|.|.....|....|
Rat 2725 QSDSDVPPETEECPSITA------EAALDSDEDGDFLPVDKAGGVSGTHHPRPGHDPPPTPLPD- 2782
Fly 3075 SRPGSMVESVTAEDEK--SEQQSRRESVAESVKADTKKDGKSQEASRPSSVDELLKDDDEKQESR 3137
.||......|...|.: |.:..|.|.:.|..:...:..|:::.|| .:|
Rat 2783 PRPSPPRPDVCMADPEGLSSESGRVERLREKGRPGRRAPGRAKPAS----------------PAR 2831
Fly 3138 RQSITGSHKAMSTMGDESPMDKADKSKEPSRPESVAESIKHENTKDEESPLGSRRDSVAESIKSD 3202
|..|.| |...|.| :.|:|:. |:...||.|....:.....||..||:.. .:...:|:.
Rat 2832 RLDIRG--KRSPTPG-KGPVDRT--SRTVPRPRSTPSQVTSAEEKDGHSPMSK---GLVNGLKAG 2888
Fly 3203 IT----KGEKSPLPSKEVSR-PESVVGSIKDEKAESRRESVAESVKPESSKDATSAPPSKEHSRP 3262
.| ||...|....:::. |....|...|:....| |..|....|..|..:..||:
Rat 2889 STALGSKGGSGPPVYVDLAYIPNHCSGKTADQDFFRR---VRASYYVVSGNDPANGEPSR----- 2945
Fly 3263 ESVLGSLKDEGDKTTSRRVSVADSIKDEKSLLVSQEASRPESEAESLKDAAAPSQET-------- 3319
:|.|::.:.|: ...|:|:....|:.:|
Rat 2946 -------------------AVLDALLEGKA-----------QWGENLQVTLIPTHDTEVTREWYQ 2980
Fly 3320 ---SRPESVTESVKDGKSPVASKEASRPASVAE 3349
.:.:.:...|....|.|..::.|.||...|
Rat 2981 QTHEQQQQLNVLVLASSSTVVMQDESFPACKIE 3013
| 
