Protein Alignment futsch and PHF3

DIOPT Version :9

• Sequence 1: NP_001096864.1
• Gene: futsch / 5740544
• FlyBaseID: FBgn0259108
• Length: 5495
• Species: Drosophila melanogaster
• Sequence 2: XP_011533950.1
• Gene: PHF3 / 23469
• HGNCID: 8921
• Length: 2048
• Species: Homo sapiens
• Alignment Length: 2596
• Identity: 495/2596 - (19%)
• Similarity: 873/2596 - (33%)
• Gaps: 848/2596 - (32%)

  Fly  1149 EEKLSKKTSDTKDDQIGAPVD--VLPV------NLQ---------ESLPEEKFSATIESGATTAP 1196
            |:.|....|| ||..:|:..:  .|||      |.|         :.:.:|  ....|||   ..
Human    51 EDSLKNMLSD-KDPMLGSASNQFCLPVLDSNDPNFQMPCSTVVGLDDIMDE--GVVKESG---ND 109

  Fly  1197 TLPEDERI-PLDQIKEDLVIEEKYVKEETKEAEAIVVATVQTLPE--------AAPLAIDTILAS 1252
            |:.|:|.| |...:::.  :||..|:...|....:....|::|.:        ||||       |
Human   110 TIDEEELILPNRNLRDK--VEENSVRSPRKSPRLMAQEQVRSLRQSTIAKRSNAAPL-------S 165

  Fly  1253 ATKDAPKDANAEALGELPDSGERVLPMKMTFEAQQNLLRDVIKTPDEVADLPVHEEADLGL---Y 1314
            .||.|              ||:.|...|..           :|.|:.   ..|.||..:.|   |
Human   166 NTKKA--------------SGKTVSTAKAG-----------VKQPER---SQVKEEVCMSLKPEY 202

  Fly  1315 EKD----SQDAG--------AKSISHKEESAKEEKETDDEKENKVGEIELGDEPNKVDI-SHVLL 1366
            .|:    |:::|        :.|.||...|:..|.:.:|..::|    ...:.|.::|: ||.|
Human   203 HKENRRCSRNSGQIEVVPEVSVSSSHSSVSSCLEMKDEDGLDSK----HKCNNPGEIDVPSHEL- 262

  Fly  1367 KESVQEVAEKVVVIETTVEKKQEEIVEATTVITQENQEDLMEQVKDKEEHEQK-----------I 1420
              :...::|..|.|.   |||.|.::|...    :.....:.:..|||||||.           :
Human   263 --NCSLLSETCVTIG---EKKNEALMECKA----KPVGSPLFKFSDKEEHEQNDSISGKTGETVV 318

  Fly  1421 ESGIITEKEAKKSASTP----------EEKETSDITSDDELPAQLADPTTVPPKSAKDREDTGSI 1475
            |..|.|.|..:.|..|.          |:..:|||:||    |...:|         ::.:...:
Human   319 EEMIATRKVEQDSKETVKLSHEDDHILEDAGSSDISSD----AACTNP---------NKTENSLV 370

  Fly  1476 ESPPTIEEAIEVEVQAKQEAQKPVPAPEEAIKTEKSPLASKETSRPESATGSVKEDTEQTKSKKS 1540
            ..|..::|..|..::.|.                               |..:.:.||.|..
Human   371 GLPSCVDEVTECNLELKD-------------------------------TMGIADKTENTLE--- 401

  Fly  1541 PVPSRPESEAKDKKSPFASGEASRPESVAESVKDEAGKAESRRESIAKTHKDESSLDKAKEQESR 1605
                      ::|..|....|                .|||.|: :..|..::|:|:...
Human   402 ----------RNKIEPLGYCE----------------DAESNRQ-LESTEFNKSNLEVVD----- 434

  Fly  1606 RESLAESIKPESGIDEKSALASKEASRPESVTDKSKEPSRRESIAESLKAESTKDEKSAPPSKEA 1670
                ..:..|||.|.|            .::.|...:.|::.:..||.|.||   .::|....:.
Human   435 ----TSTFGPESNILE------------NAICDVPDQNSKQLNAIESTKIES---HETANLQDDR 480

  Fly  1671 SRPGSVVESVKDETEKSKEPSRRESIAESAKPPIEFREVSRPESVIDGIKDESAKPESRRDSPLA 1735
            :...|.|..::.::.|||.          .||.|.                  :|.....|:|
Human   481 NSQSSSVSYLESKSVKSKH----------TKPVIH------------------SKQNMTTDAP-- 515

  Fly  1736 SKEASRPESVLESVKDEPIKSTEKSRRESVAESFKADSTKDEKSPLTSKDISRPESAVENVMDAV 1800
                    ..:.:.|.|.|.|..|...:||        .::...|.:.::..||....:..:|
Human   516 --------KKIVAAKYEVIHSKTKVNVKSV--------KRNTDVPESQQNFHRPVKVRKKQID-- 562

  Fly  1801 GSAERSQPESVTASRDVSRPESVAESEKDDTDKPESVVESVIPASDVVEIEKGAADKEKGVFVSL 1865
                 .:|:..:.:..|...::.|.|....|.:.:::|:...|      :....:||..
Human   563 -----KEPKIQSCNSGVKSVKNQAHSVLKKTLQDQTLVQIFKP------LTHSLSDKSH------ 610

  Fly  1866 EIGKPDSPSEVISRPGPVVESVKPESRRESSTEIVLPCHAEDSKEPSRPESKVECLKDESEVLKG 1930
                        :.||.:.|...|......|......||        :|:.:...:|..|.| |.
Human   611 ------------AHPGCLKEPHHPAQTGHVSHSSQKQCH--------KPQQQAPAMKTNSHV-KE 654

  Fly  1931 STRRESVAESDKSSQPFKETSRPESAVGSMKDESMSKEPSRRESVKDGAAQSRETSRPASVAESA 1995
            ......|       :.|||..:.:     :|....:.:|.:|.|.|..:........|.::|...
Human   655 ELEHPGV-------EHFKEEDKLK-----LKKPEKNLQPRQRRSSKSFSLDEPPLFIPDNIATIR 707

  Fly  1996 KDGADDLKELSRPESTTQSKEAGSIKDEKSPLAS---------EEASRPASVAESVKDEAEKSKE 2051
            ::|:|...........|.||:.|..   |.|..:         ::......|..|:....:..:|
Human   708 REGSDHSSSFESKYMWTPSKQCGFC---KKPHGNRFMVGCGRCDDWFHGDCVGLSLSQAQQMGEE 769

  Fly  2052 ESRRESVAEKSPLPSKEASRPASVAESIKDEAEKSKEESRRESVAEKSPLPSKEASRPASVAESI 2116
            :  :|.|..|.                       ..||.::..:.:               .:::
Human   770 D--KEYVCVKC-----------------------CAEEDKKTEILD---------------PDTL 794

  Fly  2117 KDEAEKSKEESRRESVAEKSPLPSKEAS--RPASVAESIKDEAEKSKEESR--------RESVAE 2171
            :::|........:....||..| ||..:  |...:.:::|.:.:..|.||.        |::..:
Human   795 ENQATVEFHSGDKTMECEKLGL-SKHTTNDRTKYIDDTVKHKVKILKRESGEGRNSSDCRDNEIK 858

  Fly  2172 KSPL-PSKEASRPASVAESIKDEAEKSKEESRRESVAEKSPLPSKEASRPASVAESIKDEAEKSK 2235
            |..| |.::..:|.....|.::::||..:||...:..      .::||:|.:          ..|
Human   859 KWQLAPLRKMGQPVLPRRSSEEKSEKIPKESTTVTCT------GEKASKPGT----------HEK 907

  Fly  2236 EESRRESVAEKSPL---PSKEASRPA------SVAESIKDEAEKSKEESRRESVAEKSPLPSKEA 2291
            :|.:::.| ||..|   |:..||:|:      ||..|:||...|...:|..:...||:
Human   908 QEMKKKKV-EKGVLNVHPAASASKPSADQIRQSVRHSLKDILMKRLTDSNLKVPEEKA------- 964

  Fly  2292 SRPASVAESIKDEAEKSKEETRRESVAEKSPLPSKEASRPASVAESIKD-----------EAEKS 2345
               |.||..|:.|......:|           .:|..::..|:..::||           :.|.:
Human   965 ---AKVATKIEKELFSFFRDT-----------DAKYKNKYRSLMFNLKDPKNNILFKKVLKGEVT 1015

  Fly  2346 KEESRRESAAEKSPLPSKEASRPASVAESVKDEADKSKEESRRESMAESGKAQSIKGDQSPLKEV 2410
            .:...|.|..|   |.|||.:            |.:.:|......|.|..:.:.   ::.|:.::
Human  1016 PDHLIRMSPEE---LASKELA------------AWRRRENRHTIEMIEKEQREV---ERRPITKI 1062

  Fly  2411 SRPESVAESVKDDPVKSKEPSRRESVAGSVTADSARDDQSPLESKGASRPESVVDSVKDEAEKQE 2475
            :....: |...|.|:|.:|              :|.:.|.|..:|...:||.      .|.:|:|
Human  1063 THKGEI-EIESDAPMKEQE--------------AAMEIQEPAANKSLEKPEG------SEKQKEE 1106

  Fly  2476 SRRESKTES------------------VIPPKAKDDKSPKEVLQPVSMTETIREDADQPMKPSQA 2522
            ....||..:                  :.||  .||.|||:|...|.:.   |:.:|     ::|
Human  1107 VDSMSKDTTSQHRQHLFDLNCKICIGRMAPP--VDDLSPKKVKVVVGVA---RKHSD-----NEA 1161

  Fly  2523 ESRRESIA-----------ESIKASSPRDEKSPLASKEASRPGSV-AESI---------KYDLDK 2566
            ||..::::           |..|..||:...||....|  .||:| .||.         |..::.
Human  1162 ESIADALSSTSNILASEFFEEEKQESPKSTFSPAPRPE--MPGTVEVESTFLARLNFIWKGFINM 1224

  Fly  2567 PQIIKDDKSTEHSRRESLEDKSAVTSEKSVSRPLSVASDHEAAVAIEDDAKSSISPKDKSRPGFV 2631
            |.:.|                 .||.    :.|:|.:.::     :.:|...||....:..|..|
Human  1225 PSVAK-----------------FVTK----AYPVSGSPEY-----LTEDLPDSIQVGGRISPQTV 1263

  Fly  2632 AETVSSPIEEATMEFSKIE---VVEKSSLALSLQGGSGGKLQTDSSPVDVAEGDFSHAVA----S 2689
            .:.|.......|.|...:.   |.|:..::.:|.                    |::..:    .
Human  1264 WDYVEKIKASGTKEICVVRFTPVTEEDQISYTLL--------------------FAYFSSRKRYG 1308

  Fly  2690 VSTVTPTLTKPAELAQIGAAKTVSSPL------DEALRTPS------APEHISRADSPAECAS-E 2741
            |:.......|...|..:||...:..||      ...|..|:      ..:.:.|..|  .||| .
Human  1309 VAANNMKQVKDMYLIPLGATDKIPHPLVPFDGPGLELHRPNLLLGLIIRQKLKRQHS--ACASTS 1371

  Fly  2742 EIASQDKSPQVLKESSRPAWVAESKDDAAQLKSSVEDLRSPVASTEISRPASAGETASSPIEEAP 2806
            .||   ::|    ||:.|..:...|      ||.:|      .||                ||||
Human  1372 HIA---ETP----ESAPPIALPPDK------KSKIE------VST----------------EEAP 1401

  Fly  2807 KDFAEFEQAEKAVL------PLTIELKGNLPTLSSP-VDVAHGDFPQ------------TSTPTS 2852
            ::..:|..:...||      |.. .|:.:|||...| ::|...:.|:            .:.||:
Human  1402 EEENDFFNSFTTVLHKQRNKPQQ-NLQEDLPTAVEPLMEVTKQEPPKPLRFLPGVLIGWENQPTT 1465

  Fly  2853 SPTVASVQPAELSKVDIEKTASSPIDEAPKSLIGCPAEERPESPAESAKDAAESVEKSKDASRPP 2917
                     .||:...:      |:|:..:||:|...:         ..|.|:||.:.......|
Human  1466 ---------LELANKPL------PVDDILQSLLGTTGQ---------VYDQAQSVMEQNTVKEIP 1506

  Fly  2918 SVVESTKADSTKGD---ISPSPESVLEGPKDDVEKSKESSRPPSVSASITGDST----------- 2968
            .:.|.|.:...|.|   ::......::...|::.:|.:.|  ..:..|:.|.|:
Human  1507 FLNEQTNSKIEKTDNVEVTDGENKEIKVKVDNISESTDKS--AEIETSVVGSSSISAGSLTSLSL 1569

  Fly  2969 ----KDVSRPASVVE-SVKDEHDKAESRRESIAKVESVIDEAGKSDSKSSSQDSQKDEKSTLASK 3028
                .|||..|.:.. |::.:.:      |::...|..:....:.|.:::.||:|....|...|.
Human  1570 RGKPPDVSTEAFLTNLSIQSKQE------ETVESKEKTLKRQLQEDQENNLQDNQTSNSSPCRSN 1628

  Fly  3029 --------EASRRESVVESS---------KDDAEKSESRPESVIASGEPVPRESKSPLDSKDTSR 3076
                    ..|..|::|.::         |.|..::..|.:.|..|      |||    ..|:.|
Human  1629 VGKGNIDGNVSCSENLVANTARSPQFINLKRDPRQAAGRSQPVTTS------ESK----DGDSCR 1683

  Fly  3077 PGS-------------MVESVTAED-----EKSE--QQSRRESVAESVKADTKKDGKSQEASRPS 3121
            .|.             :.|.:..|:     ||:.  |||....||::..:.........|.::|.
Human  1684 NGEKHMLPGLSHNKEHLTEQINVEEKLCSAEKNSCVQQSDNLKVAQNSPSVENIQTSQAEQAKPL 1748

  Fly  3122 SVDELLKDDDEKQESRRQS-ITGSHKAMSTMGDESPMDKADKSKEPSRPESVAESIKHENTKDEE 3185
            ..|.|:::.:.....||.| :..||   ..:|:..|      |:.||:..:.........|....
Human  1749 QEDILMQNIETVHPFRRGSAVATSH---FEVGNTCP------SEFPSKSITFTSRSTSPRTSTNF 1804

  Fly  3186 SPLGSRRDSVAESIKSDITKGEKSPLPSKEVSRPESVVGSIKDEKAESRRESVAESVKPESSKDA 3250
            ||:..::.:: :.:||   .....|.|......|:|:.|.         ...:...:.|......
Human  1805 SPMRPQQPNL-QHLKS---SPPGFPFPGPPNFPPQSMFGF---------PPHLPPPLLPPPGFGF 1856

  Fly  3251 TSAP----PSKEH--SRPESVLGSLKDEGDKTTSRRVSVAD--SIKDEKSLLVSQEASRPE---S 3304
            ...|    |...|  .:|:.::|.|..     .||.:...:  .:||.:         |||   |
Human  1857 AQNPMVPWPPVVHLPGQPQRMMGPLSQ-----ASRYIGPQNFYQVKDIR---------RPERRHS 1907

  Fly  3305 EAESLKDAAAPSQETSRPESVTESVKDGKSPVASKEASRPASVAENAKDSADESKEQRPESLPQS 3369
            :....:|    .|:..||      ...||.     :..|..|.:.:.|....| ||...||....
Human  1908 DPWGRQD----QQQLDRP------FNRGKG-----DRQRFYSDSHHLKRERHE-KEWEQESERHR 1956

  Fly  3370 KAGSIKDEKSPLASKDEAEKSKEESRRESVAEQFPLVSKEVSRPASVAESVKDEAEKSKEESPLM 3434
            :....:|:.....|::|..|.||.:|                    ::...:....|:..:|..:
Human  1957 RRDRSQDKDRDRKSREEGHKDKERAR--------------------LSHGDRGTDGKASRDSRNV 2001

  Fly  3435 SKEASRPASVAGSVKDEAEKSKEESRRESVAEKSPLPSKEASRPASVAESVKDEADKSKEE 3495
            .|:..:|.|      ::.||.||.       |||  ..:|..:........:|..|::|.:
Human  2002 DKKPDKPKS------EDYEKDKER-------EKS--KHREGEKDRDRYHKDRDHTDRTKSK 2047

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
futsch	NP_001096864.1	DUF966	<1925..>2112	CDD:283735	30/195 (15%)
PHF3	XP_011533950.1	PHD_PHF3	728..778	CDD:277108	8/54 (15%)
		TFIIS_M	934..1044	CDD:284835	29/145 (20%)
		SPOC	1218..1324	CDD:285043	22/151 (15%)
		PRP38_assoc	<1941..2035	CDD:289628	25/129 (19%)
		DUF1777	1954..>2048	CDD:285811	23/129 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000