DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment futsch and maph-1.1

DIOPT Version :9

Sequence 1:	NP_001096864.1	Gene:	futsch / 5740544	FlyBaseID:	FBgn0259108	Length:	5495	Species:	Drosophila melanogaster
Sequence 2:	NP_001021436.1	Gene:	maph-1.1 / 173357	WormBaseID:	WBGene00009306	Length:	878	Species:	Caenorhabditis elegans

Alignment Length:	989	Identity:	206/989 - (20%)
Similarity:	336/989 - (33%)	Gaps:	270/989 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   338 LYVFPGGQGDAALFGINGFNMLVDGGFNRKACFWDFARHLDRLDAVLMTRLNNSNVQGLGAVVSR 402
            :||..|....||||..:|..:| ||||..|..  .|..|:..:.|||:......|:....|::.:
Worm    13 IYVLGGAANTAALFDFDGVYIL-DGGFAEKNP--GFVAHVRDVSAVLLAAPTLGNLGTTSALLEQ 74

  Fly   403 KRDAHVYPQIGHFFGNVPDRKGLPSPDGDKDRDPLLIDLFERGHGIVSDLKALDLKPQCCYRNQE 467
            .:...|      |....|.:...|...|:      :....:..:.     |.|.:.|. .:..:.
Worm    75 GKPLPV------FTNTKPFKTAKPGSSGE------IAKAIQEANS-----KILSVAPP-LFNPKY 121

  Fly   468 PVN-LYHKVGHGTLDMYVISPARDSKEVKEFLQKWHAGDQRLFAARDSRDFNFPLQNLVSICALL 531
            |.| :|.....|.|.:|::  |.|.|:. |.:.|..||.......:.:.:.        ....:|
Worm   122 PANIIYQSAAKGVLSLYIL--AGDVKDA-EVITKALAGGNEAEVEKAAAEH--------GTIGVL 175

  Fly   532 VWQPANPDDTITRILFPGSTPDFKIQEGLEK-LKHLEFMKHSTCTAK------------------ 577
            :|:||..|.::.|:|..|::...:||:.|:| .|.|.|:...|..:|
Worm   176 LWRPAMTDQSVVRVLISGTSSLSRIQQSLDKAAKSLPFLNVPTVKSKDALSDIPAPAVPRPVAGK 240

  Fly   578 -SIAPAIQTVTSTRKSLKSAIEATPAPPSASYKTTKFSPVASAALAVQHPQQQDNKAKEAAAAAA 641
             |..||..|.|:||.:       .||.|:||         |..||..:.|...........||.|
Worm   241 PSARPATTTGTATRPT-------RPAVPAAS---------APRALTSRAPAGPSRPTTTRNAAPA 289

  Fly   642 AAAAAAASAATIAR-AKADSMDTDAEPEHEADPEPADTGDEAAPTEQEPEAETEPEPEHEPEAEQ 705
            ...|..:.|..:.: |.|....|.|.....:.|.|    ...||.  :|.|.|   .:.||.| |
Worm   290 PRTAVPSRATVLTKTAPASKAPTRAPVPARSAPAP----PRGAPA--KPAANT---AKAEPIA-Q 344

  Fly   706 DKDVGEEKKVE-VLIMKPQQATPAVIAASGKDGVDAASADATPTGKLSKASAKGKADKPRAEVKP 769
            .|.||   ||: ....||..|.||..|.|.....:|                      ||.:...
Worm   345 KKTVG---KVQGTAPSKPAPAAPASAATSPAPAPEA----------------------PRRDPNN 384

  Fly   770 VVRSRIDTKPPKSMDRKLAKRDEKKSSPTTTPAARAPVAQNAKPKVLSRPATKSSPSSTPAKSAK 834
            |.....|:..|:..::..|..|.....||..| .|..|||...|:
Worm   385 VTIVLDDSLSPEDFNQGSAPMDIVVIPPTPEP-PRHEVAQATHPE-------------------- 428

  Fly   835 EANNRKVLESKQQAARVQATSTVSRRVTSTASERRVQQQAEAKTAATGATQATQRKPISRRPRGV 899
                ..:::::..|       .....|...|:...|:.:......|....:......:|    |.
Worm   429 ----ESIIDAEDLA-------KAPLEVDDVANLADVEDEIPPPVDAFKKPEPHPEPNVS----GG 478

  Fly   900 SPSKRAPAPGSPVKQAKPKAAD----LKKTRLDKGG---TTDSSLVSTPSADEATAAKKLQDLTA 957
            |...:.|.|....|:..|...|    ||.:..:...   .:|..:::||..:       |.|:.|
Worm   479 SEEDKIPEPVDAFKKPDPVELDDFDPLKPSHPEPSAPVVPSDHIIIATPDPE-------LPDIVA 536

  Fly   958 S---------------QELDAEKQRELDDLKE----------------EQEVVREIEAVFSRDEM 991
            :               .:||.|.::.....:|                .:||.:.:|.....|..
Worm   537 AVPFVSPSPKGPNDGLVKLDDELEKIAPGFEEPLIPQAPRDDGTLAECSEEVSKLVEISMDTDNS 601

  Fly   992 KRQQHQQIKA--ELREMPAEGTGDGENEPDEEEEYL-IIEKEEVEQYT-------EDSIVEQESS 1046
            ........||  |:.::.|:....|.:|  :.:||: .:..:.:|..|       ..|||....|
Worm   602 AEVAADLAKAVGEVTQLSADLQNLGLDE--KTDEYVRKLSNQMIEDATLPFTSALASSIVTSNGS 664

  Fly  1047 MTKEEEIQKHQRDSQESEKKRKKSAEEEIEAAIAKVEAAERKARLEGASARQDESE--LD----- 1104
            .|.....|.|...:...:.:::....:.:::..:.:|        .||:.:.::::  ||
Worm   665 ETNGHGEQAHAAQNGGIDHQKEIPKHDLMQSRSSVIE--------NGAAVQYEKTDPALDDVLNA 721

  Fly  1105 VEPEQSKIKAEVQDII---------ATAKDIAKSRTE--EQLAKPAEEELSSPTP----EEKLSK 1154
            ...|..||.|...|.:         |.||.:..:|..  :.:..|..|:|.:...    :|.:||
Worm   722 CAQESEKIDASHPDNLHMPAAPGSAAPAKPVKFARPYYFDVVTVPRNEKLETSVAADGLQEFISK 786

  Fly  1155 KTS--------DTKDDQIGA-------------PVDVLPV--------------------NLQES 1178
            ..|        |...:|:.|             |.:|:|.                    |||.|
Worm   787 VRSRNVILASKDISGEQLQAILCGKQTWCDSAHPCNVIPTHSSPMLLDFRQKNEEQFAANNLQFS 851

  Fly  1179 LPEEKFSATIESGA 1192
            :|.||...|:.|.|
Worm   852 IPVEKQRTTVSSDA 865

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
futsch	NP_001096864.1	DUF966	<1925..>2112	CDD:283735
maph-1.1	NP_001021436.1	Atrophin-1	<229..533	CDD:331285	83/397 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13843
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4578
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.130