DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34354 and HNRNPDL

DIOPT Version :9

Sequence 1:	NP_001097953.2	Gene:	CG34354 / 5740528	FlyBaseID:	FBgn0085383	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_112740.1	Gene:	HNRNPDL / 9987	HGNCID:	5037	Length:	420	Species:	Homo sapiens

Alignment Length:	398	Identity:	92/398 - (23%)
Similarity:	150/398 - (37%)	Gaps:	112/398 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PTIAMGAPQITMGPHKPPET-----KLLAIHPAAAAAAAAQQQQQ------SVTAAHLQHNGQQQ 65
            |:...|...|..|..:.|:.     |..:|..:||||||.:..:|      |||...:     .:
Human    66 PSRLAGGAAIKGGRRRRPDLFRRHFKSSSIQRSAAAAAATRTARQHPPADSSVTMEDM-----NE 125

  Fly    66 HSQQQQQQQMSQQQQQQQQQLVGNNSKPEQFHIFVGDLSAEIETQQLKDAFTPFGEISDCRVVRD 130
            :|..::..:.|:....:.||..|.        :|:|.||.:...:.|.:..:.|||:.||.:..|
Human   126 YSNIEEFAEGSKINASKNQQDDGK--------MFIGGLSWDTSKKDLTEYLSRFGEVVDCTIKTD 182

  Fly   131 PQTLKSKGYGFVSFVKKSEAETAITAMNGQWLGSRSIRTNWATRKPPATKADMNAKPLTFDEVYN 195
            |.|.:|:|:|||.| |.:.:...:..:....|..:.|       .|...||....:|
Human   183 PVTGRSRGFGFVLF-KDAASVDKVLELKEHKLDGKLI-------DPKRAKALKGKEP-------- 231

  Fly   196 QSSPTNCTVYCGGINGALSGFLNEEILQKTFSPYGTIQEIRVFKD------KGYAFVRFSTKEAA 254
               |..  |:.||    ||...:||.:::.|..:|.|:.|.:..|      :|:.|:.::.:|..
Human   232 ---PKK--VFVGG----LSPDTSEEQIKEYFGAFGEIENIELPMDTKTNERRGFCFITYTDEEPV 287

  Fly   255 THAI------VAVNNTEIN-QQPVKCAWGKESGDPNHMSAIAGGA-------------LAQGF-- 297
            ...:      :.....||. .||.:....::........|.|||.             ..|||
Human   288 KKLLESRYHQIGSGKCEIKVAQPKEVYRQQQQQQKGGRGAAAGGRGGTRGRGRGQGQNWNQGFNN 352

  Fly   298 ----PFGSAAAAAAAAAYG--QQVAGYWYPPAPTYPAAAPASALQPGQFLQGMQGFTYGQFAGYQ 356
                .:|:     ..:|||  |..:||                   |.:  ...|:.||.: ||.
Human   353 YYDQGYGN-----YNSAYGGDQNYSGY-------------------GGY--DYTGYNYGNY-GYG 390

  Fly   357 Q--AGYMG 362
            |  |.|.|
Human   391 QGYADYSG 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34354	NP_001097953.2	RRM2_TIA1_like	97..171	CDD:240799	22/73 (30%)
CG34354	NP_001097953.2	RRM3_TIA1_like	202..278	CDD:240800	19/88 (22%)
HNRNPDL	NP_112740.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..83		4/16 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	96..120		9/23 (39%)
		RRM1_hnRPDL	149..224	CDD:410152	23/90 (26%)
		RRM2_hnRPDL	234..308	CDD:409998	17/79 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	313..348		4/34 (12%)
		Necessary for interaction with TNPO1. /evidence=ECO:0000269\|PubMed:9524220	342..420		20/84 (24%)
		Necessary for its nuclear import and export	396..420		2/3 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..420		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910