Protein Alignment CG34354 and TIAL1

DIOPT Version :10

• Sequence 1: NP_001097953.2
• Gene: CG34354 / 5740528
• FlyBaseID: FBgn0085383
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_001029097.1
• Gene: TIAL1 / 7073
• HGNCID: 11804
• Length: 392
• Species: Homo sapiens
• Alignment Length: 388
• Identity: 167/388 - (43%)
• Similarity: 201/388 - (51%)
• Gaps: 82/388 - (21%)

  Fly    37 HPAAAAAAAAQQQQQSVTAAHLQHNGQQQHSQQQQQQQMSQQQQQQQQQLVGNNSKPEQFHIFVG 101
            |..||||.||.             ||::...::.:....:....|::       .....||:|||
Human    75 HRDAAAALAAM-------------NGRKILGKEVKVNWATTPSSQKK-------DTSNHFHVFVG 119

  Fly   102 DLSAEIETQQLKDAFTPFGEISDCRVVRDPQTLKSKGYGFVSFVKKSEAETAITAMNGQWLGSRS 166
            |||.||.|:.:|.||.|||:|||.|||:|..|.||||||||||..|.:||.||..|.|||||.|.
Human   120 DLSPEITTEDIKSAFAPFGKISDARVVKDMATGKSKGYGFVSFYNKLDAENAIVHMGGQWLGGRQ 184

  Fly   167 IRTNWATRKPPATKA--DMNAKPLTFDEVYNQSSPTNCTVYCGGINGALSGFLNEEILQKTFSPY 229
            ||||||||||||.|:  :.|.|.|.|::|.|||||.|||||||||   .|| |.::::::||||:
Human   185 IRTNWATRKPPAPKSTQENNTKQLRFEDVVNQSSPKNCTVYCGGI---ASG-LTDQLMRQTFSPF 245

  Fly   230 GTIQEIRVFKDKGYAFVRFSTKEAATHAIVAVNNTEINQQPVKCAWGKESGDP----NHMSAIAG 290
            |.|.|||||.:|||:||||||.|:|.||||:||.|.|....|||.|||||.|.    ..:.....
Human   246 GQIMEIRVFPEKGYSFVRFSTHESAAHAIVSVNGTTIEGHVVKCYWGKESPDMTKNFQQVDYSQW 310

  Fly   291 GALAQ--GFPFGSAAAAAAAAAYGQQVAGYW-YPPAPTYPAAAPASALQPGQFLQGMQGFTYGQF 352
            |..:|  |.|          ..|||.:|..| .||...|.        ||    ...|||...|
Human   311 GQWSQVYGNP----------QQYGQYMANGWQVPPYGVYG--------QP----WNQQGFGVDQ- 352

  Fly   353 AGYQQAGYM-GMGVQLPGTWQSVPPQPQLASAAAATAPQITQSVGSALPQAAGVVAYPMQQFQ 414
              ...|.:| |.|.|        |||.|      |..|.|..      |..||   |.|..:|
Human   353 --SPSAAWMGGFGAQ--------PPQGQ------APPPVIPP------PNQAG---YGMASYQ 390

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34354	NP_001097953.2	PABP-1234	<90..420	CDD:130689	157/335 (47%)
		RRM2_TIA1_like	97..171	CDD:409789	49/73 (67%)
		RRM3_TIA1_like	202..276	CDD:409790	44/73 (60%)
TIAL1	NP_001029097.1	RRM1_TIAR	10..107	CDD:410028	9/44 (20%)
		RRM2_TIAR	113..192	CDD:410029	53/78 (68%)
		RRM3_TIAR	222..294	CDD:241064	46/75 (61%)