Protein Alignment CG34354 and TIA1

DIOPT Version :10

• Sequence 1: NP_001097953.2
• Gene: CG34354 / 5740528
• FlyBaseID: FBgn0085383
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_071505.2
• Gene: TIA1 / 7072
• HGNCID: 11802
• Length: 386
• Species: Homo sapiens
• Alignment Length: 396
• Identity: 167/396 - (42%)
• Similarity: 208/396 - (52%)
• Gaps: 93/396 - (23%)

  Fly    41 AAAAAAQQQQQSVTAAHLQHNGQQQHSQQQQQQQMSQQQQQQQQQLVGNNSKPEQFHIFVGDLSA 105
            ||||.|....:.:....::.|.....|.|::....|.....|:.|        :.||:||||||.
Human    59 AAAALAAMNGRKIMGKEVKVNWATTPSSQKKDTSSSTVVSTQRSQ--------DHFHVFVGDLSP 115

  Fly   106 EIETQQLKDAFTPFGEISDCRVVRDPQTLKSKGYGFVSFVKKSEAETAITAMNGQWLGSRSIRTN 170
            ||.|:.:|.||.|||.|||.|||:|..|.||||||||||..|.:||.||..|.|||||.|.||||
Human   116 EITTEDIKAAFAPFGRISDARVVKDMATGKSKGYGFVSFFNKWDAENAIQQMGGQWLGGRQIRTN 180

  Fly   171 WATRKPPATKA--DMNAKPLTFDEVYNQSSPTNCTVYCGGINGALSGFLNEEILQKTFSPYGTIQ 233
            ||||||||.|:  :.|.|.|::|||.|||||:||||||||:...|:    |:::::||||:|.|.
Human   181 WATRKPPAPKSTYESNTKQLSYDEVVNQSSPSNCTVYCGGVTSGLT----EQLMRQTFSPFGQIM 241

  Fly   234 EIRVFKDKGYAFVRFSTKEAATHAIVAVNNTEINQQPVKCAWGKESGD-------PNHMSAIAGG 291
            |||||.||||:||||::.|:|.||||:||.|.|....|||.||||:.|       .|.:
Human   242 EIRVFPDKGYSFVRFNSHESAAHAIVSVNGTTIEGHVVKCYWGKETLDMINPVQQQNQI------ 300

  Fly   292 ALAQGFPFGSAAAAAAAAAYGQQVAGYWYPPAPTYPAAAPASALQPGQFL-QGMQGFTYGQFA-- 353
                |:|          ..|||.  |.||           .:|.|.||:: .|.|...||.:.
Human   301 ----GYP----------QPYGQW--GQWY-----------GNAQQIGQYMPNGWQVPAYGMYGQA 338

  Fly   354 ----GYQQ----AGYMG--MGVQLPGTWQSVPPQPQLASAAAATAPQITQSVGSALP-QAAG--V 405
                |:.|    |.:||  .|||        |||.|               .||.|| |.:|  |
Human   339 WNQQGFNQTQSSAPWMGPNYGVQ--------PPQGQ---------------NGSMLPNQPSGYRV 380

  Fly   406 VAYPMQ 411
            ..|..|
Human   381 AGYETQ 386

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34354	NP_001097953.2	PABP-1234	<90..420	CDD:130689	156/347 (45%)
		RRM2_TIA1_like	97..171	CDD:409789	49/73 (67%)
		RRM3_TIA1_like	202..276	CDD:409790	41/73 (56%)
TIA1	NP_071505.2	RRM1_TIA1	8..81	CDD:410027	6/21 (29%)
		RRM2_TIA1	104..181	CDD:410030	50/76 (66%)
		RRM3_TIAR	214..286	CDD:241064	43/75 (57%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	354..386		17/54 (31%)