Protein Alignment CG34354 and RBM4

DIOPT Version :10

• Sequence 1: NP_001097953.2
• Gene: CG34354 / 5740528
• FlyBaseID: FBgn0085383
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_002887.2
• Gene: RBM4 / 5936
• HGNCID: 9901
• Length: 364
• Species: Homo sapiens
• Alignment Length: 459
• Identity: 96/459 - (20%)
• Similarity: 144/459 - (31%)
• Gaps: 191/459 - (41%)

  Fly   536 LSIFSSDSDSLHRGARGSST-------------GSTADRERPLSAENLLPDCSIASMTDGACG-- 585
            |::||:.|:|:    .||:.             |...:::.|.|....:|:..:.....|.|.
Human   322 LAVFSTPSNSI----PGSAVCAFDMNQVAAVFEGRFREQKSPESIWTPVPEDQVPRPRPGCCAAP 382

  Fly   586 ------------DRLNLVLHGAVSVGNTANLLTVGTSKHLIRQQTFPPL--QPYVRTRYMSSQ-- 634
                        :.||.|                  ..|.:..:..|.|  .|::....|..|
Human   383 GMQYNASSALPDEILNFV------------------KTHPLMDEAVPSLGHSPWIVRTLMRHQLT 429

  Fly   635 ---AELGACP-----------EA------LLESHSSSSNSSGSTNAAAASAALSNVESRGRVLAT 679
               .::||.|           ||      |::.::|.|.::|      .|..|...|:      .
Human   430 RVAVDVGAGPWGNQTIVFLGSEAGTVLKFLVKPNASVSGTTG------PSIFLEEFET------Y 482

  Fly   680 RKDSIKREQQPDGAG-------SSQADGAG----------KIKVP----KLSLGQKENL----DP 719
            |.|...|   |..||       |.:.|.|.          .::||    :|..|..:|.    ||
Human   483 RPDRCGR---PSSAGEWGQRLLSLELDAASGGLLAAFPRCVVRVPVARCQLYSGCMKNCIGSQDP 544

  Fly   720 SMLKRSLSRRRGSAP----VTVALPTKAS---ETAGGAASGVGIVGEIGKSFIIKTCDLMRRGSM 777
            ..         |.||    :.:...|.|:   :.:|.:.||:|            .|..:.|.|:
Human   545 YC---------GWAPDGSCIFLRPGTSATFEQDVSGASTSGLG------------DCTGLLRASL 588

  Fly   778 PVD-ALMHSKDLPASHSAAGSATAGAAGAVPSNTAQLPNSLVAPPYPGMQRRGSVPCESTNNVAL 841
            ..| |.:.|.:|..:.|.|    |...|||.|..                   ||..    .|.|
Human   589 SDDRAGLVSVNLLVTSSVA----AFVVGAVVSGF-------------------SVGW----FVGL 626

  Fly   842 RSSFSIKRRSTKKAIRRRSSGGAEILSPILSEDAAG-------GGSNGAGSSSSS---------- 889
            |....:.||..|:||  .:.||:|   .:||....|       ||..|||.....
Human   627 RERRELARRKDKEAI--LAHGGSE---AVLSVSRLGERRGTGPGGRGGAGGGPGGPPEALLAPLM 686

  Fly   890 SNAW 893
            .|.|
Human   687 QNGW 690

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34354	NP_001097953.2	PABP-1234	<90..420	CDD:130689
		RRM2_TIA1_like	97..171	CDD:409789
		RRM3_TIA1_like	202..276	CDD:409790
RBM4	NP_002887.2	RRM1_RBM4	2..68	CDD:410018
		RRM2_RBM4	78..144	CDD:410019
		PTZ00368	<145..>181	CDD:173561
		ZnF_C2HC	161..176	CDD:197667
		Interaction with TNPO3. /evidence=ECO:0000269|PubMed:12628928	196..364		10/45 (22%)