DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34354 and Tia1

DIOPT Version :9

Sequence 1:	NP_001097953.2	Gene:	CG34354 / 5740528	FlyBaseID:	FBgn0085383	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_035715.1	Gene:	Tia1 / 21841	MGIID:	107914	Length:	386	Species:	Mus musculus

Alignment Length:	394	Identity:	166/394 - (42%)
Similarity:	206/394 - (52%)	Gaps:	89/394 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 AAAAAAQQQQQSVTAAHLQHNGQQQHSQQQQQQQMSQQQQQQQQQLVGNNSKPEQFHIFVGDLSA 105
            ||||.|....:.:....::.|.....|.|::....|.....|:.|        :.||:||||||.
Mouse    59 AAAALAAMNGRKIMGKEVKVNWATTPSSQKKDTSSSTVVSTQRSQ--------DHFHVFVGDLSP 115

  Fly   106 EIETQQLKDAFTPFGEISDCRVVRDPQTLKSKGYGFVSFVKKSEAETAITAMNGQWLGSRSIRTN 170
            ||.|:.:|.||.|||.|||.|||:|..|.||||||||||..|.:||.||..|.|||||.|.||||
Mouse   116 EITTEDIKAAFAPFGRISDARVVKDMATGKSKGYGFVSFFNKWDAENAIQQMGGQWLGGRQIRTN 180

  Fly   171 WATRKPPATKA--DMNAKPLTFDEVYNQSSPTNCTVYCGGINGALSGFLNEEILQKTFSPYGTIQ 233
            ||||||||.|:  :.|.|.|::|||.:||||.||||||||:...|:    |:::::||||:|.|.
Mouse   181 WATRKPPAPKSTYESNTKQLSYDEVVSQSSPNNCTVYCGGVTSGLT----EQLMRQTFSPFGQIM 241

  Fly   234 EIRVFKDKGYAFVRFSTKEAATHAIVAVNNTEINQQPVKCAWGKESGD-------PNHMSAIAGG 291
            |||||.||||:|||||:.|:|.||||:||.|.|....|||.||||:.|       .|.:
Mouse   242 EIRVFPDKGYSFVRFSSHESAAHAIVSVNGTTIEGHVVKCYWGKETLDMINPVQQQNQI------ 300

  Fly   292 ALAQGFPFGSAAAAAAAAAYGQQVAGYWYPPAPTYPAAAPASALQPGQFL-QGMQGFTYGQFA-- 353
                |:|          ..|||.  |.||           .:|.|.||:: .|.|...||.:.
Mouse   301 ----GYP----------PTYGQW--GQWY-----------GNAQQIGQYVPNGWQVPAYGVYGQP 338

  Fly   354 ----GYQQ----AGYMGMGVQLPGTWQSVPPQPQLASAAAATAPQITQSVGSALP-QAAG--VVA 407
                |:.|    |.:||....:|      |||.|               .||.|| |.||  |..
Mouse   339 WSQQGFNQTQSSAPWMGPNYSVP------PPQGQ---------------NGSMLPSQPAGYRVAG 382

  Fly   408 YPMQ 411
            |..|
Mouse   383 YETQ 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34354	NP_001097953.2	RRM2_TIA1_like	97..171	CDD:240799	49/73 (67%)
CG34354	NP_001097953.2	RRM3_TIA1_like	202..278	CDD:240800	44/75 (59%)
Tia1	NP_035715.1	ELAV_HUD_SF	6..280	CDD:273741	121/232 (52%)
		RRM1_TIA1	8..81	CDD:241059	6/21 (29%)
		RRM2_TIA1	105..184	CDD:241062	53/78 (68%)
		RRM3_TIA1	214..287	CDD:241065	45/76 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	355..376		11/41 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	99	1.000	Domainoid score	I7056
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000924
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10352
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X831
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.010