DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34354 and DAZ1

DIOPT Version :9

Sequence 1:	NP_001097953.2	Gene:	CG34354 / 5740528	FlyBaseID:	FBgn0085383	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_004072.3	Gene:	DAZ1 / 1617	HGNCID:	2682	Length:	744	Species:	Homo sapiens

Alignment Length:	688	Identity:	137/688 - (19%)
Similarity:	211/688 - (30%)	Gaps:	257/688 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 MMPAPTIAMGAPQITMGPHKPPETKLLAIHPAAAAAAAAQQQQQSVTAAHLQHNG---------Q 63
            :.|.|        :.:.|..||:.:.:..:|........|.....|| .|:|...         .
Human   124 VQPRP--------LVVNPPPPPQFQNVWRNPNTETYLQPQITPNPVT-QHVQSAANPETPNSTIS 179

  Fly    64 QQHSQQQQQQQMSQQQQQQQQQLVGNNSKPEQFHIFVGDLSAEIETQQLKDAFTPFGEISDCRVV 128
            ::.|.|......||.....:.::|.|.       :|||.:.|.::..::...|..:|.:.:.:::
Human   180 REASTQSSSAAASQGWVLPEGKIVPNT-------VFVGGIDARMDETEIGSCFGRYGSVKEVKII 237

  Fly   129 RDPQTLKSKGYGFVSFVKKSEAETAI--------------TAMNGQWLGSRSIRTNWATRKPPAT 179
            .: :|..||||||||||...:.:..:              .|:..|.|.:|.::.......||..
Human   238 TN-RTGVSKGYGFVSFVNDVDVQKIVGSQIHFHGKKLKLGPAIRKQKLCARHVQPRPLVVNPPPP 301

  Fly   180 KADMN---------------------------AKPLTFDEVYNQSSPTNC--------------- 202
            ....|                           |.|.|.:...::.:.|..
Human   302 PQFQNVWRNPNTETYLQPQITPNPVTQHVQSAANPETPNSTISREASTQSSSAAASQGWVLPEGK 366

  Fly   203 ----TVYCGGINGALSGFLNEEILQKTFSPYGTIQEIRVFKD-----KGYAFVRF---------- 248
                ||:.|||:..    ::|..:...|..||:::|:::..:     |||.||.|
Human   367 IVPNTVFVGGIDAR----MDETEIGSCFGRYGSVKEVKIITNRTGVSKGYGFVSFVNDVDVQKIV 427

  Fly   249 ------------------STKEAATHA---IVAVN--------------NTEINQQPVKCAWGKE 278
                              ..|..|.|.   .:.||              |||...||
Human   428 GSQIHFHGKKLKLGPAIRKQKLCARHVQPRPLVVNPPPPPQFQNVWRNPNTETYLQP-------- 484

  Fly   279 SGDPN----HMSAIAGGALAQGFPFGSAAAAAAAAAYGQQVAG-----YWYPPAPTYPAAA---- 330
            ...||    |:.|.:      .:|...          ||.:.|     |.|...||||.:|
Human   485 QITPNPVTQHVQAYS------AYPHSP----------GQVITGCQLLVYNYQEYPTYPDSAFQVT 533

  Fly   331 -------------PASALQPGQFLQGMQ--GFTYGQFAGYQQAGY-MGMGVQLP-GTWQSVPPQP 378
                         ||....|.|...|.|  .:.|..|..|..:.: :..|.|.| ..:|..|..|
Human   534 TGYQLPVYNYQPFPAYPRSPFQVTAGYQLPVYNYQAFPAYPNSPFQVATGYQFPVYNYQPFPAYP 598

  Fly   379 QLASAAAATAP-QITQSVGSALP----QAAGVVAYPMQQFQVSPQLAEDEWLAPSLLVXLPXGMA 438
                    ::| |:|  .|..||    ||  ..|||...|||:...
Human   599 --------SSPFQVT--AGYQLPVYNYQA--FPAYPNSPFQVATGY------------------- 632

  Fly   439 MYPTQQHQQQQQQQQQQQMLQQQHEQQTSG------EYVKEPPYQTQQLQQLQHHQLQQQHSHNQ 497
            .:|...:|.........       .|.|:|      .|...|.|.:...|....:||..
Human   633 QFPVYNYQAFPAYPNSP-------VQVTTGYQLPVYNYQAFPAYPSSPFQVTTGYQLPV------ 684

  Fly   498 HQQQQHYIHQLY--YPSHWVQQQQQQQQQVANNEQQPQ 533
                  |.:|.:  ||:..||.....|..|.|.:..||
Human   685 ------YNYQAFPAYPNSAVQVTTGYQFHVYNYQMPPQ 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34354	NP_001097953.2	RRM2_TIA1_like	97..171	CDD:240799	21/87 (24%)
CG34354	NP_001097953.2	RRM3_TIA1_like	202..278	CDD:240800	26/144 (18%)
DAZ1	NP_004072.3	RRM_DAZL	35..116	CDD:241116
		PABP-1234	42..603	CDD:130689	102/531 (19%)
		RRM_DAZL	200..281	CDD:241116	20/88 (23%)
		RRM_DAZL	365..446	CDD:241116	16/84 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910