DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG44837 and CG42750

DIOPT Version :9

Sequence 1:	NP_001287037.1	Gene:	CG44837 / 5740513	FlyBaseID:	FBgn0266100	Length:	964	Species:	Drosophila melanogaster
Sequence 2:	NP_724101.4	Gene:	CG42750 / 35090	FlyBaseID:	FBgn0261804	Length:	1068	Species:	Drosophila melanogaster

Alignment Length:	1046	Identity:	322/1046 - (30%)
Similarity:	468/1046 - (44%)	Gaps:	251/1046 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 DPLPNPSPDVPSAKPSLTYA-----QLHPHLLKLPTIDECQ-----LMAVKQQRSAALRFSRALS 86
            |..||      :|:|...|:     :.|.:        .|:     ||.::::|      :|.||
  Fly   153 DLQPN------AARPLYEYSLERKRKTHTY--------SCEQNAQILMRLERER------NRKLS 197

  Fly    87 LSAHSLTSRTGSATAGGSGLGFGRKLKARLVGAKSSGSLSPGRHSHSYS----VSPVYTPPPMRR 147
            |        ||..|..|.|||.|..:.:   |..:.|:..|...:.|.|    :.||..||.|:|
  Fly   198 L--------TGMETGLGIGLGVGLGMGS---GGGTGGAGDPQSDTPSLSDVDVIPPVPPPPSMKR 251

  Fly   148 CATLHHTQPVRKVFKNLQQLQERKRQAA-GSHLQRIAGTG--KTYWKYGANSTAASIVGQRARQN 209
            ..::...    ::.::|||.|::::|:: .::|.::..:.  :...|...:...|:::......|
  Fly   252 NGSMRSL----RLLQHLQQQQQQQQQSSHNNNLAQLCSSDLLQECTKSALDECTATLLKCTTTSN 312

  Fly   210 QQIEVEEPNGSDELNSET----QEISEAETGSCSVPLPSKDTNEILRLMLSAASSAVTVTPTAAA 270
            .  .....|.|:..|...    ...::.:...|..|..:.:....|.   ..|:...|.|||
  Fly   313 H--SSSNSNASNNCNIAASISHNNNNQVKPDLCQPPGHAHNHRHKLH---GNATPTRTPTPT--- 369

  Fly   271 IGNGNVAGATGGAPPMRRYQNASDVEEDETVAYGAFHQAAKSFERGALLRVGSLTAQESDNSKVN 335
                    .|...||...:   :..||||     .|...:|..:.......|..|     :||.|
  Fly   370 --------TTNPPPPPPPF---AAHEEDE-----IFSPHSKKSDPSLCFLPGGNT-----SSKYN 413

  Fly   336 AISPSP------------------QNSPARETQSTAVGGTGGRRVFKSCSFDWPGEAQQHLSPQP 382
            .|.||.                  |...|...|...       |.|......:|.:.||....|.
  Fly   414 TIGPSSDYARHLAHYSRYLQKQHHQQQMAHFQQQRC-------RCFSQSLLSFPQQQQQQQQQQQ 471

  Fly   383 HQAANPVELLEQQGKDIRFRQRDHWDLEHAHFHHEALGHLTTSTTVIDDELEQHIKHCSCSCNHM 447
            ||.....|  :||              :|......|:.|    |:.:|         .|...|..
  Fly   472 HQQMQHAE--QQQ--------------QHKAAQQPAIFH----TSSMD---------WSLPINSR 507

  Fly   448 GYGNSMDYQTTGFGGLPDVTEHSNIRRTLSRQNSISNSDSGGEIASIQKSKVNFGNPLAGGVVVG 512
            .:||.::..  |.||                        :||  ..:...|:..||..:||.:..
  Fly   508 SFGNLVNID--GSGG------------------------TGG--CRVPYQKMQSGNAGSGGAMAN 544

  Fly   513 GDIVGLDAKSP---TSLGSTTGAGATGKAK------------------------------GKASR 544
            | .:||.|.|.   ||..|..|.|...:..                              |.|:.
  Fly   545 G-CLGLAASSTFTLTSFDSDIGHGLKERESQTSLHHPHTLPHPHPHTHSHSHPHHYHAHVGGAAV 608

  Fly   545 KANAGPDGG----------------------QKGRRGS---------------WLVAITLVSAIC 572
            ....|..|.                      |...|||               ||.    ||:|.
  Fly   609 SGGVGGSGSVTPQKHHQLHSSVTSIMPWKHRQCPSRGSSSSGTNSFRFDAAKHWLA----VSSIL 669

  Fly   573 LLAIAATLAYQHFLMAPSRNSHAQRLRIVRRILREVPLVDGHNNYAWNVRKYAHSSL-ELHLSHD 636
            |:..||::|....|...:.....:|||:..::|.:|||:||||:..||:||:.|:.| :.:...|
  Fly   670 LIIGAASVAVPLALRVAASAPFEERLRVAVQLLDQVPLIDGHNDLPWNIRKFLHNKLNDFNFDED 734

  Fly   637 VDHKSLWSRPAWAQTDMERLKQGLVSVQVWSAYVPCEAQGLDAVQLALEQIDIVRRLSDMYARET 701
            :.:...|.|..|:.||:.|||:|.:|.|.|:||||||||..|||||.|||||:::||:|.|:.:.
  Fly   735 LRNVMPWGRSHWSHTDLTRLKKGRISAQFWAAYVPCEAQHRDAVQLTLEQIDVIKRLTDRYSPQL 799

  Fly   702 VLATSSQDIVDAHRRGLLASLIGVEGGHTIGSSLGVLRSFYSLGARYLSLTHRCDVSWAGSSASP 766
            ...||:|||:|||:...|.||.||||||::|.||.|||:.|::|.||::||..|...||.||.:.
  Fly   800 TTCTSAQDIIDAHKNQQLCSLTGVEGGHSLGGSLAVLRTLYAIGVRYMTLTSTCHTPWADSSYAD 864

  Fly   767 A------EQGLTPFGKAIVREMNRLGMMIDLSHSSDATARDVLQVTRAPVIFSHSAARQLCNSTR 825
            |      ..|||.|||.|:|||||||||:||||.|..|.||.|:|:.||||||||:|.:|||::|
  Fly   865 APTFNMKHGGLTIFGKTIIREMNRLGMMVDLSHVSKGTMRDALEVSEAPVIFSHSSAYELCNTSR 929

  Fly   826 NVPDDILRLVAENGGLIMLSFDSEDVACGRQARLQDVIEHIKYVRAIAGIQHIGLGAGYDGIELP 890
            ||.||||:.:|:||||:|::|.|:.::|...:.:.|.:.||.:::.:|||.|:|||||||||...
  Fly   930 NVQDDILQALAKNGGLVMVNFYSKFLSCSDNSTVHDAVAHINHIKRVAGIDHVGLGAGYDGINYT 994

  Fly   891 PLGLEDVSKYPELLAALLEDHNWSEEDVAMLAGRNFLRIMETVETVRDYWKRAAIQPIEQTEPQP 955
            |.||||||.||.|.|.|| ...|:.:::..|||.||||:|:.||.:||..|.|.::|.|. .|..
  Fly   995 PKGLEDVSSYPTLFAELL-GGGWTIDELTKLAGGNFLRVMQQVEKLRDDKKAAGVKPFED-HPNF 1057

  Fly   956 KTQCTY 961
            :|...|
  Fly  1058 RTDDPY 1063

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG44837	NP_001287037.1	rDP_like	609..929	CDD:238626	172/326 (53%)
CG42750	NP_724101.4	Peptidase_M19	701..1035	CDD:279569	176/334 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	347	1.000	Domainoid score	I1002
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1272387at2759
OrthoFinder	1	1.000	-	-		FOG0001225
OrthoInspector	1	1.000	-	-		otm26602
orthoMCL	1	0.900	-	-		OOG6_102004
Panther	1	1.100	-	-	P	PTHR10443
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.920