Protein Alignment Lgr4 and LGR5

DIOPT Version :10

• Sequence 1: NP_001285192.1
• Gene: Lgr4 / 5740505
• FlyBaseID: FBgn0085440
• Length: 809
• Species: Drosophila melanogaster
• Sequence 2: NP_003658.1
• Gene: LGR5 / 8549
• HGNCID: 4504
• Length: 907
• Species: Homo sapiens
• Alignment Length: 899
• Identity: 218/899 - (24%)
• Similarity: 316/899 - (35%)
• Gaps: 303/899 - (33%)

  Fly    96 CNTTAQCVPQRANCDG----SVDCDDAS-DEVNCVNEVDAKYWDHLYRKQPFGRHDNLRIGECLW 155
            |.|...|.|     ||    .|||.|.. .|:.....|...|.|                   |.
Human    34 CPTHCHCEP-----DGRMLLRVDCSDLGLSELPSNLSVFTSYLD-------------------LS 74

  Fly   156 PNENFSCPCRGDEILCRFQQLTDIPERLPQ-HDLATLDLTGNNFETIHETFFSELPDVDSLVLKF 219
            .| |.|             ||  :|..||. ..|..|.|.||....|.:..|:.|..:..|:|:.
Human    75 MN-NIS-------------QL--LPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQN 123

  Fly   220 CSIREIASHAFDRLAD----------------------NPLRTLYMDDNKLPHLPEHFFPEGNQL 262
            ..:|.:.:.|...|..                      :.||.|::|||.|..:|...|...:.|
Human   124 NQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSAL 188

  Fly   263 SILILARNHLHHLKRSDFLNLQKLQELDLRGNRIGNFEAEVFARLPNLEVLYLNENHLKRLDPDR 327
            ..:.||.|.:||:....|.||..|..|.|..|||.:...:.|..|.:||.|.||.|:|     |.
Human   189 QAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNL-----DE 248

  Fly   328 FP---RTLLNLHTLSLAYNQIEDIAANTF-------------------------PFPRLRYLFLA 364
            ||   |||.||..|....|.|..|....|                         ..|.||.|.|.
Human   249 FPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLN 313

  Fly   365 G-NRLSHIRD---------------------ETFCN-LSNLQGLHLNENRIEGFDLEAFA-CLK- 404
            | ::::...|                     :|.|| |.|||.|.|:.|.:|  ||.:|: |.|
Human   314 GASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLE--DLPSFSVCQKL 376

  Fly   405 ----------------------NLSSLLLTGNR--------FQTLDSRVLKNLTS---------- 429
                                  :|.||.|..|:        |.||.|.:..:|:|
Human   377 QKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITG 441

  Fly   430 --------------------------LDYIYFSWFHLCSA------------------------- 443
                                      |..|...:.:.|.|
Human   442 LHGLTHLKLTGNHALQSLISSENFPELKVIEMPYAYQCCAFGVCENAYKISNQWNKGDNSSMDDL 506

  Fly   444 ----------------------------AMNVRVCDPHGDGISSKLHLLDNQILRGSVWVMASIA 480
                                        |::...|.|.........||||..::|..||.:|.:|
Human   507 HKKDAGMFQAQDERDLEDFLLDFEEDLKALHSVQCSPSPGPFKPCEHLLDGWLIRIGVWTIAVLA 571

  Fly   481 VVGNLLVLLGRYFYKSRSNVEHS-LYLRH-------LAASDFLMGIYLTLIACADISFRGEYIKY 537
            :..|.||         .|.|..| ||:..       :||.:.|.|:...::|..|....|.:.::
Human   572 LTCNALV---------TSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARH 627

  Fly   538 EETWRHSGVCAFAGFLSTFSCQSSTLLLTLVTWDRLMSVTRPLK-----PRDTEKVRIVLRLLLL 597
            ...|.:...|...||||.|:.:||..||||...:|..||....|     |..:.||.|:|..||
Human   628 GAWWENGVGCHVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALL- 691

  Fly   598 WGISFGLAAAPLLPNPYFGSHFYGNNGVCLSLHIHDPYAKGWEYSALLFILVNTLSLIFILFSYI 662
               :..:||.|||     |...||.:.:||.|...:|...|:   .:..||:|:|..:.:..:|.
Human   692 ---ALTMAAVPLL-----GGSKYGASPLCLPLPFGEPSTMGY---MVALILLNSLCFLMMTIAYT 745

  Fly   663 RMLQAIRDSGGGMRSTHSGRENV----VATRFAIIVTTDCACWLPIIVVKLAALSGCE-ISPDLY 722
            : |....|.|        ..||:    :....|:::.|:|....|:..:..::|.... |||::.
Human   746 K-LYCNLDKG--------DLENIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFISPEVI 801

  Fly   723 AWLAVLVLPVNSALNPVLYTLTTAAFKQQL-----RRYCHTL---PSCSLVNNE 768
            .::.::|:|:.:.|||:||.|....||:.|     :.|..|.   ||...:|::
Human   802 KFILLVVVPLPACLNPLLYILFNPHFKEDLVSLRKQTYVWTRSKHPSLMSINSD 855

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lgr4	NP_001285192.1	Ldl_recept_a	87..124	CDD:395011	11/32 (34%)
		LRR	167..>430	CDD:443914	98/404 (24%)
		leucine-rich repeat	188..211	CDD:275380	8/22 (36%)
		leucine-rich repeat	212..235	CDD:275380	5/22 (23%)
		leucine-rich repeat	238..261	CDD:275380	9/22 (41%)
		leucine-rich repeat	262..285	CDD:275380	9/22 (41%)
		leucine-rich repeat	286..309	CDD:275380	8/22 (36%)
		leucine-rich repeat	310..334	CDD:275380	13/26 (50%)
		leucine-rich repeat	335..357	CDD:275380	6/46 (13%)
		leucine-rich repeat	358..381	CDD:275380	10/45 (22%)
		leucine-rich repeat	382..405	CDD:275380	11/46 (24%)
		leucine-rich repeat	406..427	CDD:275380	9/28 (32%)
		7tmA_Relaxin_R	467..752	CDD:320265	85/302 (28%)
		TM helix 1	468..494	CDD:320265	8/25 (32%)
		TM helix 2	502..527	CDD:320265	8/32 (25%)
		TM helix 3	547..577	CDD:320265	14/29 (48%)
		TM helix 4	588..610	CDD:320265	8/21 (38%)
		TM helix 5	638..667	CDD:320265	7/28 (25%)
		TM helix 6	681..711	CDD:320265	6/33 (18%)
		TM helix 7	720..745	CDD:320265	8/24 (33%)
LGR5	NP_003658.1	LRRNT	33..65	CDD:396168	11/35 (31%)
		leucine-rich repeat	68..91	CDD:275380	11/57 (19%)
		LRR	92..477	CDD:443914	95/391 (24%)
		leucine-rich repeat	92..115	CDD:275380	8/22 (36%)
		leucine-rich repeat	116..139	CDD:275380	5/22 (23%)
		leucine-rich repeat	140..163	CDD:275380	0/22 (0%)
		leucine-rich repeat	164..187	CDD:275380	9/22 (41%)
		leucine-rich repeat	188..211	CDD:275380	9/22 (41%)
		leucine-rich repeat	212..235	CDD:275380	8/22 (36%)
		leucine-rich repeat	236..258	CDD:275380	13/26 (50%)
		leucine-rich repeat	259..282	CDD:275380	6/22 (27%)
		leucine-rich repeat	283..304	CDD:275380	0/20 (0%)
		leucine-rich repeat	307..353	CDD:275378	10/45 (22%)
		leucine-rich repeat	354..375	CDD:275378	10/22 (45%)
		leucine-rich repeat	376..389	CDD:275378	0/12 (0%)
		leucine-rich repeat	400..423	CDD:275378	8/22 (36%)
		leucine-rich repeat	445..459	CDD:275378	0/13 (0%)
		7tmA_LGR5	558..831	CDD:320485	85/302 (28%)
		TM helix 1	559..585	CDD:320485	10/34 (29%)
		TM helix 2	592..617	CDD:320485	5/24 (21%)
		TM helix 3	637..667	CDD:320485	14/29 (48%)
		TM helix 4	679..701	CDD:320485	9/25 (36%)
		TM helix 5	721..750	CDD:320485	7/32 (22%)
		TM helix 6	759..789	CDD:320485	4/29 (14%)
		TM helix 7	799..824	CDD:320485	8/24 (33%)