DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lgr4 and LGR5

DIOPT Version :9

Sequence 1:NP_001285192.1 Gene:Lgr4 / 5740505 FlyBaseID:FBgn0085440 Length:809 Species:Drosophila melanogaster
Sequence 2:NP_003658.1 Gene:LGR5 / 8549 HGNCID:4504 Length:907 Species:Homo sapiens


Alignment Length:899 Identity:218/899 - (24%)
Similarity:316/899 - (35%) Gaps:303/899 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    96 CNTTAQCVPQRANCDG----SVDCDDAS-DEVNCVNEVDAKYWDHLYRKQPFGRHDNLRIGECLW 155
            |.|...|.|     ||    .|||.|.. .|:.....|...|.|                   |.
Human    34 CPTHCHCEP-----DGRMLLRVDCSDLGLSELPSNLSVFTSYLD-------------------LS 74

  Fly   156 PNENFSCPCRGDEILCRFQQLTDIPERLPQ-HDLATLDLTGNNFETIHETFFSELPDVDSLVLKF 219
            .| |.|             ||  :|..||. ..|..|.|.||....|.:..|:.|..:..|:|:.
Human    75 MN-NIS-------------QL--LPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQN 123

  Fly   220 CSIREIASHAFDRLAD----------------------NPLRTLYMDDNKLPHLPEHFFPEGNQL 262
            ..:|.:.:.|...|..                      :.||.|::|||.|..:|...|...:.|
Human   124 NQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSAL 188

  Fly   263 SILILARNHLHHLKRSDFLNLQKLQELDLRGNRIGNFEAEVFARLPNLEVLYLNENHLKRLDPDR 327
            ..:.||.|.:||:....|.||..|..|.|..|||.:...:.|..|.:||.|.||.|:|     |.
Human   189 QAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNL-----DE 248

  Fly   328 FP---RTLLNLHTLSLAYNQIEDIAANTF-------------------------PFPRLRYLFLA 364
            ||   |||.||..|....|.|..|....|                         ..|.||.|.|.
Human   249 FPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLN 313

  Fly   365 G-NRLSHIRD---------------------ETFCN-LSNLQGLHLNENRIEGFDLEAFA-CLK- 404
            | ::::...|                     :|.|| |.|||.|.|:.|.:|  ||.:|: |.| 
Human   314 GASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLE--DLPSFSVCQKL 376

  Fly   405 ----------------------NLSSLLLTGNR--------FQTLDSRVLKNLTS---------- 429
                                  :|.||.|..|:        |.||.|.:..:|:|          
Human   377 QKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITG 441

  Fly   430 --------------------------LDYIYFSWFHLCSA------------------------- 443
                                      |..|...:.:.|.|                         
Human   442 LHGLTHLKLTGNHALQSLISSENFPELKVIEMPYAYQCCAFGVCENAYKISNQWNKGDNSSMDDL 506

  Fly   444 ----------------------------AMNVRVCDPHGDGISSKLHLLDNQILRGSVWVMASIA 480
                                        |::...|.|.........||||..::|..||.:|.:|
Human   507 HKKDAGMFQAQDERDLEDFLLDFEEDLKALHSVQCSPSPGPFKPCEHLLDGWLIRIGVWTIAVLA 571

  Fly   481 VVGNLLVLLGRYFYKSRSNVEHS-LYLRH-------LAASDFLMGIYLTLIACADISFRGEYIKY 537
            :..|.||         .|.|..| ||:..       :||.:.|.|:...::|..|....|.:.::
Human   572 LTCNALV---------TSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARH 627

  Fly   538 EETWRHSGVCAFAGFLSTFSCQSSTLLLTLVTWDRLMSVTRPLK-----PRDTEKVRIVLRLLLL 597
            ...|.:...|...||||.|:.:||..||||...:|..||....|     |..:.||.|:|..|| 
Human   628 GAWWENGVGCHVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALL- 691

  Fly   598 WGISFGLAAAPLLPNPYFGSHFYGNNGVCLSLHIHDPYAKGWEYSALLFILVNTLSLIFILFSYI 662
               :..:||.|||     |...||.:.:||.|...:|...|:   .:..||:|:|..:.:..:|.
Human   692 ---ALTMAAVPLL-----GGSKYGASPLCLPLPFGEPSTMGY---MVALILLNSLCFLMMTIAYT 745

  Fly   663 RMLQAIRDSGGGMRSTHSGRENV----VATRFAIIVTTDCACWLPIIVVKLAALSGCE-ISPDLY 722
            : |....|.|        ..||:    :....|:::.|:|....|:..:..::|.... |||::.
Human   746 K-LYCNLDKG--------DLENIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFISPEVI 801

  Fly   723 AWLAVLVLPVNSALNPVLYTLTTAAFKQQL-----RRYCHTL---PSCSLVNNE 768
            .::.::|:|:.:.|||:||.|....||:.|     :.|..|.   ||...:|::
Human   802 KFILLVVVPLPACLNPLLYILFNPHFKEDLVSLRKQTYVWTRSKHPSLMSINSD 855

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lgr4NP_001285192.1 Ldl_recept_a 87..124 CDD:278486 11/32 (34%)
LRR_RI <184..397 CDD:238064 78/286 (27%)
LRR_8 188..248 CDD:290566 19/81 (23%)
leucine-rich repeat 188..211 CDD:275380 8/22 (36%)
leucine-rich repeat 212..235 CDD:275380 5/22 (23%)
leucine-rich repeat 238..261 CDD:275380 9/22 (41%)
LRR_8 261..320 CDD:290566 23/58 (40%)
leucine-rich repeat 262..285 CDD:275380 9/22 (41%)
LRR_4 284..325 CDD:289563 15/40 (38%)
leucine-rich repeat 286..309 CDD:275380 8/22 (36%)
LRR_4 308..348 CDD:289563 18/42 (43%)
leucine-rich repeat 310..334 CDD:275380 13/26 (50%)
leucine-rich repeat 335..357 CDD:275380 6/46 (13%)
LRR_8 356..416 CDD:290566 28/114 (25%)
leucine-rich repeat 358..381 CDD:275380 10/45 (22%)
LRR_4 381..421 CDD:289563 20/71 (28%)
leucine-rich repeat 382..405 CDD:275380 11/46 (24%)
leucine-rich repeat 406..427 CDD:275380 9/28 (32%)
7tm_1 483..741 CDD:278431 75/275 (27%)
LGR5NP_003658.1 LRRNT 33..70 CDD:214470 12/40 (30%)
leucine-rich repeat 68..91 CDD:275380 11/57 (19%)
PLN00113 71..>426 CDD:215061 101/396 (26%)
leucine-rich repeat 92..115 CDD:275380 8/22 (36%)
leucine-rich repeat 116..139 CDD:275380 5/22 (23%)
leucine-rich repeat 140..163 CDD:275380 0/22 (0%)
leucine-rich repeat 164..187 CDD:275380 9/22 (41%)
leucine-rich repeat 188..211 CDD:275380 9/22 (41%)
leucine-rich repeat 212..235 CDD:275380 8/22 (36%)
leucine-rich repeat 236..258 CDD:275380 13/26 (50%)
leucine-rich repeat 259..282 CDD:275380 6/22 (27%)
leucine-rich repeat 283..304 CDD:275380 0/20 (0%)
leucine-rich repeat 307..353 CDD:275378 10/45 (22%)
leucine-rich repeat 354..375 CDD:275378 10/22 (45%)
leucine-rich repeat 376..389 CDD:275378 0/12 (0%)
leucine-rich repeat 400..423 CDD:275378 8/22 (36%)
leucine-rich repeat 445..459 CDD:275378 0/13 (0%)
7tmA_LGR5 558..831 CDD:320485 85/302 (28%)
TM helix 1 559..585 CDD:320485 10/34 (29%)
TM helix 2 592..617 CDD:320485 5/24 (21%)
TM helix 3 637..667 CDD:320485 14/29 (48%)
TM helix 4 679..701 CDD:320485 9/25 (36%)
TM helix 5 721..750 CDD:320485 7/32 (22%)
TM helix 6 759..789 CDD:320485 4/29 (14%)
TM helix 7 799..824 CDD:320485 8/24 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2087
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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