DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lgr4 and AT1G35710

DIOPT Version :9

Sequence 1:	NP_001285192.1	Gene:	Lgr4 / 5740505	FlyBaseID:	FBgn0085440	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	NP_174809.1	Gene:	AT1G35710 / 840475	AraportID:	AT1G35710	Length:	1120	Species:	Arabidopsis thaliana

Alignment Length:	571	Identity:	125/571 - (21%)
Similarity:	202/571 - (35%)	Gaps:	160/571 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 SCPCRGDEILCRFQQLTDIPERLPQHDLATLDLTGNNFETIHETF-FSELPDVDSLVLKFCSIRE 224
            ||..||                    .:..|:||....|...:.| |..|.::..:.|....:..
plant    72 SCNSRG--------------------SIEELNLTNTGIEGTFQDFPFISLSNLAYVDLSMNLLSG 116

  Fly   225 IASHAFDRLADNPLRTLYMDDNKLPHLPEHFFPE-GN--QLSILILARNHLHHLKRSDFLNLQKL 286
            .....|..|:    :.:|. |....||.....|. ||  .|::|.|.:|:|..:..|:..|::.:
plant   117 TIPPQFGNLS----KLIYF-DLSTNHLTGEISPSLGNLKNLTVLYLHQNYLTSVIPSELGNMESM 176

  Fly   287 QELDLRGNRIGNFEAEVFARLPNLEVLYLNENHLKRLDPDRFPRTLLNLHT---LSLAYNQIEDI 348
            .:|.|..|::..........|.||.||||.||:|..:    .|..|.|:.:   |:|:.|::...
plant   177 TDLALSQNKLTGSIPSSLGNLKNLMVLYLYENYLTGV----IPPELGNMESMTDLALSQNKLTGS 237

  Fly   349 AANTF-PFPRLRYLFLAGNRLSHIRDETFCNLSNLQGLHLNENRIEGFDLEAFACLKNLSSL--- 409
            ..:|. ....|..|:|..|.|:.:......|:.::..|.|::|::.|....:...||||:.|
plant   238 IPSTLGNLKNLMVLYLYENYLTGVIPPEIGNMESMTNLALSQNKLTGSIPSSLGNLKNLTLLSLF 302

  Fly   410 --LLTGN---RFQTLDSRV-------------------LKNLTSLDYIYFSWFHLCSAAMNVRVC 450
              .|||.   :...::|.:                   |||||.| |:|.::.        ..|.
plant   303 QNYLTGGIPPKLGNIESMIDLELSNNKLTGSIPSSLGNLKNLTIL-YLYENYL--------TGVI 358

  Fly   451 DPHGDGISSKLHL-LDNQILRGSVWVMASIAVVGNLLVLLGRYFYKSRSNVEHSLYLRHLAA--- 511
            .|....:.|.:.| |:|..|.||:     .:..|||..|  .|.|         |||.:|..
plant   359 PPELGNMESMIDLQLNNNKLTGSI-----PSSFGNLKNL--TYLY---------LYLNYLTGVIP 407

  Fly   512 -----SDFLMGIYLT---LIACADISFRGEYIKYEETW---RH-SGVCA---------------- 548
                 .:.::.:.|:   |......|| |.:.|.|..:   .| ||...
plant   408 QELGNMESMINLDLSQNKLTGSVPDSF-GNFTKLESLYLRVNHLSGAIPPGVANSSHLTTLILDT 471

  Fly   549 --FAGFLSTFSCQSSTLLLTLVTWDRLMSVTRPLKPRDTEKVRIVLRLLLLWGISFGLAAAPLLP 611
              |.||.....|:...|....:.::.|..   |: |:.....:.::|             |..|.
plant   472 NNFTGFFPETVCKGRKLQNISLDYNHLEG---PI-PKSLRDCKSLIR-------------ARFLG 519

  Fly   612 NPYFGSHF-------------YGNNGVCLSLHIHDPYAKGWEYSALLFILV 649
            |.:.|..|             :.:|      ..|...:..||.|..|..|:
plant   520 NKFTGDIFEAFGIYPDLNFIDFSHN------KFHGEISSNWEKSPKLGALI 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr4	NP_001285192.1	Ldl_recept_a	87..124	CDD:278486
		LRR_RI	<184..397	CDD:238064	54/220 (25%)
		LRR_8	188..248	CDD:290566	12/60 (20%)
		leucine-rich repeat	188..211	CDD:275380	7/23 (30%)
		leucine-rich repeat	212..235	CDD:275380	3/22 (14%)
		leucine-rich repeat	238..261	CDD:275380	7/25 (28%)
		LRR_8	261..320	CDD:290566	19/58 (33%)
		leucine-rich repeat	262..285	CDD:275380	7/22 (32%)
		LRR_4	284..325	CDD:289563	13/40 (33%)
		leucine-rich repeat	286..309	CDD:275380	4/22 (18%)
		LRR_4	308..348	CDD:289563	15/42 (36%)
		leucine-rich repeat	310..334	CDD:275380	10/23 (43%)
		leucine-rich repeat	335..357	CDD:275380	4/25 (16%)
		LRR_8	356..416	CDD:290566	18/67 (27%)
		leucine-rich repeat	358..381	CDD:275380	6/22 (27%)
		LRR_4	381..421	CDD:289563	12/47 (26%)
		leucine-rich repeat	382..405	CDD:275380	5/22 (23%)
		leucine-rich repeat	406..427	CDD:275380	8/47 (17%)
		7tm_1	483..741	CDD:278431	41/213 (19%)
AT1G35710	NP_174809.1	leucine-rich repeat	296..319	CDD:275380	5/22 (23%)
		leucine-rich repeat	320..341	CDD:275380	0/20 (0%)
		leucine-rich repeat	344..367	CDD:275380	7/31 (23%)
		leucine-rich repeat	368..415	CDD:275380	16/62 (26%)
		leucine-rich repeat	416..439	CDD:275380	5/23 (22%)
		leucine-rich repeat	440..460	CDD:275380	4/19 (21%)
		leucine-rich repeat	464..483	CDD:275380	3/18 (17%)
		leucine-rich repeat	488..535	CDD:275380	10/63 (16%)
		leucine-rich repeat	540..559	CDD:275380	5/24 (21%)
		leucine-rich repeat	560..583	CDD:275380	2/5 (40%)
		leucine-rich repeat	584..607	CDD:275380
		leucine-rich repeat	608..631	CDD:275380
		leucine-rich repeat	632..655	CDD:275380
		leucine-rich repeat	679..702	CDD:275380
		leucine-rich repeat	703..726	CDD:275380
		PLN00113	33..1118	CDD:215061	125/571 (22%)
		leucine-rich repeat	79..103	CDD:275380	7/23 (30%)
		leucine-rich repeat	104..127	CDD:275380	3/26 (12%)
		leucine-rich repeat	128..151	CDD:275380	7/23 (30%)
		leucine-rich repeat	152..175	CDD:275380	7/22 (32%)
		leucine-rich repeat	176..199	CDD:275380	4/22 (18%)
		leucine-rich repeat	200..223	CDD:275380	11/26 (42%)
		leucine-rich repeat	224..247	CDD:275380	4/22 (18%)
		leucine-rich repeat	248..271	CDD:275380	6/22 (27%)
		leucine-rich repeat	272..295	CDD:275380	5/22 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000