Protein Alignment Lgr4 and Igfals

DIOPT Version :10

• Sequence 1: NP_001285192.1
• Gene: Lgr4 / 5740505
• FlyBaseID: FBgn0085440
• Length: 809
• Species: Drosophila melanogaster
• Sequence 2: NP_445781.3
• Gene: Igfals / 79438
• RGDID: 68429
• Length: 603
• Species: Rattus norvegicus
• Alignment Length: 522
• Identity: 138/522 - (26%)
• Similarity: 207/522 - (39%)
• Gaps: 122/522 - (23%)

  Fly   161 SCPCRGDE------ILCRFQQLTDIPERLPQHDLATLDLTGNNFETIHETFFSELPDVDSLVLKF 219
            :|.|..|:      :.|..:.||.:|:.:|....| |.|.|||..:|....|..|..:|.|.|:.
  Rat    44 ACTCSHDDYTDELSVFCSSKNLTHLPDDIPVSTRA-LWLDGNNLSSIPSAAFQNLSSLDFLNLQG 107

  Fly   220 CSIREIASHAFDRLAD--------NPLRTL---------------------------------YM 243
            ..:|.:...|...|.:        |.||.|                                 ::
  Rat   108 SWLRSLEPQALLGLQNLYHLHLERNRLRNLAVGLFTHTPSLASLSLSSNLLGRLEEGLFQGLSHL 172

  Fly   244 DD-----NKLPHLPEHFFPEGNQLSILILARNHLHHLKRSDFLNLQKLQELDLRGNRIGNFEAEV 303
            .|     |.|..||:..|.....|..|:||.|.|.:|:.:.|..|.:|:||||..|.:.:.:|.|
  Rat   173 WDLNLGWNSLVVLPDTVFQGLGNLHELVLAGNKLTYLQPALFCGLGELRELDLSRNALRSVKANV 237

  Fly   304 FARLPNLEVLYLNENHLKRLDP------------------------DRFPRTLLNLHTLSLAYNQ 344
            |..||.|:.|||:.|.:..:.|                        |.|| .||.||.|.||:|.
  Rat   238 FVHLPRLQKLYLDRNLITAVAPRAFLGMKALRWLDLSHNRVAGLMEDTFP-GLLGLHVLRLAHNA 301

  Fly   345 IEDIAANTF-PFPRLRYLFLAGNRLSHIRDETFCNLSNLQGLHLNENRIEGFDLEAFACLKNLSS 408
            |..:...|| ....|..|.|..||:..:.:.||..|..|:.|.||:|:|....:.||:.|.|::.
  Rat   302 IASLRPRTFKDLHFLEELQLGHNRIRQLGERTFEGLGQLEVLTLNDNQITEVRVGAFSGLFNVAV 366

  Fly   409 LLLTGNRFQTLDSRVLKNLTSLDYIYFSWFHLCSAAMNVRVCDPHGDGISS--KLHLLDNQILRG 471
            :.|:||..::|..||.:.|..|..::..  |.|...:.:...    .|:|.  :|.|.||.|...
  Rat   367 MNLSGNCLRSLPERVFQGLDKLHSLHLE--HSCLGHVRLHTF----AGLSGLRRLFLRDNSISSI 425

  Fly   472 SVWVMASIA------VVGNLLVLLGRYFYKSRSNVEHSL----YLRHLAAS-------DFLMGI- 518
            ....:|.::      :..|.|..|.|..::...::|:.|    .|..|:|.       .|.:.|
  Rat   426 EEQSLAGLSELLELDLTTNRLTHLPRQLFQGLGHLEYLLLSYNQLTTLSAEVLGPLQRAFWLDIS 490

  Fly   519 --YLTLIACADISFRGEYIKYEETWRHSGVCAFAGFLSTFSCQS--STLLLTLVTWDRLMSVTRP 579
              :|..:|....|..|. ::|.....:|        |.|||.|.  ..|.|....||    .:.|
  Rat   491 HNHLETLAEGLFSSLGR-LRYLSLRNNS--------LQTFSPQPGLERLWLDANPWD----CSCP 542

  Fly   580 LK 581
            ||
  Rat   543 LK 544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lgr4	NP_001285192.1	Ldl_recept_a	87..124	CDD:395011
		LRR	167..>430	CDD:443914	96/339 (28%)
		leucine-rich repeat	188..211	CDD:275380	9/22 (41%)
		leucine-rich repeat	212..235	CDD:275380	6/22 (27%)
		leucine-rich repeat	238..261	CDD:275380	9/60 (15%)
		leucine-rich repeat	262..285	CDD:275380	9/22 (41%)
		leucine-rich repeat	286..309	CDD:275380	10/22 (45%)
		leucine-rich repeat	310..334	CDD:275380	10/47 (21%)
		leucine-rich repeat	335..357	CDD:275380	9/22 (41%)
		leucine-rich repeat	358..381	CDD:275380	8/22 (36%)
		leucine-rich repeat	382..405	CDD:275380	9/22 (41%)
		leucine-rich repeat	406..427	CDD:275380	6/20 (30%)
		7tmA_Relaxin_R	467..752	CDD:320265	31/137 (23%)
		TM helix 1	468..494	CDD:320265	6/31 (19%)
		TM helix 2	502..527	CDD:320265	8/38 (21%)
		TM helix 3	547..577	CDD:320265	9/31 (29%)
		TM helix 4	588..610	CDD:320265
		TM helix 5	638..667	CDD:320265
		TM helix 6	681..711	CDD:320265
		TM helix 7	720..745	CDD:320265
Igfals	NP_445781.3	LRRNT	40..78	CDD:214470	8/33 (24%)
		leucine-rich repeat	57..75	CDD:275380	5/17 (29%)
		LRR 1	75..96		8/21 (38%)
		leucine-rich repeat	79..99	CDD:275380	8/19 (42%)
		LRR	85..476	CDD:443914	104/397 (26%)
		LRR 2	99..120		5/20 (25%)
		leucine-rich repeat	103..123	CDD:275380	5/19 (26%)
		LRR 3	123..144		4/20 (20%)
		LRR 4	147..168		0/20 (0%)
		LRR 5	171..192		6/20 (30%)
		leucine-rich repeat	175..195	CDD:275380	5/19 (26%)
		LRR 6	195..216		8/20 (40%)
		leucine-rich repeat	196..219	CDD:275380	9/22 (41%)
		LRR 7	219..240		9/20 (45%)
		leucine-rich repeat	220..243	CDD:275380	10/22 (45%)
		LRR 8	243..264		6/20 (30%)
		leucine-rich repeat	244..267	CDD:275380	6/22 (27%)
		LRR 9	267..288		3/21 (14%)
		leucine-rich repeat	268..291	CDD:275380	4/23 (17%)
		LRR 10	291..312		9/20 (45%)
		leucine-rich repeat	292..315	CDD:275380	9/22 (41%)
		LRR 11	315..336		7/20 (35%)
		leucine-rich repeat	316..339	CDD:275380	8/22 (36%)
		LRR 12	339..360		8/20 (40%)
		leucine-rich repeat	340..363	CDD:275380	9/22 (41%)
		LRR 13	363..384		7/20 (35%)
		leucine-rich repeat	364..387	CDD:275380	7/22 (32%)
		LRR 14	387..408		3/26 (12%)
		leucine-rich repeat	388..411	CDD:275380	4/28 (14%)
		LRR 15	411..432		5/20 (25%)
		leucine-rich repeat	412..435	CDD:275380	6/22 (27%)
		LRR 16	435..456		4/20 (20%)
		leucine-rich repeat	436..459	CDD:275380	4/22 (18%)
		LRR 17	459..480		5/20 (25%)
		leucine-rich repeat	460..481	CDD:275380	5/20 (25%)
		LRR 18	483..504		4/20 (20%)
		leucine-rich repeat	484..507	CDD:275380	5/22 (23%)
		LRR_8	486..536	CDD:404697	14/58 (24%)
		LRR 19	507..528		7/29 (24%)
		LRRCT	535..578	CDD:214507	5/14 (36%)