| Sequence 1: | NP_001285192.1 | Gene: | Lgr4 / 5740505 | FlyBaseID: | FBgn0085440 | Length: | 809 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_000360.2 | Gene: | TSHR / 7253 | HGNCID: | 12373 | Length: | 764 | Species: | Homo sapiens |
| Alignment Length: | 713 | Identity: | 167/713 - (23%) |
|---|---|---|---|
| Similarity: | 281/713 - (39%) | Gaps: | 174/713 - (24%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 162 CPCRGDE---ILCR-FQQLTDIPERLPQHDLATLDLTGNNFETIHETFFSELPDVDSLVLKF-CS 221
Fly 222 IREIASHAFDRLAD-------NPLRTLYMDDNKLPHLP-----------EHFFPEGNQL------ 262
Fly 263 SILILARN-HLHHLKRSDFLNL-QKLQELDLRGNRIGNFEAEVFARLPNLEVLYLNEN-HLKRLD 324
Fly 325 PDRFPRTLLNLHTLSLAYNQI------------EDIAANTFPFPR----LRYLFLAGNRLSH--- 370
Fly 371 ------------IRDETFCNLSNLQGL-------------------------------------H 386
Fly 387 LN----------ENRIEGFDLEAFACLKNLSSLLLTGNRFQTLDSRVLKNLTSLDYIYFSWFHLC 441
Fly 442 SAAMNVRVCDPHGDGISSKLHLLDNQILRGSVWVMASIAVVGNLLVLLGRYFYKSRSNVEHSLYL 506
Fly 507 RHLAASDFLMGIYLTLIACADISFRGEYIKYEETWRHSGVCAFAGFLSTFSCQSSTLLLTLVTWD 571
Fly 572 RLMSVTRPLKPRDTEKVRIVLRLLLL---WGISFGLAAAPLLPNPYFGSHFYGNNGVCLSLHIHD 633
Fly 634 PYAKGWEYSALLFIL-VNTLSLIFILFSYIRMLQAIRDSGGGMRSTHSGRENVVATRFAIIVTTD 697
Fly 698 CACWLPIIVVKLAAL--------SGCEISPDLYAWLAVLVLPVNSALNPVLYTLTTAAFKQQL 752 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Lgr4 | NP_001285192.1 | Ldl_recept_a | 87..124 | CDD:395011 | |
| LRR | 167..>430 | CDD:443914 | 74/372 (20%) | ||
| leucine-rich repeat | 188..211 | CDD:275380 | 8/22 (36%) | ||
| leucine-rich repeat | 212..235 | CDD:275380 | 4/23 (17%) | ||
| leucine-rich repeat | 238..261 | CDD:275380 | 7/33 (21%) | ||
| leucine-rich repeat | 262..285 | CDD:275380 | 5/30 (17%) | ||
| leucine-rich repeat | 286..309 | CDD:275380 | 4/22 (18%) | ||
| leucine-rich repeat | 310..334 | CDD:275380 | 9/24 (38%) | ||
| leucine-rich repeat | 335..357 | CDD:275380 | 6/33 (18%) | ||
| leucine-rich repeat | 358..381 | CDD:275380 | 8/37 (22%) | ||
| leucine-rich repeat | 382..405 | CDD:275380 | 10/69 (14%) | ||
| leucine-rich repeat | 406..427 | CDD:275380 | 4/20 (20%) | ||
| 7tmA_Relaxin_R | 467..752 | CDD:320265 | 84/296 (28%) | ||
| TM helix 1 | 468..494 | CDD:320265 | 10/25 (40%) | ||
| TM helix 2 | 502..527 | CDD:320265 | 12/24 (50%) | ||
| TM helix 3 | 547..577 | CDD:320265 | 10/29 (34%) | ||
| TM helix 4 | 588..610 | CDD:320265 | 6/24 (25%) | ||
| TM helix 5 | 638..667 | CDD:320265 | 4/29 (14%) | ||
| TM helix 6 | 681..711 | CDD:320265 | 9/29 (31%) | ||
| TM helix 7 | 720..745 | CDD:320265 | 10/24 (42%) | ||
| TSHR | NP_000360.2 | leucine-rich repeat | 54..77 | CDD:275380 | 8/22 (36%) |
| LRR_5 | 66..221 | CDD:463839 | 35/155 (23%) | ||
| leucine-rich repeat | 78..102 | CDD:275380 | 4/23 (17%) | ||
| leucine-rich repeat | 103..127 | CDD:275380 | 5/23 (22%) | ||
| leucine-rich repeat | 147..179 | CDD:275380 | 5/31 (16%) | ||
| leucine-rich repeat | 180..201 | CDD:275380 | 4/21 (19%) | ||
| leucine-rich repeat | 202..229 | CDD:275380 | 9/26 (35%) | ||
| 7tmA_TSH-R | 415..689 | CDD:320630 | 84/296 (28%) | ||
| TM helix 1 | 416..442 | CDD:320630 | 10/25 (40%) | ||
| TM helix 2 | 449..474 | CDD:320630 | 12/25 (48%) | ||
| TM helix 3 | 494..524 | CDD:320630 | 10/29 (34%) | ||
| TM helix 4 | 536..558 | CDD:320630 | 5/21 (24%) | ||
| TM helix 5 | 578..607 | CDD:320630 | 5/32 (16%) | ||
| TM helix 6 | 617..647 | CDD:320630 | 9/29 (31%) | ||
| TM helix 7 | 657..682 | CDD:320630 | 12/31 (39%) | ||
| Blue background indicates that the domain is not in the aligned region. | |||||