DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lgr4 and RXFP1

DIOPT Version :9

Sequence 1:	NP_001285192.1	Gene:	Lgr4 / 5740505	FlyBaseID:	FBgn0085440	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	NP_001240656.1	Gene:	RXFP1 / 59350	HGNCID:	19718	Length:	784	Species:	Homo sapiens

Alignment Length:	718	Identity:	229/718 - (31%)
Similarity:	347/718 - (48%)	Gaps:	67/718 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 DDKCPGGYFHCNTTAQCVPQRANCDGSVDCDDASDEVNCVN------EVDAKYWDHLYR---KQP 141
            |.||..|||.|....:|:||..:|:|..||.:.:||.||.:      :.| ||:...|:   :.|
Human    24 DVKCSLGYFPCGNITKCLPQLLHCNGVDDCGNQADEDNCGDNNGWSLQFD-KYFASYYKMTSQYP 87

  Fly   142 FGRHDNLRIGEC------------LWPNENFS---------------CPCRGDEILCRFQQLTDI 179
            |    .....||            |.|:.:.:               |.|:|.|:.|....|..:
Human    88 F----EAETPECSFHFFLFITLLFLVPHCHHALPLPLDSVVGSVPVQCLCQGLELDCDETNLRAV 148

  Fly   180 PERLPQHDLATLDLTGNNFETIHETFFSELPDVDSLVLKFCSIREIASHAFDRLADNPLRTLYMD 244
            |.  ...::..:.|..|....:....|....|:..|.|:...|..|:.:||..|  |.|..||:.
Human   149 PS--VSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGL--NSLTKLYLS 209

  Fly   245 DNKLPHLPEHFFPEGNQLSILILARNHLHHLKRSDFLNLQKLQELDLRGNRIGNF-EAEVFARLP 308
            .|::..|....|.:.::|..||:..|||..:....|..|..|..|.|..|.:... :..:...:|
Human   210 HNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMP 274

  Fly   309 NLEVLYLNENHLKRLDPDRFPRTLL-----NLHTLSLAYNQIEDIAANTF-PFPRLRYLFLAGNR 367
            .|..|.|..||:..|      |.|.     ||..|.:..|:|..:..||| |..:|..|.|..|:
Human   275 RLHWLDLEGNHIHNL------RNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNK 333

  Fly   368 LSHIRDETFCNLSNLQGLHLNENRIEGFDLEAFACLKNLSSLLLTGNRFQTLDSRVLKNLTSLDY 432
            :.::....|.:|..|..|:|:.|.|:......|..|..|.||.|.|.....:..|:.:.|.:|.:
Human   334 IENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRPLMNLSH 398

  Fly   433 IYFSWFHLCSAAMNVRVCDPHGDGISSKLHLLDNQILRGSVWVMASIAVVGNLLVLLGRYFYKSR 497
            |||..|..|..|.:||.|.|:.|||||..:||.:.|.|..|||::::...||:.|:..|.:.:|.
Human   399 IYFKKFQYCGYAPHVRSCKPNTDGISSLENLLASIIQRVFVWVVSAVTCFGNIFVICMRPYIRSE 463

  Fly   498 SNVEHSLYLRHLAASDFLMGIYLTLIACADISFRGEYIKYEETWRHSGVCAFAGFLSTFSCQSST 562
            :.: :::.:..|..:|.||||||.:|...|:.|||||.|:.:.|..|..|...|.|:..|.:.|.
Human   464 NKL-YAMSIISLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWMESTHCQLVGSLAILSTEVSV 527

  Fly   563 LLLTLVTWDRLMSVTRPLKPRDTEKVRIVLRLLLLWGISFGLAAAPLLPNPYFGSHFYGNNGVCL 627
            ||||.:|.::.:.:..|.:.....|.|.:..|:|:|...|.:|..| |.|..|..::||.||||.
Human   528 LLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGFIVAFIP-LSNKEFFKNYYGTNGVCF 591

  Fly   628 SLHIHDPYAKGWE-YSALLFILVNTLSLIFILFSYIRMLQAIRDSGGGMRST----HSGRENVVA 687
            .||..|..:.|.: ||..:|:.:|..:.|.|:|||..|..::..|  .:.:|    ...:|.::|
Human   592 PLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQS--AITATEIRNQVKKEMILA 654

  Fly   688 TRFAIIVTTDCACWLPIIVVKLAALSGCEISPDLYAWLAVLVLPVNSALNPVLYTLTTAAFKQQL 752
            .||..||.||..||:||.|||..:|...||...:.:|:.:.:||:||||||:||||||..||:.:
Human   655 KRFFFIVFTDALCWIPIFVVKFLSLLQVEIPGTITSWVVIFILPINSALNPILYTLTTRPFKEMI 719

  Fly   753 RRY 755
            .|:
Human   720 HRF 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr4	NP_001285192.1	Ldl_recept_a	87..124	CDD:278486	15/36 (42%)
		LRR_RI	<184..397	CDD:238064	59/219 (27%)
		LRR_8	188..248	CDD:290566	16/59 (27%)
		leucine-rich repeat	188..211	CDD:275380	3/22 (14%)
		leucine-rich repeat	212..235	CDD:275380	7/22 (32%)
		leucine-rich repeat	238..261	CDD:275380	6/22 (27%)
		LRR_8	261..320	CDD:290566	17/59 (29%)
		leucine-rich repeat	262..285	CDD:275380	8/22 (36%)
		LRR_4	284..325	CDD:289563	11/41 (27%)
		leucine-rich repeat	286..309	CDD:275380	4/23 (17%)
		LRR_4	308..348	CDD:289563	14/44 (32%)
		leucine-rich repeat	310..334	CDD:275380	8/28 (29%)
		leucine-rich repeat	335..357	CDD:275380	8/22 (36%)
		LRR_8	356..416	CDD:290566	18/59 (31%)
		leucine-rich repeat	358..381	CDD:275380	6/22 (27%)
		LRR_4	381..421	CDD:289563	12/39 (31%)
		leucine-rich repeat	382..405	CDD:275380	7/22 (32%)
		leucine-rich repeat	406..427	CDD:275380	6/20 (30%)
		7tm_1	483..741	CDD:278431	94/262 (36%)
RXFP1	NP_001240656.1	LDLa	27..62	CDD:238060	14/34 (41%)
		leucine-rich repeat	155..178	CDD:275380	3/22 (14%)
		LRR_8	179..237	CDD:290566	18/59 (31%)
		leucine-rich repeat	179..202	CDD:275380	7/24 (29%)
		LRR_RI	<196..358	CDD:238064	50/169 (30%)
		leucine-rich repeat	203..226	CDD:275380	6/22 (27%)
		LRR_8	226..286	CDD:290566	17/59 (29%)
		leucine-rich repeat	227..250	CDD:275380	8/22 (36%)
		leucine-rich repeat	251..275	CDD:275380	4/23 (17%)
		LRR_8	274..334	CDD:290566	22/65 (34%)
		leucine-rich repeat	276..299	CDD:275380	8/28 (29%)
		leucine-rich repeat	300..323	CDD:275380	8/22 (36%)
		LRR_8	323..379	CDD:290566	17/55 (31%)
		leucine-rich repeat	324..347	CDD:275380	6/22 (27%)
		leucine-rich repeat	348..371	CDD:275380	7/22 (32%)
		leucine-rich repeat	372..393	CDD:275380	6/20 (30%)
		7tm_1	451..708	CDD:278431	92/260 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H11007
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D256258at33208
OrthoFinder	1	1.000	-	-		FOG0002061
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101648
Panther	1	1.100	-	-	O	PTHR24372
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1524
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.780