Protein Alignment Lgr4 and igfals

DIOPT Version :10

• Sequence 1: NP_001285192.1
• Gene: Lgr4 / 5740505
• FlyBaseID: FBgn0085440
• Length: 809
• Species: Drosophila melanogaster
• Sequence 2: XP_003198203.1
• Gene: igfals / 570758
• ZFINID: ZDB-GENE-061009-25
• Length: 614
• Species: Danio rerio
• Alignment Length: 468
• Identity: 126/468 - (26%)
• Similarity: 191/468 - (40%)
• Gaps: 111/468 - (23%)

  Fly   162 CPCRGDE------ILCRFQQLTDIPERLPQHDLAT--LDLTGNNFETIHETFFSELPDVDSLVLK 218
            |.|..|:      :.|..:..|.:|..:|   |:|  |.|.||.|..:....|.:|.:::.|.|:
Zfish    53 CTCLQDDYSLELNVYCSTRNFTQVPSDIP---LSTRSLWLDGNLFSNLPAGAFEKLTNLEFLNLQ 114

  Fly   219 FCSIREIASHAFD--------RLADNPLRTL----------------------YMDD-------- 245
            ...:..:.:|||.        .|..|.||:|                      .:||
Zfish   115 SSLLVSLDAHAFRGLNSLAHLHLERNNLRSLSGLVFQGTSNLATLSLNNNQMFRIDDRLFAGMSH 179

  Fly   246 --------NKLPHLPEHFFPEGNQLSILILARNHLHHLKRSDFLNLQKLQELDLRGNRIGNFEAE 302
                    |.|..|||..|.:.:.|..||||.|.|.:|:...|..|.:|:||||.||.:...:|.
Zfish   180 MWLLNLGWNLLSVLPETGFQDLHGLRELILAGNRLAYLQPQLFQGLNELKELDLTGNYLKVIKAN 244

  Fly   303 VFARLPNLEVLYLNENH--------------LKRLDPDRFPRTLL---------NLHTLSLAYNQ 344
            ||.:||.|:.|||.:|.              |:.||..|...|:|         :||.|.|:.|.
Zfish   245 VFLKLPKLQKLYLGQNQIVTVAPRAFVGMKSLRWLDLSRNRLTVLHDETFIGLQSLHVLRLSNNS 309

  Fly   345 IEDIAANTF-PFPRLRYLFLAGNRLSHIRDETFCNLSNLQGLHLNENRIEGFDLEAFACLKNLSS 408
            |..:...|| ....|..|.|..|::..:....|..|.:|:.|:|..||::...:..|..|.:|:.
Zfish   310 INSLRPGTFRDLQYLEELCLYHNQIRALGVRVFEGLGHLEVLNLENNRLQEARMGTFMGLNHLAV 374

  Fly   409 LLLTGNRFQTLDSRVLKNLTSLDYIYFSWFHLCSAAMNVRVCDPHGDGISS--KLHLLDNQIL-- 469
            :.|||:.|.:|..:|.|.|:.|..|     ||..:.: .:|......|::.  :|.|..|.|.
Zfish   375 MKLTGSCFHSLPDQVFKGLSKLHSI-----HLDRSCL-TKVSSQSFSGLTGLRRLFLQHNNISLV 433

  Fly   470 -RGSVWVMASIAVV----GNLLVLLGRYFYKSRS--------NVEHS------LYLRHLAASDFL 515
             |.|...:..:..:    ..|..:....||..::        |:.|:      |.|:||:..| |
Zfish   434 ERQSFVELQRLQQLDLRFNKLTTITSNTFYGLKNLDYLLLSGNLLHNLPAEALLPLQHLSWLD-L 497

  Fly   516 MGIYLTLIACADI 528
            .|..|.||..|.|
Zfish   498 SGNKLELILNATI 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lgr4	NP_001285192.1	Ldl_recept_a	87..124	CDD:395011
		LRR	167..>430	CDD:443914	95/340 (28%)
		leucine-rich repeat	188..211	CDD:275380	9/24 (38%)
		leucine-rich repeat	212..235	CDD:275380	6/30 (20%)
		leucine-rich repeat	238..261	CDD:275380	11/60 (18%)
		leucine-rich repeat	262..285	CDD:275380	10/22 (45%)
		leucine-rich repeat	286..309	CDD:275380	11/22 (50%)
		leucine-rich repeat	310..334	CDD:275380	11/46 (24%)
		leucine-rich repeat	335..357	CDD:275380	8/22 (36%)
		leucine-rich repeat	358..381	CDD:275380	6/22 (27%)
		leucine-rich repeat	382..405	CDD:275380	7/22 (32%)
		leucine-rich repeat	406..427	CDD:275380	8/20 (40%)
		7tmA_Relaxin_R	467..752	CDD:320265	20/83 (24%)
		TM helix 1	468..494	CDD:320265	4/32 (13%)
		TM helix 2	502..527	CDD:320265	11/30 (37%)
		TM helix 3	547..577	CDD:320265
		TM helix 4	588..610	CDD:320265
		TM helix 5	638..667	CDD:320265
		TM helix 6	681..711	CDD:320265
		TM helix 7	720..745	CDD:320265
igfals	XP_003198203.1	LRRNT	48..81	CDD:396168	6/27 (22%)
		leucine-rich repeat	65..83	CDD:275380	4/20 (20%)
		leucine-rich repeat	84..107	CDD:275380	8/22 (36%)
		LRR_8	85..142	CDD:404697	14/56 (25%)
		leucine-rich repeat	108..131	CDD:275380	5/22 (23%)
		LRR_8	131..214	CDD:404697	19/82 (23%)
		leucine-rich repeat	132..155	CDD:275380	5/22 (23%)
		leucine-rich repeat	156..203	CDD:275380	8/46 (17%)
		LRR	<196..507	CDD:443914	91/317 (29%)
		leucine-rich repeat	204..227	CDD:275380	10/22 (45%)
		leucine-rich repeat	228..251	CDD:275380	11/22 (50%)
		leucine-rich repeat	252..275	CDD:275380	5/22 (23%)
		leucine-rich repeat	276..299	CDD:275380	6/22 (27%)
		leucine-rich repeat	300..323	CDD:275380	8/22 (36%)
		leucine-rich repeat	324..347	CDD:275380	6/22 (27%)
		leucine-rich repeat	348..369	CDD:275380	6/20 (30%)
		leucine-rich repeat	396..419	CDD:275380	6/28 (21%)
		leucine-rich repeat	420..443	CDD:275380	6/22 (27%)
		leucine-rich repeat	444..467	CDD:275380	3/22 (14%)
		leucine-rich repeat	468..486	CDD:275380	2/17 (12%)
		leucine-rich repeat	492..515	CDD:275380	9/20 (45%)
		leucine-rich repeat	516..540	CDD:275380