DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lgr4 and rxfp2b

DIOPT Version :9

Sequence 1:	NP_001285192.1	Gene:	Lgr4 / 5740505	FlyBaseID:	FBgn0085440	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	NP_001315011.1	Gene:	rxfp2b / 566888	ZFINID:	ZDB-GENE-110408-27	Length:	750	Species:	Danio rerio

Alignment Length:	705	Identity:	231/705 - (32%)
Similarity:	344/705 - (48%)	Gaps:	77/705 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 PDADDKCPGGYFHCNTTAQCVPQRANCDGSVDCDDASDEVNC-VNEVDAKYWDHLYRKQPFGRHD 146
            |..|  ||.|:|.|...:.|:||..:|:...||.:.:||.|| .|...|..:|..:::   |...
Zfish    35 PSED--CPLGHFPCGNVSICLPQVLHCNNQKDCPNGADEDNCGDNSGWADLFDRTFKR---GYLQ 94

  Fly   147 NLRIGECLWPNENFSCPCRGDEILCRFQQLTDIPERLPQHDLATLDLTGNNFETIHETFFSELPD 211
            .|.. :|........|.|...||.|....|..||:           ::.|
Zfish    95 ELAT-DCQVEQYPDVCRCINTEIHCVHASLRSIPQ-----------VSAN--------------- 132

  Fly   212 VDSLVLKFCSIREIASHAFDRLADNPLRTLYMDDNKLPHLPEHFFPEGNQLSILILARNHLHHLK 276
            |.||.||...||.:...||.:..  .|:.|::.||.:..:....|....:|..|.|::|.:..|.
Zfish   133 VTSLSLKSNKIRTLPDEAFIKYI--KLQRLFLQDNCINTVSIQAFSGLYKLQKLSLSQNSISLLS 195

  Fly   277 RSDFLNLQKLQELDLRGNRIGNFEAEVFARLPNLEVLYLNENHLKRLDPDR----FP-------- 329
            ...|.:|:||:.|.|..|.|....|..||.|.:|..|.:....|:.|...|    .|
Zfish   196 PGVFRDLRKLKWLILDDNPITTIAANTFAGLSSLFFLSMVNTSLEALPSARLCAHMPFLSWLDFE 260

  Fly   330 ---------RTLL---NLHTLSLAYNQIEDIAANTFPFPRLR-YLFLAGNRLSHIRDETFCNLSN 381
                     .|||   :|..|||..|.|:.:..|||...|:. .|.|:.|.:..:....|.:|.:
Zfish   261 GNSITTLGLSTLLDCEHLTVLSLRANLIKSLPENTFQSLRMMGDLDLSNNSIKELPVGIFKDLRS 325

  Fly   382 LQGLHLNENRIEGFDLEAFACLKNLSSLLLTGNRFQTLDSRVLKNLTSLDYIYFSWFHLCSAAMN 446
            ||.|:|::|.::......|..|..|.||.|.|.....:.:.:.:.:.:|.||||..|..||.|.:
Zfish   326 LQSLNLSQNPLDHIHPGQFNHLIQLQSLGLEGVEIPNIQTSMFRPMDNLSYIYFKKFQYCSYAPH 390

  Fly   447 VRVCDPHGDGISSKLHLLDNQILRGSVWVMASIAVVGNLLVLLGRYFYKSRSNVEHSLYLRHLAA 511
            ||.|.|:.||:||...||.|.:||.||||||.|...|||.|:..|...::.:|: |:..::.|..
Zfish   391 VRKCKPNSDGLSSFEDLLANVVLRVSVWVMAFITCFGNLFVIGMRTVLRAENNL-HAFCIKVLCC 454

  Fly   512 SDFLMGIYLTLIACADISFRGEYIKYEETWRHSGVCAFAGFLSTFSCQSSTLLLTLVTWDRLMSV 576
            :|.|||:||..:...|:.|||||.|..:.|..|..|...|||:..|.:.|.:|||.:|.::.:.:
Zfish   455 ADCLMGVYLFFVGIFDVKFRGEYNKNAKVWMESLECRTIGFLAMLSSEVSVMLLTYLTLEKFLVI 519

  Fly   577 TRPLKPRDTEKVRIVLRLLLLWGISFGLAAAPLLPNPYFGSHFYGNNGVCLSLH---IHDPYAKG 638
            ..|.......|.:....|:.:|.:...:||.|||....|| ::||.||||..||   :..|.|||
Zfish   520 VFPFSHLRPSKCQTFTVLVSIWLLGISIAAVPLLNEDTFG-NYYGLNGVCFPLHSERLEKPVAKG 583

  Fly   639 WEYSALLFILVNTLSLIFILFSYIRMLQAIRDSGGGMRST------HSGRENVVATRFAIIVTTD 697
              ||..:|:.:|.|:.:.|:.||..|..:|..:  |:|:|      |  |:..:|.||..||.:|
Zfish   584 --YSTGIFLGLNLLAFLIIVVSYSSMFYSIYKT--GIRATELPGRLH--RDVAMAHRFFFIVFSD 642

  Fly   698 CACWLPIIVVKLAALSGCEISPDLYAWLAVLVLPVNSALNPVLYTLTTAAFKQQL 752
            ..||:||.:||:.:|...||...:.:|:.:.:||:||||||:||||||:.|::|:
Zfish   643 ALCWIPIFMVKILSLLEVEIPGTITSWVVIFILPINSALNPILYTLTTSFFREQV 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr4	NP_001285192.1	Ldl_recept_a	87..124	CDD:278486	13/36 (36%)
		LRR_RI	<184..397	CDD:238064	61/237 (26%)
		LRR_8	188..248	CDD:290566	14/59 (24%)
		leucine-rich repeat	188..211	CDD:275380	1/22 (5%)
		leucine-rich repeat	212..235	CDD:275380	9/22 (41%)
		leucine-rich repeat	238..261	CDD:275380	5/22 (23%)
		LRR_8	261..320	CDD:290566	19/58 (33%)
		leucine-rich repeat	262..285	CDD:275380	7/22 (32%)
		LRR_4	284..325	CDD:289563	14/40 (35%)
		leucine-rich repeat	286..309	CDD:275380	9/22 (41%)
		LRR_4	308..348	CDD:289563	15/63 (24%)
		leucine-rich repeat	310..334	CDD:275380	9/47 (19%)
		leucine-rich repeat	335..357	CDD:275380	9/21 (43%)
		LRR_8	356..416	CDD:290566	18/60 (30%)
		leucine-rich repeat	358..381	CDD:275380	5/23 (22%)
		LRR_4	381..421	CDD:289563	12/39 (31%)
		leucine-rich repeat	382..405	CDD:275380	7/22 (32%)
		leucine-rich repeat	406..427	CDD:275380	5/20 (25%)
		7tm_1	483..741	CDD:278431	95/266 (36%)
rxfp2b	NP_001315011.1	LDLa	39..74	CDD:238060	13/34 (38%)
		leucine-rich repeat	114..132	CDD:275380	6/28 (21%)
		LRR_RI	130..360	CDD:238064	68/246 (28%)
		leucine-rich repeat	133..156	CDD:275380	9/24 (38%)
		LRR_8	156..215	CDD:290566	17/58 (29%)
		leucine-rich repeat	157..180	CDD:275380	5/22 (23%)
		leucine-rich repeat	181..204	CDD:275380	7/22 (32%)
		LRR_8	203..288	CDD:290566	24/84 (29%)
		leucine-rich repeat	205..228	CDD:275380	9/22 (41%)
		leucine-rich repeat	229..253	CDD:275380	5/23 (22%)
		leucine-rich repeat	254..277	CDD:275380	3/22 (14%)
		LRR_8	277..336	CDD:290566	20/58 (34%)
		leucine-rich repeat	278..301	CDD:275380	9/22 (41%)
		leucine-rich repeat	302..325	CDD:275380	5/22 (23%)
		LRR_8	324..378	CDD:290566	14/53 (26%)
		leucine-rich repeat	326..349	CDD:275380	7/22 (32%)
		leucine-rich repeat	350..369	CDD:275380	5/18 (28%)
		7tm_4	419..>556	CDD:304433	46/137 (34%)
		7tm_1	<487..686	CDD:278431	73/205 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D256258at33208
OrthoFinder	1	1.000	-	-		FOG0002061
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101648
Panther	1	1.100	-	-	O	PTHR24372
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1524
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.780