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Protein Alignment Lgr4 and tshr

DIOPT Version :10

Sequence 1:	NP_001285192.1	Gene:	Lgr4 / 5740505	FlyBaseID:	FBgn0085440	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	NP_001139235.1	Gene:	tshr / 560609	ZFINID:	ZDB-GENE-110524-4	Length:	757	Species:	Danio rerio

Alignment Length:	779	Identity:	181/779 - (23%)
Similarity:	291/779 - (37%)	Gaps:	197/779 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 NCVNEVDAKYWDHLYRKQPFGRHDNLRIGECLWPNENFSCPCRGDEILCRFQQLTDIPE------ 181
            :|.:..:...|..|             :..|:..:...:.|.|.:.:.....:||.:|:
Zfish    22 SCPHGCECSQWKAL-------------VVSCMDVDSIPTLPERTEVLSLHETRLTRVPKDAFANM 73

  Fly   182 ---------------RLPQHDLATL-DLT------GNNFETIHETFFSELPDVDSL--------- 215
                           ||..|...:| :||      ......||...|..||::..|
Zfish    74 VNISRIYLSVDIFLSRLEMHSFHSLRELTHIEIRNTRKLTFIHPEAFKNLPNLQYLGLFNTGLTI 138

  Fly   216 --------------VLKFCS---IREIASHAFDRLADNPLRTLYMDDNKLPHLPEHFFPEGNQLS 263
                          :|:...   |.||.::||..:. |.|.:|.:..|....:..|.| .|.:|.
Zfish   139 FPDLTKIQAENSYFILEISDNPYIAEIPANAFFGIT-NDLLSLRLYSNGFTKVQPHAF-NGTKLD 201

  Fly   264 ILILARNHLHHLKRSDFLNLQKLQELDLRGNRIGNFEAEVF--------AR-LPNL-EVLYLNEN 318
            .:.|.||.          .|.:|.|....|...|....:|.        || |.:| |:...|..
Zfish   202 SVYLHRNR----------ELTRLDEKMFAGTSSGPMLLDVSESGVTSLPARGLDSLRELCARNVW 256

  Fly   319 HLKRLDPDRFPRTLLNLHTLSLAYNQIEDIAANTFPFPRLRYLFLAGNRLSHIRDETFCNLSNLQ 383
            .||:|.|   .:|..:|.|..|.|      .::...|..|:       :.....:|..|||:
Zfish   257 ALKKLPP---IKTFRHLVTADLTY------PSHCCAFKNLK-------KKRGFIEEIICNLT--- 302

  Fly   384 GLHLNENRIEGFDLEAFACLKNLSSLL-----LTGNRFQ-TLD---------------------- 420
               ..:|:::...:.||. :..|...:     |:.|.|: |.|
Zfish   303 ---ARKNQVQKRSVRAFT-IHGLQGSMEPGIDLSDNLFRDTYDHQEFFGNGHYPTYFDRHADENM 363

  Fly   421 --SRVLKNL---------TSLDYIYFSWFHLCSAAMNVRVCDPHGDGISSKLHLLDNQILRGSVW 474
              ...|||.         :..|||      :|.....| .|.|..|..:....::....||.|||
Zfish   364 GFGETLKNPQEDTSREFDSRYDYI------VCEKGEEV-ACFPAPDEFNPCEDIMGFSFLRVSVW 421

  Fly   475 VMASIAVVGNLLVLLGRYFYKSRSNVEHSLYLR-HLAASDFLMGIYLTLIACADISFRGEYIKYE 538
            .::.:||:|||||||  ....|...:..|.:|. |||.:|..|||||.|||..|:..:.||..:.
Zfish   422 FVSLLAVLGNLLVLL--VLLTSHYKLSVSRFLMCHLAVADLCMGIYLLLIASVDLHTQSEYYNHA 484

  Fly   539 ETWRHSGVCAFAGFLSTFSCQSSTLLLTLVTWDRLMSVTRPLKPRDTEKVRI---VLRLLLLWGI 600
            ..|:....|:.|||.|.|:.:.|...||.:|.:|..::|..:  |...|:|:   .:.:|:.|..
Zfish   485 IDWQTGPGCSLAGFFSVFASELSVYTLTTITLERWYAITYAM--RLDRKLRLSHASVIMLIGWIF 547

  Fly   601 SFGLAAAPLLPNPYFGSHFYGNNGVCLSLHIHDPYAKGWEYSALLFILVNTLSLIFILFSYIRML 665
            ...|...||:     |...|....:||.:   |......:...:..:::|.|:.|.|...||::.
Zfish   548 CLLLGLMPLV-----GVSSYQKVSICLPM---DTQTLVDQIYIICVLVLNILAFIVICVCYIKIY 604

  Fly   666 QAIRDSGGGMRSTH--SGRENVVATRFAIIVTTDCACWLPIIVVKLAA--------LSGCEISPD 720
            .|:.:      .:|  |.::..:|.|.|:::.||..|..||.:..:.|        :|..:|
Zfish   605 CAVHN------PSHQSSNKDTNIAKRMAVLIFTDFLCMAPISLYAMTAVLDHPLITVSNSKI--- 660

  Fly   721 LYAWLAVLVLPVNSALNPVLYTLTTAAFKQQLRRYCHTLPSCSLVNNETRSQTQTAYESGLSVS 784
                |.||..|:||..||.||.:.|.||:..:......:..|.......|.||.::..|...::
Zfish   661 ----LLVLFYPLNSCANPFLYAIFTKAFQGDVFILLSKVGLCQRQAQLFRGQTVSSKASSRGIT 720

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.