DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lgr4 and lhcgr

DIOPT Version :9

Sequence 1:	NP_001285192.1	Gene:	Lgr4 / 5740505	FlyBaseID:	FBgn0085440	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	NP_991188.1	Gene:	lhcgr / 402920	ZFINID:	ZDB-GENE-040806-3	Length:	708	Species:	Danio rerio

Alignment Length:	715	Identity:	163/715 - (22%)
Similarity:	274/715 - (38%)	Gaps:	160/715 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 GECLWPNENFSCP--CRGDEILCRFQQLTDIPERLPQHDLATLDLTGNNFETIHETFFSELPDVD 213
            |.|      |.||  ||     |..:.:|.......|..|:.|.|...:.:||....|..|..|.
Zfish    19 GVC------FECPEICR-----CSQKSITCNSATGSQKSLSRLVLNYISVKTISSRSFDGLKGVR 72

  Fly   214 SL-VLKFCSIREIASHAFDRLADNPLRTLYMDDNKLPHLPEHFFPEGNQLSILILARNHLHHLKR 277
            .: :.:..|:..|.|.||               |.||::.|          |.|....:|.|:::
Zfish    73 RIEIAQSSSVETIESEAF---------------NNLPNVSE----------ISIQNTRNLVHIQQ 112

  Fly   278 SDFLNLQKLQELDLRGNRIGNFEAEVFARLPNLEVLYLNENH----------LKRLDPDRFPRTL 332
            ..|..|.||:.|.:....|..|        |:|..::..|.|          |:.:..:.|....
Zfish   113 RAFNQLPKLRYLSISNTGISVF--------PDLTSIFSLEAHFILDICDNLNLRSVPSNAFTGMT 169

  Fly   333 LNLHTLSLAYNQIEDIAANTFPFPRLRYLFLAGNR-LSHIRDETFCNLSNLQGLHLNENRIE--- 393
            ....|::|..|..::|.::.|...::..|.|..:| |..:.::.|........|.::...:|
Zfish   170 SEYATMNLFNNGFQEIESHAFNGTKIDKLVLKNSRDLRVVHEDAFKGALGPTVLDVSSTALETLP 234

  Fly   394 --------------GFDLEAFACLKNLSSL----------------------------------- 409
                          .|.|:....||:|.||
Zfish   235 SHGLESVLMLTARSAFALKKLPPLKSLKSLREAQLTFPSHCCALINWDNSRDGSVNSALRNRSSY 299

  Fly   410 ---------LLTGNRFQTLDSRVLKNLT------SLDYIYFSWFHLCSAAMNVRVCDPHGDGISS 459
                     |...:...:|:|.|:.:.:      |:|: ::....||.....:: |.|..|..:.
Zfish   300 CGDNSSPADLSAISSDDSLESDVIGSSSVEDTFGSIDF-HYPDLDLCQQRQALQ-CSPEADAFNP 362

  Fly   460 KLHLLDNQILRGSVWVMASIAVVGNLLVLLGRYFYKSRSNVEHSLYLRHLAASDFLMGIYLTLIA 524
            ...:.....||.::|.:..:|:.|||:|||..:..:.:..|...| :.|||.:|..:||||.:||
Zfish   363 CEDIAGFSFLRVAIWFINILAIAGNLVVLLVLFTSRCKLTVPRFL-MCHLAFADLCIGIYLLMIA 426

  Fly   525 CADISFRGEYIKYEETWRHSGVCAFAGFLSTFSCQSSTLLLTLVTWDRLMSVTRPLK-PRDTEKV 588
            ..|:..||.|..:...|:....|..|||||.|..:.|...|:.:|.:|..::|..|: .|.....
Zfish   427 TVDLRTRGHYSHHAIEWQTGAGCDIAGFLSVFGGELSIYTLSTITVERWHTITHALRLERRLGLS 491

  Fly   589 RIVLRLLLLWGISFGLAAAPLLPNPYFGSHFYGNNGVCLSLHIHDPYAKGWEYSALLFILVNTLS 653
            :..|.:.:.|.:...:|..||:     |...|....:||.:.|..|.::.:   .:|.:|.|..:
Zfish   492 QASLIMTIGWLLCLAMALLPLI-----GVSSYSKVSMCLPMDIETPLSQAY---VILLLLFNVGA 548

  Fly   654 LIFILFSYIRMLQAIRDSGGGMRSTHSGR--ENVVATRFAIIVTTDCACWLPI--------IVVK 708
            .:.|...|:.:..|:|:      ....||  :..:|.|.|:::.||..|..||        ..|.
Zfish   549 FLVICGCYVCIYSAVRN------PEFPGRAADAKIAKRMAVLIFTDFLCMAPISFFAISAAFKVP 607

  Fly   709 LAALSGCEISPDLYAWLAVLVLPVNSALNPVLYTLTTAAFKQQLRRYCHTLPSCSLVNNETRSQT 773
            |..::..:|       |.||..|:||..||.||.:.|.||::.......::..|....|..|.:|
Zfish   608 LITVTNSKI-------LLVLFYPINSCANPFLYAIFTRAFRKDACILLSSMGCCQSKANLYRMKT 665

Fly 774 773
Zfish 666 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr4	NP_001285192.1	Ldl_recept_a	87..124	CDD:278486
		LRR_RI	<184..397	CDD:238064	48/241 (20%)
		LRR_8	188..248	CDD:290566	14/60 (23%)
		leucine-rich repeat	188..211	CDD:275380	7/22 (32%)
		leucine-rich repeat	212..235	CDD:275380	6/23 (26%)
		leucine-rich repeat	238..261	CDD:275380	4/22 (18%)
		LRR_8	261..320	CDD:290566	15/68 (22%)
		leucine-rich repeat	262..285	CDD:275380	6/22 (27%)
		LRR_4	284..325	CDD:289563	10/50 (20%)
		leucine-rich repeat	286..309	CDD:275380	4/22 (18%)
		LRR_4	308..348	CDD:289563	9/49 (18%)
		leucine-rich repeat	310..334	CDD:275380	5/33 (15%)
		leucine-rich repeat	335..357	CDD:275380	5/21 (24%)
		LRR_8	356..416	CDD:290566	15/121 (12%)
		leucine-rich repeat	358..381	CDD:275380	5/23 (22%)
		LRR_4	381..421	CDD:289563	11/100 (11%)
		leucine-rich repeat	382..405	CDD:275380	5/39 (13%)
		leucine-rich repeat	406..427	CDD:275380	7/64 (11%)
		7tm_1	483..741	CDD:278431	76/268 (28%)
lhcgr	NP_991188.1	leucine-rich repeat	47..70	CDD:275380	7/22 (32%)
		LRR_5	58..216	CDD:290045	41/190 (22%)
		leucine-rich repeat	71..95	CDD:275380	8/38 (21%)
		leucine-rich repeat	96..120	CDD:275380	7/33 (21%)
		leucine-rich repeat	121..142	CDD:275380	6/28 (21%)
		leucine-rich repeat	143..170	CDD:275380	4/26 (15%)
		leucine-rich repeat	171..194	CDD:275380	5/22 (23%)
		leucine-rich repeat	195..219	CDD:275380	5/23 (22%)
		leucine-rich repeat	220..257	CDD:275380	4/36 (11%)
		GnHR_trans	283..356	CDD:289164	9/74 (12%)
		7tm_1	386..633	CDD:278431	76/268 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810