DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lgr4 and LHCGR

DIOPT Version :10

Sequence 1:NP_001285192.1 Gene:Lgr4 / 5740505 FlyBaseID:FBgn0085440 Length:809 Species:Drosophila melanogaster
Sequence 2:NP_000224.2 Gene:LHCGR / 3973 HGNCID:6585 Length:699 Species:Homo sapiens


Alignment Length:761 Identity:168/761 - (22%)
Similarity:284/761 - (37%) Gaps:169/761 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    96 CNTTAQCVPQRANCDGSVDC---------------------DDASDEVNCVNEVDAKYWDHLYRK 139
            |.....|||     ||::.|                     ..|...:|.|.:::....|.|.|.
Human    30 CPEPCNCVP-----DGALRCPGPTAGLTRLSLAYLPVKVIPSQAFRGLNEVIKIEISQIDSLERI 89

  Fly   140 QPFGRHDNLRIGECLWPN-ENFSCPCRGDEILCRFQQLTDIPERLPQHDLATLDLTG-NNFETIH 202
            :.....:.|.:.|.|..| :|......|..|            .||:....::..|| ..|..:.
Human    90 EANAFDNLLNLSEILIQNTKNLRYIEPGAFI------------NLPRLKYLSICNTGIRKFPDVT 142

  Fly   203 ETFFSELPDVDSLVLKFCS---IREIASHAFDRLADNPLRTLYMDDNKLPHLPEHFFPEGNQLSI 264
            :.|.||    .:.:|:.|.   |..|..:||..: :|...||.:..|....:..|.| .|..|:.
Human   143 KVFSSE----SNFILEICDNLHITTIPGNAFQGM-NNESVTLKLYGNGFEEVQSHAF-NGTTLTS 201

  Fly   265 LILARN-HLHHLKRSDFLNLQKLQELDLRGNR---IGNFEAEVFARLPNLEVLYLNENHLKRLDP 325
            |.|..| ||..:....|......:.||:...:   :.::..|...||     :..:...||:| |
Human   202 LELKENVHLEKMHNGAFRGATGPKTLDISSTKLQALPSYGLESIQRL-----IATSSYSLKKL-P 260

  Fly   326 DRFPRTLLNLHTLSLAYNQIEDIAANTFPFPRLRYLFLAGNRLSHIRDETF---C-------NLS 380
            .|  .|.:||...:|.|      .::...|   |.|.......||...|.|   |       |..
Human   261 SR--ETFVNLLEATLTY------PSHCCAF---RNLPTKEQNFSHSISENFSKQCESTVRKVNNK 314

  Fly   381 NLQGLHLNENRIEGFDLEAFACLKNLSSLLLTGNRFQTLDSRVLKNLTSLDYIYFSWFHLCSAAM 445
            .|....|.|:.:.|:|.|...||.....                                     
Human   315 TLYSSMLAESELSGWDYEYGFCLPKTPR------------------------------------- 342

  Fly   446 NVRVCDPHGDGISSKLHLLDNQILRGSVWVMASIAVVGNLLVLLGRYFYKSRSNVEHSLYLRHLA 510
                |.|..|..:....::....||..:|::..:|::||:.||......:.:..|...| :.:|:
Human   343 ----CAPEPDAFNPCEDIMGYDFLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFL-MCNLS 402

  Fly   511 ASDFLMGIYLTLIACADISFRGEYIKYEETWRHSGVCAFAGFLSTFSCQSSTLLLTLVTWDRLMS 575
            .:||.||:||.|||..|...:|:|..:...|:....|:.|||.:.|:.:.|...||::|.:|..:
Human   403 FADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCSTAGFFTVFASELSVYTLTVITLERWHT 467

  Fly   576 VTRPLKPRDTEKVRIVLRLLLL---WGISFGLAAAPLLPNPYFGSHFYGNNGVCLSLHIHDPYAK 637
            :|..:  ...:|:|:...:|::   |..|..:|..||:     |...|....:|..:.:....::
Human   468 ITYAI--HLDQKLRLRHAILIMLGGWLFSSLIAMLPLV-----GVSNYMKVSICFPMDVETTLSQ 525

  Fly   638 GWEYSALLFILVNTLSLIFILFSYIRMLQAIRDSGGGMRSTHSGRENVVATRFAIIVTTDCACWL 702
            .:   .|..:::|.::...|...||::..|:|:.  .:.:|:  ::..:|.:.||::.||..|..
Human   526 VY---ILTILILNVVAFFIICACYIKIYFAVRNP--ELMATN--KDTKIAKKMAILIFTDFTCMA 583

  Fly   703 PI--------IVVKLAALSGCEISPDLYAWLAVLVLPVNSALNPVLYTLTTAAFKQQLRRYCHTL 759
            ||        ..|.|..::..::       |.||..|:||..||.||.:.|..|::.........
Human   584 PISFFAISAAFKVPLITVTNSKV-------LLVLFYPINSCANPFLYAIFTKTFQRDFFLLLSKF 641

  Fly   760 PSCSLVNNETRSQTQTAY---------------ESGLSVSLAHLGG 790
            ..|.......|.:..:||               :|.|.:|..|..|
Human   642 GCCKRRAELYRRKDFSAYTSNCKNGFTGSNKPSQSTLKLSTLHCQG 687

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lgr4NP_001285192.1 Ldl_recept_a 87..124 CDD:395011 8/48 (17%)
LRR 167..>430 CDD:443914 61/280 (22%)
leucine-rich repeat 188..211 CDD:275380 6/23 (26%)
leucine-rich repeat 212..235 CDD:275380 6/25 (24%)
leucine-rich repeat 238..261 CDD:275380 6/22 (27%)
leucine-rich repeat 262..285 CDD:275380 7/23 (30%)
leucine-rich repeat 286..309 CDD:275380 5/25 (20%)
leucine-rich repeat 310..334 CDD:275380 6/23 (26%)
leucine-rich repeat 335..357 CDD:275380 4/21 (19%)
leucine-rich repeat 358..381 CDD:275380 8/32 (25%)
leucine-rich repeat 382..405 CDD:275380 8/22 (36%)
leucine-rich repeat 406..427 CDD:275380 0/20 (0%)
7tmA_Relaxin_R 467..752 CDD:320265 76/295 (26%)
TM helix 1 468..494 CDD:320265 8/25 (32%)
TM helix 2 502..527 CDD:320265 11/24 (46%)
TM helix 3 547..577 CDD:320265 10/29 (34%)
TM helix 4 588..610 CDD:320265 6/24 (25%)
TM helix 5 638..667 CDD:320265 5/28 (18%)
TM helix 6 681..711 CDD:320265 10/37 (27%)
TM helix 7 720..745 CDD:320265 10/24 (42%)
LHCGRNP_000224.2 leucine-rich repeat 51..74 CDD:275380 1/22 (5%)
LRR_5 62..198 CDD:463839 34/153 (22%)
leucine-rich repeat 75..99 CDD:275380 4/23 (17%)
LRR 1 96..115 5/18 (28%)
leucine-rich repeat 100..124 CDD:275380 7/35 (20%)
LRR 2 124..145 3/20 (15%)
leucine-rich repeat 125..150 CDD:275380 6/28 (21%)
LRR 3 149..171 6/21 (29%)
leucine-rich repeat 151..174 CDD:275380 6/23 (26%)
leucine-rich repeat 175..198 CDD:275380 6/23 (26%)
LRR 4 175..196 5/21 (24%)
LRR 5 198..220 7/21 (33%)
leucine-rich repeat 199..223 CDD:275380 7/23 (30%)
LRR 6 223..244 2/20 (10%)
leucine-rich repeat 224..244 CDD:275380 2/19 (11%)
7tmA_LHCGR 360..634 CDD:320481 76/295 (26%)
TM helix 1 361..387 CDD:320481 8/25 (32%)
TM helix 2 394..419 CDD:320481 11/25 (44%)
TM helix 3 439..469 CDD:320481 10/29 (34%)
TM helix 4 481..503 CDD:320481 5/21 (24%)
TM helix 5 523..552 CDD:320481 5/31 (16%)
TM helix 6 562..592 CDD:320481 8/31 (26%)
TM helix 7 602..627 CDD:320481 10/31 (32%)

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