DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lgr4 and LHCGR

DIOPT Version :9

Sequence 1:	NP_001285192.1	Gene:	Lgr4 / 5740505	FlyBaseID:	FBgn0085440	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	NP_000224.2	Gene:	LHCGR / 3973	HGNCID:	6585	Length:	699	Species:	Homo sapiens

Alignment Length:	761	Identity:	168/761 - (22%)
Similarity:	284/761 - (37%)	Gaps:	169/761 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 CNTTAQCVPQRANCDGSVDC---------------------DDASDEVNCVNEVDAKYWDHLYRK 139
            |.....|||     ||::.|                     ..|...:|.|.:::....|.|.|.
Human    30 CPEPCNCVP-----DGALRCPGPTAGLTRLSLAYLPVKVIPSQAFRGLNEVIKIEISQIDSLERI 89

  Fly   140 QPFGRHDNLRIGECLWPN-ENFSCPCRGDEILCRFQQLTDIPERLPQHDLATLDLTG-NNFETIH 202
            :.....:.|.:.|.|..| :|......|..|            .||:....::..|| ..|..:.
Human    90 EANAFDNLLNLSEILIQNTKNLRYIEPGAFI------------NLPRLKYLSICNTGIRKFPDVT 142

  Fly   203 ETFFSELPDVDSLVLKFCS---IREIASHAFDRLADNPLRTLYMDDNKLPHLPEHFFPEGNQLSI 264
            :.|.||    .:.:|:.|.   |..|..:||..: :|...||.:..|....:..|.| .|..|:.
Human   143 KVFSSE----SNFILEICDNLHITTIPGNAFQGM-NNESVTLKLYGNGFEEVQSHAF-NGTTLTS 201

  Fly   265 LILARN-HLHHLKRSDFLNLQKLQELDLRGNR---IGNFEAEVFARLPNLEVLYLNENHLKRLDP 325
            |.|..| ||..:....|......:.||:...:   :.::..|...||     :..:...||:| |
Human   202 LELKENVHLEKMHNGAFRGATGPKTLDISSTKLQALPSYGLESIQRL-----IATSSYSLKKL-P 260

  Fly   326 DRFPRTLLNLHTLSLAYNQIEDIAANTFPFPRLRYLFLAGNRLSHIRDETF---C-------NLS 380
            .|  .|.:||...:|.|      .::...|   |.|.......||...|.|   |       |..
Human   261 SR--ETFVNLLEATLTY------PSHCCAF---RNLPTKEQNFSHSISENFSKQCESTVRKVNNK 314

  Fly   381 NLQGLHLNENRIEGFDLEAFACLKNLSSLLLTGNRFQTLDSRVLKNLTSLDYIYFSWFHLCSAAM 445
            .|....|.|:.:.|:|.|...||.....
Human   315 TLYSSMLAESELSGWDYEYGFCLPKTPR------------------------------------- 342

  Fly   446 NVRVCDPHGDGISSKLHLLDNQILRGSVWVMASIAVVGNLLVLLGRYFYKSRSNVEHSLYLRHLA 510
                |.|..|..:....::....||..:|::..:|::||:.||......:.:..|...| :.:|:
Human   343 ----CAPEPDAFNPCEDIMGYDFLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFL-MCNLS 402

  Fly   511 ASDFLMGIYLTLIACADISFRGEYIKYEETWRHSGVCAFAGFLSTFSCQSSTLLLTLVTWDRLMS 575
            .:||.||:||.|||..|...:|:|..:...|:....|:.|||.:.|:.:.|...||::|.:|..:
Human   403 FADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCSTAGFFTVFASELSVYTLTVITLERWHT 467

  Fly   576 VTRPLKPRDTEKVRIVLRLLLL---WGISFGLAAAPLLPNPYFGSHFYGNNGVCLSLHIHDPYAK 637
            :|..:  ...:|:|:...:|::   |..|..:|..||:     |...|....:|..:.:....::
Human   468 ITYAI--HLDQKLRLRHAILIMLGGWLFSSLIAMLPLV-----GVSNYMKVSICFPMDVETTLSQ 525

  Fly   638 GWEYSALLFILVNTLSLIFILFSYIRMLQAIRDSGGGMRSTHSGRENVVATRFAIIVTTDCACWL 702
            .:   .|..:::|.::...|...||::..|:|:.  .:.:|:  ::..:|.:.||::.||..|..
Human   526 VY---ILTILILNVVAFFIICACYIKIYFAVRNP--ELMATN--KDTKIAKKMAILIFTDFTCMA 583

  Fly   703 PI--------IVVKLAALSGCEISPDLYAWLAVLVLPVNSALNPVLYTLTTAAFKQQLRRYCHTL 759
            ||        ..|.|..::..::       |.||..|:||..||.||.:.|..|::.........
Human   584 PISFFAISAAFKVPLITVTNSKV-------LLVLFYPINSCANPFLYAIFTKTFQRDFFLLLSKF 641

  Fly   760 PSCSLVNNETRSQTQTAY---------------ESGLSVSLAHLGG 790
            ..|.......|.:..:||               :|.|.:|..|..|
Human   642 GCCKRRAELYRRKDFSAYTSNCKNGFTGSNKPSQSTLKLSTLHCQG 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr4	NP_001285192.1	Ldl_recept_a	87..124	CDD:278486	8/48 (17%)
		LRR_RI	<184..397	CDD:238064	55/230 (24%)
		LRR_8	188..248	CDD:290566	16/63 (25%)
		leucine-rich repeat	188..211	CDD:275380	6/23 (26%)
		leucine-rich repeat	212..235	CDD:275380	6/25 (24%)
		leucine-rich repeat	238..261	CDD:275380	6/22 (27%)
		LRR_8	261..320	CDD:290566	12/62 (19%)
		leucine-rich repeat	262..285	CDD:275380	7/23 (30%)
		LRR_4	284..325	CDD:289563	8/43 (19%)
		leucine-rich repeat	286..309	CDD:275380	5/25 (20%)
		LRR_4	308..348	CDD:289563	10/39 (26%)
		leucine-rich repeat	310..334	CDD:275380	6/23 (26%)
		leucine-rich repeat	335..357	CDD:275380	4/21 (19%)
		LRR_8	356..416	CDD:290566	16/69 (23%)
		leucine-rich repeat	358..381	CDD:275380	8/32 (25%)
		LRR_4	381..421	CDD:289563	8/39 (21%)
		leucine-rich repeat	382..405	CDD:275380	8/22 (36%)
		leucine-rich repeat	406..427	CDD:275380	0/20 (0%)
		7tm_1	483..741	CDD:278431	68/268 (25%)
LHCGR	NP_000224.2	leucine-rich repeat	51..74	CDD:275380	1/22 (5%)
		LRR_5	62..198	CDD:290045	34/153 (22%)
		leucine-rich repeat	75..99	CDD:275380	4/23 (17%)
		LRR 1	96..115		5/18 (28%)
		leucine-rich repeat	100..124	CDD:275380	7/35 (20%)
		LRR 2	124..145		3/20 (15%)
		leucine-rich repeat	125..150	CDD:275380	6/28 (21%)
		LRR 3	149..171		6/21 (29%)
		leucine-rich repeat	151..174	CDD:275380	6/23 (26%)
		leucine-rich repeat	175..198	CDD:275380	6/23 (26%)
		LRR 4	175..196		5/21 (24%)
		LRR 5	198..220		7/21 (33%)
		leucine-rich repeat	199..223	CDD:275380	7/23 (30%)
		LRR 6	223..244		2/20 (10%)
		leucine-rich repeat	224..244	CDD:275380	2/19 (11%)
		7tm_1	376..623	CDD:278431	68/268 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810