DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lgr4 and Rxfp1

DIOPT Version :9

Sequence 1:	NP_001285192.1	Gene:	Lgr4 / 5740505	FlyBaseID:	FBgn0085440	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	NP_997617.1	Gene:	Rxfp1 / 381489	MGIID:	2682211	Length:	758	Species:	Mus musculus

Alignment Length:	729	Identity:	229/729 - (31%)
Similarity:	352/729 - (48%)	Gaps:	75/729 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 DDKCPGGYFHCNTTAQCVPQRANCDGSVDCDDASDEVNCVN------EVDAKYWDHLYRKQPFGR 144
            |..||.|.|.|...::|:||..:|:|..||.:.:||.:|.:      ::| ||:.:.|:......
Mouse    24 DVSCPLGSFPCGNMSRCLPQLLHCNGVDDCGNRADEDHCGDNNGWSLQLD-KYFANYYKLASTNS 87

  Fly   145 HDNLRIGECLWPNENFSCPCRGDEILCRFQQLTDIPERLPQHDLATLDLTGNNFETIHETFFSEL 209
            .: ....|||..:....|.||..|:.|....|..:|.  ...::..:.|..|...|:....|.:.
Mouse    88 FE-AETSECLVGSVPMHCLCRDLELDCDEANLRAVPS--VSSNVTVMSLQRNFIRTLPPNGFRKY 149

  Fly   210 PDVDSLVLKFCSIREIASHAFDRLADNPLRTLYMDDNKLPHLPEHFFPEGNQLSILILARNHLHH 274
            .::..|.|:...|..::..||..|  ..|..||:..|::..|....|.:.::|..||:..|||..
Mouse   150 HELQKLCLQNNRIHSVSVSAFRGL--RSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSR 212

  Fly   275 LKRSDFLNLQ-------------------------KLQELDLRGNRIGNFEAEVFARLPNLEVLY 314
            :....|..|.                         :|..||..||||.|.....|....||.||.
Mouse   213 ISPLTFYGLNSLILLVLMNNALTRLPDKPLCQHMPRLHWLDFEGNRIHNLRNLTFISCNNLTVLV 277

  Fly   315 LNENHLKRLDPDRFPRTLLNLHTLSLAYNQIEDIAANTFPFPRLRYLFLAGNRLSHIRDETFCNL 379
            :.:|.:..|:...|.. |..|..|.|..|:||::..|.|.                       :|
Mouse   278 MRKNKINYLNEHAFTH-LQKLDELDLGSNKIENLPPNIFK-----------------------DL 318

  Fly   380 SNLQGLHLNENRIEGFDLEAFACLKNLSSLLLTGNRFQTLDSRVLKNLTSLDYIYFSWFHLCSAA 444
            ..|..|:::.|.|:..::..|.||..|.||.|.|.....:..|:.:.|.:|.:|||..|..|..|
Mouse   319 KELSQLNISYNPIQKIEVNQFDCLAKLKSLSLEGIEISNIQQRMFRPLINLSHIYFKKFQYCGYA 383

  Fly   445 MNVRVCDPHGDGISSKLHLLDNQILRGSVWVMASIAVVGNLLVLLGRYFYKSRSNVEHSLYLRHL 509
            .:||.|.|:.|||||..:||.:.|.|..|||:::|...||:.|:..|.:.:|.:.: |::.:..|
Mouse   384 PHVRSCKPNTDGISSLENLLASIIQRVFVWVVSAITCFGNIFVICMRPYIRSENKL-HAMSIISL 447

  Fly   510 AASDFLMGIYLTLIACADISFRGEYIKYEETWRHSGVCAFAGFLSTFSCQSSTLLLTLVTWDRLM 574
            ..:|.|||:||.:|...|:.|||||.|:.:.|..|..|.|.|.|:..|.:.|.||||.:|.::.:
Mouse   448 CCADCLMGVYLFVIGAFDLKFRGEYNKHAQPWMESVHCQFMGSLAILSTEVSVLLLTFLTLEKYI 512

  Fly   575 SVTRP---LKPRDTEKVRIVLRLLLLWGISFGLAAAPLLPNPYFGSHFYGNNGVCLSLHIHDPYA 636
            .:..|   |:||   |.|.:..|:.:|.|.|.:|.|| |.|..|..::||.||||..||..|..:
Mouse   513 CIVYPFRCLRPR---KCRTITVLIFIWIIGFIVAFAP-LGNKEFFKNYYGTNGVCFPLHSEDTGS 573

  Fly   637 KGWE-YSALLFILVNTLSLIFILFSYIRMLQAIRDSGGGMRSTHS--GRENVVATRFAIIVTTDC 698
            .|.: ||.::|:.:|.::.|.|:|||..|..::..|...:.....  .:|.|:|.||..||.||.
Mouse   574 TGAQIYSVVIFLGINLVAFIIIVFSYGSMFYSVHQSSVTVTEIQKQVKKEVVLAKRFFFIVFTDA 638

  Fly   699 ACWLPIIVVKLAALSGCEISPDLYAWLAVLVLPVNSALNPVLYTLTTAAFKQQLRRYCHTLPSCS 763
            .||:||.::|..:|...||...:.:|:.:.:||:||||||::|||||..||:.:.:..|......
Mouse   639 LCWIPIFILKFLSLLQVEIPDSITSWVVIFILPINSALNPIIYTLTTRPFKEMIHQLWHNYRQRR 703

  Fly   764 LVNNETRSQTQTAY 777
            .|:   |.:||.||
Mouse   704 SVD---RKETQKAY 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr4	NP_001285192.1	Ldl_recept_a	87..124	CDD:278486	14/36 (39%)
		LRR_RI	<184..397	CDD:238064	54/237 (23%)
		LRR_8	188..248	CDD:290566	14/59 (24%)
		leucine-rich repeat	188..211	CDD:275380	4/22 (18%)
		leucine-rich repeat	212..235	CDD:275380	6/22 (27%)
		leucine-rich repeat	238..261	CDD:275380	6/22 (27%)
		LRR_8	261..320	CDD:290566	22/83 (27%)
		leucine-rich repeat	262..285	CDD:275380	8/47 (17%)
		LRR_4	284..325	CDD:289563	15/65 (23%)
		leucine-rich repeat	286..309	CDD:275380	9/22 (41%)
		LRR_4	308..348	CDD:289563	14/39 (36%)
		leucine-rich repeat	310..334	CDD:275380	7/23 (30%)
		leucine-rich repeat	335..357	CDD:275380	8/21 (38%)
		LRR_8	356..416	CDD:290566	13/59 (22%)
		leucine-rich repeat	358..381	CDD:275380	1/22 (5%)
		LRR_4	381..421	CDD:289563	12/39 (31%)
		leucine-rich repeat	382..405	CDD:275380	7/22 (32%)
		leucine-rich repeat	406..427	CDD:275380	6/20 (30%)
		7tm_1	483..741	CDD:278431	97/263 (37%)
Rxfp1	NP_997617.1	LDLa	27..62	CDD:238060	14/34 (41%)
		leucine-rich repeat	110..127	CDD:275378	4/18 (22%)
		LRR 1	127..148		4/20 (20%)
		leucine-rich repeat	128..151	CDD:275380	4/22 (18%)
		LRR_RI	147..331	CDD:238064	49/209 (23%)
		LRR_8	151..210	CDD:290566	16/60 (27%)
		LRR 2	151..172		5/20 (25%)
		leucine-rich repeat	152..175	CDD:275380	6/24 (25%)
		LRR 3	175..196		6/20 (30%)
		leucine-rich repeat	176..199	CDD:275380	6/22 (27%)
		LRR_8	199..259	CDD:290566	13/59 (22%)
		LRR 4	199..220		7/20 (35%)
		leucine-rich repeat	200..223	CDD:275380	8/22 (36%)
		LRR 5	223..244		0/20 (0%)
		leucine-rich repeat	224..248	CDD:275380	0/23 (0%)
		LRR 6	248..269		9/20 (45%)
		leucine-rich repeat	249..272	CDD:275380	9/22 (41%)
		LRR_8	272..331	CDD:290566	20/82 (24%)
		LRR 7	272..293		7/20 (35%)
		leucine-rich repeat	273..296	CDD:275380	7/23 (30%)
		LRR 8	296..317		8/43 (19%)
		leucine-rich repeat	297..320	CDD:275380	9/45 (20%)
		LRR 9	320..341		5/20 (25%)
		leucine-rich repeat	321..344	CDD:275380	7/22 (32%)
		LRR 10	344..365		6/20 (30%)
		leucine-rich repeat	345..366	CDD:275380	6/20 (30%)
		7tm_1	422..681	CDD:278431	97/263 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H11007
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002061
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101648
Panther	1	1.100	-	-	O	PTHR24372
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1524
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.770