DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lgr4 and Rxfp2

DIOPT Version :9

Sequence 1:	NP_001285192.1	Gene:	Lgr4 / 5740505	FlyBaseID:	FBgn0085440	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	NP_001012493.1	Gene:	Rxfp2 / 363866	RGDID:	1309449	Length:	737	Species:	Rattus norvegicus

Alignment Length:	706	Identity:	240/706 - (33%)
Similarity:	354/706 - (50%)	Gaps:	36/706 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 VISLLGIIDG--AESDILVPDADDKCPGGYFHCNTTAQCVPQRANCDGSVDCDDASDEVNCVNEV 128
            |:.|:.:.|.  |.|:::.|    .||.|||.|....:|:|:..:|||..||.:.:||.||   .
  Rat     7 VVLLMEVKDFTLAGSNMVAP----LCPKGYFPCGNLTKCLPRAFHCDGVDDCGNGADEDNC---G 64

  Fly   129 DAKYWDHLYRKQPFGR-HDNLR----IGECLWPNENFSCPCRGDEILCRFQQLTDIPERLPQHDL 188
            |...|..:     ||. |.|:.    ..||........|.||.:|:.|....|..:|:  ...::
  Rat    65 DTSGWTTI-----FGTVHGNVNKVTLTEECFLSRYPQHCYCRENELECVNADLKAVPK--VSSNV 122

  Fly   189 ATLDLTGNNFETIHETFFSELPDVDSLVLKFCSIREIASHAFDRLADNPLRTLYMDDNKLPHLPE 253
            ..|.|..|....:....||:..::..:.|:...|..|:..||  |..:.|:.||:..|.:..|..
  Rat   123 TLLSLKKNKIHRLPVKVFSKYAELRKIFLQHNCITHISRRAF--LGLHNLQILYLSHNCITSLRP 185

  Fly   254 HFFPEGNQLSILILARNHLHHLKRSDFLNLQKLQELDLRGNRIGNFEAEVFARLPNLEVLYLNEN 318
            ..|.:.:||:.|||..|.:..:.:..|..|..|..|.:..||:......:.|::|.|..:.|..|
  Rat   186 GIFKDLHQLAWLILDDNPITRISQRSFTGLNSLFFLSMVSNRLEALPERLCAQMPQLNWVDLANN 250

  Fly   319 HLKRLDPDRFPRTLLNLHTLSLAYNQIEDIAANTF-PFPRLRYLFLAGNRLSHIRDETFCNLSNL 382
            .:|.:....| .|..:|..|.|..|||..:...|| ....|..|.|:.|.::.:....|.:|..|
  Rat   251 GIKFITNSTF-LTCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNVIAKLPAHLFSDLHLL 314

  Fly   383 QGLHLNENRIEGFDLEAFACLKNLSSLLLTGNRFQTLDSRVLKNLTSLDYIYFSWFHLCSAAMNV 447
            |.|:|:.|.:.......|..||.|.||.|.......:::.:.:.:.:|.:||...|..||...:|
  Rat   315 QKLNLSSNPLLYVHKNQFGSLKQLQSLDLERIEIPNINTGMFRPMKNLSHIYLKTFRYCSYVPHV 379

  Fly   448 RVCDPHGDGISSKLHLLDNQILRGSVWVMASIAVVGNLLVLLGRYFYKSRSNVEHSLYLRHLAAS 512
            |:|.|..|||||...||.|.|||.||||:|.|...||.||:..|...|: .|..|::.::.|..:
  Rat   380 RICMPSTDGISSSEDLLANSILRVSVWVIAFITCAGNFLVIAVRSLIKA-ENTTHAMSIKILCCA 443

  Fly   513 DFLMGIYLTLIACADISFRGEYIKYEETWRHSGVCAFAGFLSTFSCQSSTLLLTLVTWDRLMSVT 577
            |.|||:||..:...||.:||:|.||...|..|..|...|||:|.|.:.|.||||.:|.::.:.:.
  Rat   444 DCLMGVYLFSVGVFDIKYRGQYQKYALLWMESVPCRLLGFLATLSTEVSVLLLTFLTLEKFLVIV 508

  Fly   578 RPLKPRDTEKVRIVLRLLLLWGISFGLAAAPLLPNPYFGSHFYGNNGVCLSLH---IHDPYAKGW 639
            .|.......|.:..:.|..:|...|.:||.|.....||| :|||.||||..||   ..|..::|
  Rat   509 FPFSNLRLGKRQTAVVLASIWVAGFLIAAVPFTSEDYFG-NFYGKNGVCFPLHYDQAEDFGSRG- 571

  Fly   640 EYSALLFILVNTLSLIFILFSYIRMLQAIRDSG---GGMRSTHSGRENVVATRFAIIVTTDCACW 701
             ||..:|:.||.|:.:.|.|||:.|..:|:.:.   ..:|| |.|:|..||.||..||.:|..||
  Rat   572 -YSLGIFLGVNLLAFLVITFSYVTMFCSIQKTALQTAEVRS-HIGKEVAVANRFFFIVFSDAICW 634

  Fly   702 LPIIVVKLAALSGCEISPDLYAWLAVLVLPVNSALNPVLYTLTTAAFKQQLRRYCH 757
            :|:.|||:.:|...||...:.:|:.|..|||||||||:||||||:.||.:|::..|
  Rat   635 IPVFVVKILSLLQVEIPGTITSWIVVFFLPVNSALNPILYTLTTSLFKDKLKQLLH 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr4	NP_001285192.1	Ldl_recept_a	87..124	CDD:278486	15/36 (42%)
		LRR_RI	<184..397	CDD:238064	56/213 (26%)
		LRR_8	188..248	CDD:290566	15/59 (25%)
		leucine-rich repeat	188..211	CDD:275380	5/22 (23%)
		leucine-rich repeat	212..235	CDD:275380	6/22 (27%)
		leucine-rich repeat	238..261	CDD:275380	6/22 (27%)
		LRR_8	261..320	CDD:290566	17/58 (29%)
		leucine-rich repeat	262..285	CDD:275380	7/22 (32%)
		LRR_4	284..325	CDD:289563	10/40 (25%)
		leucine-rich repeat	286..309	CDD:275380	5/22 (23%)
		LRR_4	308..348	CDD:289563	13/39 (33%)
		leucine-rich repeat	310..334	CDD:275380	6/23 (26%)
		leucine-rich repeat	335..357	CDD:275380	8/22 (36%)
		LRR_8	356..416	CDD:290566	18/59 (31%)
		leucine-rich repeat	358..381	CDD:275380	6/22 (27%)
		LRR_4	381..421	CDD:289563	12/39 (31%)
		leucine-rich repeat	382..405	CDD:275380	7/22 (32%)
		leucine-rich repeat	406..427	CDD:275380	4/20 (20%)
		7tm_1	483..741	CDD:278431	102/263 (39%)
Rxfp2	NP_001012493.1	LDLa	28..63	CDD:238060	15/34 (44%)
		leucine-rich repeat	96..121	CDD:275380	7/26 (27%)
		leucine-rich repeat	122..145	CDD:275380	5/22 (23%)
		LRR_RI	134..343	CDD:238064	59/211 (28%)
		LRR_8	145..204	CDD:290566	18/60 (30%)
		leucine-rich repeat	146..169	CDD:275380	6/24 (25%)
		leucine-rich repeat	170..193	CDD:275380	6/22 (27%)
		LRR_8	193..252	CDD:290566	17/58 (29%)
		leucine-rich repeat	194..217	CDD:275380	7/22 (32%)
		leucine-rich repeat	218..241	CDD:275380	5/22 (23%)
		leucine-rich repeat	242..265	CDD:275380	6/23 (26%)
		LRR_8	265..324	CDD:290566	19/58 (33%)
		leucine-rich repeat	266..289	CDD:275380	8/22 (36%)
		leucine-rich repeat	290..313	CDD:275380	6/22 (27%)
		LRR_8	314..367	CDD:290566	14/52 (27%)
		leucine-rich repeat	314..337	CDD:275380	7/22 (32%)
		leucine-rich repeat	338..357	CDD:275380	4/18 (22%)
		7tm_1	415..674	CDD:278431	102/263 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D256258at33208
OrthoFinder	1	1.000	-	-		FOG0002061
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101648
Panther	1	1.100	-	-	O	PTHR24372
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1524
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.780