DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lgr4 and rk

DIOPT Version :10

Sequence 1:NP_001285192.1 Gene:Lgr4 / 5740505 FlyBaseID:FBgn0085440 Length:809 Species:Drosophila melanogaster
Sequence 2:NP_476702.1 Gene:rk / 34819 FlyBaseID:FBgn0003255 Length:1360 Species:Drosophila melanogaster


Alignment Length:825 Identity:184/825 - (22%)
Similarity:299/825 - (36%) Gaps:272/825 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   182 RLPQHDLA------TLDLTGNNFETIHETFFSELPDVDSLVLKFCSIREIASHAFDRLADNPLRT 240
            |:|.:.||      .|:|..|....|::..|..:|::..|:||...|.:|::.|...|  ..|:.
  Fly   289 RIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNL--TALKV 351

  Fly   241 LYMDDNKLPHLPEHFFPEGNQLSILILARNHLHHLKRSDFLNLQKLQELDLRGNRIGNFEAEVF- 304
            |.:|||.:..|||. ..:.:||..|.:..|.|..:..::.  .:.:|.||:|.|.:.......| 
  Fly   352 LELDDNLISSLPEG-LSKLSQLQELSITSNRLRWINDTEL--PRSMQMLDMRANPLSTISPGAFR 413

  Fly   305 --------------------------------------------------------------ARL 307
                                                                          .|:
  Fly   414 GMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRI 478

  Fly   308 PN------LEVLYLNENHLKRLDPDRFPRTLLNLHTLSLAYNQIEDIAANTFP-FPRLRYLFLAG 365
            ||      |.:|.|:.|.::::....| ..|..|:.|.|:||:|:.:..:.|. .|:|:.|.|.|
  Fly   479 PNLSSCRDLRLLDLSSNQIEKIQGKPF-NGLKQLNDLLLSYNRIKALPQDAFQGIPKLQLLDLEG 542

  Fly   366 NRLSHIRDETFCNLSNLQGLHLNEN---RIEGFDLEAFACLKNLSSLLL-------TGNRFQTLD 420
            |.:|:|..|.|...:.|:.|:|..|   .:....|.|...||..::..|       |..|.||| 
  Fly   543 NEISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTFNNPKLREFPPPDTFPRIQTL- 606

  Fly   421 SRVLKNLTSLDYIYFSWFHLC-----------------------------------SAAMNV--- 447
                    .|.|.|    |.|                                   ::.||:   
  Fly   607 --------ILSYAY----HCCAFLPLVAMSSQKKTSQVQEAVLFPSDAEFDMTLWNNSMMNIWPQ 659

  Fly   448 ----------RVCDP------------------------------------------HGDGISSK 460
                      .:.||                                          .|.|:.|.
  Fly   660 MHNLSKQLGASMHDPWETAINFNEEQLQTQTGGQIATSYMEEYFEEHDVSGPATGYGFGTGLFSG 724

  Fly   461 L-----------------------HLLDNQILRGSVWVMASIAVVGNLLVLLGRYFYKSRSNVEH 502
            :                       .|.|...||..|||:..::::||..|:......:|:.:|..
  Fly   725 MSTEDFQPGSVQCLPMPGPFLPCADLFDWWTLRCGVWVVFLLSLLGNGTVVFVLLCSRSKMDVPR 789

  Fly   503 SLYLRHLAASDFLMGIYLTLIACADISFRGEYIKYEETWRHSGVCAFAGFLSTFSCQSSTLLLTL 567
            .| :.:|||:||.|||||.::|..|.:..||:..:...|:.|.:|..:|||:..|.:.|...|.:
  Fly   790 FL-VCNLAAADFFMGIYLGILAIVDAATLGEFRMFAIPWQMSVLCQLSGFLAVLSSELSVYTLAV 853

  Fly   568 VTWDRLMSVTRPLKPRDTEKVRIVLR-----LLLLWGISFGLAAAPLLPNPYFGSHFYGNNGVCL 627
            :|.:|..::|..:....    |:.|:     :.:.|..:..:|..||:     |...|....|||
  Fly   854 ITLERNYAITHAIHLNK----RLSLKQAGYIMSVGWVFALIMALMPLV-----GVSDYRKFAVCL 909

  Fly   628 SLHIHDPYAKGWEYSALLFIL----VNTLSLIFILFSYIRMLQAIRDSGGGMRSTHSGRENVVAT 688
                  |:......::|.:::    :|..:.:.::..|::|..|||  |....:|:..|   :|.
  Fly   910 ------PFETTTGPASLTYVISLMFINGCAFLTLMGCYLKMYWAIR--GSQAWNTNDSR---IAK 963

  Fly   689 RFAIIVTTDCACWLPIIVVKLAALSGCE-ISPDLYAWLAVLVLPVNSALNPVLYTLTTAAFKQQL 752
            |.|::|.||..||.||....:.|:.|.: ||.:......|.|||:||..||.||.:.|..||:..
  Fly   964 RMALLVFTDFLCWSPIAFFSITAIFGLQLISLEQAKIFTVFVLPLNSCCNPFLYAIMTKQFKKDC 1028

  Fly   753 RRYCHTLPSCSLVNNETRSQTQTAYESGLSVSLAHLGGGVGGGSG 797
            ...|.......:|                       |||..||.|
  Fly  1029 VTLCKHFEESRVV-----------------------GGGGPGGRG 1050

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lgr4NP_001285192.1 Ldl_recept_a 87..124 CDD:395011
LRR 167..>430 CDD:443914 76/333 (23%)
leucine-rich repeat 188..211 CDD:275380 7/28 (25%)
leucine-rich repeat 212..235 CDD:275380 7/22 (32%)
leucine-rich repeat 238..261 CDD:275380 8/22 (36%)
leucine-rich repeat 262..285 CDD:275380 4/22 (18%)
leucine-rich repeat 286..309 CDD:275380 7/85 (8%)
leucine-rich repeat 310..334 CDD:275380 6/23 (26%)
leucine-rich repeat 335..357 CDD:275380 7/22 (32%)
leucine-rich repeat 358..381 CDD:275380 9/22 (41%)
leucine-rich repeat 382..405 CDD:275380 7/25 (28%)
leucine-rich repeat 406..427 CDD:275380 6/27 (22%)
7tmA_Relaxin_R 467..752 CDD:320265 86/294 (29%)
TM helix 1 468..494 CDD:320265 8/25 (32%)
TM helix 2 502..527 CDD:320265 12/24 (50%)
TM helix 3 547..577 CDD:320265 9/29 (31%)
TM helix 4 588..610 CDD:320265 5/26 (19%)
TM helix 5 638..667 CDD:320265 4/32 (13%)
TM helix 6 681..711 CDD:320265 11/29 (38%)
TM helix 7 720..745 CDD:320265 10/24 (42%)
rkNP_476702.1 LRR <157..390 CDD:443914 30/103 (29%)
leucine-rich repeat 158..179 CDD:275380
leucine-rich repeat 183..204 CDD:275380
leucine-rich repeat 205..228 CDD:275380
leucine-rich repeat 229..252 CDD:275380
leucine-rich repeat 253..276 CDD:275380
leucine-rich repeat 277..300 CDD:275380 4/10 (40%)
LRR 292..612 CDD:443914 76/334 (23%)
leucine-rich repeat 301..324 CDD:275380 5/22 (23%)
leucine-rich repeat 325..348 CDD:275380 7/24 (29%)
leucine-rich repeat 349..371 CDD:275380 8/22 (36%)
leucine-rich repeat 372..393 CDD:275380 4/22 (18%)
leucine-rich repeat 394..415 CDD:275380 6/20 (30%)
leucine-rich repeat 418..486 CDD:275380 3/67 (4%)
leucine-rich repeat 441..464 CDD:275378 0/22 (0%)
leucine-rich repeat 487..510 CDD:275380 6/23 (26%)
leucine-rich repeat 511..534 CDD:275380 7/22 (32%)
leucine-rich repeat 535..558 CDD:275380 9/22 (41%)
leucine-rich repeat 559..580 CDD:275380 5/20 (25%)
7tmA_Glyco_hormone_R 754..1028 CDD:320264 86/294 (29%)
TM helix 1 755..781 CDD:320264 8/25 (32%)
TM helix 2 788..813 CDD:320264 12/25 (48%)
TM helix 3 833..863 CDD:320264 9/29 (31%)
TM helix 4 875..897 CDD:320264 3/21 (14%)
TM helix 5 918..947 CDD:320264 4/28 (14%)
TM helix 6 956..986 CDD:320264 12/32 (38%)
TM helix 7 996..1021 CDD:320264 10/24 (42%)
Blue background indicates that the domain is not in the aligned region.

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