Protein Alignment Lgr4 and Lgr6

DIOPT Version :10

• Sequence 1: NP_001285192.1
• Gene: Lgr4 / 5740505
• FlyBaseID: FBgn0085440
• Length: 809
• Species: Drosophila melanogaster
• Sequence 2: NP_001405234.1
• Gene: Lgr6 / 329252
• MGIID: 2441805
• Length: 1004
• Species: Mus musculus
• Alignment Length: 896
• Identity: 211/896 - (23%)
• Similarity: 302/896 - (33%)
• Gaps: 299/896 - (33%)

  Fly   104 PQRANC--DG---SVDCDDASDEVNCVNEVD--AKYWD----HLYRKQPFGRHDNLRIGECLWPN 157
            |...:|  ||   |.||.:....| ...::|  ..|.|    :|...|| |...:||..|
Mouse    36 PAPCHCQEDGIMLSADCSELGLSV-VPADLDPLTAYLDLSMNNLTELQP-GLFHHLRFLE----- 93

  Fly   158 ENFSCPCRGDEILCRFQQLTDIPERL--PQHDLATLDLTGNNFETIHETFFSELPDVDSLVLKFC 220
                      |:......|:.||.:.  ..|.|..|.|..|....|......|||.:.||.|...
Mouse    94 ----------ELRLSGNHLSHIPGQAFSGLHSLKILMLQSNQLRGIPAEALWELPSLQSLRLDAN 148

  Fly   221 SIREIASHAFDRLADNPLRTLYMDDNKLPHLPEHFFPEGNQLSILILARNHLHHLKRSDFLNLQK 285
            .|..:...:|:.|:.  ||.|::|||.|..:|.........|..:.||.||:.|:....|.||..
Mouse   149 LISLVPERSFEGLSS--LRHLWLDDNALTEIPVRALNNLPALQAMTLALNHIRHIPDYAFQNLTS 211

  Fly   286 LQELDLRGNRIGNFEAEVFARLPNLEVLY------------------------------------ 314
            |..|.|..|||.:.....|..|.|||.|.
Mouse   212 LVVLHLHNNRIQHVGTHSFEGLHNLETLVFFLFCSPERFLGEPAGEGRCGGGGAAARMKGGRNDR 276

  Fly   315 -LNENHLKRL-----------------------------------------DPDRFP-----RTL 332
             ||.|.|:..                                         :|.:|.     :.|
Mouse   277 DLNYNELQEFPLAIRTLGRLQELGFHNNNIKAIPEKAFMGSPLLQTIHFYDNPIQFVGRSAFQYL 341

  Fly   333 LNLHTLSLAYNQIEDIAANTFP----------------------------FPRLRYLFLA----- 364
            ..||||||  |...||  ..||                            .||||.|.|:
Mouse   342 SKLHTLSL--NGATDI--QEFPDLKGTTSLEILTLTRAGIRLLPPGVCQQLPRLRILELSHNQIE 402

  Fly   365 -----------------GNRLSHIRDETFCNLSNLQGLHLNENRIEGFDLEAFACLKNLSSLLLT 412
                             .||:..|..:||..|.:||.|.|:.|.|.....|||:.|::|..|.||
Mouse   403 ELPSLHRCQKLEEIGLRHNRIKEIGADTFSQLGSLQALDLSWNAIRAIHPEAFSTLRSLVKLDLT 467

  Fly   413 GNRFQTL-------------------------DSRVLKNLTSLDYIY---------------FSW 437
            .|:..||                         ||.....:..:.|.|               ..|
Mouse   468 DNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCAYGICASFFKTSGQW 532

  Fly   438 ----FH-------------------------LCSAAMNVRVCDPHGDGISSKL--------HLLD 465
                ||                         |....|......||.....|.:        ||.:
Mouse   533 QAEDFHPEEEEAPKRPLGLLAGQAENHYDLDLDELQMGTEDSKPHPSVQCSPVPGPFKPCEHLFE 597

  Fly   466 NQILRGSVWVMASIAVVGNLLVLLGRYFYKSRSNVEH-SLYLRHLAASDFLMGIYLTLIACADIS 529
            :..:|.:||.:..::|:.|.|||| ..|....|.:.. .|.:..:|.::.|.||...|:|..|..
Mouse   598 SWGIRLAVWAIVLLSVLCNGLVLL-TVFASGPSPLSPVKLVVGAMAGANALSGISCGLLASVDAL 661

  Fly   530 FRGEYIKYEETWRHSGVCAFAGFLSTFSCQSSTLLLTLVTWDRLMSVT--RPL-KPRDTEKVRI- 590
            ..|::.:|...|.....|...|||:....::|.|||||......:|||  |.. |......||.
Mouse   662 TYGQFAEYGARWESGLGCQATGFLAVLGSEASVLLLTLAAVQCSISVTCVRAYGKAPSPGSVRAG 726

  Fly   591 VLRLLLLWGISFGLAAAPLLPNPYFGSHFYGNNGVCLSLHIHDPYAK--------GWEYSALLFI 647
            .|..|.|    .|||||  ||....|.  ||.:.:||      |||.        |:   |:..:
Mouse   727 ALGCLAL----AGLAAA--LPLASVGE--YGASPLCL------PYAPPEGRPAALGF---AVALV 774

  Fly   648 LVNTLSLIFILFSYIRM--------LQAIRDSGGGMRSTHSGRENVVATRFAIIVTTDCACWLPI 704
            ::|:|..:.:..:||::        .:|:.|.             .:....|.::..|...:.|:
Mouse   775 MMNSLCFLVVAGAYIKLYCDLPRGDFEAVWDC-------------AMVRHVAWLIFADGLLYCPV 826

  Fly   705 IVVKLAALSGC-EISPDLYAWLAVLVLPVNSALNPVLYTLTTAAFKQQLRR 754
            ..:..|::.|. .::|:....:.::|||:.:.|||:||.|....|:..|||
Mouse   827 AFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDLRR 877

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lgr4	NP_001285192.1	Ldl_recept_a	87..124	CDD:395011	8/24 (33%)
		LRR	167..>430	CDD:443914	97/422 (23%)
		leucine-rich repeat	188..211	CDD:275380	7/22 (32%)
		leucine-rich repeat	212..235	CDD:275380	6/22 (27%)
		leucine-rich repeat	238..261	CDD:275380	8/22 (36%)
		leucine-rich repeat	262..285	CDD:275380	9/22 (41%)
		leucine-rich repeat	286..309	CDD:275380	8/22 (36%)
		leucine-rich repeat	310..334	CDD:275380	10/106 (9%)
		leucine-rich repeat	335..357	CDD:275380	11/49 (22%)
		leucine-rich repeat	358..381	CDD:275380	10/44 (23%)
		leucine-rich repeat	382..405	CDD:275380	10/22 (45%)
		leucine-rich repeat	406..427	CDD:275380	9/45 (20%)
		7tmA_Relaxin_R	467..752	CDD:320265	81/306 (26%)
		TM helix 1	468..494	CDD:320265	9/25 (36%)
		TM helix 2	502..527	CDD:320265	7/25 (28%)
		TM helix 3	547..577	CDD:320265	11/29 (38%)
		TM helix 4	588..610	CDD:320265	10/22 (45%)
		TM helix 5	638..667	CDD:320265	6/36 (17%)
		TM helix 6	681..711	CDD:320265	3/29 (10%)
		TM helix 7	720..745	CDD:320265	9/24 (38%)
Lgr6	NP_001405234.1	LRR	<51..350	CDD:443914	74/319 (23%)
		leucine-rich repeat	70..91	CDD:275380	7/21 (33%)
		leucine-rich repeat	92..115	CDD:275380	5/37 (14%)
		leucine-rich repeat	116..139	CDD:275380	7/22 (32%)
		leucine-rich repeat	140..163	CDD:275380	6/22 (27%)
		leucine-rich repeat	164..187	CDD:275380	8/22 (36%)
		leucine-rich repeat	188..211	CDD:275380	9/22 (41%)
		leucine-rich repeat	212..235	CDD:275380	8/22 (36%)
		leucine-rich repeat	236..295	CDD:275380	7/58 (12%)
		LRR	277..>508	CDD:443914	49/234 (21%)
		leucine-rich repeat	296..319	CDD:275380	0/22 (0%)
		leucine-rich repeat	320..341	CDD:275380	2/20 (10%)
		leucine-rich repeat	344..385	CDD:275380	11/44 (25%)
		leucine-rich repeat	391..412	CDD:275380	4/20 (20%)
		leucine-rich repeat	413..436	CDD:275380	6/22 (27%)
		leucine-rich repeat	437..458	CDD:275380	9/20 (45%)
		leucine-rich repeat	461..481	CDD:275380	7/19 (37%)
		7tmA_LGR6	599..875	CDD:320484	81/306 (26%)
		TM helix 1	600..626	CDD:320484	10/26 (38%)
		TM helix 2	634..659	CDD:320484	7/24 (29%)
		TM helix 3	679..709	CDD:320484	11/29 (38%)
		TM helix 4	721..743	CDD:320484	12/27 (44%)
		TM helix 5	765..794	CDD:320484	6/31 (19%)
		TM helix 6	803..833	CDD:320484	4/42 (10%)
		TM helix 7	843..868	CDD:320484	9/24 (38%)