DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lgr4 and Lgr6

DIOPT Version :9

Sequence 1:NP_001285192.1 Gene:Lgr4 / 5740505 FlyBaseID:FBgn0085440 Length:809 Species:Drosophila melanogaster
Sequence 2:NP_001028581.1 Gene:Lgr6 / 329252 MGIID:2441805 Length:967 Species:Mus musculus


Alignment Length:859 Identity:211/859 - (24%)
Similarity:302/859 - (35%) Gaps:262/859 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   104 PQRANC--DG---SVDCDDASDEVNCVNEVD--AKYWD----HLYRKQPFGRHDNLRIGECLWPN 157
            |...:|  ||   |.||.:....| ...::|  ..|.|    :|...|| |...:||..|     
Mouse    36 PAPCHCQEDGIMLSADCSELGLSV-VPADLDPLTAYLDLSMNNLTELQP-GLFHHLRFLE----- 93

  Fly   158 ENFSCPCRGDEILCRFQQLTDIPERL--PQHDLATLDLTGNNFETIHETFFSELPDVDSLVLKFC 220
                      |:......|:.||.:.  ..|.|..|.|..|....|......|||.:.||.|...
Mouse    94 ----------ELRLSGNHLSHIPGQAFSGLHSLKILMLQSNQLRGIPAEALWELPSLQSLRLDAN 148

  Fly   221 SIREIASHAFDRLADNPLRTLYMDDNKLPHLPEHFFPEGNQLSILILARNHLHHLKRSDFLNLQK 285
            .|..:...:|:.|:.  ||.|::|||.|..:|.........|..:.||.||:.|:....|.||..
Mouse   149 LISLVPERSFEGLSS--LRHLWLDDNALTEIPVRALNNLPALQAMTLALNHIRHIPDYAFQNLTS 211

  Fly   286 LQELDLRGNRIGNFEAEVFARLPNLEVLYLNENHLKRL--------------------------- 323
            |..|.|..|||.:.....|..|.|||.|.||.|.|:..                           
Mouse   212 LVVLHLHNNRIQHVGTHSFEGLHNLETLDLNYNELQEFPLAIRTLGRLQELGFHNNNIKAIPEKA 276

  Fly   324 --------------DPDRFP-----RTLLNLHTLSLAYNQIEDIAANTFP--------------- 354
                          :|.:|.     :.|..||||||  |...||  ..||               
Mouse   277 FMGSPLLQTIHFYDNPIQFVGRSAFQYLSKLHTLSL--NGATDI--QEFPDLKGTTSLEILTLTR 337

  Fly   355 -------------FPRLRYLFLA----------------------GNRLSHIRDETFCNLSNLQG 384
                         .||||.|.|:                      .||:..|..:||..|.:||.
Mouse   338 AGIRLLPPGVCQQLPRLRILELSHNQIEELPSLHRCQKLEEIGLRHNRIKEIGADTFSQLGSLQA 402

  Fly   385 LHLNENRIEGFDLEAFACLKNLSSLLLTGNRFQTL-------------------------DSRVL 424
            |.|:.|.|.....|||:.|::|..|.||.|:..||                         ||...
Mouse   403 LDLSWNAIRAIHPEAFSTLRSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPK 467

  Fly   425 KNLTSLDYIY---------------FSW----FH-------------------------LCSAAM 445
            ..:..:.|.|               ..|    ||                         |....|
Mouse   468 LRILEVPYAYQCCAYGICASFFKTSGQWQAEDFHPEEEEAPKRPLGLLAGQAENHYDLDLDELQM 532

  Fly   446 NVRVCDPHGDGISSKL--------HLLDNQILRGSVWVMASIAVVGNLLVLLGRYFYKSRSNVEH 502
            ......||.....|.:        ||.::..:|.:||.:..::|:.|.|||| ..|....|.:..
Mouse   533 GTEDSKPHPSVQCSPVPGPFKPCEHLFESWGIRLAVWAIVLLSVLCNGLVLL-TVFASGPSPLSP 596

  Fly   503 -SLYLRHLAASDFLMGIYLTLIACADISFRGEYIKYEETWRHSGVCAFAGFLSTFSCQSSTLLLT 566
             .|.:..:|.::.|.||...|:|..|....|::.:|...|.....|...|||:....::|.||||
Mouse   597 VKLVVGAMAGANALSGISCGLLASVDALTYGQFAEYGARWESGLGCQATGFLAVLGSEASVLLLT 661

  Fly   567 LVTWDRLMSVT--RPL-KPRDTEKVRI-VLRLLLLWGISFGLAAAPLLPNPYFGSHFYGNNGVCL 627
            |......:|||  |.. |......||. .|..|.|    .|||||  ||....|.  ||.:.:||
Mouse   662 LAAVQCSISVTCVRAYGKAPSPGSVRAGALGCLAL----AGLAAA--LPLASVGE--YGASPLCL 718

  Fly   628 SLHIHDPYAK--------GWEYSALLFILVNTLSLIFILFSYIRM--------LQAIRDSGGGMR 676
                  |||.        |:   |:..:::|:|..:.:..:||::        .:|:.|.     
Mouse   719 ------PYAPPEGRPAALGF---AVALVMMNSLCFLVVAGAYIKLYCDLPRGDFEAVWDC----- 769

  Fly   677 STHSGRENVVATRFAIIVTTDCACWLPIIVVKLAALSGC-EISPDLYAWLAVLVLPVNSALNPVL 740
                    .:....|.::..|...:.|:..:..|::.|. .::|:....:.::|||:.:.|||:|
Mouse   770 --------AMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLL 826

  Fly   741 YTLTTAAFKQQLRR 754
            |.|....|:..|||
Mouse   827 YLLFNPHFRDDLRR 840

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lgr4NP_001285192.1 Ldl_recept_a 87..124 CDD:278486 8/24 (33%)
LRR_RI <184..397 CDD:238064 80/308 (26%)
LRR_8 188..248 CDD:290566 20/59 (34%)
leucine-rich repeat 188..211 CDD:275380 7/22 (32%)
leucine-rich repeat 212..235 CDD:275380 6/22 (27%)
leucine-rich repeat 238..261 CDD:275380 8/22 (36%)
LRR_8 261..320 CDD:290566 24/58 (41%)
leucine-rich repeat 262..285 CDD:275380 9/22 (41%)
LRR_4 284..325 CDD:289563 16/81 (20%)
leucine-rich repeat 286..309 CDD:275380 8/22 (36%)
LRR_4 308..348 CDD:289563 18/85 (21%)
leucine-rich repeat 310..334 CDD:275380 10/69 (14%)
leucine-rich repeat 335..357 CDD:275380 11/49 (22%)
LRR_8 356..416 CDD:290566 27/81 (33%)
leucine-rich repeat 358..381 CDD:275380 10/44 (23%)
LRR_4 381..421 CDD:289563 17/64 (27%)
leucine-rich repeat 382..405 CDD:275380 10/22 (45%)
leucine-rich repeat 406..427 CDD:275380 9/45 (20%)
7tm_1 483..741 CDD:278431 73/279 (26%)
Lgr6NP_001028581.1 LRRNT 34..68 CDD:214470 9/32 (28%)
LRR_4 70..107 CDD:289563 12/52 (23%)
leucine-rich repeat 70..91 CDD:275380 7/21 (33%)
LRR 1 91..112 5/35 (14%)
LRR_8 92..150 CDD:290566 17/72 (24%)
LRR_4 92..131 CDD:289563 11/53 (21%)
leucine-rich repeat 92..115 CDD:275380 5/37 (14%)
LRR 2 115..136 5/20 (25%)
leucine-rich repeat 116..139 CDD:275380 7/22 (32%)
LRR_8 138..198 CDD:290566 19/61 (31%)
LRR 3 139..160 5/20 (25%)
leucine-rich repeat 140..163 CDD:275380 6/22 (27%)
LRR_RI 143..392 CDD:238064 61/254 (24%)
LRR 4 163..186 8/24 (33%)
leucine-rich repeat 164..187 CDD:275380 8/22 (36%)
LRR_8 186..246 CDD:290566 24/59 (41%)
LRR 5 187..208 7/20 (35%)
leucine-rich repeat 188..211 CDD:275380 9/22 (41%)
LRR 6 211..232 7/20 (35%)
leucine-rich repeat 212..235 CDD:275380 8/22 (36%)
LRR 7 235..256 8/20 (40%)
leucine-rich repeat 236..258 CDD:275380 7/21 (33%)
LRR_8 258..314 CDD:290566 9/57 (16%)
LRR 8 258..279 0/20 (0%)
leucine-rich repeat 259..282 CDD:275380 0/22 (0%)
LRR 9 282..302 2/19 (11%)
leucine-rich repeat 283..304 CDD:275380 2/20 (10%)
LRR 10 303..325 12/25 (48%)
LRR_8 305..364 CDD:290566 17/62 (27%)
leucine-rich repeat 307..348 CDD:275380 11/44 (25%)
LRR 11 329..350 0/20 (0%)
LRR 12 353..374 5/20 (25%)
leucine-rich repeat 354..375 CDD:275380 4/20 (20%)
LRR_8 375..434 CDD:290566 21/58 (36%)
LRR 13 375..396 5/20 (25%)
leucine-rich repeat 376..399 CDD:275380 6/22 (27%)
LRR 14 399..420 9/20 (45%)
leucine-rich repeat 400..421 CDD:275380 9/20 (45%)
LRR 15 423..443 7/19 (37%)
leucine-rich repeat 424..444 CDD:275380 7/19 (37%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2087
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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