| Sequence 1: | NP_001285192.1 | Gene: | Lgr4 / 5740505 | FlyBaseID: | FBgn0085440 | Length: | 809 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_775450.2 | Gene: | Lgr4 / 286994 | RGDID: | 628615 | Length: | 951 | Species: | Rattus norvegicus |
| Alignment Length: | 854 | Identity: | 193/854 - (22%) |
|---|---|---|---|
| Similarity: | 294/854 - (34%) | Gaps: | 254/854 - (29%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 162 CPCRGD-EILCRFQQLTDIPE-----------------RLPQHD------LATLDLTGNNFETIH 202
Fly 203 ETFFSELPDVDSLVLKFCSIREIASHAFD--------RLADN--------------PLRTLYMDD 245
Fly 246 NKLPHLPEHFFPEGNQLSILILARNHLHHLKRSDFLNLQKLQELDLRGNRIGNFEAEVFARLPNL 310
Fly 311 EVLYLNENHLKRLDPDRFPR--------------------------------------------- 330
Fly 331 ------TLLNLH-----------------------------------------------TLSLAY 342
Fly 343 NQIED----------------------IAANTFP-FPRLRYLFLAGNRLSHIRDETFCNLSNLQG 384
Fly 385 LHLNENRIEGFDLEAFACLKNLSSLLLTGNRFQTLDSRVLKNLTSLDYIYFSWFHLCSA------ 443
Fly 444 ------------------------AMNVRV-------------CDPHGDGISSKLHLLDNQILRG 471
Fly 472 SVWVMASIAVVGNLLVLLGRYFYKSRSNVEHSLYLRHLAASDFLMGIYLTLIACADISFRGEYIK 536
Fly 537 YEETWRHSGVCAFAGFLSTFSCQSSTLLLTLVTWDRLMSVTRPLKPRDTEKVR--IVLRLLLLWG 599
Fly 600 ISFGLAAAPLLPNPYFGSHFYGNNGVCLSLHIHDPYAKGWEYSALLF----ILVNTLSLIFILFS 660
Fly 661 YIRMLQAIRDSGGGMRSTHSGRENVVATRFAIIVTTDCACWLPIIVVKLAAL-SGCEISPDLYAW 724
Fly 725 LAVLVLPVNSALNPVLYTLTTAAFKQQ---LRRYC---HTLPSCSLVNNETRSQTQTAYESGLSV 783
Fly 784 SLAHLGGGV 792 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Lgr4 | NP_001285192.1 | Ldl_recept_a | 87..124 | CDD:278486 | |
| LRR_RI | <184..397 | CDD:238064 | 77/361 (21%) | ||
| LRR_8 | 188..248 | CDD:290566 | 23/81 (28%) | ||
| leucine-rich repeat | 188..211 | CDD:275380 | 9/22 (41%) | ||
| leucine-rich repeat | 212..235 | CDD:275380 | 7/30 (23%) | ||
| leucine-rich repeat | 238..261 | CDD:275380 | 8/22 (36%) | ||
| LRR_8 | 261..320 | CDD:290566 | 22/58 (38%) | ||
| leucine-rich repeat | 262..285 | CDD:275380 | 8/22 (36%) | ||
| LRR_4 | 284..325 | CDD:289563 | 15/40 (38%) | ||
| leucine-rich repeat | 286..309 | CDD:275380 | 7/22 (32%) | ||
| LRR_4 | 308..348 | CDD:289563 | 21/159 (13%) | ||
| leucine-rich repeat | 310..334 | CDD:275380 | 11/74 (15%) | ||
| leucine-rich repeat | 335..357 | CDD:275380 | 13/91 (14%) | ||
| LRR_8 | 356..416 | CDD:290566 | 18/59 (31%) | ||
| leucine-rich repeat | 358..381 | CDD:275380 | 8/22 (36%) | ||
| LRR_4 | 381..421 | CDD:289563 | 11/39 (28%) | ||
| leucine-rich repeat | 382..405 | CDD:275380 | 5/22 (23%) | ||
| leucine-rich repeat | 406..427 | CDD:275380 | 7/20 (35%) | ||
| 7tm_1 | 483..741 | CDD:278431 | 69/264 (26%) | ||
| Lgr4 | NP_775450.2 | LRRNT | 29..61 | CDD:214470 | 12/51 (24%) |
| LRR 1 | 58..79 | 7/26 (27%) | |||
| leucine-rich repeat | 59..82 | CDD:275380 | 9/22 (41%) | ||
| LRR | <62..301 | CDD:227223 | 84/381 (22%) | ||
| LRR 2 | 82..103 | 5/28 (18%) | |||
| leucine-rich repeat | 83..106 | CDD:275380 | 7/30 (23%) | ||
| LRR 3 | 106..127 | 9/34 (26%) | |||
| leucine-rich repeat | 107..130 | CDD:275380 | 9/36 (25%) | ||
| LRR 4 | 130..151 | 5/20 (25%) | |||
| leucine-rich repeat | 131..154 | CDD:275380 | 6/22 (27%) | ||
| LRR 5 | 154..177 | 7/22 (32%) | |||
| leucine-rich repeat | 155..178 | CDD:275380 | 6/22 (27%) | ||
| LRR 6 | 178..199 | 10/20 (50%) | |||
| leucine-rich repeat | 179..202 | CDD:275380 | 11/73 (15%) | ||
| LRR 7 | 202..223 | 11/89 (12%) | |||
| leucine-rich repeat | 203..226 | CDD:275380 | 14/92 (15%) | ||
| LRR 8 | 226..247 | 6/20 (30%) | |||
| leucine-rich repeat | 227..249 | CDD:275380 | 7/21 (33%) | ||
| LRR 9 | 249..270 | 4/20 (20%) | |||
| leucine-rich repeat | 250..273 | CDD:275380 | 5/22 (23%) | ||
| LRR 10 | 273..294 | 8/20 (40%) | |||
| leucine-rich repeat | 274..295 | CDD:275380 | 8/20 (40%) | ||
| LRR | 275..>465 | CDD:227223 | 53/234 (23%) | ||
| LRR 11 | 320..341 | 4/33 (12%) | |||
| leucine-rich repeat | 321..344 | CDD:275378 | 5/22 (23%) | ||
| LRR 12 | 344..365 | 8/20 (40%) | |||
| LRR_8 | 345..401 | CDD:404697 | 17/55 (31%) | ||
| leucine-rich repeat | 345..366 | CDD:275378 | 8/20 (40%) | ||
| LRR 13 | 366..387 | 3/20 (15%) | |||
| leucine-rich repeat | 367..390 | CDD:275378 | 6/22 (27%) | ||
| LRR 14 | 390..411 | 3/20 (15%) | |||
| leucine-rich repeat | 391..414 | CDD:275378 | 3/22 (14%) | ||
| LRR 15 | 414..435 | 7/20 (35%) | |||
| leucine-rich repeat | 415..427 | CDD:275378 | 4/11 (36%) | ||
| leucine-rich repeat | 436..461 | CDD:275380 | 6/26 (23%) | ||
| 7tmA_LGR4 | 539..812 | CDD:320483 | 31/132 (23%) | ||
| TM helix 1 | 541..565 | CDD:320483 | 4/23 (17%) | ||
| TM helix 2 | 574..595 | CDD:320483 | 6/21 (29%) | ||
| TM helix 3 | 619..641 | CDD:320483 | 7/27 (26%) | ||
| TM helix 4 | 664..680 | CDD:320483 | 193/854 (23%) | ||
| TM helix 5 | 704..727 | CDD:320483 | |||
| TM helix 6 | 746..768 | CDD:320483 | |||
| TM helix 7 | 780..805 | CDD:320483 | |||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E1_KOG2087 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 1 | 1.000 | - | - | ||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| 3 | 2.810 | |||||