DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lgr4 and Fshr

DIOPT Version :9

Sequence 1:	NP_001285192.1	Gene:	Lgr4 / 5740505	FlyBaseID:	FBgn0085440	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	NP_954707.1	Gene:	Fshr / 25449	RGDID:	2632	Length:	692	Species:	Rattus norvegicus

Alignment Length:	687	Identity:	166/687 - (24%)
Similarity:	286/687 - (41%)	Gaps:	123/687 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 CPCRGDEILCRFQQLTDIPERLPQH-----------------------DLATLDLTGNN-FETIH 202
            |.|.....||:..::|:||..||::                       ||..::::.|: .|.|.
  Rat    23 CHCSNRVFLCQDSKVTEIPTDLPRNAIELRFVLTKLRVIPKGSFAGFGDLEKIEISQNDVLEVIE 87

  Fly   203 ETFFSELPDVDSL-VLKFCSIREIASHAFDRLADNPLRTLYMDDNKLPHLPEHFFPEGNQLSILI 266
            ...||.||.:..: :.|..::..|...||..|..  ||.|.:.:..:.|||.....:..|..:|.
  Rat    88 ADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPS--LRYLLISNTGIKHLPAVHKIQSLQKVLLD 150

  Fly   267 LARN-HLHHLKRSDFLNLQKLQELDLRGNRIGNFEAEVFARLPNLEVLYLNENHLKRLDPDRFPR 330
            :..| ::|.:.|:.|:.|              :||:         .:|:|::|.::.:....|..
  Rat   151 IQDNINIHIVARNSFMGL--------------SFES---------VILWLSKNGIEEIHNCAFNG 192

  Fly   331 TLLNLHTLSLAYNQIEDIAANTF---------PFPRLRYLFLAGN---RLSHIRDETFCNLSNLQ 383
            |.|:...|| ..|.:|::..:.|         ...|.:...|..:   .|..:|..:...|..|.
  Rat   193 TQLDELNLS-DNNNLEELPNDVFQGASGPVILDISRTKVHSLPNHGLENLKKLRARSTYRLKKLP 256

  Fly   384 GLHLNENRIEGFDLE------AFACLK-NLSSLLLTGNRF---QTLD--SRVLKNLTSL------ 430
            .|......:|. .|.      |||.|| .:|.|....|:.   |.:|  :::.....||
  Rat   257 NLDKFVTLMEA-SLTYPSHCCAFANLKRQISELHPICNKSILRQDIDDMTQIGDQRVSLIDDEPS 320

  Fly   431 -----DYIYFSW-FHLCSAAMNVRVCDPHGDGISSKLHLLDNQILRGSVWVMASIAVVGNLLVLL 489
                 |.:|..: :.||:..::| .|.|..|..:....::...|||..:|.::.:|:.||..||:
  Rat   321 YGKGSDMMYNEFDYDLCNEVVDV-TCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNTTVLV 384

  Fly   490 GRYFYKSRSNVEHSLYLRHLAASDFLMGIYLTLIACADISFRGEYIKYEETWRHSGVCAFAGFLS 554
            .....:.:..|...| :.:||.:|..:||||.|||..||..:.:|..|...|:....|..|||.:
  Rat   385 VLTTSQYKLTVPRFL-MCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFT 448

  Fly   555 TFSCQSSTLLLTLVTWDRLMSVTRPLKPRDTEKVRIVLRLLLLWGISFGLAAAPLLPNPYFGSHF 619
            .|:.:.|...||.:|.:|..::|..::.....::|....:::| |.:|..|||..   |.||...
  Rat   449 VFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASVMVL-GWTFAFAAALF---PIFGISS 509

  Fly   620 YGNNGVCLSLHIHDPYAKGWEYSALLFILVNTLSLIFILFSYIRMLQAIRDSGGGMRSTHSGREN 684
            |....:||.:.|..|.:   :...:..:::|.|:.:.|...|..:...:|:.    ....|..:.
  Rat   510 YMKVSICLPMDIDSPLS---QLYVMALLVLNVLAFVVICGCYTHIYLTVRNP----TIVSSSSDT 567

  Fly   685 VVATRFAIIVTTDCACWLPI--------IVVKLAALSGCEISPDLYAWLAVLVLPVNSALNPVLY 741
            .:|.|.|.::.||..|..||        :.|.|..:|..:|       |.||..|:||..||.||
  Rat   568 KIAKRMATLIFTDFLCMAPISFFAISASLKVPLITVSKAKI-------LLVLFYPINSCANPFLY 625

  Fly   742 TLTTAAFKQQ----LRRY-CHTLPSCSLVNNETRSQT 773
            .:.|..|::.    |.:: |:.: ...:...||.|.|
  Rat   626 AIFTKNFRRDFFILLSKFGCYEM-QAQIYRTETSSAT 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr4	NP_001285192.1	Ldl_recept_a	87..124	CDD:278486
		LRR_RI	<184..397	CDD:238064	49/250 (20%)
		LRR_8	188..248	CDD:290566	16/61 (26%)
		leucine-rich repeat	188..211	CDD:275380	7/23 (30%)
		leucine-rich repeat	212..235	CDD:275380	5/23 (22%)
		leucine-rich repeat	238..261	CDD:275380	6/22 (27%)
		LRR_8	261..320	CDD:290566	12/59 (20%)
		leucine-rich repeat	262..285	CDD:275380	6/23 (26%)
		LRR_4	284..325	CDD:289563	5/40 (13%)
		leucine-rich repeat	286..309	CDD:275380	2/22 (9%)
		LRR_4	308..348	CDD:289563	10/39 (26%)
		leucine-rich repeat	310..334	CDD:275380	5/23 (22%)
		leucine-rich repeat	335..357	CDD:275380	5/30 (17%)
		LRR_8	356..416	CDD:290566	17/69 (25%)
		leucine-rich repeat	358..381	CDD:275380	4/25 (16%)
		LRR_4	381..421	CDD:289563	14/51 (27%)
		leucine-rich repeat	382..405	CDD:275380	9/29 (31%)
		leucine-rich repeat	406..427	CDD:275380	5/25 (20%)
		7tm_1	483..741	CDD:278431	73/265 (28%)
Fshr	NP_954707.1	LRRNT	23..50	CDD:214470	9/26 (35%)
		LRR 1	49..72		0/22 (0%)
		LRR_8	72..132	CDD:290566	16/61 (26%)
		leucine-rich repeat	72..96	CDD:275380	7/23 (30%)
		LRR 2	73..97		7/23 (30%)
		leucine-rich repeat	97..121	CDD:275380	5/23 (22%)
		LRR 3	98..118		4/19 (21%)
		LRR 4	119..143		7/25 (28%)
		leucine-rich repeat	122..143	CDD:275380	6/20 (30%)
		leucine-rich repeat	144..171	CDD:275380	7/40 (18%)
		LRR 5	144..169		7/38 (18%)
		LRR 6	170..192		6/30 (20%)
		leucine-rich repeat	172..194	CDD:275380	4/30 (13%)
		LRR_8	193..245	CDD:290566	10/52 (19%)
		LRR 7	193..216		7/23 (30%)
		leucine-rich repeat	195..219	CDD:275380	6/24 (25%)
		LRR 8	217..240		2/22 (9%)
		leucine-rich repeat	220..243	CDD:275380	3/22 (14%)
		LRR 9	241..259		4/17 (24%)
		GnHR_trans	282..348	CDD:289164	14/66 (21%)
		7tm_1	378..625	CDD:278431	73/265 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810