DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lgr4 and FSHR

DIOPT Version :9

Sequence 1:NP_001285192.1 Gene:Lgr4 / 5740505 FlyBaseID:FBgn0085440 Length:809 Species:Drosophila melanogaster
Sequence 2:XP_011531035.1 Gene:FSHR / 2492 HGNCID:3969 Length:729 Species:Homo sapiens


Alignment Length:757 Identity:169/757 - (22%)
Similarity:291/757 - (38%) Gaps:183/757 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   162 CPCRGDEILCRFQQLTDIPERLPQH-----------------------DLATLDLTGNN-FETIH 202
            |.|.....||:..::|:||..||::                       ||..::::.|: .|.|.
Human    23 CHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIE 87

  Fly   203 ETFFSELPDVDSL-VLKFCSIREIASHAFDRLADNPLRTLYMDDNKLPHLPEHFFPEGNQLSILI 266
            ...||.||.:..: :.|..::..|...||..|.:  |:.|.:.:..:.|||:.......|..:|.
Human    88 ADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPN--LQYLLISNTGIKHLPDVHKIHSLQKVLLD 150

  Fly   267 LARN-HLHHLKRSDFLNLQKLQELDLRGNRIGNFEAEVFARLPNLEVLYLNENHLKRLDPDRFPR 330
            :..| ::|.::|:.|:.|              :||:         .:|:||:|.::.:....|..
Human   151 IQDNINIHTIERNSFVGL--------------SFES---------VILWLNKNGIQEIHNCAFNG 192

  Fly   331 TLLNLHTLSLAYNQIEDIAANTF------------------------PFPRLRYLFLAGNRLS-- 369
            |.|:...|| ..|.:|::..:.|                        .:|..:.:......||  
Human   193 TQLDELNLS-DNNNLEELPNDVFHGASGPVILNRRTRTPTEPNVLLAKYPSGQGVLEEPESLSSS 256

  Fly   370 ------HIRDETFCNLSNLQGLHLNENRIEGFDLEAFACLKNLSSLL---LT------------- 412
                  .|.......|.||:.|.....    ::|:....|:.|.:|:   ||             
Human   257 IDISRTRIHSLPSYGLENLKKLRARST----YNLKKLPTLEKLVALMEASLTYPSHCCAFANWRR 317

  Fly   413 -------------------------GNRFQTLDSRVLKNLTSLDYIYFSW-FHLCSAAMNVRVCD 451
                                     |.|....:..........|..|..: :.||:..::| .|.
Human   318 QISELHPICNKSILRQEVDYMTQARGQRSSLAEDNESSYSRGFDMTYTEFDYDLCNEVVDV-TCS 381

  Fly   452 PHGDGISSKLHLLDNQILRGSVWVMASIAVVGNLLVLLGRYFYKSRSNVEHSLYLRHLAASDFLM 516
            |..|..:....::...|||..:|.::.:|:.||::||:.....:.:..|...| :.:||.:|..:
Human   382 PKPDAFNPCEDIMGYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFL-MCNLAFADLCI 445

  Fly   517 GIYLTLIACADISFRGEYIKYEETWRHSGVCAFAGFLSTFSCQSSTLLLTLVTWDRLMSVTRPLK 581
            ||||.|||..||..:.:|..|...|:....|..|||.:.|:.:.|...||.:|.:|..::|..::
Human   446 GIYLLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQ 510

  Fly   582 PRDTEKVRIVLRLLLLWGISFGLAAAPLLPNPYFGSHFYGNNGVCLSLHIHDPYAKGWEYSALLF 646
            .....::|....:::: |..|..|||..   |.||...|....:||.:.|..|.::.:..|.|  
Human   511 LDCKVQLRHAASVMVM-GWIFAFAAALF---PIFGISSYMKVSICLPMDIDSPLSQLYVMSLL-- 569

  Fly   647 ILVNTLSLIFILFSYIRMLQAIRDSGGGMRSTHSGRENVVATRFAIIVTTDCACWLPI------- 704
             ::|.|:.:.|...||.:...:|:.    ....|..:..:|.|.|:::.||..|..||       
Human   570 -VLNVLAFVVICGCYIHIYLTVRNP----NIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISA 629

  Fly   705 -IVVKLAALSGCEISPDLYAWLAVLVLPVNSALNPVLYTLTTAAFKQQLRRYCHTLPSC------ 762
             :.|.|..:|..:|       |.||..|:||..||.||.:.|..|:   |.:...|..|      
Human   630 SLKVPLITVSKAKI-------LLVLFHPINSCANPFLYAIFTKNFR---RDFFILLSKCGCYEMQ 684

  Fly   763 -SLVNNETRSQTQTAY------------ESG---LSVSLAHL 788
             .:...||.|.....:            .||   :.|.|:||
Human   685 AQIYRTETSSTVHNTHPRNGHCSSAPRVTSGSTYILVPLSHL 726

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lgr4NP_001285192.1 Ldl_recept_a 87..124 CDD:278486
LRR_RI <184..397 CDD:238064 49/270 (18%)
LRR_8 188..248 CDD:290566 15/61 (25%)
leucine-rich repeat 188..211 CDD:275380 7/23 (30%)
leucine-rich repeat 212..235 CDD:275380 5/23 (22%)
leucine-rich repeat 238..261 CDD:275380 5/22 (23%)
LRR_8 261..320 CDD:290566 13/59 (22%)
leucine-rich repeat 262..285 CDD:275380 6/23 (26%)
LRR_4 284..325 CDD:289563 6/40 (15%)
leucine-rich repeat 286..309 CDD:275380 2/22 (9%)
LRR_4 308..348 CDD:289563 11/39 (28%)
leucine-rich repeat 310..334 CDD:275380 6/23 (26%)
leucine-rich repeat 335..357 CDD:275380 5/45 (11%)
LRR_8 356..416 CDD:290566 15/108 (14%)
leucine-rich repeat 358..381 CDD:275380 4/30 (13%)
LRR_4 381..421 CDD:289563 11/80 (14%)
leucine-rich repeat 382..405 CDD:275380 4/22 (18%)
leucine-rich repeat 406..427 CDD:275380 6/61 (10%)
7tm_1 483..741 CDD:278431 75/265 (28%)
FSHRXP_011531035.1 LRRNT 20..50 CDD:214470 9/26 (35%)
LRR_5 61..216 CDD:290045 40/180 (22%)
leucine-rich repeat 72..96 CDD:275380 7/23 (30%)
leucine-rich repeat 97..121 CDD:275380 5/23 (22%)
leucine-rich repeat 122..143 CDD:275380 5/20 (25%)
leucine-rich repeat 144..172 CDD:275380 8/41 (20%)
leucine-rich repeat 173..194 CDD:275380 5/20 (25%)
leucine-rich repeat 195..216 CDD:275380 6/21 (29%)
leucine-rich repeat 220..246 CDD:275380 1/25 (4%)
leucine-rich repeat 247..277 CDD:275380 6/29 (21%)
GnHR_trans 316..383 CDD:289164 8/67 (12%)
7tm_1 413..660 CDD:278431 75/265 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2087
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.