DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lgr4 and FLRT2

DIOPT Version :9

Sequence 1:	NP_001285192.1	Gene:	Lgr4 / 5740505	FlyBaseID:	FBgn0085440	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	NP_001333072.1	Gene:	FLRT2 / 23768	HGNCID:	3761	Length:	660	Species:	Homo sapiens

Alignment Length:	572	Identity:	116/572 - (20%)
Similarity:	200/572 - (34%)	Gaps:	204/572 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 SCP--CRGDE--ILCRFQQLTDIPERLPQHDLATLDLTGNNFETIHETFFSELPDVDSLVLKFCS 221
            :||  ||.|.  :.|..:.||.:|..:|: .:..|.|..|...  :..|.:||.:|.|
Human    35 ACPSVCRCDRNFVYCNERSLTSVPLGIPE-GVTVLYLHNNQIN--NAGFPAELHNVQS------- 89

  Fly   222 IREIASHAFDRLADNPLRTLYMDDNKLPHLPEHFFPEGNQLSILILARNHLHHLKRSDFLNLQKL 286
                            :.|:|:..|:|...|.: .|:  .:.:|.|..|::..:.|:....|.||
Human    90 ----------------VHTVYLYGNQLDEFPMN-LPK--NVRVLHLQENNIQTISRAALAQLLKL 135

  Fly   287 QELDLRGNRIGNFEAE--VFARLPNLEVLYLNENHLKRLDPDRFPRTLLNLHTLSLAYNQIEDIA 349
            :||.|..|.|.....|  .|....:|::|:|::|||..: |...|   ::|..|.:..|:|..|:
Human   136 EELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSV-PVGLP---VDLQELRVDENRIAVIS 196

  Fly   350 ANTFP-FPRLRYLFLAGNRLSH--IRDETFCNLSNLQ----------------------GLHLNE 389
            ...|. ...|..|.:.||.|::  |.:.||.:|:.|:                      .|:|.:
Human   197 DMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQD 261

  Fly   390 NRIEGFDLEAFACLKNLSSLLLTGNRFQTLDSRVLKNLTSLDYIYF---SWFHLCS--------- 442
            |:|....|.||:.|:.|..|.::.|:.:.|...|..||::|..:..   .||..||
Human   262 NQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLTARNNPWFCDCSIKWVTEWLK 326

  Fly   443 ---AAMNVR--VCD--------------------------------------------------- 451
               :::|||  :|.
Human   327 YIPSSLNVRGFMCQGPEQVRGMAVRELNMNLLSCPTTTPGLPLFTPAPSTASPTTQPPTLSIPNP 391

  Fly   452 -----------------PHGDG-----------ISSKLHLLDNQILRGS------------VWVM 476
                             |..||           |...:|.:::..::.|            .||.
Human   392 SRSYTPPTPTTSKLPTIPDWDGRERVTPPISERIQLSIHFVNDTSIQVSWLSLFTVMAYKLTWVK 456

  Fly   477 ASIAVVGNLL---VLLGRYFYKSRSNVE-HSLY---------LRHLAASDFLMGIYLTLIACADI 528
            ...::||.::   ::.|...:.|..|:| .|.|         ..:.|..|.:         |::.
Human   457 MGHSLVGGIVQERIVSGEKQHLSLVNLEPRSTYRICLVPLDAFNYRAVEDTI---------CSEA 512

  Fly   529 SFRGEYI--------KYEETWRHSGVCAF--AGFLSTFSCQSSTLLLTLVTW 570
            :....|:        .:|:|..||....|  ||.:.........:||::..|
Human   513 TTHASYLNNGSNTASSHEQTTSHSMGSPFLLAGLIGGAVIFVLVVLLSVFCW 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr4	NP_001285192.1	Ldl_recept_a	87..124	CDD:278486
		LRR_RI	<184..397	CDD:238064	57/239 (24%)
		LRR_8	188..248	CDD:290566	11/59 (19%)
		leucine-rich repeat	188..211	CDD:275380	6/22 (27%)
		leucine-rich repeat	212..235	CDD:275380	2/22 (9%)
		leucine-rich repeat	238..261	CDD:275380	6/22 (27%)
		LRR_8	261..320	CDD:290566	18/60 (30%)
		leucine-rich repeat	262..285	CDD:275380	5/22 (23%)
		LRR_4	284..325	CDD:289563	15/42 (36%)
		leucine-rich repeat	286..309	CDD:275380	8/24 (33%)
		LRR_4	308..348	CDD:289563	12/39 (31%)
		leucine-rich repeat	310..334	CDD:275380	8/23 (35%)
		leucine-rich repeat	335..357	CDD:275380	6/22 (27%)
		LRR_8	356..416	CDD:290566	21/83 (25%)
		leucine-rich repeat	358..381	CDD:275380	9/24 (38%)
		LRR_4	381..421	CDD:289563	13/61 (21%)
		leucine-rich repeat	382..405	CDD:275380	9/44 (20%)
		leucine-rich repeat	406..427	CDD:275380	5/20 (25%)
		7tm_1	483..741	CDD:278431	21/111 (19%)
FLRT2	NP_001333072.1	LRRNT	35..66	CDD:214470	10/31 (32%)
		NEL	<54..>265	CDD:330839	59/243 (24%)
		LRR 1	64..85		5/22 (23%)
		leucine-rich repeat	65..86	CDD:275378	6/22 (27%)
		LRR 2	89..109		6/43 (14%)
		leucine-rich repeat	90..110	CDD:275380	6/22 (27%)
		LRR 3	110..131		4/20 (20%)
		leucine-rich repeat	111..134	CDD:275380	5/22 (23%)
		LRR 4	134..155		8/20 (40%)
		leucine-rich repeat	135..160	CDD:275380	8/24 (33%)
		LRR 5	160..181		8/24 (33%)
		leucine-rich repeat	161..181	CDD:275380	8/23 (35%)
		leucine-rich repeat	182..205	CDD:275380	6/22 (27%)
		LRR 6	182..202		6/19 (32%)
		LRR 7	205..225		6/19 (32%)
		leucine-rich repeat	206..231	CDD:275380	9/24 (38%)
		LRR 8	231..252		1/20 (5%)
		leucine-rich repeat	232..253	CDD:275380	1/20 (5%)
		LRR_8	252..311	CDD:316378	16/58 (28%)
		LRR 9	253..274		7/20 (35%)
		leucine-rich repeat	254..277	CDD:275380	8/22 (36%)
		LRR 10	277..298		5/20 (25%)
		leucine-rich repeat	278..301	CDD:275380	7/22 (32%)
		PCC	282..>359	CDD:188093	14/76 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	373..413		1/39 (3%)
		fn3	426..494	CDD:306538	12/67 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000