DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lgr4 and Tshr

DIOPT Version :10

Sequence 1:NP_001285192.1 Gene:Lgr4 / 5740505 FlyBaseID:FBgn0085440 Length:809 Species:Drosophila melanogaster
Sequence 2:NP_035778.3 Gene:Tshr / 22095 MGIID:98849 Length:764 Species:Mus musculus


Alignment Length:762 Identity:179/762 - (23%)
Similarity:301/762 - (39%) Gaps:191/762 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   147 NLRIGECLWPNENFSCPCRGDE---ILCRFQQLTDIPERLPQHDLATLDLTGNNFETIHETFFSE 208
            :||..||..|    .|.|..::   :.|:  :|..||...|  ...||.|...:.:||....||.
Mouse    18 SLRGKECASP----PCECHQEDDFRVTCK--ELHRIPSLPP--STQTLKLIETHLKTIPSLAFSS 74

  Fly   209 LPDVDSLVLKF-CSIREIASHAFDRLAD-------NPLRTLYMDDNKLPHLP-----------EH 254
            ||::..:.|.. .:::.:..|:|..|:.       |.....|:|.:.|..||           ..
Mouse    75 LPNISRIYLSIDATLQRLEPHSFYNLSKMTHIEIRNTRSLTYIDPDALTELPLLKFLGIFNTGLR 139

  Fly   255 FFPEGNQL------SILILARN-HLHHLKRSDFLNL-QKLQELDLRGNRIGNFEAEVFARLPNLE 311
            .||:..::      .||.:..| ::..:..:.|..| .:...|.|..|...:.:...| ....|:
Mouse   140 IFPDLTKIYSTDIFFILEITDNPYMTSVPENAFQGLCNETLTLKLYNNGFTSVQGHAF-NGTKLD 203

  Fly   312 VLYLNEN-HLKRLDPDRF------PRTLLNLHTLSLA-------YNQIEDIAANTFPFPR----L 358
            .:|||:| :|..:|.|.|      | |||::.:.|:.       .:..|.||.:|:...:    |
Mouse   204 AVYLNKNKYLTAIDNDAFGGVYSGP-TLLDVSSTSVTALPSKGLEHLKELIAKDTWTLKKLPLSL 267

  Fly   359 RYLFLAGNRLSHIRDETFCNLSNLQGLHLNENRIEGFDLEAFAC----LKNL----SSLLLTG-- 413
            .:|.|....||:   .:.|....      |:.:|.|. ||:..|    ::||    |..:|.|  
Mouse   268 SFLHLTRADLSY---PSHCCAFK------NQKKIRGI-LESLMCNESSIRNLRQRKSVNILRGPI 322

  Fly   414 ------------------NRFQTLDSRVLKNLTSLDYIYFSW----------------------- 437
                              ::||...|      .|..|::|..                       
Mouse   323 YQEYEEDPGDNSVGYKQNSKFQESPS------NSHYYVFFEEQEDEVVGFGQELKNPQEETLQAF 381

  Fly   438 -----FHLCSAAMNVRVCDPHGDGISSKLHLLDNQILRGSVWVMASIAVVGNLLVLLGRYFYKSR 497
                 :.:|....:: ||.|..|..:....::..:.||..||.::.:|::||:.|||.......:
Mouse   382 ESHYDYTVCGDNEDM-VCTPKSDEFNPCEDIMGYRFLRIVVWFVSLLALLGNIFVLLILLTSHYK 445

  Fly   498 SNVEHSLYLRHLAASDFLMGIYLTLIACADISFRGEYIKYEETWRHSGVCAFAGFLSTFSCQSST 562
            ..|...| :.:||.:||.||:||.|||..|:....||..:...|:....|..|||.:.|:.:.|.
Mouse   446 LTVPRFL-MCNLAFADFCMGVYLLLIASVDLYTHSEYYNHAIDWQTGPGCNTAGFFTVFASELSV 509

  Fly   563 LLLTLVTWDRLMSVTRPLKPRDTEKVRIVLRLLLL---WGISFGLAAAPLLPNPYFGSHFYGNNG 624
            ..||::|.:|..::|..:  |...|:|:.....::   |...|.||..|::     |...|....
Mouse   510 YTLTVITLERWYAITFAM--RLDRKIRLRHAYTIMAGGWVSCFLLALLPMV-----GISSYAKVS 567

  Fly   625 VCLSLHIHDPYAKGWEYSALLFILVNTLSLIFILFSYIRMLQAIRDSGGGMRSTHSGRENVVATR 689
            :||.:....|.|..:   .:|.:|:|.::.:.:...|:::...:|:.....|.    ::..:|.|
Mouse   568 ICLPMDTDTPLALAY---IVLVLLLNVVAFVVVCSCYVKIYITVRNPQYNPRD----KDTKIAKR 625

  Fly   690 FAIIVTTDCACWLPIIVVKLAAL--------SGCEISPDLYAWLAVLVLPVNSALNPVLYTLTTA 746
            .|:::.||..|..||....|:||        :..:|       |.||..|:||..||.||.:.|.
Mouse   626 MAVLIFTDFMCMAPISFYALSALMNKPLITVTNSKI-------LLVLFYPLNSCANPFLYAIFTK 683

  Fly   747 AFKQ-------------------QLRRYCHTLPSCSLVNNETRSQTQ 774
            ||::                   |.:|.|        .||.|..|.|
Mouse   684 AFQRDVFILLSKFGICKRQAQAYQGQRVC--------PNNSTGIQIQ 722

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lgr4NP_001285192.1 Ldl_recept_a 87..124 CDD:395011
LRR 167..>430 CDD:443914 73/338 (22%)
leucine-rich repeat 188..211 CDD:275380 8/22 (36%)
leucine-rich repeat 212..235 CDD:275380 4/23 (17%)
leucine-rich repeat 238..261 CDD:275380 7/33 (21%)
leucine-rich repeat 262..285 CDD:275380 5/30 (17%)
leucine-rich repeat 286..309 CDD:275380 4/22 (18%)
leucine-rich repeat 310..334 CDD:275380 12/30 (40%)
leucine-rich repeat 335..357 CDD:275380 5/28 (18%)
leucine-rich repeat 358..381 CDD:275380 6/22 (27%)
leucine-rich repeat 382..405 CDD:275380 6/26 (23%)
leucine-rich repeat 406..427 CDD:275380 7/44 (16%)
7tmA_Relaxin_R 467..752 CDD:320265 83/314 (26%)
TM helix 1 468..494 CDD:320265 10/25 (40%)
TM helix 2 502..527 CDD:320265 12/24 (50%)
TM helix 3 547..577 CDD:320265 10/29 (34%)
TM helix 4 588..610 CDD:320265 6/24 (25%)
TM helix 5 638..667 CDD:320265 4/28 (14%)
TM helix 6 681..711 CDD:320265 9/29 (31%)
TM helix 7 720..745 CDD:320265 10/24 (42%)
TshrNP_035778.3 leucine-rich repeat 54..77 CDD:275380 8/22 (36%)
LRR_5 65..221 CDD:463839 35/156 (22%)
leucine-rich repeat 78..102 CDD:275380 4/23 (17%)
LRR 1 100..124 5/23 (22%)
leucine-rich repeat 103..127 CDD:275380 5/23 (22%)
LRR 2 125..150 4/24 (17%)
leucine-rich repeat 128..152 CDD:275380 2/23 (9%)
LRR 3 151..174 4/22 (18%)
leucine-rich repeat 153..177 CDD:275380 5/23 (22%)
LRR 4 176..199 4/23 (17%)
leucine-rich repeat 181..201 CDD:275380 4/20 (20%)
LRR 5 200..223 9/22 (41%)
leucine-rich repeat 202..226 CDD:275380 9/23 (39%)
LRR 6 225..248 5/23 (22%)
LRR 7 264..288 6/32 (19%)
7tmA_TSH-R 415..689 CDD:320630 83/295 (28%)
TM helix 1 416..442 CDD:320630 10/25 (40%)
TM helix 2 449..474 CDD:320630 12/25 (48%)
TM helix 3 494..524 CDD:320630 10/29 (34%)
TM helix 4 536..558 CDD:320630 5/21 (24%)
TM helix 5 578..607 CDD:320630 5/31 (16%)
TM helix 6 617..647 CDD:320630 9/33 (27%)
TM helix 7 657..682 CDD:320630 11/31 (35%)
PDZ-binding 762..764
Blue background indicates that the domain is not in the aligned region.

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