DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lgr4 and fshr

DIOPT Version :9

Sequence 1:	NP_001285192.1	Gene:	Lgr4 / 5740505	FlyBaseID:	FBgn0085440	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	NP_001001812.1	Gene:	fshr / 195820	ZFINID:	ZDB-GENE-020423-5	Length:	668	Species:	Danio rerio

Alignment Length:	730	Identity:	166/730 - (22%)
Similarity:	267/730 - (36%)	Gaps:	187/730 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 CLWPNENFSCPCRGDEILCRFQQLTDIPERLPQHDLATLDLTGNNFETIHETFFSELPDVDSLVL 217
            |.:.....|..|.|:::|       :||.|:|.:                 |.|.|:......|.
Zfish    28 CAFNGSTRSFVCLGNKVL-------EIPRRIPTN-----------------TTFVEIKLTQISVF 68

  Fly   218 KFCSIREIASHAFDRLADNPLRTLYMDDNKLPHLPEHFFPEGNQLSILILARNHLHHLKRSDFLN 282
            :..::.|:  |...|                               |::.....|..::...|.|
Zfish    69 RRAALSEL--HELKR-------------------------------IVVSENGALERIEALAFFN 100

  Fly   283 LQKLQELDLRGNRIGNFEAEVFARLPNLEVLYLNENHLKRLDPD--------------------- 326
            |.:|:|:.:..::......:.|.|||.|..|.::...||.| ||
Zfish   101 LTELEEITITKSKNLVMHKDAFWRLPKLRYLTISNTGLKIL-PDFSKINSAALEFLFDLQDNMHI 164

  Fly   327 -RFPR------TLLNLHTLSLAYNQIEDIAANTFPFPRLRYLFLAGN-RLSHIRDETFCNLSNLQ 383
             |.|.      |...:..|.|..|.|.:|.::.|...::..|||.|| :|:||....|
Zfish   165 ERIPSNAFLGLTNATITELRLTKNGIREIDSHAFNGTKIGKLFLMGNQQLNHIHSYAF------- 222

  Fly   384 GLHLNENRIEG---FDLEAFACLKNLSSLLLTGNRFQTLDSRVLKNLTSLDYI------------ 433
                  ...||   .|:...|......|:|.|......:....|:.|.||:..
Zfish   223 ------KGAEGPVVLDISRTAVHTLPESMLKTLKLLMAVSVYSLRKLPSLELFTELTQANLTYPS 281

  Fly   434 -----------------------------YFSWFH-LCSAAMNVRVCDPHGDGISSKLHLLDNQI 468
                                         :|::|: .|...:.| .|.|..|..:....::....
Zfish   282 HCCAFKNFKKHKSVKNQMCNVTGAHEEPDFFNFFNDHCKDVIEV-TCYPTPDAFNPCEDIMGFTF 345

  Fly   469 LRGSVWVMASIAVVGNLLVLLGRYFYKSRSNVEHSLYLRHLAASDFLMGIYLTLIACADISFRGE 533
            ||..:|.::.:|:|||.:|||.....:.:..|...| :.|||.:|..|||||.|||..||..:..
Zfish   346 LRVLIWFISVLAIVGNTVVLLVLLTSRYKLTVPRFL-MCHLAFADLCMGIYLLLIAAVDIHTQSR 409

  Fly   534 YIKYEETWRHSGVCAFAGFLSTFSCQSSTLLLTLVTWDRLMSVTRPLKPRDTEKVRIVLRLLLLW 598
            |..|...|:....|..|||.:.||.:.|...||.:|.:|..::|..::.....::|... |::..
Zfish   410 YYNYGIDWQTGAGCHVAGFFTVFSSELSVYTLTAITLERWHTITYAMQLERQMRLRHAC-LVMAT 473

  Fly   599 GISFGLAAAPLLPNPYFGSHFYGNNGVCLSLHIHDPYAKGWEYSALLFILVNTLSLIFILFSYIR 663
            |..|.|.||.:   |.||...|....:||.:.:....::|:   .:|.:|:|..:.:.:...|..
Zfish   474 GWLFSLLAALM---PMFGVSSYSKTSICLPMDVETLLSQGY---VVLLLLLNAAAFLVVCVCYTL 532

  Fly   664 MLQAIRD-----SGGGMRSTHSGRENVVATRFAIIVTTDCACWLPIIVVKLAALSGCEISPDLYA 723
            :...:|:     :...||         :|.|.|:::.||..|..||....::|.....:....:|
Zfish   533 IYLTVRNPAFVPANADMR---------IAKRMAVLIFTDFLCMAPISFFAISAAFKLPLITASHA 588

  Fly   724 -WLAVLVLPVNSALNPVLYTLTTAAFKQQL-----------RR---YCHTLPSCSLVNNETRSQT 773
             .|.||..|:||..||.||...|..||:..           ||   ||..:.|..  |.......
Zfish   589 KVLLVLFYPINSCSNPFLYAFFTKTFKRDFFILTSRFGCFKRRAHIYCTEISSGQ--NGAVVPSP 651

  Fly   774 QTAYESGLSVSLAHL 788
            :|:  .|...||.|:
Zfish   652 KTS--DGTLYSLVHI 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr4	NP_001285192.1	Ldl_recept_a	87..124	CDD:278486
		LRR_RI	<184..397	CDD:238064	46/244 (19%)
		LRR_8	188..248	CDD:290566	7/59 (12%)
		leucine-rich repeat	188..211	CDD:275380	3/22 (14%)
		leucine-rich repeat	212..235	CDD:275380	4/22 (18%)
		leucine-rich repeat	238..261	CDD:275380	0/22 (0%)
		LRR_8	261..320	CDD:290566	13/58 (22%)
		leucine-rich repeat	262..285	CDD:275380	5/22 (23%)
		LRR_4	284..325	CDD:289563	11/40 (28%)
		leucine-rich repeat	286..309	CDD:275380	5/22 (23%)
		LRR_4	308..348	CDD:289563	15/67 (22%)
		leucine-rich repeat	310..334	CDD:275380	10/51 (20%)
		leucine-rich repeat	335..357	CDD:275380	6/21 (29%)
		LRR_8	356..416	CDD:290566	16/63 (25%)
		leucine-rich repeat	358..381	CDD:275380	9/23 (39%)
		LRR_4	381..421	CDD:289563	7/42 (17%)
		leucine-rich repeat	382..405	CDD:275380	4/25 (16%)
		leucine-rich repeat	406..427	CDD:275380	4/20 (20%)
		7tm_1	483..741	CDD:278431	75/263 (29%)
fshr	NP_001001812.1	leucine-rich repeat	79..103	CDD:275380	6/54 (11%)
		LRR_5	93..224	CDD:290045	34/144 (24%)
		leucine-rich repeat	104..127	CDD:275380	5/22 (23%)
		leucine-rich repeat	128..151	CDD:275380	7/23 (30%)
		leucine-rich repeat	152..177	CDD:275380	2/24 (8%)
		leucine-rich repeat	180..202	CDD:275380	6/21 (29%)
		leucine-rich repeat	203..227	CDD:275380	9/36 (25%)
		leucine-rich repeat	228..251	CDD:275380	5/22 (23%)
		leucine-rich repeat	252..274	CDD:275380	4/21 (19%)
		7tm_1	360..607	CDD:278431	75/263 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810