DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lgr4 and fshr

DIOPT Version :10

Sequence 1:NP_001285192.1 Gene:Lgr4 / 5740505 FlyBaseID:FBgn0085440 Length:809 Species:Drosophila melanogaster
Sequence 2:NP_001001812.1 Gene:fshr / 195820 ZFINID:ZDB-GENE-020423-5 Length:668 Species:Danio rerio


Alignment Length:730 Identity:166/730 - (22%)
Similarity:267/730 - (36%) Gaps:187/730 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   153 CLWPNENFSCPCRGDEILCRFQQLTDIPERLPQHDLATLDLTGNNFETIHETFFSELPDVDSLVL 217
            |.:.....|..|.|:::|       :||.|:|.:                 |.|.|:......|.
Zfish    28 CAFNGSTRSFVCLGNKVL-------EIPRRIPTN-----------------TTFVEIKLTQISVF 68

  Fly   218 KFCSIREIASHAFDRLADNPLRTLYMDDNKLPHLPEHFFPEGNQLSILILARNHLHHLKRSDFLN 282
            :..::.|:  |...|                               |::.....|..::...|.|
Zfish    69 RRAALSEL--HELKR-------------------------------IVVSENGALERIEALAFFN 100

  Fly   283 LQKLQELDLRGNRIGNFEAEVFARLPNLEVLYLNENHLKRLDPD--------------------- 326
            |.:|:|:.:..::......:.|.|||.|..|.::...||.| ||                     
Zfish   101 LTELEEITITKSKNLVMHKDAFWRLPKLRYLTISNTGLKIL-PDFSKINSAALEFLFDLQDNMHI 164

  Fly   327 -RFPR------TLLNLHTLSLAYNQIEDIAANTFPFPRLRYLFLAGN-RLSHIRDETFCNLSNLQ 383
             |.|.      |...:..|.|..|.|.:|.::.|...::..|||.|| :|:||....|       
Zfish   165 ERIPSNAFLGLTNATITELRLTKNGIREIDSHAFNGTKIGKLFLMGNQQLNHIHSYAF------- 222

  Fly   384 GLHLNENRIEG---FDLEAFACLKNLSSLLLTGNRFQTLDSRVLKNLTSLDYI------------ 433
                  ...||   .|:...|......|:|.|......:....|:.|.||:..            
Zfish   223 ------KGAEGPVVLDISRTAVHTLPESMLKTLKLLMAVSVYSLRKLPSLELFTELTQANLTYPS 281

  Fly   434 -----------------------------YFSWFH-LCSAAMNVRVCDPHGDGISSKLHLLDNQI 468
                                         :|::|: .|...:.| .|.|..|..:....::....
Zfish   282 HCCAFKNFKKHKSVKNQMCNVTGAHEEPDFFNFFNDHCKDVIEV-TCYPTPDAFNPCEDIMGFTF 345

  Fly   469 LRGSVWVMASIAVVGNLLVLLGRYFYKSRSNVEHSLYLRHLAASDFLMGIYLTLIACADISFRGE 533
            ||..:|.::.:|:|||.:|||.....:.:..|...| :.|||.:|..|||||.|||..||..:..
Zfish   346 LRVLIWFISVLAIVGNTVVLLVLLTSRYKLTVPRFL-MCHLAFADLCMGIYLLLIAAVDIHTQSR 409

  Fly   534 YIKYEETWRHSGVCAFAGFLSTFSCQSSTLLLTLVTWDRLMSVTRPLKPRDTEKVRIVLRLLLLW 598
            |..|...|:....|..|||.:.||.:.|...||.:|.:|..::|..::.....::|... |::..
Zfish   410 YYNYGIDWQTGAGCHVAGFFTVFSSELSVYTLTAITLERWHTITYAMQLERQMRLRHAC-LVMAT 473

  Fly   599 GISFGLAAAPLLPNPYFGSHFYGNNGVCLSLHIHDPYAKGWEYSALLFILVNTLSLIFILFSYIR 663
            |..|.|.||.:   |.||...|....:||.:.:....::|:   .:|.:|:|..:.:.:...|..
Zfish   474 GWLFSLLAALM---PMFGVSSYSKTSICLPMDVETLLSQGY---VVLLLLLNAAAFLVVCVCYTL 532

  Fly   664 MLQAIRD-----SGGGMRSTHSGRENVVATRFAIIVTTDCACWLPIIVVKLAALSGCEISPDLYA 723
            :...:|:     :...||         :|.|.|:::.||..|..||....::|.....:....:|
Zfish   533 IYLTVRNPAFVPANADMR---------IAKRMAVLIFTDFLCMAPISFFAISAAFKLPLITASHA 588

  Fly   724 -WLAVLVLPVNSALNPVLYTLTTAAFKQQL-----------RR---YCHTLPSCSLVNNETRSQT 773
             .|.||..|:||..||.||...|..||:..           ||   ||..:.|..  |.......
Zfish   589 KVLLVLFYPINSCSNPFLYAFFTKTFKRDFFILTSRFGCFKRRAHIYCTEISSGQ--NGAVVPSP 651

  Fly   774 QTAYESGLSVSLAHL 788
            :|:  .|...||.|:
Zfish   652 KTS--DGTLYSLVHI 664

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lgr4NP_001285192.1 Ldl_recept_a 87..124 CDD:395011
LRR 167..>430 CDD:443914 57/294 (19%)
leucine-rich repeat 188..211 CDD:275380 3/22 (14%)
leucine-rich repeat 212..235 CDD:275380 4/22 (18%)
leucine-rich repeat 238..261 CDD:275380 0/22 (0%)
leucine-rich repeat 262..285 CDD:275380 5/22 (23%)
leucine-rich repeat 286..309 CDD:275380 5/22 (23%)
leucine-rich repeat 310..334 CDD:275380 10/51 (20%)
leucine-rich repeat 335..357 CDD:275380 6/21 (29%)
leucine-rich repeat 358..381 CDD:275380 9/23 (39%)
leucine-rich repeat 382..405 CDD:275380 4/25 (16%)
leucine-rich repeat 406..427 CDD:275380 4/20 (20%)
7tmA_Relaxin_R 467..752 CDD:320265 85/290 (29%)
TM helix 1 468..494 CDD:320265 10/25 (40%)
TM helix 2 502..527 CDD:320265 13/24 (54%)
TM helix 3 547..577 CDD:320265 11/29 (38%)
TM helix 4 588..610 CDD:320265 7/21 (33%)
TM helix 5 638..667 CDD:320265 5/28 (18%)
TM helix 6 681..711 CDD:320265 8/29 (28%)
TM helix 7 720..745 CDD:320265 11/25 (44%)
fshrNP_001001812.1 LRR <41..282 CDD:443914 60/311 (19%)
leucine-rich repeat 79..103 CDD:275380 6/54 (11%)
leucine-rich repeat 104..127 CDD:275380 5/22 (23%)
leucine-rich repeat 128..151 CDD:275380 7/23 (30%)
leucine-rich repeat 152..177 CDD:275380 2/24 (8%)
leucine-rich repeat 180..202 CDD:275380 6/21 (29%)
leucine-rich repeat 203..227 CDD:275380 9/36 (25%)
leucine-rich repeat 228..251 CDD:275380 5/22 (23%)
leucine-rich repeat 252..274 CDD:275380 4/21 (19%)
7tmA_Glyco_hormone_R 345..618 CDD:320264 85/289 (29%)
TM helix 1 345..371 CDD:320264 10/25 (40%)
TM helix 2 378..403 CDD:320264 13/25 (52%)
TM helix 3 423..453 CDD:320264 11/29 (38%)
TM helix 4 465..487 CDD:320264 8/25 (32%)
TM helix 5 507..536 CDD:320264 5/31 (16%)
TM helix 6 546..576 CDD:320264 10/38 (26%)
TM helix 7 586..611 CDD:320264 11/24 (46%)
Blue background indicates that the domain is not in the aligned region.

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