DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lgr4 and lron-14

DIOPT Version :9

Sequence 1:	NP_001285192.1	Gene:	Lgr4 / 5740505	FlyBaseID:	FBgn0085440	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	NP_001255400.1	Gene:	lron-14 / 188075	WormBaseID:	WBGene00011454	Length:	747	Species:	Caenorhabditis elegans

Alignment Length:	334	Identity:	86/334 - (25%)
Similarity:	133/334 - (39%)	Gaps:	61/334 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 FSCP----CRGD-------EILCRFQQLTDIPERLPQHDLA-TLDLT----GNNFETIHETFFSE 208
            |.||    |..|       .::|:::||.....:|.:.||. ||.:.    .....|...:.|..
Worm    28 FPCPTRCQCYADNEQNQQVHLICKWEQLNVTTLQLARPDLVRTLTIKCPYHSPKVSTPPHSLFQG 92

  Fly   209 LPDVDSLVLKFCSIREIASHAFDRLADNPLRTLYMDDNKLPHLPEHFFPEGNQLSILILARNHLH 273
            ..::|.|.|..|.|..:....|..|..  |.:|.:.:.|:...|...|.....|..|.|:.|.|
Worm    93 FRNLDRLELDRCLIDTVPEGLFAGLGQ--LYSLIVKNAKITDFPREIFAHVPNLMTLDLSGNRL- 154

  Fly   274 HLKRSDFLNLQKLQELDLRGNRIGNFEAEVFARLPNLEVLYLNENHLKRLDPDRFPRTLL----- 333
            .::.....:||.|..||:..|.|| |.......|..|:|:.:|.|.:..:|..|||..|.
Worm   155 RIEPYSLRSLQNLIHLDVSDNDIG-FLTNTLISLTKLKVITMNNNKITNIDFRRFPENLTDLSIR 218

  Fly   334 ---------------NLHTLSLAYNQIEDI------AANTFPFPRLRYLFLAGNRLSHIRDETFC 377
                           ||..|.||.|::|.:      |.|..| ..|:::.|:.|:|:::.|..|.
Worm   219 HNLVSTIHYVPASARNLKRLDLAGNRMEFVGGLTTGAVNVLP-AELKHVDLSNNKLTYLHDHAFE 282

  Fly   378 NLSNLQGLHLNENRIEGFDLEAFACLKNLSSLLLTGNRFQTLDSRVLKNLTSLDYIYFSWFHLCS 442
            :|:||..|.|..|           .||.:.|....|::||.  ...|.....|.:....|. :.|
Worm   283 HLTNLILLDLKNN-----------SLKEVKSSSFAGSKFQV--KLFLSENPLLCHCNHKWL-MDS 333

  Fly   443 AAMNVRVCD 451
            :|.|:.:.|
Worm   334 SAKNISIGD 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr4	NP_001285192.1	Ldl_recept_a	87..124	CDD:278486
		LRR_RI	<184..397	CDD:238064	64/243 (26%)
		LRR_8	188..248	CDD:290566	14/64 (22%)
		leucine-rich repeat	188..211	CDD:275380	5/27 (19%)
		leucine-rich repeat	212..235	CDD:275380	7/22 (32%)
		leucine-rich repeat	238..261	CDD:275380	5/22 (23%)
		LRR_8	261..320	CDD:290566	19/58 (33%)
		leucine-rich repeat	262..285	CDD:275380	6/22 (27%)
		LRR_4	284..325	CDD:289563	13/40 (33%)
		leucine-rich repeat	286..309	CDD:275380	8/22 (36%)
		LRR_4	308..348	CDD:289563	16/59 (27%)
		leucine-rich repeat	310..334	CDD:275380	9/43 (21%)
		leucine-rich repeat	335..357	CDD:275380	9/27 (33%)
		LRR_8	356..416	CDD:290566	16/59 (27%)
		leucine-rich repeat	358..381	CDD:275380	7/22 (32%)
		LRR_4	381..421	CDD:289563	11/39 (28%)
		leucine-rich repeat	382..405	CDD:275380	5/22 (23%)
		leucine-rich repeat	406..427	CDD:275380	5/20 (25%)
		7tm_1	483..741	CDD:278431
lron-14	NP_001255400.1	leucine-rich repeat	98..119	CDD:275380	6/20 (30%)
		LRR_8	119..177	CDD:290566	16/60 (27%)
		leucine-rich repeat	120..143	CDD:275380	5/22 (23%)
		LRR_RI	142..389	CDD:238064	59/218 (27%)
		leucine-rich repeat	144..166	CDD:275380	6/22 (27%)
		leucine-rich repeat	167..189	CDD:275380	8/22 (36%)
		leucine-rich repeat	190..211	CDD:275380	8/20 (40%)
		leucine-rich repeat	212..234	CDD:275380	1/21 (5%)
		leucine-rich repeat	235..261	CDD:275380	9/26 (35%)
		LRR_8	262..321	CDD:290566	19/71 (27%)
		leucine-rich repeat	263..286	CDD:275380	7/22 (32%)
		leucine-rich repeat	287..310	CDD:275380	8/33 (24%)
		leucine-rich repeat	349..404	CDD:275380
		LRR_8	456..515	CDD:290566
		leucine-rich repeat	458..481	CDD:275380
		LRR_4	481..520	CDD:289563
		leucine-rich repeat	482..504	CDD:275380
		leucine-rich repeat	505..526	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24372
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100