DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lgr4 and Lhcgr

DIOPT Version :10

Sequence 1:NP_001285192.1 Gene:Lgr4 / 5740505 FlyBaseID:FBgn0085440 Length:809 Species:Drosophila melanogaster
Sequence 2:NP_038610.1 Gene:Lhcgr / 16867 MGIID:96783 Length:700 Species:Mus musculus


Alignment Length:799 Identity:174/799 - (21%)
Similarity:304/799 - (38%) Gaps:189/799 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    62 PVREVISLLGIIDGAESDILVPD-ADDKCPGGYFHCNTTAQCVPQRANCDGSVDC---------- 115
            |....:.:|.::...:|.:..|: :..:||       ....|.|     ||::.|          
Mouse     6 PALRQLLVLAMLVLKQSQLHSPELSGSRCP-------EPCDCAP-----DGALRCPGPRAGLARL 58

  Fly   116 -----------DDASDEVNCVNEVDAKYWDHLYRKQPFGRHDNLRIGECLWPNENFSCPCRGDEI 169
                       ..|...:|.|.:::....|.|.|.:.....:.|.:.|.|..|..       :.:
Mouse    59 SLTYLPVKVIPSQAFRGLNEVVKIEISQSDSLERIEANAFDNLLNLSEILIQNTK-------NLL 116

  Fly   170 LCRFQQLTDIPERLPQHDLATLDLTGNNFETIHETFFSELPDVDSL-------VLKFCS---IRE 224
            .......|::| ||             .:.:|..|....||||..:       :|:.|.   |..
Mouse   117 YIEPGAFTNLP-RL-------------KYLSICNTGIRTLPDVSKISSSEFNFILEICDNLYITT 167

  Fly   225 IASHAFDRLADNPLRTLYMDDNKLPHLPEHFFPEGNQLSILILARN-HLHHLKRSDF-------- 280
            |..:||..: :|...||.:..|....:..|.| .|..|..|.|..| :|..:....|        
Mouse   168 IPGNAFQGM-NNESITLKLYGNGFEEVQSHAF-NGTTLISLELKENIYLEKMHSGTFQGATGPSI 230

  Fly   281 --LNLQKLQELDLRGNRIGNFEAEVFARLPNLEVLYLNENHLKRLDPDRFPRTLLNLHTLSLAYN 343
              ::..|||.|...|             |.:::.|....::..:..|.|...|.|.:.||     
Mouse   231 LDVSSTKLQALPSHG-------------LESIQTLIATSSYSLKTLPSREKFTSLLVATL----- 277

  Fly   344 QIEDIAANTFPFPRLRYLFLAGNRLSHIRDETFCNLSNLQGLHLNENRIEGFDLEAFACLKNLS- 407
                    |:|              ||.     |...||      ..:.:.|   :|:..:|.| 
Mouse   278 --------TYP--------------SHC-----CAFRNL------PKKEQNF---SFSIFENFSK 306

  Fly   408 ---SLLLTGNRFQTLDSRVLK--NLTSLDYIYFSWFHLCSAAMNVRVCDPHGDGISSKLHLLDNQ 467
               |.:...|. :||.|.:.:  .|:..||.|    ..||.  ....|.|..|..:....::...
Mouse   307 QCESTVREANN-ETLYSAIFEENELSGWDYDY----DFCSP--KTLQCTPEPDAFNPCEDIMGYA 364

  Fly   468 ILRGSVWVMASIAVVGNLLVLLGRYFYKSRSNVEHSLYLRHLAASDFLMGIYLTLIACADISFRG 532
            .||..:|::..:|:.|||.||......:.:..|...| :.:|:.:||.||:||.|||..|...:|
Mouse   365 FLRVLIWLINILAIFGNLTVLFVLLTSRYKLTVPRFL-MCNLSFADFCMGLYLLLIASVDSQTKG 428

  Fly   533 EYIKYEETWRHSGVCAFAGFLSTFSCQSSTLLLTLVTWDRLMSVTRPLKPRDTEKVRIVLRLLL- 596
            :|..:...|:....|:.|||.:.|:.:.|...||::|.:|..::|..::.....::|..:.::| 
Mouse   429 QYYNHAIDWQTGSGCSAAGFFTVFASELSVYTLTVITLERWHTITYAVQLDQKLRLRHAIPIMLG 493

  Fly   597 LWGISFGLAAAPLLPNPYFGSHFYGNNGVCLSLHIHDPYAKGWEYSALLFILVNTLSLIFILFSY 661
            .|..|..:|..||:     |...|....:||.:.:....::.:   .|..:|:|.::.:.|...|
Mouse   494 GWIFSTLMATLPLV-----GVSSYMKVSICLPMDVESTLSQVY---ILSILLLNAVAFVVICACY 550

  Fly   662 IRMLQAIRDSGGGMRSTHSGRENVVATRFAIIVTTDCACWLPI--------IVVKLAALSGCEIS 718
            :|:..|:::.    ..|...::..:|.:.||::.||..|..||        ..|.|..::..:: 
Mouse   551 VRIYFAVQNP----ELTAPNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKV- 610

  Fly   719 PDLYAWLAVLVLPVNSALNPVLYTLTTAAFKQQ----LRRY--C---------HTLPSCSLVNNE 768
                  |.||..||||..||.||.:.|.||::.    |.|:  |         ....:|:..:..
Mouse   611 ------LLVLFYPVNSCANPFLYAVFTKAFQRDFFLLLSRFGCCKHRAELYRRKEFSACTFNSKN 669

  Fly   769 TRSQTQTAYESGLSVSLAH 787
            ...::....::.|.:|:.|
Mouse   670 GFPRSSKPSQAALKLSIVH 688

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lgr4NP_001285192.1 Ldl_recept_a 87..124 CDD:395011 8/57 (14%)
LRR 167..>430 CDD:443914 59/289 (20%)
leucine-rich repeat 188..211 CDD:275380 3/22 (14%)
leucine-rich repeat 212..235 CDD:275380 7/32 (22%)
leucine-rich repeat 238..261 CDD:275380 6/22 (27%)
leucine-rich repeat 262..285 CDD:275380 6/33 (18%)
leucine-rich repeat 286..309 CDD:275380 5/22 (23%)
leucine-rich repeat 310..334 CDD:275380 4/23 (17%)
leucine-rich repeat 335..357 CDD:275380 4/21 (19%)
leucine-rich repeat 358..381 CDD:275380 3/22 (14%)
leucine-rich repeat 382..405 CDD:275380 3/22 (14%)
leucine-rich repeat 406..427 CDD:275380 6/26 (23%)
7tmA_Relaxin_R 467..752 CDD:320265 79/297 (27%)
TM helix 1 468..494 CDD:320265 9/25 (36%)
TM helix 2 502..527 CDD:320265 11/24 (46%)
TM helix 3 547..577 CDD:320265 10/29 (34%)
TM helix 4 588..610 CDD:320265 6/22 (27%)
TM helix 5 638..667 CDD:320265 6/28 (21%)
TM helix 6 681..711 CDD:320265 10/37 (27%)
TM helix 7 720..745 CDD:320265 11/24 (46%)
LhcgrNP_038610.1 LRR 1 52..75 1/22 (5%)
leucine-rich repeat 55..78 CDD:275380 1/22 (5%)
LRR_5 66..204 CDD:463839 33/160 (21%)
leucine-rich repeat 79..103 CDD:275380 4/23 (17%)
leucine-rich repeat 104..128 CDD:275380 5/31 (16%)
LRR 2 126..150 9/37 (24%)
leucine-rich repeat 129..150 CDD:275380 7/33 (21%)
leucine-rich repeat 155..178 CDD:275380 6/23 (26%)
LRR 3 176..200 6/25 (24%)
leucine-rich repeat 180..202 CDD:275380 6/22 (27%)
leucine-rich repeat 203..227 CDD:275380 6/23 (26%)
LRR 4 225..248 6/35 (17%)
leucine-rich repeat 228..248 CDD:275380 6/32 (19%)
7tmA_LHCGR 365..638 CDD:320481 79/292 (27%)
TM helix 1 365..391 CDD:320481 9/25 (36%)
TM helix 2 398..423 CDD:320481 11/25 (44%)
TM helix 3 443..473 CDD:320481 10/29 (34%)
TM helix 4 485..507 CDD:320481 6/21 (29%)
TM helix 5 527..556 CDD:320481 6/31 (19%)
TM helix 6 566..596 CDD:320481 8/29 (28%)
TM helix 7 606..631 CDD:320481 11/31 (35%)

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